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Nutrition: Antidoxidants

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Total 731 results found since Jan 2013.

MiR-34b Protects Against Focal Cerebral Ischemia-Reperfusion (I/R) Injury in Rat by Targeting Keap1
Ischemic stroke is one of the leading causes of death and disability globally and has been regarded as a major public health problem. Understanding the mechanism of ischemia/reperfusion (I/R)-induced oxidative stress injury may provide new treatment for ischemic stroke. Kelch-like ECH-associated protein 1 (Keap1)/ NF-E2-related factor 2 (Nrf2)/ antioxidant response elements (ARE) signaling pathway has been considered to be the major cellular defense against oxidative stress. In the present study, our objective is to evaluate the molecular mechanism of miR-34b/Keap1 in modulating focal cerebral I/R induced oxidative injury.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Rong Huang, Juan Ma, Bo Niu, Jin Li, Jian Chang, Yanrui Zhang, Peng Liu, Xinping Luan Source Type: research

Hydrogen Sulfide: Therapeutic or Injurious in Ischemic Stroke?
Publication date: Available online 12 November 2018Source: PathophysiologyAuthor(s): P.K. Prasai, B. Shrestha, A.M. Kaskas, J. Green, J.S. Alexander, C.B. PattilloAbstractHydrogen sulfide (H2S) has been identified as a vasodilatory, neuromodulatory, and anti-inflammatory gasotransmitter with antioxidant properties. Studies focused in cardiac tissue suggest H2S functions as a protective agent; however in the central nervous system (CNS) the effects of H2S during states of stress or injury, such as stroke, remain controversial. Currently, the application of H2S donors and modulators in stroke depends on the type of H2S donor...
Source: Pathophysiology - November 14, 2018 Category: Pathology Source Type: research

Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation
Conclusion: Taken together, this study suggests that overexpression of CCR2 on MSCs enhances their targeted migration to the ischemic hemisphere and improves the therapeutic outcomes, which is attributed to the PRDX4-mediated BBB preservation.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yinong Huang, Jiancheng Wang, Jianye Cai, Yuan Qiu, Haiqing Zheng, Xiaofan Lai, Xin Sui, Yi Wang, Qiying Lu, Yanan Zhang, Meng Yuan, Jin Gong, Wei Cai, Xin Liu, Yilong Shan, Zhezhi Deng, Yue Shi, Yaqing Shu, Lei Zhang, Wei Qiu, Lisheng Peng, Jie Ren, Zhen Tags: Research Paper Source Type: research

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
Publication date: Available online 7 January 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Jiabing Wang, Lili Huang, Chanchan Cheng, Ge Li, Jingwen Xie, Mengya Shen, Qian Chen, Wulan Li, Wenfei He, Peihong Qiu, Jianzhang WuAbstractScavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized...
Source: Acta Pharmaceutica Sinica B - January 8, 2019 Category: Cancer & Oncology Source Type: research

Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice
AbstractMalnutrition predisposes to poor stroke outcome. In animal models, undernutrition protected against ischemic injury in some, but not in other studies. In view of diverse stroke models and food restriction paradigms, the consequences of undernutrition are poorly understood. Herein, we exposed mice to energy-reduced and protein-energy-reduced diets for 7 –30 days and subsequently induced intraluminal middle cerebral artery occlusion. Undernutrition phase dependently influenced ischemic injury. Short-lasting 7 days of protein-energy undernutrition, but not energy undernutrition, decreased post-ischemic brain leuko...
Source: Translational Stroke Research - March 17, 2019 Category: Neurology Source Type: research

Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway.
CONCLUSIONS: Leonurine exerted neuroprotective effects, promoted antioxidant responses, and upregulated VEGF expression by activating the Nrf-2 pathway. PMID: 31087454 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 12, 2019 Category: Neuroscience Authors: Xie YZ, Zhang XJ, Zhang C, Yang Y, He JN, Chen YX Tags: CNS Neurosci Ther Source Type: research

Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.
Authors: Link TW, Santillan A, Patsalides A Abstract Mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion has been shown to significantly improve outcomes. However, despite efficient rates of recanalization (60-90%), the rates of functional independence remain suboptimal (14-58%), most likely due to pathways of cell death in the brain that have already committed despite successful reperfusion. Pharmacologic neuroprotection provides a potential means of preventing this inevitable damage through targeting excitotoxicity, reactive oxygen species, cellular apoptosis, and inflammation. Numerou...
Source: Interventional Neuroradiology - May 21, 2020 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research

Early predictive blood markers of hemorrhagic stroke - influence of cytoflavin therapy.
This study aimed to determine early changes in the parameters of oxidative stress and routine biochemistry blood tests in patients with HS and to assess their relationship with clinical outcome. The effects of early applied cytoflavin were also investigated. The prospective study included 151 patients with HS. 48% of patients in the standard conservative therapy was added cytoflavin antioxidant energy therapy from the first day of hospitalization. The neurological status, neuroimaging, biochemical blood tests and free radical processes were assessed on days 1, 5, 10, 20 of hospitalization. In patients with HS, an imbalance...
Source: Canadian Journal of Physiology and Pharmacology - September 9, 2020 Category: Drugs & Pharmacology Authors: Silina E, Rumyantceva SA, Stupin VA, Parfenov VA, Bolevich S Tags: Can J Physiol Pharmacol Source Type: research

Mortality prediction of ischemic stroke patients without thrombectomy by blood total antioxidant capacity.
Abstract It has been previously established that total antioxidant capacity concentrations of blood on the first day of ischemic stroke could predict mortality. Therefore, our study objective was to determine whether total antioxidant capacity concentrations in the blood during the first week of a cerebral infarction could help predict mortality. We included severe and malignant middle cerebral artery infarction patients (affecting 50% or more of the territory in computed tomography and a score of nine or fewer points in the Glasgow Coma Scale). Serum total antioxidant capacity concentrations were determined on da...
Source: Journal of Integrative Neuroscience - September 30, 2020 Category: Neuroscience Authors: Lorente L, Martín MM, González-Rivero AF, Pérez-Cejas A, Abreu-González P, Sabatel R, Ramos-Gómez L, Argueso M, Solé-Violán J, Cáceres JJ, Jiménez A, García-Marín V Tags: J Integr Neurosci Source Type: research

Superoxide Dismutase Gene Polymorphism is Associated With Ischemic Stroke Risk in the China Dali Region Han Population
Conclusion: The SOD3 gene rs7655372 locus polymorphism is a risk factor for IS in the Dali region.
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

DNA Hypomethylation of the MPO Gene in Peripheral Blood Leukocytes Is Associated with Cerebral Stroke in the Acute Phase
In this study, we assessed the association of DNA methylation levels of these genes with CS and clinical features of CS. We quantitatively analyzed DNA methylation patterns in the promoter or regulatory regions of 4 genes (GCLM,GSTP1,TXNRD1, andMPO) in peripheral blood leukocytes of 59 patients with CS in the acute phase and in 83 relatively healthy individuals (controls) without cardiovascular and cerebrovascular diseases. We  found that in both groups, the methylation level of CpG sites in genesTXNRD1 andGSTP1 was  ≤ 5%. Lower methylation levels were registered at a CpG site (chr1:94,374,293, GRCh37 [hg19]) inGCLM ...
Source: Journal of Molecular Neuroscience - April 17, 2021 Category: Neuroscience Source Type: research

Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism
CONCLUSIONS Our findings suggest that ß-asarone treatment ameliorated the cerebral infarction in MCAO rats, which could be related to activation of the Nrf2-ARE pathway.PMID:34083500 | DOI:10.12659/MSM.931884
Source: Medical Science Monitor - June 4, 2021 Category: Research Authors: Huiying Pan Yi Xu Qian Cai Meiling Wu Mingxing Ding Source Type: research

Alamandine Induces Neuroprotection in Ischemic Stroke Models
CONCLUSION: This study showed, for the first time, a neuroprotective role for Alamandine in different ischemic stroke models.PMID:35125076 | DOI:10.2174/0929867329666220204145730
Source: Current Medicinal Chemistry - February 7, 2022 Category: Chemistry Authors: Sth éfanie C A Gonçalves Beatriz L T Bassi Lucas M Kangussu Daniele T Alves Lorena K S Ramos Lorena F Fernandes Marco T R Alves Ruben Sinisterra Gisele E Bruch Robson A S Santos Andr é R Massensini Maria Jos é Campagnole-Santos Source Type: research