Withdrawal
“Comparative Efficacy of Sirolimus‐Eluting Stents and Paclitaxel‐Eluting Stents in East Asian Versus non‐East Asian Patients: A Systematic Review& Meta ‐Analysis” by Zhao, R., Lu, Q., Yang, R., Du, J., Deng, S. and She, Q.1The above article from theCardiovascular Therapeutics, published online on 05 January 2017 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn.REFERENCE1. Zhao, R., Lu, Q., Yang, R., Du, J., Deng, S. and She, Q. (2017), Comparative Efficacy of Sirolimus ‐Eluting Stents and Paclitaxel‐Eluting Stents in East Asian Versus non‐East Asian Patients: A System...
Source: Cardiovascular Therapeutics - March 9, 2021 Category: Cardiology Tags: WITHDRAWAL Source Type: research

Withdrawal
‘MicroRNA‐27a mediates the Wnt/β‐catenin pathway to affect the myocardial fibrosis in rats with chronic heart failure’ by Zhuang, Y., Liao, Y., Liu, B., Fang, Z., Chen, L., Min, L. and Chen, W.1The above article from theCardiovascular Therapeutics, published online on 20 September 2018 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn.REFERENCE1. Zhuang, Y., Liao, Y., Liu, B., Fang, Z., Chen, L., Min, L. and Chen, W. (2019), MicroRNA ‐27a mediates the Wnt/β‐catenin pathway to affect the myocardial fibrosis in rats with chronic heart failure. Cardiovasc Ther. Accepted A...
Source: Cardiovascular Therapeutics - March 22, 2019 Category: Cardiology Tags: WITHDRAWAL Source Type: research

Withdrawal
“Comparative Efficacy of Sirolimus‐Eluting Stents and Paclitaxel‐Eluting Stents in East Asian Versus non‐East Asian Patients: A Systematic Review& Meta ‐Analysis” by Zhao, R., Lu, Q., Yang, R., Du, J., Deng, S. and She, Q.1The above article from theCardiovascular Therapeutics, published online on 05 January 2017 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn.REFERENCE1. Zhao, R., Lu, Q., Yang, R., Du, J., Deng, S. and She, Q. (2017), Comparative Efficacy of Sirolimus ‐Eluting Stents and Paclitaxel‐Eluting Stents in East Asian Versus non‐East Asian Patients: A System...
Source: Cardiovascular Therapeutics - March 21, 2019 Category: Cardiology Tags: WITHDRAWAL Source Type: research

Use of acetazolamide in the treatment of patients with refractory congestive heart failure
ConclusionIn a cohort of patients with refractory CHF treated with an intensive diuretic treatment, the addition of acetazolamide was associated with improvement in functional class and surrogates of fluid overload. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Julio N úñez, Raquel Heredia, Ana Payá, Ignacio Sanchis, Susana Prado, Gema Miñana, Enrique Santas, Rafael Espriella, Eduardo Núñez, Juan Sanchis, Antoni Bayés‐Genís Tags: SHORT COMMUNICATION Source Type: research

Management of arterial hypertension with angiotensin receptor blockers: Current evidence and the role of olmesartan
SummaryElevated blood pressure (BP) is a major determinant of morbidity and mortality burden related to cardio ‐metabolic risk. Current guidelines indicate that controlling and lowering BP promotes cardiovascular (CV) risk reduction. Among antihypertensive agents, angiotensin receptor blockers (ARBs) are characterized by an efficacy profile equivalent to other antihypertensive agents and are provided with excellent tolerability and low discontinuation rates during chronic treatments. Moreover, CV outcomes are reduced by ARBs. Olmesartan is a long‐lasting ARB which proved to achieve a comparable or more effective action...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Stefano Omboni, Massimo Volpe Tags: UNSOLICITED REVIEW Source Type: research

Issue Information
(Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research

Evidence ‐based pharmacotherapies used in the postdischarge phase are associated with improved one‐year survival in senior patients hospitalized with heart failure
SummaryAimHospitalized heart failure (HF) patients have a poor prognosis postdischarge. We determined whether renin ‐angiotensin system inhibitors (RASI) and β‐blockers dispensed to patients within 60 days post‐HF hospital discharge are associated with improved 1‐year survival.MethodsA retrospective population ‐based study was conducted in 4897 seniors, aged 65‐84 years, alive at 60 days postindex HF hospitalization in Western Australia over 2003‐2008. Dispensing of RASI and β‐blocker dispensing was identified from the Pharmaceutical Benefits Scheme claims database linked to hospita...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Xiwen Qin, Joseph Hung, Matthew Knuiman, Tiew ‐Hwa K. Teng, Tom Briffa, Frank M. Sanfilippo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Role of interleukin ‐7 in fusion of rat bone marrow mesenchymal stem cells with cardiomyocytes in vitro and improvement of cardiac function in vivo
SummaryAimsMesenchymal stem cells (MSCs) hold significant promise as potential therapeutic candidates following cardiac injury. However, to ensure survival of transplanted cells in ischemic environment, it is beneficial to precondition them with growth factors that play important role in cell survival and proliferation. Aim of this study is to use interleukin ‐7 (IL‐7), a cell survival growth factor, to enhance the potential of rat bone marrow MSCs in terms of cell fusion in vitro and cardiac function in vivo.MethodsMesenchymal stem cells were transfected with IL ‐7 gene through retroviral vector. Normal and transfec...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Kanwal Haneef, Anwar Ali, Irfan Khan, Nadia Naeem, Siddiqua Jamall, Asmat Salim Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Activation of AMPK alleviates cardiopulmonary bypass ‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder
In conclusion, it was suggested in this study that preactivation of AMPK by AICAR improved myocardial glucose uptake by promoting AS160 dependent myocardial membrane GLUT‐4 translocation, which ultimately provided a potent cardioprotective effect. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Zhifa Wang, Yukun Cao, Qiang Yin, Yuehu Han, Yunya Wang, Guocheng Sun, Hailong Zhu, Ming Xu, Chunhu Gu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Statins and risk of cataracts: A systematic review and meta ‐analysis of observational studies
ConclusionsThe results point out an increased risk of cataract development with statins. However, since the magnitude of the effect is low and between ‐studies heterogeneity is high, the extent in which these results have impact on the benefit/risk ratio of statins is difficult to ascertain due to the uncertainty of the findings. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Carlos Alves, Diogo Mendes, Francisco Batel Marques Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Clinical effectiveness and safety of antazoline ‐based therapy in patients with stable coronary artery disease undergoing pharmacological cardioversion of short‐duration atrial fibrillation in the emergency department
ConclusionsIn selected patients with a stable CAD, even with a history of MI, antazoline ‐based CV of short‐duration AF may be an effective and safe therapeutic option. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Michal M. Farkowski, Aleksander Maciag, Malgorzata Zurawska, Ilona Kowalik, Hanna Szwed, Mariusz Pytkowski Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Beneficial effects of tolvaptan on atrial remodeling induced by chronic intermittent hypoxia in rats
ConclusionsCIH ‐induced significant atrial remodeling in our rat model, which was attenuated by tolvaptan. These changes may be explained due to alterations in miR‐21/Spry1/ERK/MMP‐9, miR‐21/PTEN/PI3K/AKT, and NF‐κB pathways by tolvaptan. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Kai Zhang, Zuowang Ma, Weiding Wang, Ruimeng Liu, Yue Zhang, Meng Yuan, Guangping Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effect of evidence ‐based cardiac drug therapy on mortality in patients with acute coronary syndrome: Findings from the Gulf COAST registry
SummaryAimTo evaluate the prevalence and impact of the prescribing of an evidence ‐based cardiac medication (EBM) combination on 1‐month, 6‐months, and 12‐months all‐cause mortality in patients with acute coronary syndrome (ACS).MethodsData were analyzed from 3681 consecutive patients diagnosed with ACS admitted to 29 hospitals in 4 Middle Eastern countries from January 2012 to January 2013. The EBM combination consisted of concurrent prescribing of an antiplatelet therapy, angiotensin ‐converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB), β‐blocker, and a statin, at hospital disch...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Ibrahim Al ‐Zakwani, Mohammad Zubaid, Alawi A. Alsheikh‐Ali, Wael Almahmeed, Wafa Rashed Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effect of multidisciplinary cardiac rehabilitation on the response to cardiac resynchronization therapy
SummaryBackgroundBoth cardiac resynchronization therapy (CRT) and Multidisciplinary Cardiac Rehabilitation (CR) beneficially influence symptomatic status, exercise capacity, quality of life, and heart failure readmission rates. However, the interaction between both therapies remain incompletely addressed.MethodsConsecutive CRT patients implanted in a single tertiary care center were retrospectively analyzed. Patients were dived according to the participation in a structured CR ‐program following CRT‐implant. The effect on functional status (New York Heart Association; NYHA‐class), reverse remodeling (change in left v...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Pieter Martens, Guy Jacobs, Matthias Dupont, Wilfried Mullens Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Upstream therapeutic strategies of valsartan and fluvastatin on hypertensive patients with non ‐permanent atrial fibrillation
SummaryAimTo investigate the upstream therapeutic effects of fluvastatin and valsartan on hypertensive patients with non ‐permanent atrial fibrillation (AF).MethodsA total of 189 patients who were admitted to outpatient and inpatient department from eight medical centers in China, diagnosed as hypertension with non ‐permanent AF, were divided into four groups randomly: the CCBs group (group A, n = 45); CCB + fluvastatin group (group B, n = 48); valsartan group (group C, n = 46); valsartan + fluvastatin group (group D, n = 50). The four groups were followed up ...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Zhiqiang Zhao, Xiaowei Niu, Zhaojie Dong, Wenwei Qi, Enzhao Liu, Tong Liu, Lifeng Li, Yingzi Liang, Guangping Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Fasudil exerts a cardio ‐protective effect on mice with coxsackievirus B3‐induced acute viral myocarditis
ConclusionsROCK pathway inhibition was cardio ‐protective in viral myocarditis with increased survival, decreased viral replication, and inflammatory response. These findings suggest that Fasudil might be a potential therapeutic agent for patients with viral myocarditis. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Kezhi Dai, Yaoyao Wang, Sichao Tai, Huajing Ni, Hao Lian, Yan Yu, Weifang Liao, Cheng Zheng, Qing Chen, Aarti Kuver, Jia Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low ‐density lipoprotein receptor knockout mice
ConclusionsOur results suggest that combination therapy with pravastatin and cilostazol exerts beneficial effects by decreasing atherosclerotic lesion progression and improving the pro ‐inflammatory state in the vascular endothelium. These effects are mediated by the reduction in adhesion molecule expression, immune cell infiltration, and cytokine levels and the antiatherosclerotic modulation of serum cholesterol levels. Therefore, we conclude that combined treatment with pravas tatin and cilostazol may be a more effective antiatherosclerotic strategy than treatment with either agent alone. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Kyung ‐Yeon Park, Tae‐Hwe Heo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The incidence of atrial fibrillation with trastuzumab treatment: A systematic review and meta ‐analysis
ConclusionsAtrial fibrillation incidence in breast cancer patients receiving trastuzumab was around 1.2%. It was not influenced by the formulation of trastuzumab, the additional use of neoplastic agents, anthracycline exposure status, or concurrent radiotherapy. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Ming Yuan, Gary Tse, Zhiwei Zhang, Xu Han, William K. K. Wu, Guangping Li, Yunlong Xia, Tong Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Calcium channel blockers are associated with improved survival and lower cardiovascular mortality in patients with renovascular disease
SummaryBackground and objectiveResults of interventional trials in renovascular hypertension have been disappointing, and medical therapy is the current recommended gold standard. However, the comparative long ‐term benefits of different antihypertensive drug classes in atherosclerotic renal artery stenosis are not known. We aim to assess the effect of different antihypertensive drug classes on outcomes in renovascular hypertensionDesign, setting, participants, and measurementsUsing Tayside Health Informatics Centre database, anonymized data over a 6 ‐year period was analyzed. Biochemistry, prescribing data, morbidity,...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Harshal Deshmukh, Emma Barker, Thineshkrishna Anbarasan, Daniel Levin, Samira Bell, Miles D. Witham, Jacob George Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT
SummaryObjectiveIn a subgroup analysis of the China Stroke Primary Prevention Trial, we aimed to explore the impact of folic acid supplementation on arterial stiffness and assess the modifying effect of the methylenetetrahydrofolate reductase (MTHFR) gene in Chinese patients with hypertension.MethodsThis prospective study enrolled 2529 hypertensive Chinese patients. Participants were randomized to receive treatment with either a combination of enalapril and folic acid or enalapril. Brachial ‐ankle pulse wave velocity (PWV) was measured by trained medical staff using PWV instruments at both baseline and exit visits, appro...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Xin Yang, Minghua Zhang, Rensheng Song, Changfu Liu, Yong Huo, Geng Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effects of tranexamic acid on short ‐term and long‐term outcomes of on‐pump coronary artery bypass grafting: Randomized trial and 7‐year follow‐up
SummaryAimsSafety evaluations of tranexamic acid (TXA) remain sparse, especially with respect to its impact on long ‐term outcomes in patients undergoing on‐pump coronary artery bypass grafting (CABG). We hypothesized that the effects of TXA on perioperative bleeding and allogeneic transfusion and its impact on long‐term clinical outcomes of patients receiving on‐pump CABG are superior to those in the con trol group.MethodsIn this prospective, randomized, placebo ‐controlled trial, 210 patients undergoing primary and isolated on‐pump CABG were randomly assigned to receive TXA or a corresponding volume of saline...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Yu Zhang, Xurong Gao, Su Yuan, Jingfei Guo, Huanran Lv, Yong Zhou, Yuefu Wang, Hongwen Ji, Guyan Wang, Lihuan Li, Jia Shi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double ‐blind randomized study
SummaryIntroductionBlood donation has been proposed as a potential therapy to reduce risk of cardiovascular disease, but the effects of phlebotomy on vascular function in human subjects have not been well characterized.AimsWe conducted a prospective randomized double ‐blind study to determine the effects of serial phlebotomy on vascular endothelial function in the brachial artery. Eighty‐four iron‐replete, non‐anemic subjects were randomly assigned to one of three study treatment groups: (a) four serial phlebotomy procedures each followed by intravenous infusion of placebo normal saline; (b) four serial phlebotomy ...
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Qurat ‐ul‐ain Jelani, Bhisham Harchandani, Ritchard G. Cable, Yu Guo, Hua Zhong, Timothy Hilbert, Jonathan D. Newman, Stuart D. Katz Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Hydromorphine postconditioning protects isolated rat heart against ischemia ‐reperfusion injury via activating P13K/Akt/eNOS signaling
ConclusionsThese findings suggest that hydromorphine postconditioning may protect isolated rat heart against reperfusion injury via activating P13K/Akt/eNOS signaling. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Qing Liu, Zhengfen Li, Yuexin Liu, Qiuxia Xiao, Xuan Peng, Qi Chen, Rui Deng, Zhiwei Gao, Fengxu Yu, Ying Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Issue Information
Cardiovascular Therapeutics, Volume 36, Issue 6, December 2018. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research

Activation of AMPK alleviates cardiopulmonary bypass ‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder
In conclusion, it was suggested in this study that preactivation of AMPK by AICAR improved myocardial glucose uptake by promoting AS160 dependent myocardial membrane GLUT‐4 translocation, which ultimately provided a potent cardioprotective effect. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Zhifa Wang, Yukun Cao, Qiang Yin, Yuehu Han, Yunya Wang, Guocheng Sun, Hailong Zhu, Ming Xu, Chunhu Gu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Hydromorphine postconditioning protects isolated rat heart against ischemia ‐reperfusion injury via activating P13K/Akt/eNOS signaling
ConclusionsThese findings suggest that hydromorphine postconditioning may protect isolated rat heart against reperfusion injury via activating P13K/Akt/eNOS signaling. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Qing Liu, Zhengfen Li, Yuexin Liu, Qiuxia Xiao, Xuan Peng, Qi Chen, Rui Deng, Zhiwei Gao, Fengxu Yu, Ying Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Activation of AMPK alleviates cardiopulmonary bypass induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder
In conclusion, it was suggested in this study that pre‐activation of AMPK by AICAR improved myocardial glucose uptake by promoting AS160 dependent myocardial membrane GLUT‐4 translocat ion, which ultimately provided a potent cardioprotective effect.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - January 11, 2019 Category: Cardiology Authors: Zhifa Wang, Yukun Cao, Qiang Yin, Yuehu Han, Yunya Wang, Guocheng Sun, Hailong Zhu, Ming Xu, Chunhu Gu Tags: Original Research Article Source Type: research

Hydromorphone Postconditioning Protects Isolated Rat Heart against Ischemia ‐Reperfusion Injury via Activating P13K/Akt/eNOS Signaling
ConclusionsThese findings suggest that hydromorphone postconditioning may protect isolated rat heart against reperfusion injury via activating P13K/Akt/eNOS signaling.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Qing Liu, Zhengfen Li, Yuexin Liu, Qiuxia Xiao, Xuan Peng, Qi Chen, Rui Deng, Zhiwei Gao, Fengxu Yu, Ying Zhang Tags: Original Research Article Source Type: research

Statins and risk of cataracts: a systematic review and meta ‐analysis of observational studies
ConclusionsThe results point out an increased risk of cataract development with statins. However, since the magnitude of the effect is low and between ‐studies heterogeneity is high, the extent in which these results have impact on the benefit/risk ratio of statins is difficult to ascertain due to the uncertainty of the findings.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Carlos Alves, Diogo Mendes, Francisco Batel Marques Tags: Original Research Article Source Type: research

Hydromorphone Postconditioning Protects Isolated Rat Heart against Ischemia ‐Reperfusion Injury via Activating P13K/Akt/eNOS Signaling
ConclusionsThese findings suggest that hydromorphone postconditioning may protect isolated rat heart against reperfusion injury via activating P13K/Akt/eNOS signaling.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Qing Liu, Zhengfen Li, Yuexin Liu, Qiuxia Xiao, Xuan Peng, Qi Chen, Rui Deng, Zhiwei Gao, Fengxu Yu, Ying Zhang Tags: Original Research Article Source Type: research

Statins and risk of cataracts: a systematic review and meta ‐analysis of observational studies
ConclusionsThe results point out an increased risk of cataract development with statins. However, since the magnitude of the effect is low and between ‐studies heterogeneity is high, the extent in which these results have impact on the benefit/risk ratio of statins is difficult to ascertain due to the uncertainty of the findings.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Carlos Alves, Diogo Mendes, Francisco Batel Marques Tags: Original Research Article Source Type: research

Role of interleukin ‐7 in fusion of rat bone marrow mesenchymal stem cells with cardiomyocytes in vitro and improvement of cardiac function in vivo
SummaryAimsMesenchymal stem cells (MSCs) hold significant promise as potential therapeutic candidates following cardiac injury. However, to ensure survival of transplanted cells in ischemic environment, it is beneficial to precondition them with growth factors that play important role in cell survival and proliferation. Aim of this study is to use interleukin ‐7 (IL‐7), a cell survival growth factor, to enhance the potential of rat bone marrow MSCs in terms of cell fusion in vitro and cardiac function in vivo.MethodsMesenchymal stem cells were transfected with IL ‐7 gene through retroviral vector. Normal and transfec...
Source: Cardiovascular Therapeutics - December 6, 2018 Category: Cardiology Authors: Kanwal Haneef, Anwar Ali, Irfan Khan, Nadia Naeem, Siddiqua Jamall, Asmat Salim Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Calcium channel blockers are associated with improved survival and lower cardiovascular mortality in patients with renovascular disease
SummaryBackground and objectiveResults of interventional trials in renovascular hypertension have been disappointing, and medical therapy is the current recommended gold standard. However, the comparative long ‐term benefits of different antihypertensive drug classes in atherosclerotic renal artery stenosis are not known. We aim to assess the effect of different antihypertensive drug classes on outcomes in renovascular hypertensionDesign, setting, participants, and measurementsUsing Tayside Health Informatics Centre database, anonymized data over a 6 ‐year period was analyzed. Biochemistry, prescribing data, morbidity,...
Source: Cardiovascular Therapeutics - December 4, 2018 Category: Cardiology Authors: Harshal Deshmukh, Emma Barker, Thineshkrishna Anbarasan, Daniel Levin, Samira Bell, Miles D. Witham, Jacob George Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low ‐density lipoprotein receptor knockout mice
ConclusionsOur results suggest that combination therapy with pravastatin and cilostazol exerts beneficial effects by decreasing atherosclerotic lesion progression and improving the pro ‐inflammatory state in the vascular endothelium. These effects are mediated by the reduction in adhesion molecule expression, immune cell infiltration, and cytokine levels and the antiatherosclerotic modulation of serum cholesterol levels. Therefore, we conclude that combined treatment with pravas tatin and cilostazol may be a more effective antiatherosclerotic strategy than treatment with either agent alone. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 29, 2018 Category: Cardiology Authors: Kyung ‐Yeon Park, Tae‐Hwe Heo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Fasudil exerts a cardio ‐protective effect on mice with coxsackievirus B3‐induced acute viral myocarditis
ConclusionsROCK pathway inhibition was cardio ‐protective in viral myocarditis with increased survival, decreased viral replication, and inflammatory response. These findings suggest that Fasudil might be a potential therapeutic agent for patients with viral myocarditis. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 28, 2018 Category: Cardiology Authors: Kezhi Dai, Yaoyao Wang, Sichao Tai, Huajing Ni, Hao Lian, Yan Yu, Weifang Liao, Cheng Zheng, Qing Chen, Aarti Kuver, Jia Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The incidence of atrial fibrillation with trastuzumab treatment: A systematic review and meta ‐analysis
ConclusionsAtrial fibrillation incidence in breast cancer patients receiving trastuzumab was around 1.2%. It was not influenced by the formulation of trastuzumab, the additional use of neoplastic agents, anthracycline exposure status, or concurrent radiotherapy. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 28, 2018 Category: Cardiology Authors: Ming Yuan, Gary Tse, Zhiwei Zhang, Xu Han, William K. K. Wu, Guangping Li, Yunlong Xia, Tong Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Upstream therapeutic strategies of valsartan and fluvastatin on hypertensive patients with non ‐permanent atrial fibrillation
SummaryAimTo investigate the upstream therapeutic effects of fluvastatin and valsartan on hypertensive patients with non ‐permanent atrial fibrillation (AF).MethodsA total of 189 patients who were admitted to outpatient and inpatient department from eight medical centers in China, diagnosed as hypertension with non ‐permanent AF, were divided into four groups randomly: the CCBs group (group A, n = 45); CCB + fluvastatin group (group B, n = 48); valsartan group (group C, n = 46); valsartan + fluvastatin group (group D, n = 50). The four groups were followed up ...
Source: Cardiovascular Therapeutics - November 28, 2018 Category: Cardiology Authors: Zhiqiang Zhao, Xiaowei Niu, Zhaojie Dong, Wenwei Qi, Enzhao Liu, Tong Liu, Lifeng Li, Yingzi Liang, Guangping Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT
SummaryObjectiveIn a subgroup analysis of the China Stroke Primary Prevention Trial, we aimed to explore the impact of folic acid supplementation on arterial stiffness and assess the modifying effect of the methylenetetrahydrofolate reductase (MTHFR) gene in Chinese patients with hypertension.MethodsThis prospective study enrolled 2529 hypertensive Chinese patients. Participants were randomized to receive treatment with either a combination of enalapril and folic acid or enalapril. Brachial ‐ankle pulse wave velocity (PWV) was measured by trained medical staff using PWV instruments at both baseline and exit visits, appro...
Source: Cardiovascular Therapeutics - November 20, 2018 Category: Cardiology Authors: Xin Yang, Minghua Zhang, Rensheng Song, Changfu Liu, Yong Huo, Geng Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Role of IL ‐7 in Fusion of Rat Bone Marrow Mesenchymal Stem Cells with Cardiomyocytes in vitro and Improvement of Cardiac Function in vivo
AbstractAimsMesenchymal stem cells (MSCs) hold significant promise as potential therapeutic candidates following cardiac injury. However, to ensure survival of transplanted cells in ischemic environment, it is beneficial to precondition them with growth factors that play important role in cell survival and proliferation. Aim of this study is to use interleukin ‐7 (IL‐7), a cell survival growth factor, to enhance the potential of rat bone marrow MSCs in terms of cell fusionin vitro and cardiac functionin vivo.MethodsMSCs were transfected with IL ‐7 gene through retroviral vector. Normal and transfected MSCs were co‐...
Source: Cardiovascular Therapeutics - November 19, 2018 Category: Cardiology Authors: Kanwal Haneef, Anwar Ali, Irfan Khan, Nadia Naeem, Siddiqua Jamall, Asmat Salim Tags: Original Research Article Source Type: research

Effects of tranexamic acid on short ‐term and long‐term outcomes of on‐pump coronary artery bypass grafting: Randomized trial and 7‐year follow‐up
SummaryAimsSafety evaluations of tranexamic acid (TXA) remain sparse, especially with respect to its impact on long ‐term outcomes in patients undergoing on‐pump coronary artery bypass grafting (CABG). We hypothesized that the effects of TXA on perioperative bleeding and allogeneic transfusion and its impact on long‐term clinical outcomes of patients receiving on‐pump CABG are superior to those in the con trol group.MethodsIn this prospective, randomized, placebo ‐controlled trial, 210 patients undergoing primary and isolated on‐pump CABG were randomly assigned to receive TXA or a corresponding volume of saline...
Source: Cardiovascular Therapeutics - November 16, 2018 Category: Cardiology Authors: Yu Zhang, Xurong Gao, Su Yuan, Jingfei Guo, Huanran Lv, Yong Zhou, Yuefu Wang, Hongwen Ji, Guyan Wang, Lihuan Li, Jia Shi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double ‐blind randomized study
SummaryIntroductionBlood donation has been proposed as a potential therapy to reduce risk of cardiovascular disease, but the effects of phlebotomy on vascular function in human subjects have not been well characterized.AimsWe conducted a prospective randomized double ‐blind study to determine the effects of serial phlebotomy on vascular endothelial function in the brachial artery. Eighty‐four iron‐replete, non‐anemic subjects were randomly assigned to one of three study treatment groups: (a) four serial phlebotomy procedures each followed by intravenous infusion of placebo normal saline; (b) four serial phlebotomy ...
Source: Cardiovascular Therapeutics - November 13, 2018 Category: Cardiology Authors: Qurat ‐ul‐ain Jelani, Bhisham Harchandani, Ritchard G. Cable, Yu Guo, Hua Zhong, Timothy Hilbert, Jonathan D. Newman, Stuart D. Katz Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Management of arterial hypertension with angiotensin receptor blockers: Current evidence and the role of olmesartan
SummaryElevated blood pressure (BP) is a major determinant of morbidity and mortality burden related to cardio ‐metabolic risk. Current guidelines indicate that controlling and lowering BP promotes cardiovascular (CV) risk reduction. Among antihypertensive agents, angiotensin receptor blockers (ARBs) are characterized by an efficacy profile equivalent to other antihypertensive agents and are provided with excellent tolerability and low discontinuation rates during chronic treatments. Moreover, CV outcomes are reduced by ARBs. Olmesartan is a long‐lasting ARB which proved to achieve a comparable or more effective action...
Source: Cardiovascular Therapeutics - November 13, 2018 Category: Cardiology Authors: Stefano Omboni, Massimo Volpe Tags: UNSOLICITED REVIEW Source Type: research

Upstream therapeutic strategies of Valsartan and Fluvastatin on Hypertensive patients with non ‐permanent Atrial Fibrillation (VF‐HT‐AF)
Cardiovascular Therapeutics,Volume 0, Issue ja, -Not available-. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 3, 2018 Category: Cardiology Authors: Zhao Zhiqiang, Xiaowei Niu, ZhaoJie Dong, Wenwei Qi, Enzhao Liu, Tong Liu, Lifeng Li, Yingzi Liang, Guangping Li Source Type: research

Fasudil exerts a cardio ‐protective effect on mice with coxsackievirus B3‐induced acute viral myocarditis
Cardiovascular Therapeutics,Volume 0, Issue ja, -Not available-. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - October 31, 2018 Category: Cardiology Authors: Kezhi Dai, Yaoyao Wang, Sichao Tai, Huajing Ni, Hao Lian, Yu Yan, Weifang Liao, Zheng Cheng, Qing Chen, Aarti Kuver, Jia Li Source Type: research

Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in LDLR KO mice
Cardiovascular Therapeutics,Volume 0, Issue ja, -Not available-. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - October 31, 2018 Category: Cardiology Authors: Kyung ‐Yeon Park, Tae‐Hwe Heo Source Type: research