CD99 expression is strongly associated with clinical outcome in children with B ‐cell precursor acute lymphoblastic leukaemia
SummaryOur study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B ‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high‐risk BCP‐ALL, e.g.BCR ‐ABL1 andCRLF2Re/Hi, and that highCD99mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP ‐ALL. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Dongfeng Chen, Alessandro Camponeschi, Qingqing Wu, Natalija Gerasimcik, Huiqi Li, Xue Shen, Yujie Tan, Helene Sj ögren, Jessica Nordlund, Gudmar Lönnerholm, Jonas Abrahamsson, Linda Fogelstrand, Inga‐Lill Mårtensson Tags: Short Report Source Type: research

Plasma cells in classical Hodgkin lymphoma: a new player in the microenvironment?
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Lydia Visser Tags: Editorial Comment Source Type: research

Therapeutic recommendations for early stage Hodgkin lymphomas
SummaryCombined modality treatment has been the standard option for the treatment of early stage Hodgkin lymphoma for several decades. Because of the high success rate and the risk of late toxicities, recent clinical trials have focused on reducing the treatment burden. Field and dose of radiotherapy, and number of cycles of chemotherapy have been successfully reduced, particularly for favourable early stage patients. However, the impact of these treatment reductions on the rate of secondary malignancies remains still unclear. Positron emission tomography ‐computed tomography (PET‐CT) scanning has emerged as a very imp...
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Julien Depaus, Anne Delcourt, Marc Andr é Tags: Review Source Type: research

Modern principles in the management of nodular lymphocyte ‐predominant Hodgkin lymphoma
SummaryNodular lymphocyte ‐predominant Hodgkin lymphoma (NLPHL) is a unique rare subtype of Hodgkin lymphoma (HL) which differs clinically, pathologically and biologically from classic HL, warranting a nuanced approach to treatment. CD20 expression by malignant lymphocyte‐predominant cells, a tendency for late relapses, and the risk of transformation to aggressive large B‐cell lymphoma are characteristic features with important implications for treatment and follow‐up. Recognition of histopathological variant patterns is also critical, with important implications for prognosis and treatment. The optimal managem ent...
Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Michael A. Spinner, Gaurav Varma, Ranjana H. Advani Tags: Review Source Type: research

Venetoclax for chronic lymphocytic leukaemia patients who progress after more than one B ‐cell receptor pathway inhibitor
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Authors: William G. Wierda, John C. Byrd, Matthew S. Davids, Richard R. Furman, Bruce D. Cheson, Paul M. Barr, Herbert Eradat, Leonard Heffner, Lang Zhou, Maria Verdugo, Jalaja Potluri, Michael Choi Tags: Correspondence Source Type: research

A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Authors: Mary Frances McMullin, Claire N. Harrison, Sahra Ali, Catherine Cargo, Frederick Chen, Joanne Ewing, Mamta Garg, Anna Godfrey, Steven Knapper S, Donal P. McLornan, Jyoti Nangalia, Mallika Sekhar, Frances Wadelin, Adam J. Mead, on behalf of t Tags: Guidelines Source Type: research

Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case ‐control study
SummaryIt is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self ‐reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Authors: Ruifang Li ‐Gao, Vânia M. Morelli, Willem M. Lijfering, Suzanne C. Cannegieter, Frits R. Rosendaal, Astrid Hylckama Vlieg Tags: Short Report Source Type: research

Issue Information
British Journal of Haematology, Volume 183, Issue 4, Page 525-533, November 2018. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 27, 2018 Category: Hematology Tags: Issue Information Source Type: research

Phase II trial to investigate efficacy and safety of bendamustine, dexamethasone and thalidomide in relapsed or refractory multiple myeloma patients after treatment with lenalidomide and bortezomib
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Michael Mian, Norbert Pescosta, Stefania Badiali, Paola Cristina Cappelletto, Luigi Marcheselli, Stefano Luminari, Francesca Patriarca, Renato Zambello, Anna Pascarella, Giuseppe Tagariello, Alessandra Marabese, Patrizia Mondello, Atto Billio, Tags: Correspondence Source Type: research

Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon ‐α and ATRA
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Ariunzaya Bat ‐Erdene, Shingen Nakamura, Asuka Oda, Masami Iwasa, Jumpei Teramachi, Mohannad Ashtar, Takeshi Harada, Hirokazu Miki, Hirofumi Tenshin, Masahiro Hiasa, Shiro Fujii, Kimiko Sogabe, Masahiro Oura, Kengo Udaka, Kumiko Kagawa, S Tags: Correspondence Source Type: research

Receiving treatment at a specialist centre confers an overall survival benefit for patients with mantle cell lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Rory McCulloch, Alexandra Smith, Nicola Crosbie, Russell Patmore, Simon Rule Tags: Correspondence Source Type: research

Erythropoietin and ferritin response in native highlanders aged 4 –19 years from the Leh‐Ladakh region of India
SummaryThe pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19  years) from Leh‐Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively . The mean EP...
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Uday Yanamandra, Harikishan Senee, Sushma Yanamadra, Subrat K. Das, Srinivas A. Bhattachar, Reena Das, Suman Kumar, Pankaj Malhotra, Subhash Varma, Neelam Varma, Velu Nair Tags: Research Paper Source Type: research

Refining statistics clarifies leukaemic stem cell genomics
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Shelley M. Herbrich, Keith A. Baggerly, Marina Konopleva Tags: Correspondence Source Type: research

Carcinocythaemia in an advanced stage of invasive ductal carcinoma of the breast
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 26, 2018 Category: Hematology Authors: Aina Oliver ‐Caldes, Blanca Gonzalez‐Farre, Anna Merino, Maria Rozman Tags: Images in Haematology Source Type: research

Guidelines for the diagnosis and management of primary central nervous system diffuse large B ‐cell lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 23, 2018 Category: Hematology Authors: Christopher P. Fox, Elizabeth H. Phillips, Jeffery Smith, Kim Linton, Eve Gallop ‐Evans, Claire Hemmaway, Dorothee P. Auer, Charlotte Fuller, Andrew J. Davies, Pamela McKay, Kate Cwynarski, on behalf of the British Society for Haematology Tags: Guideline Source Type: research

Impact of graft ‐versus‐lymphoma effect on outcomes after reduced intensity conditioned‐alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies
SummaryAllogeneic haematopoietic stem cell transplant (allo ‐HSCT) offers potentially curative therapy for patients with relapsed/refractory lymphoid malignancies. Reduced‐intensity conditioning (RIC) with Alemtuzumab reduces transplant‐related mortality and graft‐versus‐host disease (GvHD), but may be associated with increased risk of relapse. Wit h the aim of studying the effect of GVHD and donor lymphocyte infusions (DLI) on relapse, we performed a retrospective study of 288 patients (57% non‐Hodgkin lymphoma, 24% Hodgkin lymphoma and 19% chronic lymphocytic leukaemia; 58% were relapsed/refractory) who under...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Charlotte K. Brierley, Francesca M. Jones, Katharine Hanlon, Andy J. Peniket, Chris Hatton, Graham P. Collins, Anna Schuh, Patrick Medd, Andrew Clark, Janice Ward, Sridar Chaganti, Ram Malladi, Anne Parker, Charles Craddock, Robert Danby, V Tags: Research Paper Source Type: research

Cardiac biomarkers and health ‐related quality of life in patients with light chain (AL) amyloidosis
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Kristen L. McCausland, Tiffany P. Quock, Avery A. Rizio, Martha S. Bayliss, Michelle K. White, Spencer D. Guthrie, Vaishali Sanchorawala Tags: Correspondence Source Type: research

New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso ‐occlusive crises
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Claudine Lapoumeroulie, Philippe Connes, Sara El Hoss, Regine Hierso, Keyne Charlot, Nathalie Lemonne, Jacques Elion, Caroline Le Van Kim, Marc Romana, Marie ‐Dominique Hardy‐Dessources Tags: Correspondence Source Type: research

Prevalence and correlates of growth failure in young African patients with sickle cell disease
SummaryGrowth failure (GF) in children with sickle cell disease (SCD) tends to decline in high ‐income countries, but data are lacking in sub‐Saharan Africa. We performed a cross‐sectional study nested in the CADRE (Cœur, Artères et DREpanocytose) cohort in Mali, Senegal, Cameroon, Gabon and the Ivory Coast. SCD patients and healthy controls aged 5–21 years old were recruited (n = 2583). Frequency of GF, defined as a height, weight or body mass index below the 5th percentile on World health Organization growth charts, was calculated. We assessed associations between GF and SCD phenot...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Laure Alexandre ‐Heymann, Marie Dubert, Dapa A. Diallo, Saliou Diop, Aissata Tolo, Suzanne Belinga, Ibrahima Sanogo, Ibrahima Diagne, Guillaume Wamba, Kouakou Boidy, Indou Deme Ly, Ismaël Kamara, Youssouf Traore, Lucile Offredo, Xavier Jo Tags: Research Paper Source Type: research

Exome analysis of treatment ‐related AML after APL suggests secondary evolution
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Tianjiao Wang, Meagan A. Jacoby, Eric J. Duncavage, Christopher A. Miller, Sharon Heath, Ramy Rahme, Pierre Fenaux, Lionel Ades, Aline Renneville, Bruno Cassinat, Akihiro Takeshita, Norio Asou, Yasushi Miyazaki, Hitoshi Kiyoi, Farhad Ravandi Tags: Correspondence Source Type: research

Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation in acute leukaemia – a matched pair analysis by the Acute Leukaemia Working Party of EBMT
SummaryStrategies for relapse prevention after allogeneic transplantation in acute leukaemia are warranted. A registry ‐based matched‐pair analysis evaluated the efficacy of prophylactic donor lymphocyte infusion (proDLI). Adults receiving proDLI in complete remission (CR) and controls were pair‐matched for age, diagnosis, cytogenetics, stage, donor, gender, conditioning and T‐cell depletion. Eighty‐nine p airs were identified (median follow‐up: 6.9 years). Within the entire cohort, no difference was observed. However, among patients with high‐risk acute myeloid leukaemia (AML) (unfavourable cytogenetics...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Christoph Schmid, Myriam Labopin, Nicolaas Schaap, Hendrik Veelken, Michael Schleuning, Michael Stadler, Juergen Finke, Erin Hurst, Frederic Baron, Olle Ringden, Gesine Bug, Didier Blaise, Johanna Tischer, Adrian Bloor, Jordi Esteve, Sebast Tags: Short Report Source Type: research

Cancer specific survival in patients with sickle cell disease
SummarySickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state‐wide hospitalisation data, were linked to the California Cancer Registry (1988–2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3‐fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer‐specific survival,...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Ann Brunson, Theresa H. M. Keegan, Anjlee Mahajan, Susan Paulukonis, Ted Wun Tags: Short Report Source Type: research

Evolution of multiple myeloma treatment practices in Europe from 2014 to 2016
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Marc S. Raab, Leah Fink, Paul Schoen, Sebastian Gonzalez ‐McQuire, Alain Flinois, Michele Cavo, Maria‐Victoria Mateos, Kwee Yong Tags: Correspondence Source Type: research

Comment on: type 1 cryoglobulinaemia leading to gangrene of the toes and ischaemic ulceration
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Mathew Sheridan Tags: Correspondence Source Type: research

Differential expression of long non ‐coding RNAs are related to proliferation and histological diversity in follicular lymphomas
SummaryLong non ‐coding RNAs (lncRNAs) comprise a family of non‐coding transcripts that are emerging as relevant gene expression regulators of different processes, including tumour development. To determine the possible contribution of lncRNA to the pathogenesis of follicular lymphoma (FL) we performed RNA‐se quencing at high depth sequencing in primary FL samples ranging from grade 1‐3A to aggressive grade 3B variants using unpurified (n = 16) and purified (n = 12) tumour cell suspensions from nodal samples. FL grade 3B had a significantly higher number of differentially expressed lncRNAs (dif...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Alejandro Roisman, Giancarlo Castellano, Alba Navarro, Blanca Gonzalez ‐Farre, Patricia Pérez‐Galan, Anna Esteve‐Codina, Marc Dabad, Simon Heath, Marta Gut, Mattia Bosio, Pau Bellot, Philippe Salembier, Albert Oliveras, Irma Slavutsky, Tags: Research Paper Source Type: research

Risk factors affecting outcome of unrelated cord blood transplantation for children with familial haemophagocytic lymphohistiocytosis
SummaryAllogeneic haematopoietic stem cell transplantation is still the only available curative option for Familial Haemophagocytic Lymphohistiocytosis (FHLH). Most studies report outcomes after bone marrow or peripheral blood stem cell transplantation. We analysed the outcomes of 118 children with FHLH undergoing single ‐unit umbilical cord blood transplantation performed from 1996 to 2014. Myeloablative conditioning regimen was given to 90% of the patients, and was mostly busulfan‐based (n = 81, 76%), including anti‐thymocyte globulin or alemtuzumab (n = 102, 86%). The cumulative incidence of Da...
Source: British Journal of Haematology - November 21, 2018 Category: Hematology Authors: Juliana Montibeller Furtado ‐Silva, Annalisa Paviglianiti, Annalisa Ruggeri, Jaap Jan Boelens, Paul Veys, Ali Abdallah Ahmari, Marco Zecca, Franco Locatelli, Gerard Michel, Fernanda Volt, Chantal Kenzey, Petr Sedlacek, Kanchan Rao, Arjan La Tags: Research Paper Source Type: research

Effect of renin ‐angiotensin‐aldosterone system blocking agents on progression of glomerulopathy in sickle cell disease
SummaryAlthough renin ‐angiotensin‐aldosterone system (RAAS) blocking agents decrease albuminuria in short‐term studies, there is no evidence confirming their long‐term efficacy in sickle cell disease (SCD). In a single‐centre, retrospective study, we evaluated the long‐term effect of RAAS blocking agents on proteinuria and declining estimated glomerular filtration rates (eGFR). Eighty‐six patients on RAAS blocking agents for proteinuria, followed for a median of 2·28 years, were compared with 68 patients with proteinuria followed for 2·24 years who were not receiving such treatment. T...
Source: British Journal of Haematology - November 21, 2018 Category: Hematology Authors: Ashley Thrower, Emily J. Ciccone, Poulami Maitra, Vimal K. Derebail, Jianwen Cai, Kenneth I. Ataga Tags: Research Paper Source Type: research

Outcome of patients aged 80  years or older treated for chronic lymphocytic leukaemia
SummaryClinical management of chronic lymphocytic leukaemia (CLL) in patients aged ≥80 years is based on limited evidence due to the lack of published information. Therefore, we analysed CLL patients aged ≥80 years using data from seven phase III clinical trials of the German CLL Study Group. Among 3552 participants, 152 were ≥80 years old at initiation of first‐line st udy treatment. Median age was 82 years (range 80–90). Concomitant diseases were present in 99% of the patients, with a median cumulative illness rating scale score of 8 (0–18). Chemoimmunotherapy with chlorambucil...
Source: British Journal of Haematology - November 21, 2018 Category: Hematology Authors: Othman Al ‐Sawaf, Jasmin Bahlo, Sandra Robrecht, Kirsten Fischer, Carmen D. Herling, Manuela Hoechstetter, Anna‐Maria Fink, Julia Tresckow, Petra Langerbeins, Paula Cramer, Stephan Stilgenbauer, Clemens M. Wendtner, Barbara Eichhorst, Mic Tags: Research Paper Source Type: research

Phase 2 study of all ‐oral ixazomib, cyclophosphamide and low‐dose dexamethasone for relapsed/refractory multiple myeloma
SummaryThere is a need for efficacious, convenient treatments with long ‐term tolerability for patients with relapsed/refractory multiple myeloma (RRMM). This phase 2 study evaluated the all‐oral combination of ixazomib, cyclophosphamide and dexamethasone (ICd). Patients with RRMM received ixazomib 4 mg and cyclophosphamide 300 mg/m2 on days 1, 8 and 15, and dexamethasone 40  mg on days 1, 8, 15 and 22 in 28‐day cycles. The primary endpoint was overall response rate (ORR). Seventy‐eight patients were enrolled (median age 63·5 years). At data cut‐off, patients had received a median of 12...
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Shaji K. Kumar, Norbert Grzasko, Sosana Delimpasi, Wieslaw W. Jedrzejczak, Sebastian Grosicki, Marie ‐Christine Kyrtsonis, Andrew Spencer, Neeraj Gupta, Zhaoyang Teng, Catriona Byrne, Richard Labotka, Meletios A. Dimopoulos Tags: Research Paper Source Type: research

Aplastic anaemia in pregnancy – a single centre, North American series
We describe 19 pregnancies in 9 women at a tertiary care centre over a period of 30  years. Spontaneous resolution of AA did not occur postpartum in the five pregnancies where AA was first diagnosed in pregnancy. In the remaining pregnancies, although haematological indices declined and transfusion support was needed in 35% of pregnancies, relapses were not observed. There were no deaths, but complications occurred in 79% of pregnancies. Preterm delivery and postpartum haemorrhage were observed in 21% and 26% of pregnancies, respectively. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Kelly E. McGowan, Ann K. Malinowski, Andre C. Schuh, Wendy Whittle, Nadine Shehata Tags: Short Report Source Type: research

Bortezomib consolidation post ‐ASCT as frontline therapy for multiple myeloma deepens disease response and MRD‐negative rate whilst maintaining QOL and response to re‐treatment at relapse
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Oliver C. Cohen, Nicholas Counsell, Neil Rabin, Rakesh Popat, Roger G. Owen, Bilyana Popova, Oliver Schofield, Laura Clifton ‐Hadley, Janet Lyons‐Lewis, Andy Rawstron, Christopher Spence, Ruth M. Tute, Derralynn Hughes, Sally Moore, Paul Tags: Correspondence Source Type: research

Low risk of Pneumocystis jirovecii pneumonia and invasive aspergillosis in patients with Waldenstr öm macroglobulinaemia on ibrutinib
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Matthew P. Cheng, Amanda E. Kusztos, Joshua N. Gustine, Scott L. Dryden ‐Peterson, Toni E. Dubeau, Ann E. Woolley, Sarah P. Hammond, Lindsey R. Baden, Steven P. Treon, Jorge J. Castillo, Nicolas C. Issa Tags: Correspondence Source Type: research

Spontaneous remission in a Diamond ‐Blackfan anaemia patient due to a revertant uniparental disomy ablating a de novo RPS19 mutation
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Emanuela Garelli, Paola Quarello, Elisa Giorgio, Adriana Carando, Elisa Menegatti, Cecilia Mancini, Eleonora Di Gregorio, Nicoletta Crescenzio, Orazio Palumbo, Massimo Carella, Paola Dimartino, Tommaso Pippucci, Irma Dianzani, Ugo Ramenghi, Tags: Correspondence Source Type: research

Current considerations in AYA Hodgkin lymphoma
SummaryHodgkin lymphoma (HL) commonly occurs in adolescents and young adults (AYA), defined by the National Cancer Institute as people diagnosed with cancer between the ages of 15 and 39  years. Despite therapeutic advances, the AYA population has derived less incremental benefit compared to both paediatric and adult counterparts. Although the exact aetiology is unclear, contributing factors probably include differences in disease biology, delayed diagnosis, decreased participation in clinical trials and treatment adherence secondary to complex social factors. As such, while HL remains highly curable, there is not a c...
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Jennifer L. Crombie, Ann S. LaCasce Tags: Review Source Type: research

Detailed molecular analysis and evaluation of prognosis in cases with high grade B ‐cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Anna Stengel, Wolfgang Kern, Manja Meggendorfer, Torsten Haferlach, Claudia Haferlach Tags: Correspondence Source Type: research

A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 19, 2018 Category: Hematology Authors: Hartmut D öhner, Carsten Müller‐Tidow, Michael Lübbert, Walter Fiedler, Alwin Krämer, Jörg Westermann, Gesine Bug, Richard F. Schlenk, Utz Krug, Rainer‐Georg Goeldner, James Hilbert, Tillmann Taube, Oliver G. Ottmann Tags: Correspondence Source Type: research

Ventricular global longitudinal strain is altered in children with sickle cell disease
SummaryCardiac disease is the primary cause of death in sickle cell disease (SCD). Right and left ventricular global longitudinal strain (RVGLS, LVGLS) are early markers of systolic dysfunction but are not well investigated among children with SCD. One hundred and forty ‐three patients with HbSS or HbSβ0‐thalassaemia (median age 11 years, range 5–19 years) and 71 controls matched for age and sex were compared. RVGLS and LVGLS were measured and compared with conventional measures of echocardiography and markers of haemolysis and inflammation. RVGLS was higher in children with SCD than in contr ols (...
Source: British Journal of Haematology - November 19, 2018 Category: Hematology Authors: Nicholas S. Whipple, Ronak J. Naik, Guolian Kang, Joseph Moen, Sarala D. Govindaswamy, James A. Fowler, Jolanta Dowdy, Rhiannon Penkert, Vijaya M. Joshi, Jane S. Hankins Tags: Research Paper Source Type: research

Insulin ‐like growth factor levels and chronic lymphocytic leukaemia: results from the MCC‐Spain and EpiLymph‐Spain studies
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 19, 2018 Category: Hematology Authors: Delphine Casabonne, Yolanda Benavente, Laura Costas, Claudia Robles, Eva Gonzalez ‐Barca, Esmeralda Banda, Esther Alonso, Marta Aymerich, Elías Campo, Rafael Marcos‐Gragera, Adonina Tardón, Rocío Olmedo‐Requena, Eva Gimeno, Alba Mart Tags: Correspondence Source Type: research

Venous thromboembolism in multiple myeloma – choice of prophylaxis, role of direct oral anticoagulants and special considerations
SummaryMultiple myeloma is associated with a significant risk of venous thromboembolism (VTE), causing substantial levels of morbidity and mortality. The thrombogenicity of myeloma is multifactorial, with disease ‐ and treatment‐related factors playing important roles. Immunomodulatory drugs (IMiDs) and high‐dose dexamethasone, in particular, are known to enhance the thrombotic potential of myeloma. For this reason, assessment of the VTE risk has long been advocated prior to treatment initiation in pat ients with myeloma requiring IMiD‐based regimens. However, despite routine use of thromboprophylaxis, these patien...
Source: British Journal of Haematology - November 18, 2018 Category: Hematology Authors: Dawn Swan, Alberto Rocci, Charlotte Bradbury, Jecko Thachil Tags: Review Source Type: research

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 18, 2018 Category: Hematology Authors: Martina Barone, Francesca Ricci, Daria Sollazzo, Emanuela Ottaviani, Marco Romano, Giuseppe Auteri, Daniela Bartoletti, Maria L. B. Reggiani, Nicola Vianelli, Pier L. Tazzari, Michele Cavo, Dorian Forte, Francesca Palandri, Lucia Catani Tags: Correspondence Source Type: research

Bioimpedance vector analysis for the detection of extracellular volume overload and sarcopenia in systemic AL amyloidosis
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 18, 2018 Category: Hematology Authors: Tamer Rezk, Andrew Davenport, Jaslyn J. Gan, Helen J. Lachmann, Marianna Fontana, Ana Martinez ‐Naharro, Sajitha Sachchithanantham, Christianne Guillotte, Shameem Mahmood, Aviva Petrie, Carol J. Whelan, Jennifer H. Pinney, Darren Foard, Thi Tags: Correspondence Source Type: research

Genetic predisposition to PEG ‐asparaginase hypersensitivity in children treated according to NOPHO ALL2008
This study associated variants inCNOT3 and in the human leucocyte antigen (HLA) region with PEG ‐asparaginase hypersensitivity, suggesting that not only genetic variations in the HLA region, but also regulation of these genes are of importance in the biology of this toxicity. Furthermore, our study emphasizes the importance of using asparaginase enzyme activity measurements to identify PEG‐ asparaginase hypersensitivity. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 18, 2018 Category: Hematology Authors: Sofie G. H øjfeldt, Benjamin O. Wolthers, Morten Tulstrup, Jonas Abrahamsson, Ramneek Gupta, Arja Harila‐Saari, Mats Heyman, Louise T. Henriksen, Òlafur G. Jónsson, Päivi M. Lähteenmäki, Bendik Lund, Kaie Pruunsild, Goda Vaitkeviciene, Tags: Research Paper Source Type: research

Saposin C is a frequent target of paraproteins in Gaucher disease ‐associated MGUS/multiple myeloma
SummaryPatients with Gaucher disease (GD) have an increased risk of monoclonal gammopathies for which antigenic targets might play a role in their pathogenesis. Here we report the identification of saposin C (sapC) as high ‐titre (1:1 000 000) target structure of 7/16 GD‐associated paraproteins. Anti‐sapC immunoglobulin (Ig) showed identity with the paraprotein Ig type and subclass in each patient that showed anti‐sapC immunoreactivity. Absorption and depletion studies completely removed the paraprotein from the sera of GD patients. No immunoreactivity against sapC was detected in healthy donors and in ot...
Source: British Journal of Haematology - November 18, 2018 Category: Hematology Authors: Klaus ‐Dieter Preuss, Carla E. M. Hollak, Natalie Fadle, Marinus Oers, Evi Regitz, Michael Pfreundschuh Tags: Research Paper Source Type: research

Mature outcomes and prognostic indices in diffuse large B ‐cell lymphoma in Malawi: a prospective cohort
We report mature data from one of the first prospective SSA cohorts. Patients aged ≥18 years with DLBCL were enrolled in Malawi 2013–2017. Participants were treated with CHOP (cyclophosphamide, doxorubicin, vincristine , prednisone) chemotherapy and concurrent antiretroviral therapy (ART) if positive for human immunodeficiency virus (HIV+). Eighty‐six participants (mean age 47 years, standard deviation 13) were enrolled: 54 (63%) were male and 51 (59%) were HIV+, of whom 34 (67%) were on ART at DLBCL diagnosis. Median CD4 count was 0·113 cells × 109/l (interquartile range [IQR] 0...
Source: British Journal of Haematology - November 18, 2018 Category: Hematology Authors: Matthew S. Painschab, Edwards Kasonkanji, Takondwa Zuze, Bongani Kaimila, Tamiwe Tomoka, Richard Nyasosela, Ruth Nyirenda, Bal M. Dhungel, Maurice Mulenga, Maria Chikasema, Blessings Tewete, Asekanadziwa Mtangwanika, Sarah Chiyoyola, Wilberfo Tags: Research Paper Source Type: research

Ticagrelor does not impact patient ‐reported pain in young adults with sickle cell disease: a multicentre, randomised phase IIb study
SummaryTicagrelor is an antiplatelet agent for adults with coronary artery disease. The inhibition of platelet activation may decrease the frequency of vaso ‐occlusion crisis (VOC) in sickle cell disease (SCD). The HESTIA2 study (NCT02482298) randomised 87 adults with SCD (aged 18–30 years) 1:1:1 to twice‐daily ticagrelor 10, 45 mg or placebo for 12 weeks. Numerical decreases from baseline in mean proportion of days with patient‐reported pain (primary endpoint) were seen in all three groups, as well as in pain intensity and analgesic use, with no significant differences between placebo and ticagr...
Source: British Journal of Haematology - November 16, 2018 Category: Hematology Authors: Julie Kanter, Miguel R. Abboud, Banu Kaya, Videlis Nduba, Carl Amilon, Christer Gottfridsson, Martin Rensfeldt, Maria Leonsson ‐Zachrisson, on behalf of the HESTIA2 study investigators Tags: Research Paper Source Type: research

SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia
SummaryAlteration in RNA splicing is implicated in carcinogenesis and progression. Mutations in spliceosome genes and alternative splicing of other genes have been noted in chronic lymphocytic leukaemia (CLL), a common B cell malignancy with heterogeneous outcomes. We previously demonstrated that differences in the amount of SET oncoprotein (a physiological inhibitor of the serine/threonine phosphatase, PP2A) is associated with clinical aggressiveness in patients with CLL. It is unknown if alternative splicing of gene transcripts regulating kinases and phosphatases affects disease pathobiology and CLL progression. We show ...
Source: British Journal of Haematology - November 15, 2018 Category: Hematology Authors: Danielle M. Brander, Daphne R. Friedman, Alicia D. Volkheimer, Dale J. Christensen, Laura Z. Rassenti, Thomas J. Kipps, Eross Guadalupe, Youwei Chen, Dadong Zhang, Xi Wang, Carter Davis, Kouros Owzar, J. Brice Weinberg Tags: Research Paper Source Type: research

Utility of the DASH score after unprovoked venous thromboembolism; a single centre study
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 15, 2018 Category: Hematology Authors: Stephen MacDonald, Rajani Chengal, Anida Hanxhiu, Emily Symington, Karen Sheares, Martin Besser, Will Thomas Tags: Correspondence Source Type: research

Interim FDG ‐PET does not predict outcome in advanced‐stage Hodgkin lymphoma patients treated with BEACOPP
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 14, 2018 Category: Hematology Authors: Hugo J. A. Adams, Thomas C. Kwee Tags: Correspondence Source Type: research

Sickle cell screening in Europe: the time has come
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 14, 2018 Category: Hematology Authors: Lisa M. Shook, Russell E. Ware Tags: Editorial Comment Source Type: research

Circulating dendritic cells deficiencies as a new biomarker in classical Hodgkin lymphoma
SummaryNo robust biomarkers have been yet validated to identify the recurrence of disease in classical Hodgkin Lymphoma (cHL) patients upon induction treatment. The relevance of the inflammatory microenvironment in cHL prompted us to investigate the key immunomodulator myeloid dendritic cells type ‐1 (mDC1), type‐2 (mDC2) and plasmacytoid dendritic cells (pDC). Blood DC levels were assessed in 52 newly diagnosed patients through multiparametric flow‐cytometry. All but two patients received ABVD regimen (doxorubicin, bleomycin, vinblastine, dacarbazine). The median counts of all DC subse ts were lower in cHL patients ...
Source: British Journal of Haematology - November 13, 2018 Category: Hematology Authors: Domenico Galati, Serena Zanotta, Gaetano Corazzelli, Dario Bruzzese, Gaetana Capobianco, Emanuela Morelli, Manuela Arcamone, Rosaria De Filippi, Antonio Pinto Tags: Research Paper Source Type: research