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Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
Neuroprotective effects of an < em > in vitro < /em > BBB permeable phenoxythiophene sulfonamide small molecule in glutamate-induced oxidative injury
Exp Ther Med. 2022 Jan;23(1):79. doi: 10.3892/etm.2021.11002. Epub 2021 Nov 25.ABSTRACTReactive oxygen species (ROS) play a central role in oxidative stress-associated neuronal cell death during ischemia. Further investigation into the inhibition of excessive ROS generation post-stroke is urgently required for the treatment of ischemic stroke. In the present study, the neuroprotective properties of the blood-brain barrier (BBB) penetrant B355227 were investigated. B355227 is a chemical analogue of B355252, and the role of the phenoxythiophene sulfonamide compound B355227 was further investigated in a glutamate-induced oxid...
Source: Experimental and Therapeutic Medicine - December 23, 2021 Category: General Medicine Authors: Smritee Pokharel Nailya S Gliyazova Srinivasa R Dandepally Alfred L Williams Gordon C Ibeanu Source Type: research
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat
Neuropharmacology. 2021 Dec 27:108935. doi: 10.1016/j.neuropharm.2021.108935. Online ahead of print.ABSTRACTAIMS: Acetaminophen or paracetamol (PAR), the recommended antipyretic in COVID-19 and clinically used to alleviate stroke-associated hyperthermia interestingly activates cannabinoid receptor (CB1) through its AM404 metabolite, however, to date, no study reports the in vivo activation of PAR/AM404/CB1 axis in stroke. The current study deciphers the neuroprotective effect of PAR in cerebral ischemia/reperfusion (IR) rat model and unmasks its link with AM404/CB1/PI3K/Akt axis.MATERIALS AND METHODS: Animals were allocate...
Source: Neuropharmacology - December 30, 2021 Category: Drugs & Pharmacology Authors: Sherif S Abdel Mageed Ramy M Ammar Noha N Nassar Helmy Moawad Ahmed S Kamel Source Type: research
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat
Neuropharmacology. 2021 Dec 27:108935. doi: 10.1016/j.neuropharm.2021.108935. Online ahead of print.ABSTRACTAIMS: Acetaminophen or paracetamol (PAR), the recommended antipyretic in COVID-19 and clinically used to alleviate stroke-associated hyperthermia interestingly activates cannabinoid receptor (CB1) through its AM404 metabolite, however, to date, no study reports the in vivo activation of PAR/AM404/CB1 axis in stroke. The current study deciphers the neuroprotective effect of PAR in cerebral ischemia/reperfusion (IR) rat model and unmasks its link with AM404/CB1/PI3K/Akt axis.MATERIALS AND METHODS: Animals were allocate...
Source: Neuropharmacology - December 30, 2021 Category: Drugs & Pharmacology Authors: Sherif S Abdel Mageed Ramy M Ammar Noha N Nassar Helmy Moawad Ahmed S Kamel Source Type: research
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
Tomato concentrate could help reduce chronic intestinal inflammation associated with HIV
New UCLA-led research in mice suggests that adding a certain type of tomato concentrate to the diet can reduce the intestinal inflammation that is associated with HIV. Left untreated, intestinal inflammation can accelerate arterial disease, which in turn can lead to heart attack and stroke.The findings provide clues to how the altered intestinal tract affects disease-causing inflammation in people with chronic HIV infection, suggesting that targeting the inflamed intestinal wall may be a novel way to prevent the systemic inflammation that persists even when antiviral therapy is effective in controlling a person ’s HIV.Th...
Source: UCLA Newsroom: Health Sciences - January 11, 2022 Category: Universities & Medical Training Source Type: news
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat
Neuropharmacology. 2021 Dec 27:108935. doi: 10.1016/j.neuropharm.2021.108935. Online ahead of print.ABSTRACTAIMS: Acetaminophen or paracetamol (PAR), the recommended antipyretic in COVID-19 and clinically used to alleviate stroke-associated hyperthermia interestingly activates cannabinoid receptor (CB1) through its AM404 metabolite, however, to date, no study reports the in vivo activation of PAR/AM404/CB1 axis in stroke. The current study deciphers the neuroprotective effect of PAR in cerebral ischemia/reperfusion (IR) rat model and unmasks its link with AM404/CB1/PI3K/Akt axis.MATERIALS AND METHODS: Animals were allocate...
Source: Neuropharmacology - December 30, 2021 Category: Drugs & Pharmacology Authors: Sherif S Abdel Mageed Ramy M Ammar Noha N Nassar Helmy Moawad Ahmed S Kamel Source Type: research
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research
