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Total 3346 results found since Jan 2013.

The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.
CONCLUSIONS In patients with acute ischemic stroke, mechanical cerebral artery thrombectomy resulted in a good clinical outcome in 47% of cases, with and without intravenous thrombolysis therapy. PMID: 29887594 [PubMed - in process]
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Relation Between Asymmetry of Prefrontal Activity and Autonomic Nervous System in Post-stroke Patients with a Disorder of Consciousness.
Authors: Moriya M, Sakatani K Abstract Early mobilization and rehabilitation of stroke patients can improve functional recovery. However, effects of mobilization on the responses of the autonomic nervous system (ANS) and emotions in post-stroke patients are not yet clear, particularly in patients with disorders of consciousness. We evaluated the effects of standing load on the ANS and emotions of post-stroke patients (n = 8, 70.8 ± 11.8 years) with a disorder of consciousness by measuring the prefrontal cortex (PFC) activity, which plays important roles in regulation of the ANS and emotions. Employing near infr...
Source: Advances in Experimental Medicine and Biology - September 6, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Is the 1298A & gt;C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis
In conclusion, the 1298A>C polymorphism in theMTHFR gene is not a risk factor for ischaemic stroke in paediatric patients.
Source: Clinical and Experimental Medicine - August 1, 2018 Category: Research Source Type: research

Application of Muse Cell Therapy to Stroke.
Authors: Niizuma K, Borlongan CV, Tominaga T Abstract Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. The number of stroke patients is increasing, and stroke represents a serious problem from the viewpoint of the national medical economy. Even with the current sophisticated treatments, more ...
Source: Advances in Experimental Medicine and Biology - November 30, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

T-lymphocyte subsets as a predictive biomarker for stroke-associated pneumonia.
Authors: Feng HX, Cheng Y, Zhu W, Jiang LL, Dong XF, Gui Q, Wu GH, Xu QR, Shen MQ, Cheng QZ Abstract The aim of this study was to facilitate the clinical treatment and prognosis of stroke-associated pneumonia (SAP) by examining changes in T-lymphocyte subsets. Stroke patients admitted in Suzhou Hospital between 2014 and 2016 participated in the study. Patients were divided into a pneumonia group (50 patients) and a non-pneumonia group (254 patients) based on a diagnosis of pneumonia. Information regarding risk factors for ischemic stroke was collected from all patients using a questionnaire. Compared with non-SAP p...
Source: American Journal of Translational Research - January 24, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Translation and Initial Validation of the Chinese Version of the Action Research Arm Test in People with Stroke.
Conclusions: The C-ARAT demonstrated excellent internal consistency and good-to-excellent concurrent validity. This test could be used to evaluate upper extremity function in stroke patients without cognitive impairment. PMID: 30805366 [PubMed - in process]
Source: Biomed Res - February 28, 2019 Category: Research Authors: Zhao JL, Chen PM, Li WF, Bian RH, Ding MH, Li H, Lin Q, Xu ZQ, Mao YR, Huang DF Tags: Biomed Res Int Source Type: research

ALDH2 and Stroke: A Systematic Review of the Evidence.
Authors: Xu H, Zhang Y, Ren J Abstract Cerebral stroke is one of the leading causes of mortality and disability worldwide. The prevalence of cerebral stroke is the result of the synergistic effect of genetic susceptibility and numerous vascular risk factors, including hypertension, diabetes, excessive alcohol intake, obesity, and dyslipidemia. Mitochondrial aldehyde dehydrogenase (ALDH2) is a vital enzyme metabolizing various acetaldehyde and toxic aldehydes. The ALDH2 enzymatic activity is severely decreased in the individuals with ALDH2*2 gene mutation, especially in East Asians. Increasing epidemiological survey...
Source: Advances in Experimental Medicine and Biology - August 2, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Role of Glial Fibrillary Acidic protein as a biomarker in differentiating intracerebral hemorrhage from ischemic stroke and stroke mimics: A meta-analysis.
Conclusion: Our meta-analysis suggests that GFAP has a promising diagnostic accuracy for the differentiation of ICH from IS and mimics. Further, phase II and phase III diagnostic test studies are required to validate the findings before using GFAP as a blood based biomarker for clinical use.Trial Registration: This study was registered in OSF registries 10.17605/OSF.IO/B9JP4. PMID: 31702405 [PubMed - as supplied by publisher]
Source: Biomarkers - November 10, 2019 Category: Research Tags: Biomarkers Source Type: research

Neuropathic pain releasing calcitonin gene related peptide protects against stroke in rats.
Authors: Wang Y, Liu Z, Ge X, Hu X, Cao X, Li L, Xia J, Li F, Gao L Abstract Neuropathic pain (NPP) is deemed as a potential risk of stroke; however, recent pieces of evidence showed that calcitonin gene-related peptide is involving in pain progression as well as organ protection. The mechanisms underlying the neuroprotection of calcitonin gene-related peptide are yet poorly described with respect to stroke. The present study showed that the elevated level of calcitonin gene-related peptide-induced by NPP exerts a protective effect against stroke in rats, which was further confirmed in vivo and vitro via mitigation...
Source: American Journal of Translational Research - February 15, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Virtual Reality Design for Stroke Rehabilitation.
Authors: Charles D, Holmes D, Charles T, McDonough S Abstract Stroke is a leading cause of disability, and with the stroke survivor population rising in most countries it is increasingly difficult to provide optimal treatment to patients once they return home. Assistive technology solutions can potentially contribute to meeting demand, and also be cost effective. In this chapter, we consider the design and development of engaging serious virtual reality (VR) games for upper arm stroke rehabilitation. Fundamental design principles are summarised and related to our experience of creating game-based VR rehabilitation....
Source: Advances in Experimental Medicine and Biology - June 4, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Development of a three-channel automatic climbing training system for rat rehabilitation after ischemic stroke.
Abstract This paper reports the development of a three-channel automatic speed-matching climbing training system that could train three rats at the same time for rehabilitation after an ischemic stroke. An infrared (IR) remote sensor was installed at the end of each channel to monitor the real-time position of a climbing rat. This research was carried out in five stages: i) system design; ii) hardware circuit; iii) running speed control; iv) functional testing; and v) verification using an animal model of cerebral stroke. The rehabilitated group significantly outperformed the middle cerebral artery occlusion (MCAo...
Source: Braz J Med Biol Res - June 21, 2020 Category: Research Authors: Chen CC, Chang CP Tags: Braz J Med Biol Res Source Type: research

Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis.
CONCLUSIONS Silencing of SNHG15 led to CXCL13 upregulation through sequestering miR-18a and the following ERK/MEK activation, thus enhancing viability while reducing apoptosis of N2a cells. SNHG15 may serve as a novel target for ischemic stroke treatment. PMID: 32862188 [PubMed - in process]
Source: Medical Science Monitor - September 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Patent foramen ovale closure in the management of cryptogenic stroke: a review of current literature and guideline statements.
CONCLUSION: PFO closure can be considered for the prevention of recurrent cryptogenic stroke in patients aged ≤60 years after a thorough evaluation and discussion about benefits and potential risks (including but not limited to atrial fibrillation) of the procedure. Accumulating evidence supports prognostic, quality of life, and economic benefit from percutaneous PFO closure with newer generation closure devices in the right subset of patients. PMID: 33460329 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Dynamic Structural and Functional Reorganizations Following Motor Stroke
CONCLUSIONS Our results show dynamic structural and functional reorganizations following motor stroke, and structure reorganization may be more related to motor recovery at the late subacute phase. These results may play a role in guiding neurological rehabilitation.PMID:33707406 | DOI:10.12659/MSM.929092
Source: Medical Science Monitor - March 12, 2021 Category: Research Authors: Yumei Xia Gelun Huang Xuemei Quan Qixiong Qin Hui Li Ci Xu Zhijian Liang Source Type: research