10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
In conclusion, PTZ was hypothesized to act effectively on mitochondria of HepG2 cells; hence it should proceed into detailed drug targeting mechanism research. PMID: 32464002 [PubMed - indexed for MEDLINE] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Discrimination by RT-Nested PCR of Alpha-Lactalbumin Transcript Expression in Mammary Tumors.
In conclusion, we designed specific and sensitive methods to detect LALBA transcripts. We show for the first time a differential expression of these transcripts, but we need to confirm their potential use as markers in breast cancer. PMID: 32464003 [PubMed - indexed for MEDLINE] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Celecoxib Targeted Therapy Attenuates Mouse Colon Carcinogenesis through Modulation of Expression Patterns of Cancer Stem Cells.
This study was designated to explore the role of cancer stem cells (CSCs) during chemically induced mouse colon carcinogenesis (by 1,2- dimethylhydrazine dihydrochloride, DMH) with/or without the treatment with a targeted (anti-COX-2) therapeutic drug, celecoxib. Two experiments were conducted. The first, a short-term, 16-week mouse colon carcinogenesis bioassay, demonstrates the early stages of colon carcinogenesis. The other is a medium-term, 32-week mouse colon cancer experiment that mimics an end point of colon malignancy. Colon tumors were detected in animals after 32 weeks; histopathologically, they varied from benig...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

The Role of Micronucleus Assay to Detect Genetic Instability in Respiratory Cancer Patients.
This study aims to evaluate micronuclei (MN) frequency as a biomarker of genome instability in peripheral blood lymphocytes of PM and lung cancer (LC) patients when compared with healthy controls (HCs) and patients with nonneoplastic respiratory diseases (RDs). Lymphocyte cytokinesis-block MN assay was carried out on 317 subjects. Mutagen sensitivity, measured by quantifying MN frequency after an in vitro challenge with ionizing radiation, was evaluated in 252 subjects. A significant increase in MN frequency was observed in cancer patients compared to HCs, with a mean ratio (MR) of 1.35 and 1.36 at baseline and 1.43 and 1....
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Shielding the Negative Impact of Cadmium in Avian Embryos by Supplementing with Beetroot Juice.
In conclusion, this study confirms that BRJ reduces the rate of congenital malformations with Cd exposure in utero and suggests the importance of dietary supplements for pregnant women. PMID: 32464006 [PubMed - indexed for MEDLINE] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Restorative Effect of Fucoxanthin in an Ovalbumin-Induced Allergic Rhinitis Animal Model through NF- κB p65 and STAT3 Signaling.
In this study, allergic rhinitis in male BALB/c mice was induced with OVA. The object was to evaluate the effect of fucoxanthin on consequently allergic mice. Allergic responses like rubbing and sneezing were scored to reveal the effect of fucoxanthin in the induced and treated groups. Mean histological scores demonstrated variation in and between OVA-induced and fucoxanthin-treated groups in terms of ciliary loss, eosinophil infiltration, and the like. Lipid profiling (malondialdehyde) confirmed the restraining effect of fucoxanthin on allergic rhinitis. The present study showed that cytokine production, the induction of ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Biochemical Investigation of Tissue Oxidative Stress and Angiogenesis with Associated Trace Elements in Breast Disease Patients in Uttarakhand, India.
This study is designed to determine level changes in total antioxidant status and markers of lipid peroxidation melondialdehyde (MDA) and angiogenesis vascular endothelial growth factor (VEGF) along with related micronutrients of copper, zinc, magnesium, and iron in malignant and benign breast disease tissue extracts. We assess specificity and sensitivity of those markers using the area under the curve of receiver operator characteristic (ROC) curve analysis. Association studies are done with correlation analysis. The tissue extract level of MDA markers is found to be significantly higher (14.118 ± 1.47 nmol/g tissue; p
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 4, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Clozapine Improves Behavioral and Biochemical Outcomes in a MK-801-Induced Mouse Model of Schizophrenia.
In this study, we investigate the effect of clozapine on MK-801-induced neurochemical and neurobehavioral alterations in the prefrontal cortex of mice. Acute administration of NMDA noncompetitive antagonist MK-801 impairs motor coordination, grip strength, and locomotor activity. Clozapine is the only medication that is indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents; however, its mechanism is not well understood. To understand its mechanism, we investigated the effects of clozapine on motor coordination, locomotor activity, and grip strength in mice against the ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis.
Authors: Zhang H, Lv P, Xiao Z, Jothi EA, Yang J Abstract Breast cancer is a widespread disease that affects women globally. Diagnostic processes and remedial approaches to breast carcinogenesis have improved in recent decades, but continuous survival of patients with breast carcinogenesis is still lacking due to increased cell proliferation. The aim of the present work is to explore the anticell proliferative effects of nobiletin (NOB) against 7,12-dimethylbenz[a]anthracene (DMBA)-treated mammary tumorigenesis in rats. We stimulate mammary carcinogenesis using oral gavage of DMBA (25 mg/kg body weight) mixed with ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Effects of Tobacco on Biochemical Parameters in Healthy and Type 2 Diabetic Subjects.
Authors: Upadhyay B, Dwivedi S, Wajid S, Jain SK Abstract Diabetes and tobacco use are two of the largest public health challenges of our time. We aim to investigate the association between the two by comparing biochemical profiles of diabetic tobacco users (TUs) and tobacco nonus-ers (TNUs) to provide insight into the joint effect of tobacco and diabetes on body systems. This case-controlled study included 265 subjects, aged 18-60 yr, from the suburban population of Delhi, India. With the help of a questionnaire, participants are interviewed regarding their history of tobacco use. Results show association of tobac...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Identification of Potential Oncogenic Long Non-Coding RNA Set as a Biomarker Associated with Colon Cancer Prognosis.
Authors: Chen M, Fan M, Yang J, Lang J Abstract Colon cancer (CC) is the most common type of gastrointestinal cancer and is the third leading cause of cancer patient's death worldwide. Long non-coding RNAs (lncRNAs) are important regulatory molecules involved in various cellular processes, and many of them are shown as significant prognosis biomarkers of malignant tumors. In the present study, we identified differentially expressed lncRNAs between CC and adjacent normal tissues based on two TCGA database (GEPIA and circlncRNAnet). Over 1500 differentially expressed lncRNAs between CC and adjacent normal tissues wer...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Evaluation of Cytotoxicity of Different Part Extracts of Ipomoea turpethum against Breast Cancer Cell Lines.
In conclusion, results showed that the root extract possess the highest cytotoxicity among all other tested extracts toward both breast cancer cell lines (MCF-7 and MDA MB-231). PMID: 32479012 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Antiatherosclerotic Activity of Eriocitrin in High-Fat-Diet-Induced Atherosclerosis Model Rats.
Authors: Wan J, Feng Y, Du L, Veeraraghavan VP, Mohan SK, Guo S Abstract Atherosclerosis is a multifactorial disease that develops and progresses in the arterial wall in response to a variety of stimuli. Among various other stimuli, hyperlipidemia is an extremely important factor that is correlated with the development of atherosclerosis. Lemon and citrus fruits contain various bioactive flavonoids, such as eriocitrin, that prevent obesity and related metabolic diseases. Therefore we concentrated on eriocitrin, a potent flavonoid with numerous therapeutic properties, particularly its beneficial lipid-lowering actio...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Nobiletin Inhibits Helicobacterium pylori Infection-Induced Gastric Carcinogenic Signaling by Blocking Inflammation, Apoptosis, and Mitogen-Activated Protein Kinase Events in Gastric Epithelial-1 Cells.
Authors: Ouyang Y, Li L, Ling P Abstract Helicobacter pylori causes a Gram-negative bacterial infection that can increase the risk of gastric cancer. Consequently, meticulous prevention of an H. pylori infection is significant for averting gastric cancer in humans. Nobiletin, an important dietary polymethoxylated flavonoid in citrus fruits, possesses multidimensional pharmaceutical properties, including its ability to act as an anticancer, anti-inflammatory, antioxidative, cardiovascularly defensive, neuroprotective, and antimetabolic agent. Our study evaluates the role of nobiletin in inflammation-mediated gastric...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Tilianin Protects Diabetic Retina through the Modulation of Nrf2/TXNIP/NLRP3 Inflammasome Pathways.
Authors: Zhang Y, Gao Z, Gao X, Yuan Z, Ma T, Li G, Zhang X Abstract Oxidative stress and inflammation are regarded as prime reasons for the progression and development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related factor 2 (Nrf2), thioredoxin interacting protein (TXNIP) and NLRP3 inflammasome pathways are under increasing focus in research on oxidative stress and inflammation-related diseases. On the other hand, tilianin (TN) has received much attention because of its various pharmacological properties. Based on results of these studies, this investigation was performed to inspect the ther...
Source: Journal of Environmental Pathology, Toxicology and Oncology - June 3, 2020 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Role of Herbal Medicine in the Management of Urolithiasis- A Review for Future Perspectives.
CONCLUSION: The present review reveals the severity of the progression of the occurrence of urolithiasis worldwide. The epidemiology gave in this review clearly indicates that stress-related factors and dietary complications, the key factors in the development of urolithiasis. are increasing. In this review, we acknowledge the limitations of conventional therapy. Many natural drug options are abundantly available throughout the world and can be useful for the management of urolithiasis. Future Perspectives: The development of a suitable formulation of bioactive components obtained from natural sources is being widely resea...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Evaluation of LncRNA ANRIL Potential in Hepatic Cancer Progression.
CONCLUSION: ANRIL is involved in HCC progression by direct targeting of miR-384 and STAT3. Also, ANRIL could act as a potential candidate for HCC diagnosis, prognosis, and therapy. PMID: 31679275 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Metformin: A Salutary Candidate for Colorectal Cancer Treatment in Patients with Diabetes.
Authors: Samuel VP, Dahiya R, Singh Y, Gupta G, Sah SK, Gubbiyappa SK, Chellappan DK, Dua K Abstract The current study is a review of the literature on patients with diabetes who are diagnosed with colorectal cancer (CRC), encompassing recent research on CRC and the molecular level changes occurring in these patients on the basis of varying environmental as well as non-environmental factors. It has been noted that nearly 50% of all patients undergo the systemic treatment module; however, most of them exhibit drug resistance. In addition, targeted gene therapy has also been used in treatment but has been found to be...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity.
In conclusion, the potential antioxidant effect of genistein may be because of its modulatory effect on Nrf2/HO-1 signalling pathway and by this means exhibits cardioprotective effects from Dox-induced oxidative injury. PMID: 31679277 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Rutin Protects against Doxorubicin-Induced Cognitive Dysfunction While Retaining the Anticancer Potential of Dox in a Murine Model of N-Methyl-N-Nitrosourea - Induced Mammary Carcinoma.
Authors: Ramalingayya GV, Gourishetti K, Nayak PG, Rao CM, Kishore A, Alnaseer SM, Hussain SM, Nandakumar K Abstract Chemobrain is a significant post-chemotherapy complication for which no approved treatments are available. We had previously identified that rutin inhibits doxorubicin (Dox-) -induced cognitive decline in healthy rats. However, it was important to also establish that it does so in rats with mammary carcinoma without compromising Dox's antitumor potential. Mammary carcinoma was induced in female rats by intraperitonial administration of N-methyl-N-nitrosourea (i.p.). Rats that developed mammary carcin...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Analysis of Lead, Cadmium, and Nickel in Blood Donors in Relation to Smoking-A Comparative Study.
In this study, an attempt was made to determine the effect of smoking on concentration of cadmium, nickel, and lead in donor blood. A semistructured questionnaire was prepared and given to participants. It showed that 79% (two groups: 65 smokers and 65 nonsmokers) smoked at least one cigarette per day. Collected blood samples were then subjected to atomic absorption spectrometry (AAS). In comparing blood levels between smoking and nonsmoking participants, we noted a high positive correlation between lead and nickel concentrations. There were statistically significant correlations between cadmium, lead, and nickel concentra...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Increased Expression of TGF- β and IFN-γ in Peripheral Blood Mononuclear Cells (PBMCs) Cultured in Conditioned Medium (CM) of K562 Cell Culture.
Increased Expression of TGF-β and IFN-γ in Peripheral Blood Mononuclear Cells (PBMCs) Cultured in Conditioned Medium (CM) of K562 Cell Culture. J Environ Pathol Toxicol Oncol. 2019;38(2):173-183 Authors: Adil AAM, Vallinayagam L, Chitra K, Jamal S, Pandurangan AK, Ahmed N Abstract In the present study, we investigated the effects of conditioned media (CM) collected from the cancer cell lines (K562, MCF-7, and HeLa) on peripheral blood mononuclear cells (PBMCs) isolated from the healthy human blood. The soluble factors in the CM are probably responsible for the differential mRNA expressions o...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

AgNPs from Nigella sativa Control Breast Cancer: An In Vitro Study.
Authors: Rohini B, Akther T, Waseem M, Khan J, Kashif M, Hemalatha S Abstract In our current study, we synthesized silver nanoparticles (AgNPs) from an aqueous seed extract of Nigella sativa. The seed extract contains phytochemical compounds including phenols, terpenoids, and flavonoids that may act as reducing agents and are able to convert metal ions to metal nanoparticles. The formation of synthesized AgNPs was characterized using UV-visible spectroscopy, Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM) and energy dispersive analysis of X-rays (EDX). The efficacy of N-AgNPs ag...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression.
Authors: Zhao Z, Malhotra A, Seng WY Abstract UNCI 19 expression has been reported to be significantly higher in hepatic cancer cells (HCC). However, the clinical significance of modulating UNC119 expression in HCC is not well understood. The study described here aimed to explore the potential of curcumin in modulation of UNC119 expression in HCC by assessment with quantitative real-time PCR, western blot, and immune-histochemical analyses in HCC cell lines and tissues. The biological functions of UNC119 in the proliferation, growth, and cycle of tumor cells were analyzed both in vitro and in vivo. UNC119 expressio...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms.
Authors: Soon L, Ng PQ, Chellian J, Madheswaran T, Panneerselvam J, Gupta G, Nammi S, Hansbro NG, Hsu A, Dureja H, Mehta M, Satija S, Hansbro PM, Dua K, Collet T, Chellappan DK Abstract Artemisia vulgaris is a traditional Chinese herb believed to have a wide range of healing properties; it is traditionally used to treat numerous health ailments. The plant is commonly called mugwort or riverside wormwood. The plant is edible, and in addition to its medicinal properties, it is also used as a culinary herb in Asian cooking in the form of a vegetable or in soup. The plant has garnered the attention of researchers in th...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Atractylenolide III Enhances the Anti-Neoplastic Efficacy of Docetaxel in Gastric Cancer Cell by Inhibiting Fibroblast Growth Factor Receptors 1, -2, and -4 Expression.
CONCLUSIONS: ATL and docetaxel treatment performed the synergistic effects on the inhibition of growth and induction of apoptosis in gastric cancer cells, and the underlying mechanism was mediated, at least partially, through the inhibition of FGFR1, -2, and -4. PMID: 31679309 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Assessment of the Therapeutic Effects of Fucoxanthin by Attenuating Inflammation in Ovalbumin-Induced Asthma in an Experimental Animal Model.
Authors: Yang X, Guo G, Dang M, Yan L, Kang X, Jia K, Ren H Abstract Asthma has affected more than 300 million people worldwide and is considered one of the most debilitating global public health problems based on a recent statistical report from the Global Initiative for Asthma. Inflammation of the airways leads to the various interrelated mechanisms of innate and adaptive immunity acting mutually with the epithelium of the respiratory organ. Fucoxanthin is an orange or brown pigment which is naturally found in various seaweeds. To the best of our knowledge, there are no scientific claims or evidence of the curati...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice.
Authors: Chen W, Zhang H, Liu Y Abstract Fucoxanthin, a potent carotenoid present in various natural sources especially from seaweeds; it exhibits several biological effects like anti-neoplastic, anti-mutagenic, anti-diabetic, anti-obesity and anti-inflammatory actions. Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here. Oral administration of fucoxanthin with and without B(a)P were studied, the results from our study shows that fucoxanthin significantly decreased tumor progression in mice exposed to B(a)P, the obtained data were correlated...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Oxidative Stress Parameters, Selenium Levels, DNA Damage, and Phthalate Levels in Plastic Workers.
The objective of this study was to determine sex hormone levels, oxidative stress parameters, selenium levels, DNA damage, and phthalate levels in plastics workers (n = 24, age = 20-58 years) working in the production of rubber mechanical goods and exposed to DEHP in workplace. The control group (n = 29, age = 25-54, all male) was selected from age-matched healthy adults. Antioxidant parameters and DNA damage were determined by spectrophotometry. Selenium levels were determined by atomic absorption spectroscopy. Plasma hormone levels were measured by chemiluminescence microparticle immunoassay. Plasma phthalate levels were...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Low-Magnitude, High-Frequency Vibration Promotes Osteogenic Differentiation via Intensifying miRNA-335-5p Expression.
In this study, we found that miR-335-5p is significantly upregulated after low-magnitude, high-frequency vibration, which suppresses the expression of the Wnt signaling inhibitor Dickkopf-related protein 1. Inhibition of miR-335-5p greatly reduced the osteogenic differentiation. Furthermore, the increase of miR-335-5p level was also confirmed in vivo after LMHF vibration in rabbit. Our study elucidates the prominent role of miRNAs that links the LMHF vibration and osteogenic differentiation. PMID: 31679313 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF- κB Pathway.
D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway. J Environ Pathol Toxicol Oncol. 2019;38(3):285-295 Authors: Ma J, Feng S, Ai D, Liu Y, Yang X Abstract Psoriasis is an autoregulated immune and inflammation-based skin disease affecting approximately 3-4% of the worldwide population. Pinitol, conservatively used in ayurvedic medicine, has been shown to disclose an antiinflammatory effect, hold back the T-helper cells, and postpone cardiovascular diseases. In the present study we aimed to reveal the effect of D-pinitol on imiquimod (IMQ)...
Source: Journal of Environmental Pathology, Toxicology and Oncology - November 5, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine-Induced Toxicity in Wistar Rats.
Authors: Shree A, Hasan SK, Islam J, Vafa A, Afzal SM, Barnwal P, Siddiqi A, Ali R, Sultana S Abstract The protective efficacy of methanolic bark extract of Acacia catechu Willd. (MEBA) against 1,2-dimethylhydrazine (DMH)-induced colon toxicity was investigated. Acacia catechu is considered one of the most potent medicines for various diseases in Ayurveda, a traditional system of Indian medicine. It is a widely used herb that contains a variety of bioactive components such as phenolic acids, alkaloids, and flavonoids among others. In the present study, MEBA was used as a pretreatment orally at two doses (250 and 50...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Antiarthritic Activity of Diallyl Disulfide against Freund's Adjuvant-Induced Arthritic Rat Model.
Authors: Chen Y, Xue R, Jin X, Tan X Abstract Diallyl disulfide (DADS) is an organosulfur compound derived mainly from garlic and genus Allium plants, which possess diverse biological properties. The aim of the present study was to evaluate the antiarthritic activity of DADS in rats with arthritis induced using complete Freund's adjuvant (CFA). DADS (20 mg/kg and 50 mg/kg) was administered and tested against CFA-induced arthritic rats by assessing various parameters: body weight, paw volume, arthritic score, organ indices (spleen and thymus), hematological and biochemical parameters, and proinflammatory cytokines. ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Potential Role of Induced Pluripotent Stem Cells as Regenerative Medicine in Retinal Cell Damage.
Authors: Sun YJ, Pan YR, Fan B, Li GY Abstract Induced pluripotent stem cells (also called iPSCs) are somatic cells reprogrammed by overexpressing four nuclear transcriptional factors containing Sox2, Klf4, c-myc and Oct4 is the one of research hotspots. Its pluripotency, self-renewal capacity and wide accessibility to donor tissues have made possible the means for modified regenerative medicine. They are considered a possible basis of healthy tissue to cure diseases, like ophthalmic diseases, degenerative diseases, age-related macular degeneration (AMD), are primarily because of the weakening capability of photore...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Investigating the Role of Mitochondrial Respiratory Dysfunction during Hexavalent Chromium-Induced Lung Carcinogenesis.
In this study, we treated human lung epithelial cells (BEAS-2B) with Cr(VI) for 6 months and obtained malignantly transformed cells from an isolated colony grown in soft agar. We also used Cr(VI)-transformed cells from two other human lung cell lines (BEP2D and WTHBF-6 cells). Overall, we found that all the Cr(VI)-transformed cells had no changes in their mitochondrial respiratory functions (measured by the Seahorse Analyzer) compared with passaged-matched control cells. Using a xenograft tumor growth model, we generated tumors from these transformed cells in Nude mice. Using cells obtained from the xenograft tumor tissues...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Studying the in Silico Effect of Ellagic Acid on HIF-2 α to Improve Efficacy of Anticancer Therapy.
Studying the in Silico Effect of Ellagic Acid on HIF-2α to Improve Efficacy of Anticancer Therapy. J Environ Pathol Toxicol Oncol. 2018;37(4):331-339 Authors: Ahire V, Das D, Arora S, Kumar A, Ramakrishna G, Mishra KP Abstract The hypoxic tumor microenvironment is one of the major causes of the enhanced chemoresistant and radioresistant behavior of cancer cells. Therefore, the hypoxia-induced factor (HIF) pathway can be endorsed, for not only the malignant phenotype of the cells, but also its metastatic potential. Many drugs targeting the HIF pathways have failed in the clinical setting to demons...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells.
Authors: Zhang WL, Zhao YN, Shi ZZ, Cong D, Bai YS Abstract Cancer, the uncontrolled growth of cells, is a major disease that threatens the worldwide population. Among all cancer types, lung cancer has the highest morbidity rate, with a survival rate of less than 5%. Various studies have focused on discovering a potent anticancer drug that will increase the survival rate of lung cancer patients. Lutein (3,3'-dihydroxy-β, ε-carotene), a carotenoid present in fruits and vegetables, is one such compound that possesses excellent antioxidant properties. The present study was designed to determine the antica...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Evaluation of Anti-Nociceptive and Anti-Inflammatory Effect of Luteolin in Mice.
Authors: Fan X, Du K, Li N, Zheng Z, Qin Y, Liu J, Sun R, Su Y Abstract Flavonoids are polyphenolic compounds that not only impart coloration to plants and fruits, but also protect plants from pathogens, radiation, etc. They serve as a nutrient to plants and possess immense anti-oxidant properties. Research has shown that they exhibit anti-inflammatory, anti-cancer, and neuroprotective properties in both in vitro and in vivo analyses. Luteolin is one such flavonoid belongs to the group of flavones present in herbs such as thyme, chamomile, celery, and green pepper. The epidemiological data on luteolin consumption s...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway.
Authors: Yang G, Shang X, Cui G, Zhao L, Zhao H, Wang N Abstract Liver cancer is the fifth commonly occurring cancer worldwide with the annual death rate of 9.1%. Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis. Because the cancer is generally detected only in the later stages, it is often treated with therapies such as radiation, ablation, and chemotherapy, which produces serious side effects and has a low recovery rate. Therefore, researchers are now focused on herbal-based drugs with increased efficacy and with no s...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Autophagy is Required to Regulate Mitochondria Renewal, Cell Attachment, and All-trans-Retinoic Acid-Induced Differentiation in NB4 Acute Promyelocytic Leukemia Cells.
We examined expression of Beclin-1 and B-cell lymphoma-2 (Bcl-2) and levels of mechanistic target of rapamycin (mTOR) after ATRA treatment. ATRA inhibits Bcl-2, up-regulates Beclin-1 expression, and reduces induction of mTOR activation/phosphorylation in NB4 cells. Our results reveal that autophagy has roles in regulation of differentiation, mitochondria elimination, and cell attachment during ATRA-induced APL differentiation. PMID: 30806286 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Predicting the Efficacy of 5-Fluorouracil-Based Adjuvant Chemotherapy in Gastric Cancer by Microsatellite Instability: A Meta-Analysis.
Authors: Zhao F, Yuan X, Ren D, Shen G, Wang Z, Zheng F, Ahmad R, Ma Z, Zhao J Abstract Microsatellite instability (MSI) implies the deletion of mismatch repair genes caused by DNA methylation or gene mutation. MSI is a good predictor for efficacy of 5-fluorouracil (FU)-based chemotherapy in the treatment of colorectal cancer. Some gastric cancer studies have reported that MSI has no apparent impact on prognosis after patients receive 5-FU-based adjuvant chemotherapy. However, other studies suggest that high-frequency MSI (MSI-H) status reduced survival in patients receiving 5-FU-based adjuvant chemotherapy. Thus, ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF- κB Signaling.
Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF-κB Signaling. J Environ Pathol Toxicol Oncol. 2019;38(1):29-39 Authors: Shen J, Li N, Zhang X Abstract Ulcerative colitis (UC) and Crohn's disease (CD) are collectively referred to as inflammatory bowel diseases (IBDs). The increased pathogenesis of UC leads to a series of complications. We aimed to analyze the anticolitic effect of daidzein (DA) in a dextran sulfate sodium (DSS)-induced colitis mouse model and in activated macrophage RAW264.7 cells. Thirty BALB/c male mice were randomly divided into...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats.
In conclusion, 6-gingerol has a protective effect on lungs in ovalbumin-sensitized asthma in rats. PMID: 30806289 [PubMed - in process] (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer.
Authors: Lu H, Guo Y, Gupta G, Tian X Abstract The eukaryotic cell cycle via mitogen-activated protein kinase (MAPK) has been considered as an effective signaling cascade pathway for anticancer therapy. In addition to the MAPK signaling pathway, the Rat Sarcoma Virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MAPK-ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is a signaling cascade that has a crucial role to play in cell survival and development of cancer, especially breast cancer. Novel drugs and clinical trials need to be investigated, taking into consideration the already studied genetic...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Common Variants rs3815188 and rs1043994 on Notch3 Gene Confer Susceptibility to Lung Cancer: A Hospital-Based Case-Control Study.
In this study, DNA samples were extracted from the venous blood sample of 200 subjects (100 lung cancer patients and 100 controls). Notch3 rs3815188 (C381T) and rs1043994 (G684A) polymorphisms were determined using the restriction fragment length polymorphism method. A statistically significant difference was found between the patient and control groups for Notch3 gene rs3815188 and rs1043994 polymorphisms when evaluated in terms of genotype (p = 0.002 and p
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

PI3K/Akt Pathway and miR-21 are Involved in N-Ethyl-N-Nitrosourea-Induced F1 Mouse Lung Tumorigenesis: Effect of Inositol Hexaphosphate.
In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR-21) in transplacental lung tumorigenesis and its prevention by dietary compound inositol hexaphosphate (IP6) in F1 mice. Balb/c mice were exposed to the N-ethyl-N-nitrosourea (ENU) intraperitoneally on the 17th day of gestation. After weaning, half of the litters were fed with oral 2% IP6. At the end of 30, 120, or 240 days, we did not observe any effect on fetal viability or weight between ENU-exposed and non-exposed litters and the same was true of IP6. Altered expressions of the PI3K/Akt pathway w...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Reduction of Gamma Radiation-Induced Damage by Hydro-Alcoholic Extract of Nardostachys jatamansi.
Authors: Menon A, Chacko T, Nair PR, Majeed T, Nair CKK Abstract The search for a nontoxic radioprotector has not yielded any promising results. Many antioxidant compounds, though effective under in vitro conditions as radioprotectors, have failed under in vivo settings due to their toxicity. The Indian medical system of Ayurveda uses a variety of plants with antioxidant potential, and these may be harboring molecules with radioprotective properties. In the present work, the radioprotective property of Nardostachys jatamansi was investigated. A hydro-alcoholic extract of this plant provided protection to the cellul...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 28, 2019 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Detrimental Effects of Heavy Metals in Soil, Plants, and Aquatic Ecosystems and in Humans.
Authors: Jaiswal A, Verma A, Jaiswal P Abstract Environmental pollution has posed a major threat to flora as well as fauna for the past few decades. Industries release effluents into the environment which act as the major source of pollution. The hazardous effects of heavy metals released from these industries impact the soil and due to bioaccumulation of these compounds in the food chain, they ultimately result in a serious human health hazard. The concentration of metals like chromium (Cr), lead (Pb), nickel (Ni), cadmium (Cd), zinc (Zn), titanium (Ti), cobalt (Co), and several others in plants as well as in aqua...
Source: Journal of Environmental Pathology, Toxicology and Oncology - October 17, 2018 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Herbal Medicines in Neurodegenerative Disorders: An Evolutionary Approach through Novel Drug Delivery System.
Authors: Dubey SK, Singhvi G, Krishna KV, Agnihotri T, Saha RN, Gupta G Abstract Neurodegenerative disorders are one of the most debilitating, chronic, and often irreversible disorders of the brain and have gained a widespread attention of researchers. Since current therapeutics seem to be inadequate treatment of these disorders, scientists are exploring their options with herbal drugs. This review discusses herbal constituents with the potential to treat neurological disorders. These herbal drugs, when combined with a novel delivery system, provide added advantages to nanocarrier systems. The review also presents ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - October 17, 2018 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research

Nanoparticles in Daily Life: Applications, Toxicity and Regulations.
Authors: Gupta R, Xie H Abstract At nanoscale, man-made materials may show unique properties that differ from bulk and dissolved counterparts. The unique properties of engineered nanomaterials not only impart critical advantages but also confer toxicity because of their unwanted interactions with different biological compartments and cellular processes. In this review, we discuss various entry routes of nanomaterials in the human body, their applications in daily life, and the mechanisms underlying their toxicity. We further explore the passage of nanomaterials into air, water, and soil ecosystems, resulting in div...
Source: Journal of Environmental Pathology, Toxicology and Oncology - October 17, 2018 Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research