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Condition: Anemia
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Total 684 results found since Jan 2013.

Resting Ventricular-Vascular Function and Exercise Capacity in Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study Original Articles
Conclusions— In heart failure with preserved ejection fraction, potentially modifiable factors (obesity, anemia, and chronotropic incompetence) are strongly associated with exercise capacity, whereas resting measures of ventricular and vascular structure and function are not. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00763867
Source: Circulation: Heart Failure - July 15, 2014 Category: Cardiology Authors: Mohammed, S. F., Borlaug, B. A., McNulty, S., Lewis, G. D., Lin, G., Zakeri, R., Semigran, M. J., LeWinter, M., Hernandez, A. F., Braunwald, E., Redfield, M. M. Tags: Congestive, Exercise/exercise testing/rehabilitation Original Articles Source Type: research

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis.
CONCLUSIONS: In the CKD setting, there is currently insufficient evidence to suggest the superiority of any ESA formulation based on available safety and efficacy data. Directly comparative data for the effectiveness of different ESA formulations based on patient-centred outcomes (such as quality of life, fatigue, and functional status) are sparse and poorly reported and current research studies are unable to inform care. All proprietary ESAs (epoetin alfa, epoetin beta, darbepoetin alfa, and methoxy polyethylene glycol-epoetin beta) prevent blood transfusions but information for biosimilar ESAs is less conclusive. Compara...
Source: Cochrane Database of Systematic Reviews - December 8, 2014 Category: Journals (General) Authors: Palmer SC, Saglimbene V, Mavridis D, Salanti G, Craig JC, Tonelli M, Wiebe N, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research

Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload
Summary Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (−8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well‐tolerated, with net iron removal in most children who completed 30...
Source: British Journal of Haematology - January 22, 2015 Category: Hematology Authors: Banu Aygun, Nicole A. Mortier, Karen Kesler, Alexandre Lockhart, William H. Schultz, Alan R. Cohen, Ofelia Alvarez, Zora R. Rogers, Janet L. Kwiatkowski, Scott T. Miller, Pamela Sylvestre, Rathi Iyer, Peter A. Lane, Russell E. Ware, Tags: Short Report Source Type: research

Safety of Ventricular Tachycardia Ablation in Clinical Practice: Findings from 9699 Hospital Discharge Records Original Articles
Conclusions— VT ablation–associated AE rates in clinical practice are similar to those reported in the literature. Over time rates have increased as have the number of AE risk factors per patient. Ablations done electively and at hospitals with higher procedural volume are associated with lower incidence of AEs.
Source: Circulation: Arrhythmia and Electrophysiology - April 21, 2015 Category: Cardiology Authors: Katz, D. F., Turakhia, M. P., Sauer, W. H., Tzou, W. S., Heath, R. R., Zipse, M. M., Aleong, R. G., Varosy, P. D., Kao, D. P. Tags: Health policy and outcome research, Ablation/ICD/surgery Original Articles Source Type: research

G6PD deficiency and absence of α‐thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia
This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - June 13, 2015 Category: Hematology Authors: Philippe Joly, Nathalie Garnier, Kamila Kebaili, Céline Renoux, Arthur Dony, Nathalie Cheikh, Cécile Renard, Antony Ceraulo, Daniela Cuzzubbo, Corinne Pondarré, Cyril Martin, Vincent Pialoux, Alain Francina, Yves Bertrand, Philippe Connes Tags: Original Article Source Type: research

Meta‐analysis of the association between preoperative anaemia and mortality after surgery
ConclusionPreoperative anaemia is associated with poor outcomes after surgery, although heterogeneity between studies was significant. It remains unclear whether anaemia is an independent risk factor for poor outcome or simply a marker of underlying chronic disease. However, red cell transfusion is much more frequent amongst anaemic patients.
Source: British Journal of Surgery - September 9, 2015 Category: Surgery Authors: A. J. Fowler, T. Ahmad, M. K. Phull, S. Allard, M. A. Gillies, R. M. Pearse Tags: Systematic review Source Type: research

Meta-analysis of the association between preoperative anaemia and mortality after surgery.
CONCLUSION: Preoperative anaemia is associated with poor outcomes after surgery, although heterogeneity between studies was significant. It remains unclear whether anaemia is an independent risk factor for poor outcome or simply a marker of underlying chronic disease. However, red cell transfusion is much more frequent amongst anaemic patients. PMID: 26349842 [PubMed - in process]
Source: The British Journal of Surgery - September 12, 2015 Category: Surgery Authors: Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM Tags: Br J Surg Source Type: research

Do CHA2DS2VASc and HAS‐BLED scores influence ‘real‐world’ anticoagulation management in atrial fibrillation? 1556 patient registry from the reference cardiology centre
ConclusionsAntithrombotic management in AF is well implemented in Polish conditions, but we show the lack of pattern concerning who is being treated with OAC and ASA when it comes to the risk of stroke and bleeding. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - September 30, 2015 Category: Drugs & Pharmacology Authors: Paulina Lopatowska, Anna Tomaszuk‐Kazberuk, Elzbieta Mlodawska, Hanna Bachorzewska‐Gajewska, Jolanta Malyszko, Slawomir Dobrzycki, Wlodzimierz J. Musial Tags: Original Report Source Type: research

Impact of anemia on long-term outcomes in patients treated with first and second-generation drug-eluting stents Katowice-Zabrze Registry.
CONCLUSIONS: In patients with anemia is significant higher risk of death in the 12-month follow-up, while anemia has no impact on the incidence of MI, repeat revascularization, and stroke. There is no advantage DES II over DES I generation in terms of MACCE and TVR in patients with anemia. PMID: 26575311 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - November 17, 2015 Category: Cardiology Authors: Wańha W, Kawecki D, Roleder T, Pluta A, Marcinkiewicz K, Dola J, Morawiec B, Krzych Ł, Pawłowski T, Smolka G, Ochała A, Nowalany-Kozielska E, Tendera M, Wojakowski W Tags: Kardiol Pol Source Type: research

Frailty, dependency and mortality predictors in a cohort of Cuban older adults, 2003-2011.
CONCLUSIONS: Given the challenge for developing countries presented by demographic and epidemiologic transition; the high prevalence in older adults of frailty syndrome, dependency and chronic non-communicable diseases; and the association of all these with higher mortality, attention should be targeted to older adults as a risk group. This should include greater social protection, age-appropriate health services, and modification and control of cardiovascular risk factors. PMID: 24487672 [PubMed - indexed for MEDLINE]
Source: MEDICC Review - November 21, 2015 Category: Global & Universal Tags: MEDICC Rev Source Type: research

Anaemia and low body mass index are associated with increased cardiovascular disease in patients with Takayasu arteritis.
CONCLUSIONS: Our study suggests that in addition to traditional CV risk factors, anaemia and low body mass index are independently associated with increased CVD in patients with TA. PMID: 26633551 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - December 4, 2015 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial
This study is registered with ClinicalTrials.gov, number NCT01425307. Findings Between Sept 20, 2011, and April 17, 2013, 159 patients consented and enrolled in TWiTCH. 121 participants passed screening and were then randomly assigned to treatment (61 to transfusions and 60 to hydroxycarbamide). At the first scheduled interim analysis, non-inferiority was shown and the sponsor terminated the study. Final model-based TCD velocities were 143 cm/s (95% CI 140–146) in children who received standard transfusions and 138 cm/s (135–142) in those who received hydroxycarbamide, with a difference of 4·54 (0·10–8·98). Non-i...
Source: The Lancet - December 7, 2015 Category: Journals (General) Source Type: research

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities
We present the long-term follow-up of SCA children from the Créteil newborn cohort (1992-2012) detected at risk by TCD and placed on chronic transfusions. Patients with normalized velocities and no stenosis were treated with hydroxyurea, known to decrease anemia and hemolytic rate. Trimestrial Doppler was performed and transfusions restarted immediately in the case of reversion to abnormal velocities. Patients with a genoidentical donor underwent transplant. Abnormal time-averaged maximum mean velocities (TAMMV) ≥200 cm/s were detected in 92 SCA children at a mean age of 3.7 years (range, 1.3-8.3 years). No strok...
Source: Blood - April 6, 2016 Category: Hematology Authors: Bernaudin, F., Verlhac, S., Arnaud, C., Kamdem, A., Hau, I., Leveille, E., Vasile, M., Kasbi, F., Madhi, F., Fourmaux, C., Biscardi, S., Gluckman, E., Socie, G., Dalle, J.-H., Epaud, R., Pondarre, C. Tags: Pediatric Hematology, Sickle Cell Disease, Free Research Articles, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: research

Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India
ConclusionsSCD‐related complications are more frequent in Indian children than that observed in CSSCD. Further study is indicated to define SCD phenotype in India.
Source: Pediatric Blood and Cancer - June 9, 2016 Category: Cancer & Oncology Authors: Dipty Jain, Aishwarya Arjunan, Vijaya Sarathi, Harshwardhan Jain, Amol Bhandarwar, Marike Vuga, Lakshmanan Krishnamurti Tags: Research Article Source Type: research

Warfarin persistence among atrial fibrillation patients – why is treatment ended?
ConclusionsAlthough persistence to warfarin among AF patients proves higher than previously reported, there is room for improvement since half of the discontinuers have questionable reasons for treatment stop and the majority of them receive no other efficient stroke prophylaxis.This article is protected by copyright. All rights reserved.
Source: Cardiovascular Therapeutics - August 26, 2016 Category: Cardiology Authors: Fredrik Bj örck, E k Agnes, Lars Johansson, Anders Själander Tags: Original Research Article Source Type: research