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Condition: Anemia
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Total 684 results found since Jan 2013.

Association between aspirin-induced hemoglobin decline and outcome after acute ischemic stroke in G6PD-deficient patients
CONCLUSION: Hemoglobin decrease with bilirubin increase after aspirin treatment in patients with G6PD deficiency suggests hemolysis, which may influence stroke prognosis. The risk of hemoglobin decline should be carefully monitored in G6PD-deficient patients with ischemic stroke taking aspirin.PMID:34369077 | DOI:10.1111/cns.13711
Source: CNS Neuroscience and Therapeutics - August 9, 2021 Category: Neuroscience Authors: Yicong Chen Jianle Li Zilin Ou Yusheng Zhang Zhijian Liang Weisheng Deng Weixian Huang Fubing Ouyang Jian Yu Shihui Xing Jinsheng Zeng Source Type: research

The association between obstructive sleep apnea and stroke in sickle-cell disease children
ConclusionPatients who had OSA had a higher prevalence of stroke compared to non-OSA patients by 16% with almost three times higher odds. The difference was statistically significant in bivariant but not multivariant analysis. The rate of hospitalization, emergency visit, and blood transfusion were not affected by OSA status. Screening for OSA in high-risk patients such as SCD children and early management could prevent the risk of SCD complications.
Source: European Archives of Oto-Rhino-Laryngology - January 29, 2022 Category: ENT & OMF Source Type: research

A single-site retrospective study of pediatric arterial ischemic stroke etiology, clinical presentation, and radiologic features.
CONCLUSIONS: PAIS occurs more frequently in younger children and this group most frequently presents with convulsion as the initial symptom. The overall etiologies of PAIS may be different from those of adult stroke and the involved regions may be distinguishing features of PAIS or its different forms, but more research is required. PMID: 24034087 [PubMed - in process]
Source: Chinese Medical Journal - September 1, 2013 Category: Journals (General) Authors: Sun D, Wu XM, Wang ZW, Jin RM, Liu ZS, Liu F, Huang S, Wang HQ, Hu JS Tags: Chin Med J (Engl) Source Type: research

High mortality among children with sickle cell anemia and overt stroke who discontinue blood transfusion after transition to an adult program.
CONCLUSION: Efforts must be made to maintain adequate chronic simple or exchange blood transfusion for children with SS and stroke after transition to adult care. PMID: 26593779 [PubMed - as supplied by publisher]
Source: Transfusion - November 23, 2015 Category: Hematology Authors: McLaughlin JF, Ballas SK Tags: Transfusion Source Type: research

Atrial fibrillation, anticoagulation management and risk of stroke in the Cardiomyopathy/Myocarditis registry of the EURObservational Research Programme of the European Society of Cardiology
ConclusionsThe study reveals a high prevalence and diverse distribution of AF in patients with cardiomyopathies, inadequate anticoagulation regimen, and high risk of stroke/TIA in this population.
Source: ESC Heart Failure - September 16, 2020 Category: Cardiology Authors: Katarzyna Mizia ‐Stec, Alida L.P. Caforio, Philippe Charron, Juan R. Gimeno, Perry Elliott, Juan Pablo Kaski, Aldo P. Maggioni, Luigi Tavazzi, Angelos G. Rigopoulos, Cecile Laroche, Attila Frigy, Elisabetta Zachara, Maria Luisa Pena‐Pena, Tags: Original Research Article Source Type: research

Mineralizing angiopathy with basal ganglia stroke after minor head trauma; a clinical profile and follow up study of a large series of paediatric patients from North India
CONCLUSION: Minor head trauma leading to basal ganglia stroke in children was the most common cause of paediatric stroke in our patients. In follow-up most patients had recovered fully, though a significant minority did not recover completely.PMID:34077857 | DOI:10.1016/j.ejpn.2021.05.011
Source: European Journal of Paediatric Neurology - June 2, 2021 Category: Neurology Authors: Roshni Bahri Radhe Shyam Sharma Vivek Jain Source Type: research

Stroke with intracranial stenosis is associated with increased platelet activation in sickle cell anemia
ConclusionStroke with intracranial stenosis is associated with increased platelet activation in sickle cell anemia, and further investigation is needed on the role of anti‐platelet agents in this high‐risk population. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - March 18, 2013 Category: Cancer & Oncology Authors: Suvankar Majumdar, Samantha Webb, Erin Norcross, Venkat Mannam, Naveed Ahmad, Seth Lirette, Rathi Iyer Tags: Research Article Source Type: research

Abstract 217: How well does the CHADS2 Stroke Risk Score Predict Major Hemorrhage in Patients with Atrial Fibrillation? Poster Session II
Conclusions: Although some clinical markers of stroke risk such as those included in the CHADS2 risk score are also associated with increased hemorrhage risk, the CHADS2 risk score should not be used instead of a validated hemorrhage risk tool to estimate hemorrhage risk.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Quinn, G. R., Singer, D. E., Go, A. S., Chang, Y., Borowsky, L., Pomernacki, N., Udaltsova, N., Fang, M. C. Tags: Poster Session II Source Type: research

Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk
Abstract Stroke is one of the most disabling complications of sickle cell anemia (SCA). The molecular mechanisms leading to stroke in SCA or by which packed red blood cell (PRBC) transfusion prevents strokes are not understood. We investigated the effects of PRBC transfusion on serum biomarkers in children with SCA who were at high‐risk for stroke. Serum samples from 80 subjects were analyzed, including baseline, study exit time point and 1 year after study exit. Forty of the 80 samples were from subjects randomized to standard care and 40 from transfusion arm. Samples were assayed for levels of BDNF, sVCAM‐1, sICAM‐...
Source: American Journal of Hematology - August 31, 2013 Category: Hematology Authors: Hyacinth I. Hyacinth, Robert J. Adams, Jenifer H. Voeks, Jacqueline M. Hibbert, Beatrice E. Gee Tags: Research Article Source Type: research

Anemia and stroke: Where do we stand?
Anemia seems to have a clear relationship with cerebrovascular events (CVEs), as there is a direct connection between central nervous system, blood supply, and tissue oxygen delivery. Anemia is considered a hyperkinetic state which disturbs endothelial adhesion molecule genes that may lead to thrombus formation. Furthermore, blood flow augmentation and turbulence may result in the migration of this thrombus, thus producing artery‐to‐artery embolism. It is for this reason that anemia is characterized as “the fifth cardiovascular risk factor.” Anemia is consistently present in patients with acute stroke, ranging from...
Source: Acta Neurologica Scandinavica - August 2, 2016 Category: Neurology Authors: G. Kaiafa, C. Savopoulos, I. Kanellos, K. S. Mylonas, G. Tsikalakis, T. Tegos, N. Kakaletsis, A. I. Hatzitolios Tags: Review Article Source Type: research

Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportu nity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.RESUMO Doppler transcraniano (DTC) é um componente estratégico da prevenção primária do acidente vascular cerebral (AVC) em crianças com doença falciforme (DF). Este estudo foi realizado para examinar as características do DTC de crianças com DF em nove centros médicos diferentes no Brasil. Métodos: DTC foi...
Source: Arquivos de Neuro-Psiquiatria - January 16, 2017 Category: Neurology Source Type: research

Hypoperfusion, vascular pruning, and transient hemiparesis mimicking stroke in transient erythroblastopenia of childhood (P4.161)
Conclusions:The patient’s transient cerebrovascular and electrophysiologic abnormalities are consistent with those described in the literature for hemiplegic migraine. However, he did not meet International Headache Society criteria for hemiplegic migraine, such as headache with presentation or recurrent events. We hypothesize that transient vascular narrowing and resultant hypoperfusion, compounded by cerebral hypoxia from significant anemia, may explain the transient neurologic symptoms concurrent with anemia in TEC.Disclosure: Dr. Calahan has nothing to disclose. Dr. Lehman has nothing to disclose. Dr. Rivkin has ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Calahan, C., Lehman, L., Rivkin, M., Lipton, J., Danehy, A., Robertson, R., Ozuah, N., Trenor, C., Bernson-Leung, M. Tags: Child Neurology II Source Type: research