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Association between nocturnal oxygen desaturation and ischaemic stroke outcomes
CONCLUSIONS AND CLINICAL IMPLICATIONS: This study demonstrated that long-lasting desaturation episodes during the night, depicted by the 'total desaturation burden', were correlated with worse functional outcomes in AIS, while measures of shorter desaturation episodes were not correlated. In future clinical trials, indications for oxygen supplementation should include the methodology of personalised medicine and introduce individual approaches based on specially formulated, novel multifactorial algorithms.PMID:35607842 | DOI:10.5603/PJNNS.a2022.0033
Source: Neurologia i Neurochirurgia Polska - May 24, 2022 Category: Neurology Authors: Izabela Wojtasz Andrzej Tomski Rados ław Kaźmierski Source Type: research
Stroke Prevention with Hydroxyurea Enabled through Research and Education (SPHERE): a Phase 2 primary stroke prevention trial in sub-Saharan Africa
Conclusion: SPHERE has built local capacity with high-quality research infrastructure and TCD screening for SCA in Tanzania. Fully enrolled, participants have a high prevalence of elevated baseline TCD velocities and splenomegaly. SPHERE will prospectively determine the benefits of hydroxyurea at MTD for primary stroke prevention, anticipating expanded access to hydroxyurea treatment across Tanzania.
Source: Acta Haematologica - August 17, 2022 Category: Hematology Source Type: research
