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Is anticoagulating haemodialysis patients with non ‐valvular atrial fibrillation too risky?
This article aims to discuss the problem of AF in dialysis patients, summarise the current evidence around the use of oral anticoagulants for AF in ESRD and provide some practical suggestions on management of AF in the haemodialysis population. (Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Kathrine Parker, Sandip Mitra, Jecko Thachil Tags: Review Source Type: research

New insights in Type I and II CD20 antibody mechanisms ‐of‐action with a panel of novel CD20 antibodies
Summary Based on their mechanisms‐of‐action, CD20 monoclonal antibodies (mAbs) are grouped into Type I [complement‐dependent cytotoxicity (CDC) and antibody‐dependent cell‐mediated cytotoxicity (ADCC)] and Type II [programmed cell death (PCD) and ADCC] mAbs. We generated 17 new hybridomas producing CD20 mAbs of different isotypes and determined unique heavy and light chain sequence pairs for 13 of them. We studied their epitope binding, binding kinetics and structural properties and investigated their predictive value for effector functions, i.e. PCD, CDC and ADCC. Peptide mapping and CD20 mutant screens revealed...
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Saskia Meyer, Mitchell Evers, Johannes H. M. Jansen, Jos Buijs, Blanca Broek, Stephanie E. Reitsma, Petra Moerer, Mojtaba Amini, Anna Kretschmer, Toine ten Broeke, Marcel T. den Hartog, Mark Rijke, Christian Klein, Thomas Valerius, Peter Boross, Jeanette Tags: Research paper Source Type: research

Early morphological response is significantly associated with, but does not accurately predict, relapse in teenagers and young adults aged 10 –24 years with acute lymphoblastic leukaemia (ALL): results from UKALL2003
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Caroline L. Furness, Amy Kirkwood, Clare Rowntree, Ajay Vora, Chris Mitchell, Sujith Samarasinghe, Nicholas Goulden, Anthony Moorman, Rachael Hough Tags: Correspondence Source Type: research

Response and survival for primary therapy combination regimens and maintenance rituximab in Waldenstr öm macroglobulinaemia
In this study, we compared response and survival outcomes in WM patients who received primary therapy with cyclophosphamide‐dexamethasone‐rituximab (CDR), bortezomib‐dexamethasone‐rituximab (BDR) and bendamustine‐rituximab (Benda‐R), as well as maintenance rituximab following primary therapy. Analyses were adjusted for relevant clinical factors associated with response and survival. Maintenance rituximab was analysed as a time‐varying covariate. Our study included 182 patients, of which 57 (31%) received Benda‐R, 87 (48%) BDR and 38 (21%) CDR; 116 (64%) received maintenance rituximab. The median time to bes...
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Jorge J. Castillo, Joshua N. Gustine, Kirsten Meid, Toni E. Dubeau, Patricia Severns, Lian Xu, Guang Yang, Zachary R. Hunter, Steven P. Treon Tags: Research Paper Source Type: research

Brentuximab vedotin prior to allogeneic stem cell transplantation in Hodgkin lymphoma: a report from the EBMT Lymphoma Working Party
Summary Brentuximab vedotin (BV) is an anti‐CD30 antibody‐drug conjugate. Preliminary data suggest that BV might improve outcomes after allogeneic stem cell transplantation (SCT) for Hodgkin lymphoma (HL) when used as pre‐transplant salvage therapy. Between 2010 and 2014, 428 adult patients underwent an allogeneic SCT for classical HL at participating centres of the European Society for Blood and Marrow Transplantation. We compared the outcomes of 210 patients who received BV prior to allogeneic SCT with that of 218 patients who did not receive BV. The median follow‐up for survivors was 41 months. Patients in ...
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Ali Bazarbachi, Ariane Boumendil, Herv é Finel, Mohamad Mohty, Luca Castagna, Karl S. Peggs, Didier Blaise, Boris Afanasyev, José L. Diez‐Martin, Jorge Sierra, Adrian Bloor, Carmen Martinez, Stephen Robinson, Ram Malladi, Jean El‐Cheikh, Paolo Corra Tags: Research Paper Source Type: research

Idelalisib ‐rituximab induces durable remissions in TP53 disrupted B‐PLL but results in significant toxicity: updated results of the UK‐wide compassionate use programme
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Toby A. Eyre, Christopher P. Fox, Ali Boden, Adrian Bloor, Moez Dungawalla, Paneesha Shankara, Richard Went, Anna H. Schuh Tags: Correspondence Source Type: research

Radiological imaging and bone marrow biopsy in staging of cutaneous B ‐cell lymphoma
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Pankit Vachhani, Vishala T. Neppalli, Christopher J. Cancino, Paul Bogner, Charles L. Roche, Gyorgy Paragh, Marcelle A. Grassi, Francisco J. Hernandez ‐Ilizaliturri Tags: Correspondence Source Type: research

Multinucleated giant myeloma cells after failure of daratumumab therapy
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Francisca Guijarro, Mar ía Rozman, Estella Matutes Tags: Images in Haematology Source Type: research

A blueberry muffin rash at birth
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Camille Debord, Audrey Grain, Olivier Theisen, Robin Boutault, Fanny Rialland, Marion Eveillard Tags: Images in Haematology Source Type: research

Cord gas parameters in infants born to women with sickle cell disease: a retrospective matched cohort study
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Ann K. Malinowski, Patrina Cheung, Junmin Yang, Rohan D'Souza, Nadine Shehata, Richard Ward, Kevin H. M. Kuo, Kellie Murphy Tags: Correspondence Source Type: research

Time trend analysis of long term outcome of patients with haematological malignancies admitted at dutch intensive care units
Summary A few decades ago, the chances of survival for patients with a haematological malignancy needing Intensive Care Unit (ICU) support were minimal. As a consequence, ICU admission policy was cautious. We hypothesized that the long‐term outcome of patients with a haematological malignancy admitted to the ICU has improved in recent years. Furthermore, our objective was to evaluate the predictive value of the Acute Physiology and Chronic Health Evaluation (APACHE) II score. A total of 1095 patients from 5 Dutch university hospitals were included from 2003 until 2015. We studied the prevalence of patients' characteristi...
Source: British Journal of Haematology - February 22, 2018 Category: Hematology Authors: Vera A. Vries, Marcella C. A. M üller, M. Sesmu Arbous, Bart J. Biemond, Nicole M. A. Blijlevens, Nuray Kusadasi, Goda C. W. Choi, Alexander P. J. Vlaar, David J. Westerloo, Hanneke C. Kluin‐Nelemans, Walter M. Bergh, Tags: Research Paper Source Type: research

High ‐dose melphalan‐based sequential conditioning chemotherapy followed by allogeneic haematopoietic stem cell transplantation in adult patients with relapsed or refractory acute myeloid leukaemia
Summary Considering the unsatisfactory results of salvage therapies for patients with relapsed/refractory acute myeloid leukaemia (R/R‐AML), their value before allogeneic haematopoietic stem cell transplantation (HSCT) remains questionable. However, direct allogeneic HSCT following established conditioning regimens applied in patients with R/R‐AML during active disease has been equally disappointing. In this retrospective observational study, high‐dose melphalan, as part of a sequential preparative regimen, followed by a total body irradiation (4 × 2 Gy)‐based or a treosulfan‐based dose‐ada...
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Nina K. Steckel, Christoph Groth, Jan ‐Henrik Mikesch, Rudolf Trenschel, Hellmut Ottinger, Lambros Kordelas, Carsten Mueller‐Tidow, Christoph Schliemann, Christian Reicherts, Joern C. Albring, Gerda Silling, Eva Schmidt, Wolfgang E. Berdel, Georg Lenz Tags: Research paper Source Type: research

Dose ‐intense chemoimmunotherapy plus radioimmunotherapy in high‐risk diffuse large B‐cell lymphoma and mantle cell lymphoma: a phase II study
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Kathryn E. Hudson, David Rizzieri, Samantha M. Thomas, Thomas W. LeBlanc, Zachary Powell, Louis Diehl, Joseph O. Moore, Carlos DeCastro, Anne W. Beaven Tags: Correspondence Source Type: research

Hepatitis E virus – key points for the clinical haematologist
Summary In recent years there has been a paradigm shift in our understanding of the epidemiology and clinical features of hepatitis E virus (HEV) infection. Once classically described as an acute hepatitis associated with waterborne outbreaks in areas of poor sanitation, HEV is now recognised to be endemic in Europe and is probably zoonotic in origin. Evidence for transfusion‐transmitted HEV has prompted the introduction of blood donor screening in a number of countries, but the risk to the haematology patient from food sources remains. The aim of this review therefore, is to equip the clinical haematologist with the kno...
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Joanne O'Gorman, Áine Burke, Niamh O'Flaherty Tags: Review Source Type: research

Ferritin as a functional biomarker of iron status in children and young adults
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Corey Markus, Ben Saxon, Michael Metz Tags: Correspondence Source Type: research

Factor XIa ‐triggered thrombin generation in severe haemophilia A
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Michael J. R. Desborough, Hassan Naeem, Peter Baker, Nicola Curry Tags: Correspondence Source Type: research

Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment ‐free and overall survival in Chronic Lymphocytic Leukaemia
Summary Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P 
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Kyle R. Crassini, Eva Zhang, Shalini Balendran, Jane A. Freeman, O. Giles Best, Cecily J. Forsyth, Naomi J. Mackinlay, Ping Han, William S. Stevenson, Stephen P. Mulligan Tags: Short Report Source Type: research

Anti ‐thymocyte globulin for graft‐versus‐host disease prophylaxis in patients with intermediate‐ or high‐risk acute myeloid leukaemia undergoing reduced‐intensity conditioning allogeneic stem cell transplantation in first complete remission – a survey on behalf of the Acute Leukaemia Worki ng Party of the European Society for Blood and Marrow Transplantation
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Authors: Yishai Ofran, Eric Beohou, Myriam Labopin, Didier Blaise, Jan J. Cornelissen, Marco R. Groot, Gerard Soci é, Anne Huynh, Johan Maertens, Frederic Baron, Mohamad Mohty, Arnon Nagler Tags: Correspondence Source Type: research

Issue Information
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 21, 2018 Category: Hematology Tags: Issue Information Source Type: research

Impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 7, 2018 Category: Hematology Authors: Niels W. C. J. Donk, Tineke Casneuf, Alessandro Di Cara, Paul W. Parren, Sonja Zweegman, Berris Kessel, Henk M. Lokhorst, Saad Z. Usmani, Sagar Lonial, Paul G. Richardson, Christopher Chiu, Tuna Mutis, Inger S. Nijhof, A. Kate Sasser Tags: Correspondence Source Type: research

A phase 1 dose ‐finding study of intravenous L‐citrulline in sickle cell disease: a potential novel therapy for sickle cell pain crisis
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 7, 2018 Category: Hematology Authors: Suvankar Majumdar, Rommel Tirona, Hafsat Mashegu, Jagdish Desai, Neil T. Shannon, Marshall Summar, Gary Cunningham, Deepika Darbari, Robert Nickel, Andrew Campbell, Frederick E. Barr Tags: Correspondence Source Type: research

Follow ‐up of a randomised phase II study of chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T‐cell leukaemia‐lymphoma: impact on allogeneic haematopoietic stem cell transplantation
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 7, 2018 Category: Hematology Authors: Takashi Ishida, Tatsuro Jo, Shigeki Takemoto, Hitoshi Suzushima, Youko Suehiro, Ilseung Choi, Makoto Yoshimitsu, Yoshio Saburi, Kisato Nosaka, Atae Utsunomiya, Yukio Kobayashi, Kazuhito Yamamoto, Hiroshi Fujiwara, Kenji Ishitsuka, Shinichiro Yoshida, Naoy Tags: Correspondence Source Type: research

Gender differences in the development of cardiac complications: a multicentre study in a large cohort of thalassaemia major patients to optimize the timing of cardiac follow ‐up
Summary We assessed whether male gender was associated with a higher risk of cardiac iron accumulation and fibrosis, heart dysfunction and complications in a large, multicentre cohort of thalassaemia major (TM) patients, in order to optimize the timing in cardiac follow‐up. We considered 1711 TM patients (899 females, 31·09 ± 9·08 years), enrolled in the Myocardial Iron Overload in Thalassaemia Network. Clinical/instrumental data are recorded from birth to the first Cardiovascular Magnetic Resonance Imaging scan. Although having a similar risk of accumulating iron, males showed a signi...
Source: British Journal of Haematology - February 7, 2018 Category: Hematology Authors: Alessia Pepe, Maria R. Gamberini, Massimiliano Missere, Laura Pistoia, Maurizio Mangione, Liana Cuccia, Anna Spasiano, Silvia Maffei, Christian Cadeddu, Massimo Midiri, Caterina Borgna, Antonella Meloni, Tags: Research Paper Source Type: research

Blastic plasmacytoid dendritic cell neoplasm with unusual morphology, MYC rearrangement and TET2 and DNMT3A mutations
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 7, 2018 Category: Hematology Authors: Habibe Kurt, Joseph D. Khoury, L. Jeffrey Medeiros, Yang O. Huh Tags: Images in Haematology Source Type: research

Issue Information
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 6, 2018 Category: Hematology Tags: Issue Information Source Type: research

Low ‐level TP53 mutational load antecedes clonal expansion in chronic lymphocytic leukaemia
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Anna Maria Pinto, Filomena T. Papa, Elisa Frullanti, Ilaria Meloni, Rossella Tita, Rossella Caselli, Chiara Fallerini, Diego Lopergolo, Francesco Cetta, Maria Antonietta Mencarelli, Monica Bocchia, Alessandro Gozzetti, Alessandra Renieri Tags: Correspondence Source Type: research

Acute myeloid/T ‐lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy
Summary Advances in the classification of acute leukaemias have led to improved outcomes for a substantial fraction of patients. However, chemotherapy resistance remains a major problem for specific subsets of acute leukaemias. Here, we propose that a molecularly distinct subtype of acute leukaemia with shared myeloid and T cell lymphoblastic features, which we term acute myeloid/T‐lymphoblastic leukaemia (AMTL), is divided across 3 diagnostic categories owing to variable expression of markers deemed to be defining of myeloid and T‐lymphoid lineages, such as myeloperoxidase and CD3. This proposed diagnostic group is su...
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Alejandro Gutierrez, Alex Kentsis Tags: Annotation Source Type: research

Ibrutinib alone or with dexamethasone for relapsed or relapsed and refractory multiple myeloma: phase 2 trial results
This study examined various doses of ibrutinib ± low‐dose dexamethasone in patients who received ≥2 prior lines of therapy, including an immunomodulatory agent. Daily ibrutinib ± weekly dexamethasone 40 mg was assessed in 4 cohorts using a Simon 2‐stage design. The primary objective was clinical benefit rate (CBR; ≥minimal response); secondary objectives included safety. Patients (n = 92) received a median of 4 prior regimens. Ibrutinib + dexamethasone produced the highest CBR (28%) in Cohort 4 (840 mg + dexamethasone; n = 43), wi...
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Paul G. Richardson, William I. Bensinger, Carol Ann Huff, Caitlin L. Costello, Nikoletta Lendvai, Jesus G. Berdeja, Larry D. Anderson, David S. Siegel, Daniel Lebovic, Sundar Jagannath, Jacob P. Laubach, Keith E. Stockerl ‐Goldstein, Long Kwei, Fong Clo Tags: Research Paper Source Type: research

Rituximab ‐Bendamustine (R‐Benda) in MALT lymphoma complicating primary Sjögren syndrome (pSS)
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Lucie Demaria, Julien Henry, Raphaele Seror, Laurent Frenzel, Olivier Hermine, Xavier Mariette, Gaetane Nocturne Tags: Correspondence Source Type: research

Parameters critical for the effector mechanism of anti ‐CD20 antibodies revisited
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Grzegorz Stasi łojć, Anna Felberg, Marcin Okrój Tags: Editorial Comment Source Type: research

N ‐acetyl‐L‐cysteine improves mesenchymal stem cell function in prolonged isolated thrombocytopenia post‐allotransplant
Summary Prolonged isolated thrombocytopenia (PT) is a serious complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT). Murine studies and in vitro experiments suggest that mesenchymal stem cells (MSCs) can, not only to support haematopoiesis, but also preferentially support megakaryocytopoiesis in bone marrow (BM). However, little is known about the quantity and function of BM MSCs in PT patients. In a case‐control study, we found that BM MSCs from PT patients exhibited significantly reduced proliferative capacities, increased reactive oxygen species and senescence. Antioxidant (N‐acetyl...
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Yuan Kong, Yang Song, Fei ‐Fei Tang, Hong‐Yan Zhao, Yu‐Hong Chen, Wei Han, Chen‐Hua Yan, Yu Wang, Xiao‐Hui Zhang, Lan‐Ping Xu, Xiao‐Jun Huang Tags: Research Paper Source Type: research

Diagnosis of a lymphoma associated with human herpes virus 8 aided by flow cytometric immunophenotyping
(Source: British Journal of Haematology)
Source: British Journal of Haematology - February 1, 2018 Category: Hematology Authors: Robin Boutault, Julian Le Glaunec, Camille Debord, Nelly Robillard, Laurent Nicolet, Marion Eveillard Tags: Images in Haematology Source Type: research

BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 31, 2018 Category: Hematology Authors: Keith R. Sibson, Tina T. Biss, Caroline L. Furness, John D. Grainger, Rachael E. Hough, Christine Macartney, Jeanette H. Payne, Elizabeth A. Chalmers, Tags: Guideline Source Type: research

Platelets at the crossroads of thrombosis, inflammation and haemolysis
Summary Platelets play a critical role at the interphase of thrombosis and inflammation, key features in haemolysis‐associated disorders. Exercising this role requires expression of pattern recognition receptors by platelets, including toll‐like receptor 4 (TLR4) and nucleotide‐binding domain leucine rich repeat containing protein 3 (NLRP3), the latter forming intraplatelet multiprotein inflammasome complexes. Platelets are a potential target of various damage‐associated molecular pattern (DAMP) molecules, such as free haem, a degradation by‐product of haemoglobin oxidation during haemolysis, and high‐mobility ...
Source: British Journal of Haematology - January 31, 2018 Category: Hematology Authors: Sebastian Vogel, Swee Lay Thein Tags: Annotation Source Type: research

Autologous stem cell transplant and combination immunotherapy of rituximab and interferon ‐α induces prolonged clinical and molecular remissions in patients with follicular lymphoma
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 30, 2018 Category: Hematology Authors: Liam Smyth, Rena Buckstein, Nancy Pennell, Rashmi Weerasinghe, Matthew C. Cheung, Kevin Imrie, David Spaner, Eugenia Piliotis, Lisa Chodirker, Marciano Reis, Zeina Ghorab, Liying Zhang, Violet Boudreau, Angela Miliken, Neil Berinstein Tags: Correspondence Source Type: research

Venetoclax as a single agent and in combination with PI3K ‐MTOR1/2 kinase inhibitors against ibrutinib sensitive and resistant mantle cell lymphoma
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 30, 2018 Category: Hematology Authors: Huijuan Jiang, Tint Lwin, Xiaohong Zhao, Yuan Ren, Grace Li, Lynn Moscinski, Bijal Shah, Jianguo Tao Tags: Correspondence Source Type: research

Bone marrow biopsies not indicated for response assessment in follicular lymphoma trials regardless of type of imaging study – Response to Adams and Kwee
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 29, 2018 Category: Hematology Authors: Sarah C. Rutherford, John P. Leonard Tags: Correspondence Source Type: research

How I manage red cell transfusions in patients with sickle cell disease
Summary Sickle cell disease is one of the commonest serious inherited diseases in the world, and red cell transfusion is still one of the few effective treatments for acute and chronic complications. Transfusion corrects anaemia and dilutes out the number of red cells able to cause vaso‐occlusion and vascular damage. Urgent red cell transfusions are used to correct acute anaemia, treat acute chest syndrome and patients with acute neurological symptoms. We use elective transfusions preoperatively for moderate risk surgery, and in some pregnant women. There is good evidence for the use of long‐term regular transfusions i...
Source: British Journal of Haematology - January 29, 2018 Category: Hematology Authors: David C. Rees, Susan Robinson, Jo Howard Tags: Annotation Source Type: research

Megakaryocytes harbour the del(5q) abnormality despite complete clinical and cytogenetic remission induced by lenalidomide treatment
Summary The mechanisms underlying lenalidomide‐resistance of del(5q) MDS stem cells remain to be elucidated and may include cell‐intrinsic as well as microenvironmental causes. Abnormal hypolobated megakaryocytes constitute one of the hallmarks of del(5q) MDS. We hypothesized that these cells have potential implications for the regulation of haematopoietic stem cells (HSC) similarly to what has recently been described for megakaryocytes in the murine system. Therefore, we conducted a study to determine the response of abnormal hypolobated megakaryocytes to lenalidomide therapy. We studied lenalidomide‐treated patient...
Source: British Journal of Haematology - January 29, 2018 Category: Hematology Authors: Christian Scharenberg, Monika Jansson, Leonie Saft, Eva Hellstr öm‐Lindberg Tags: Research Paper Source Type: research

Pancytopenia and megaloblastic erythropoiesis reveal a novel GIF mutation
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 25, 2018 Category: Hematology Authors: Paul Saultier, Marie Loosveld, Jean ‐François Benoist, Gérard Michel Tags: Images in haematology Source Type: research

Haematology patients and the risk of transfusion transmitted infection
Summary A 2014 study by NHS Blood and Transplant indicated that over one quarter of red cells were transfused to patients with haematological conditions. For platelet components, the figure is higher. Certain diagnostic groups, such as haemoglobinopathies, myelodysplastic syndromes and some haemato‐oncology patients, receive multiple transfusion episodes, either over long periods, or more intensively over shorter periods. Haematology patients account for the majority of the multi‐transfused population. The risk of transfusion‐transmitted infection (TTI) increases with number of donor exposures, and the consequences o...
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Louise I. Ainley, Patricia E Hewitt Tags: Review Source Type: research

Issue Information
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Tags: Issue Information Source Type: research

Ofatumumab is a feasible alternative anti ‐CD20 therapy in patients intolerant of rituximab
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Lucia Y. Chen, Raakhee Shah, Kate Cwynarski, Jonathan Lambert, Christopher McNamara, Sajir G. Mohamedbhai, Andres Virchis, William Townsend, Shirley D'Sa, Kirit M. Ardeshna Tags: Correspondence Source Type: research

Assessing complete remission status in incurable follicular lymphomas, to what purpose?
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Hugo J. A. Adams, Thomas C. Kwee Tags: Correspondence Source Type: research

The “escape” model: a versatile mechanism for clonal expansion
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Lucio Luzzatto, Rosario Notaro Tags: Correspondence Source Type: research

Graft ‐versus‐host disease‐associated hepatic portal venous gas
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Arun K. Singavi, Nirav N. Shah Tags: Images in Haematology Source Type: research

Potential influence of concomitant chemotherapy on CXCR4 expression in receptor directed endoradiotherapy
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Constantin Lapa, Katharina L ückerath, Stefan Kircher, Heribert Hänscheid, Götz U. Grigoleit, Andreas Rosenwald, Antje Stolzenburg, Saskia Kropf, Hermann Einsele, Hans‐Jürgen Wester, Andreas K. Buck, Klaus M. Kortüm, Andreas Schirbel Tags: Correspondence Source Type: research

Diagnostic approach to pulmonary embolism in pregnancy: are the winds of change upon us or is it d éjà vu all over again?
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Ann Kinga Malinowski Tags: Editorial Comment Source Type: research

Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine
Summary Heparin anticoagulation followed by protamine reversal is commonly used in cardiopulmonary bypass (CPB). As an alternative to protamine, a recombinant inactive antithrombin (riAT) was designed as an antidote to heparin and was previously shown to be as potent as protamine in‐vitro. In the present study, riAT was assessed for its ability to neutralize heparin after CPB in a rat model. After 60 min of CPB under heparin, rats received 5 mg/kg protamine, 37.5 mg/kg riAT or phosphate buffered saline (PBS) as placebo. Residual anticoagulant activity was assessed using the activated partial thromboplastin...
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Elsa P. Bianchini, Alexandre Sebestyen, Toufik Abache, Yasmine Bourti, Alexandre Fontayne, Vincent Richard, Fabienne Tamion, Jean ‐Luc Plantier, Fabien Doguet, Delphine Borgel Tags: Research Paper Source Type: research

Serum hepcidin potentially identifies iron deficiency in survivors of critical illness at the time of hospital discharge
(Source: British Journal of Haematology)
Source: British Journal of Haematology - January 24, 2018 Category: Hematology Authors: Akshay Shah, Katherine Wray, Timothy James, Brian Shine, Reza Morovat, Simon Stanworth, Stuart McKechnie, Rachael Kirkbride, David M. Griffith, Timothy S. Walsh, Hal Drakesmith, No émi Roy Tags: Correspondence Source Type: research