Year in Review in Cardiac Electrophysiology [Review]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 16, 2018 Category: Cardiology Authors: Kapa, S., Davis, D. R., Park, D. S., Steinberg, B. A., Viswanathan, M. N., Tzou, W., Madhavan, M., Ceresnak, S. R., Wang, P. J. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation, Sudden Cardiac Death Review Source Type: research

Risk Stratification of Type 2 Long-QT Syndrome Mutation Carriers With Normal QTc Interval: The Value of Sex, T-Wave Morphology, and Mutation Type [Original Articles]
Background: Long-QT (LQT) syndrome mutation carriers have higher risk of cardiac events than unaffected family members even in the absence of QTc prolongation. Changes in T-wave morphology may reflect penetrance of LQT syndrome mutations. We aimed to assess whether T-wave morphology may improve risk stratification of LQT2 mutation carriers with normal QTc interval. Methods: LQT2 mutation carriers with QTc
Source: Circulation: Arrhythmia and Electrophysiology - July 16, 2018 Category: Cardiology Authors: Platonov, P. G., McNitt, S., Polonsky, B., Rosero, S. Z., Kutyifa, V., Huang, A., Moss, A. J., Zareba, W. Tags: Arrhythmias, Sudden Cardiac Death, Ventricular Fibrillation, Risk Factors, Electrocardiology (ECG) Original Articles Source Type: research

Race and Socioeconomic Status Regulate Lifetime Risk of Atrial Fibrillation [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 12, 2018 Category: Cardiology Authors: McCauley, M. D., Darbar, D. Tags: Atrial Fibrillation, Race and Ethnicity Editorial Source Type: research

Measuring Success in Ablation of Atrial Fibrillation: Time for a Paradigm Shift? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 12, 2018 Category: Cardiology Authors: Terricabras, M., Verma, A., Morillo, C. A. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Editorial Source Type: research

Lifetime Risk of Atrial Fibrillation by Race and Socioeconomic Status: ARIC Study (Atherosclerosis Risk in Communities) [Original Articles]
Conclusions: Lifetime risk of AF in the ARIC cohort was 1 in 3 among whites and 1 in 5 among African Americans. Socioeconomic status was inversely associated with cumulative incidence of AF before the last decades of life. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 12, 2018 Category: Cardiology Authors: Mou, L., Norby, F. L., Chen, L. Y., ONeal, W. T., Lewis, T. T., Loehr, L. R., Soliman, E. Z., Alonso, A. Tags: Atrial Fibrillation, Epidemiology, Race and Ethnicity Original Articles Source Type: research

Thirty-Second Gold Standard Definition of Atrial Fibrillation and Its Relationship With Subsequent Arrhythmia Patterns: Analysis of a Large Prospective Device Database [Original Articles]
Background: The Heart Rhythm Society consensus statement arbitrarily defines atrial fibrillation (AF) ablation failure as any episode ≥30 seconds. However, if brief AF events are not correlated to longer events, the rationale for this end point is questionable. We determined the impact of AF episode duration threshold on AF incidence and burden. Methods: Patients with a pacemaker in a prospective registry with device-detected AF and follow-up>30 days were analyzed. AF patterns were calculated for various AF duration thresholds (30 s; 2 and 6 minutes; 3.8, 5.5, and 24 hours) selected based on published consensus stat...
Source: Circulation: Arrhythmia and Electrophysiology - July 12, 2018 Category: Cardiology Authors: Steinberg, J. S., OConnell, H., Li, S., Ziegler, P. D. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death [Original Articles]
Background: Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. Methods: We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm. Established electrogram criteria were used to identify the presence of structural alterations. Results: VF occurred spontaneously i...
Source: Circulation: Arrhythmia and Electrophysiology - July 12, 2018 Category: Cardiology Authors: Haissaguerre, M., Hocini, M., Cheniti, G., Duchateau, J., Sacher, F., Puyo, S., Cochet, H., Takigawa, M., Denis, A., Martin, R., Derval, N., Bordachar, P., Ritter, P., Ploux, S., Pambrun, T., Klotz, N., Massoullie, G., Pillois, X., Dallet, C., Schott, J.- Tags: Arrhythmias, Sudden Cardiac Death, Ventricular Fibrillation Original Articles Source Type: research

Slow and Unsteady in the Fast Lane [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 9, 2018 Category: Cardiology Authors: Witt, C. M., Asirvatham, S. J. Tags: Arrhythmias, Electrophysiology Editorial Source Type: research

Letter by Schuster Regarding Article, "Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation" [Letter to the Editor]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 9, 2018 Category: Cardiology Authors: Schuster, P. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Letter to the Editor Source Type: research

Electrophysiological Characteristics of Bundle Branch Reentry Ventricular Tachycardia in Patients Without Structural Heart Disease [Original Articles]
Conclusions: Bundle branch reentry VT can occur in young patients with extensive conduction disturbances within HIS-Purkinje system. Ablation targeting at the distal left BB which bifurcates into left posterior and anterior fascicle can preserve the residual atrioventricular conduction, but intensive follow-up is needed. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - July 9, 2018 Category: Cardiology Authors: Chen, H., Shi, L., Yang, B., Ju, W., Zhang, F., Yang, G., Gu, K., Li, M., Cao, K., Ouyang, F., Chen, M. Tags: Arrhythmias, Electrophysiology Original Articles Source Type: research

Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults [Original Articles]
Background: The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized. Methods: We determined the frequency of rhythm abnormalities in the UK Biobank, a national prospective cohort. We tested associations between risk factors and incident rhythm abnormalities using multivariable proportional hazards regression. Results: Of 502 627 adults (median age, 58 years [interquartile range, 13]; 54.4% women), 2.35% had a baseline rhythm abnormality. The prevalence increased with age with 4.84% of individuals aged 65 to 73 years affected. During 3 368 332 person-yea...
Source: Circulation: Arrhythmia and Electrophysiology - June 28, 2018 Category: Cardiology Authors: Khurshid, S., Choi, S. H., Weng, L.-C., Wang, E. Y., Trinquart, L., Benjamin, E. J., Ellinor, P. T., Lubitz, S. A. Tags: Arrhythmias, Atrial Fibrillation, Epidemiology, Risk Factors Original Articles Source Type: research

Minimally Invasive Implantation of a Micropacemaker Into the Pericardial Space [Original Articles]
Conclusions: A novel micropacemaker system allows cardiac pacing without entering the vascular space or surgical exposure of the heart. This pericardial pacemaker system may be an option for a large number of patients currently requiring transvenous pacemakers but is particularly relevant for patients with restricted vascular access, young children, or those with congenital heart disease who require epicardial access. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 26, 2018 Category: Cardiology Authors: Bar-Cohen, Y., Silka, M. J., Hill, A. C., Pruetz, J. D., Chmait, R. H., Zhou, L., Rabin, S. M., Norekyan, V., Loeb, G. E. Tags: Pacemaker Original Articles Source Type: research

The US Experience of the Wearable Cardioverter-Defibrillator in Pediatric Patients [Original Articles]
The objectives of the study are to examine the effectiveness, safety, and compliance of the WCD in the identification and treatment of life-threatening ventricular arrhythmias in pediatric patients. Methods: All United States pediatric patients 20 hours in both groups. Wear duration was shorter in the implantable cardioverter-defibrillator problem group, 26 days versus 35 days, P
Source: Circulation: Arrhythmia and Electrophysiology - June 26, 2018 Category: Cardiology Authors: Spar, D. S., Bianco, N. R., Knilans, T. K., Czosek, R. J., Anderson, J. B. Tags: Arrhythmias, Sudden Cardiac Death, Cardiomyopathy, Congenital Heart Disease Original Articles Source Type: research

Electrocardiograms in Healthy North American Children in the Digital Age [Original Articles]
Background: Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results to commonly used published datasets. Methods: Digital ECGs (12-lead) were retrospectively collected for children ≤18 years old with normal echocardiograms at 19 centers in the Pediatric Heart Network. Patients were classified into 36 groups: 6 age, 2 sex, and 3 race (white, black, and other...
Source: Circulation: Arrhythmia and Electrophysiology - June 21, 2018 Category: Cardiology Authors: Saarel, E. V., Granger, S., Kaltman, J. R., Minich, L. L., Tristani-Firouzi, M., Kim, J. J., Ash, K., Tsao, S. S., Berul, C. I., Stephenson, E. A., Gamboa, D. G., Trachtenberg, F., Fischbach, P., Vetter, V. L., Czosek, R. J., Johnson, T. R., Salerno, J. C Tags: Pediatrics, Race and Ethnicity, Women, Diagnostic Testing, Electrocardiology (ECG) Original Articles Source Type: research

Individualized Left Anterior Oblique Projection: A Highly Reliable Patient-Tailored Fluoroscopy Criterion for Right Ventricular Lead Positioning [Original Articles]
Conclusion: Individualized LAO is a quick and highly reliable patient-tailored fluoroscopy projection for RV lead positioning. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 20, 2018 Category: Cardiology Authors: Squara, F., Scarlatti, D., Riccini, P., Garret, G., Moceri, P., Ferrari, E. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Imaging, Pacemaker Original Articles Source Type: research

Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers [Original Articles]
Conclusions: EHT from hiPSC-CMs shows a lower repolarization reserve than human LV working myocardium and could thereby serve as a sensitive and specific human-based model for repolarization studies and arrhythmia, similar to Purkinje fibers. In both human LV and EHT, IKs only contributed to repolarization under adrenergic stimulation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 20, 2018 Category: Cardiology Authors: Lemoine, M. D., Krause, T., Koivumaki, J. T., Prondzynski, M., Schulze, M. L., Girdauskas, E., Willems, S., Hansen, A., Eschenhagen, T., Christ, T. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Ion Channels/Membrane Transport, Stem Cells Original Articles Source Type: research

Catheter Ablation of Atrial Fibrillation: A Life or Death Situation? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Terricabras, M., Verma, A. Tags: Arrhythmias, Atrial Fibrillation Editorial Source Type: research

Interaction of Localized Drivers and Disorganized Activation in Persistent Atrial Fibrillation: Reconciling Putative Mechanisms Using Multiple Mapping Techniques [Original Articles]
Conclusions: Sites at which persistent AF terminated by ablation show organized activation that fluctuate over time, because of collision from concurrent organized zones or fibrillatory waves, yet recur in conserved spatial regions. Results were similar by 2 mapping methods. This network of competing mechanisms should be reconciled with existing disorganized or driver mechanisms for AF, to improve clinical mapping and ablation of persistent AF. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02997254. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Kowalewski, C. A. B., Shenasa, F., Rodrigo, M., Clopton, P., Meckler, G., Alhusseini, M. I., Swerdlow, M. A., Joshi, V., Hossainy, S., Zaman, J. A. B., Baykaner, T., Rogers, A. J., Brachmann, J., Miller, J. M., Krummen, D. E., Sauer, W. H., Peters, N. S., Tags: Electrophysiology, Atrial Fibrillation, Computational Biology, Mechanisms Original Articles Source Type: research

CAABL-AF (California Study of Ablation for Atrial Fibrillation): Mortality and Stroke, 2005 to 2013 [Original Articles]
Conclusions: In this large population-based study of hospitalized patients with nonvalvular AF, ablation was associated with lower mortality, ischemic stroke, and hemorrhagic stroke compared with controls. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Srivatsa, U. N., Danielsen, B., Amsterdam, E. A., Pezeshkian, N., Yang, Y., Nordsieck, E., Fan, D., Chiamvimonvat, N., White, R. H. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models [Original Articles]
Conclusions: The combination of high-resolution imaging data and ventricular simulations revealed the 3-dimensional distribution of surviving tissue surrounding the scar and demonstrated its involvement in VT pathways. The new knowledge obtained in this study contributes toward a better understanding of infarct-related VT. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 7, 2018 Category: Cardiology Authors: Pashakhanloo, F., Herzka, D. A., Halperin, H., McVeigh, E. R., Trayanova, N. A. Tags: Arrhythmias, Electrophysiology, Mechanisms, Myocardial Infarction, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4 [Original Articles]
Background: Spontaneous firing of sinoatrial node cells (SANCs) is regulated by cAMP-mediated, PKA (protein kinase A)-dependent (cAMP/PKA) local subsarcolemmal Ca2+ releases (LCRs) from RyRs (ryanodine receptors). LCRs occur during diastolic depolarization and activate an inward Na+/Ca2+ exchange current that accelerates diastolic depolarization rate prompting the next action potential. PDEs (phosphodiesterases) regulate cAMP-mediated signaling; PDE3/PDE4 represent major PDE activities in SANC, but how they modulate LCRs and basal spontaneous SANC firing remains unknown. Methods: Real-time polymerase chain reaction, Weste...
Source: Circulation: Arrhythmia and Electrophysiology - June 7, 2018 Category: Cardiology Authors: Vinogradova, T. M., Sirenko, S., Lukyanenko, Y. O., Yang, D., Tarasov, K. V., Lyashkov, A. E., Varghese, N. J., Li, Y., Chakir, K., Ziman, B., Lakatta, E. G. Tags: Calcium Cycling/Excitation-Contraction Coupling, Cell Signaling/Signal Transduction, Ion Channels/Membrane Transport Original Articles Source Type: research

Atrial Tachycardias After Atrial Fibrillation Ablation: What Matters for Identification of the Region of Interest? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Liu, Y., Shehata, M., Wang, X. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Editorial Source Type: research

Coronary Sinus Activation and ECG Characteristics of Roof-Dependent Left Atrial Flutter After Pulmonary Vein Isolation [Original Articles]
Conclusions: Roof-dependent flutter around right PVs is more common than around left PVs. The ECG pattern for roof-dependent flutter around right PVs is similar to MA flutter with frontal plane axis dictated by septal activation. Roof-dependent flutter can be distinguished from MA flutter by more simultaneous rather than sequential coronary sinus activation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Casado Arroyo, R., Laţcu, D. G., Maeda, S., Kubala, M., Santangeli, P., Garcia, F. C., Enache, B., Eljamili, M., Hayashi, T., Zado, E. S., Saoudi, N., Marchlinski, F. E. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research

Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial Fibrillation: Results From the STARLIGHT Study [Original Articles]
Conclusions: No sustained rotors or localized drivers were detected, and instead, the mechanism of arrhythmia maintenance was consistent with the multiple wavelet hypothesis, with passive activation of short-lived rotational activity. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01765075. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Child, N., Clayton, R. H., Roney, C. R., Laughner, J. I., Shuros, A., Neuzil, P., Petru, J., Jackson, T., Porter, B., Bostock, J., Niederer, S. A., Razavi, R. S., Rinaldi, C. A., Taggart, P., Wright, M. J., Gill, J. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Mechanisms Original Articles Source Type: research

Nationwide Study of Sudden Cardiac Death in People With Congenital Heart Defects Aged 0 to 35 Years [Original Articles]
Background: Congenital heart defects (CHD) are among the leading causes of sudden cardiac death (SCD) in the young. Nationwide incidence of SCD in people with CHD (SCD-CHD) has not been established in the young general population. The aims of this study were to investigate incidence of SCD-CHD and whether incidence of SCD-CHD in infants declined after implementation of nationwide fetal ultrasound screening in Denmark. Methods: All deaths (n=11 451) among people aged 0 to 35 years in Denmark in 2000 to 2009 (24.4 million person-years) were included. Danish death certificates, autopsy reports, records from hospitals and gen...
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Lynge, T. H., Jeppesen, A. G., Winkel, B. G., Glinge, C., Schmidt, M. R., Sondergaard, L., Risgaard, B., Tfelt-Hansen, J. Tags: Arrhythmias, Sudden Cardiac Death, Epidemiology, Congenital Heart Disease, Echocardiography Original Articles Source Type: research

Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation [Original Articles]
Background: Atrial fibrosis is a hallmark of arrhythmogenic structural remodeling in patients with persistent atrial fibrillation (AF) and is negatively correlated with procedure outcome in patients undergoing ablation. However, noninvasive methods to determine the extent of atrial fibrosis are limited. Here, we used microRNA (miRNA) expression analysis to detect markers of left atrial low-voltage areas (LVAs) in patients with persistent AF undergoing catheter ablation. Methods: We performed 3-dimensional voltage mapping in 102 patients (average age 62.1±13.1 years, CHA2DS2-VASc score of 2.3±1.6, LA size 41....
Source: Circulation: Arrhythmia and Electrophysiology - May 30, 2018 Category: Cardiology Authors: Zhou, Q., Maleck, C., von Ungern-Sternberg, S. N. I., Neupane, B., Heinzmann, D., Marquardt, J., Duckheim, M., Scheckenbach, C., Stimpfle, F., Gawaz, M., Schreieck, J., Seizer, P., Gramlich, M. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation, Biomarkers, Fibrosis Original Articles Source Type: research

Right Ventricular Dysfunction and Long-Term Risk of Sudden Cardiac Death in Patients With and Without Severe Left Ventricular Dysfunction [Original Articles]
This study examined the risk of SCD associated with RVD in patients with heterogeneous underlying cardiac diseases. Methods: The Mayo Clinic cardiac care unit database included 5463 consecutive patients with complete echocardiographic evaluation to assess right ventricular systolic function and RVD severity. Prospective surveillance follow-up was obtained for all patients. SCD was adjudicated when a malignant ventricular arrhythmia was documented as the primary rhythm leading to death. RESULTS: The prevalence of mild RVD and moderate-severe RVD was 14.9% and 17.1%, respectively. Patients with RVD were more likely to have...
Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Naksuk, N., Tan, N., Padmanabhan, D., Kancharla, K., Makkar, N., Yogeswaran, V., Gaba, P., Kaginele, P., Riley, D. C., Sugrue, A. M., Rosenbaum, A. N., El-Harasis, M. A., Asirvatham, S. J., Kapa, S., McLeod, C. J. Tags: Sudden Cardiac Death, Cardiomyopathy Original Articles Source Type: research

Comprehensive Multicenter Study of the Common Isthmus in Post-Atrial Fibrillation Ablation Multiple-Loop Atrial Tachycardia [Original Articles]
Background: Characteristics of multiple-loop atrial tachycardia (AT) circuits have never precisely examined. Methods: In 193 consecutive post–atrial fibrillation ablation patients with AT, 44 multiple-loop ATs including 42 dual-loop AT and 2 triple-loop AT in 41 (21.2%) were diagnosed with the high-resolution mapping system and analyzed off-line. RESULTS: In dual-loop ATs, 3 types were identified: type M, a combination of 2 anatomic macroreentrant ATs (AMATs) in 19 (43.2%); type MN, with 1 AMAT and 1 non-AMAT in 12 (27.3%); and type N with 2 non-AMATs in 11 (25.0%). The remaining 2 triple-loop ATs (4.5%) were a com...
Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Takigawa, M., Derval, N., Maury, P., Martin, R., Denis, A., Miyazaki, S., Yamashita, S., Frontera, A., Vlachos, K., Kitamura, T., Cheniti, G., Massoulliee, G., Thompson, N., Martin, C. A., Wolf, M., Pillois, X., Duchateau, J., Klotz, N., Duparc, A., Rolli Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1 [Original Articles]
Conclusions: Ito heterogeneity creates both triggers and an arrhythmogenic substrate in LQT1. In the absence of IKs, Ito interactions with ICa,L and IKr promote EADs in the RV while prolonging action potential duration in the left ventricle. This heterogeneity of action potential enhances dispersion of refractoriness and facilitates conduction blocks that initiate pVTs. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Choi, B.-R., Li, W., Terentyev, D., Kabakov, A. Y., Zhong, M., Rees, C. M., Terentyeva, R., Kim, T. Y., Qu, Z., Peng, X., Karma, A., Koren, G. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Mechanisms Original Articles Source Type: research

Pulmonary Vein Stenosis After Atrial Fibrillation Ablation: An Iatrogenic Problem Larger Than the Primary Problem [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Padala, S. K., Ellenbogen, K. A. Tags: Atrial Fibrillation Editorial Source Type: research

Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation [Original Articles]
Conclusions: The incidence of severe PV stenosis is low but remains associated with significant morbidity. In patients with recurrent arrhythmia, conduction recovery at the stenosed or stented veins is common. Care must be taken to ablate antrally to avoid stenosis progression. In patients with prior PV stents, we suggest to avoid using Lasso. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Raeisi-Giglou, P., Wazni, O. M., Saliba, W. I., Barakat, A., Tarakji, K. G., Rickard, J., Cantillon, D., Baranowski, B., Tchou, P. J., Bhargava, M., Dresing, T. J., Callahan, T. D., Kanj, M., Lindsay, B. D., Hussein, A. A. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research

Effects of Prolonged Spaceflight on Atrial Size, Atrial Electrophysiology, and Risk of Atrial Fibrillation [Original Articles]
Conclusions: Six months of spaceflight may be sufficient to cause transient changes in left atrial structure and atrial electrophysiology that increase the risk of AF. However, there was no definite evidence of increased supraventricular arrhythmias and no identified episodes of AF. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Khine, H. W., Steding-Ehrenborg, K., Hastings, J. L., Kowal, J., Daniels, J. D., Page, R. L., Goldberger, J. J., Ng, J., Adams-Huet, B., Bungo, M. W., Levine, B. D. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research

Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel [Original Articles]
Background: Heterologous functional validation studies of putative long-QT syndrome subtype 2–associated variants clarify their pathological potential and identify disease mechanism(s) for most variants studied. The purpose of this study is to clarify the pathological potential for rare nonsynonymous KCNH2 variants seemingly associated with sudden infant death syndrome. Methods: Genetic testing of 292 sudden infant death syndrome cases identified 9 KCNH2 variants: E90K, R181Q, A190T, G294V, R791W, P967L, R1005W, R1047L, and Q1068R. Previous studies show R181Q-, P967L-, and R1047L-Kv11.1 channels function similar to ...
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Smith, J. L., Tester, D. J., Hall, A. R., Burgess, D. E., Hsu, C.-C., Claude Elayi, S., Anderson, C. L., January, C. T., Luo, J. Z., Hartzel, D. N., Mirshahi, U. L., Murray, M. F., Mirshahi, T., Ackerman, M. J., Delisle, B. P. Tags: Arrhythmias, Sudden Cardiac Death, Ventricular Fibrillation, Ion Channels/Membrane Transport, Functional Genomics Original Articles Source Type: research

Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation [Original Articles]
Conclusions: The pericardium is an underutilized therapeutic site and may be a new treatment strategy for AF and other cardiovascular diseases. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 10, 2018 Category: Cardiology Authors: Garcia, J. R., Campbell, P. F., Kumar, G., Langberg, J. J., Cesar, L., Deppen, J. N., Shin, E. Y., Bhatia, N. K., Wang, L., Xu, K., Schneider, F., Robinson, B., Garcia, A. J., Levit, R. D. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Animal Models of Human Disease, Treatment Original Articles Source Type: research

Interleukin 10 Treatment Ameliorates High-Fat Diet-Induced Inflammatory Atrial Remodeling and Fibrillation [Original Articles]
Conclusions: Our results highlight IL-10 treatment as a potential therapeutic approach to limit the progression of HFD-induced obesity-caused atrial fibrillation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 10, 2018 Category: Cardiology Authors: Kondo, H., Abe, I., Gotoh, K., Fukui, A., Takanari, H., Ishii, Y., Ikebe, Y., Kira, S., Oniki, T., Saito, S., Aoki, K., Tanino, T., Mitarai, K., Kawano, K., Miyoshi, M., Fujinami, M., Yoshimura, S., Ayabe, R., Okada, N., Nagano, Y., Akioka, H., Shinohara, Tags: Atrial Fibrillation, Animal Models of Human Disease, Fibrosis, Inflammation, Obesity Original Articles Source Type: research

Does High-Intensity Endurance Training Increase the Risk of Atrial Fibrillation?: A Longitudinal Study of Left Atrial Structure and Function [Original Articles]
Background: Exercise mitigates many cardiovascular risk factors associated with atrial fibrillation. Endurance training has been associated with atrial structural changes which can increase the risk for atrial fibrillation. The dose of exercise training required for these changes is uncertain. We sought to evaluate the impact of exercise on left atrial (LA) mechanical and electrical function in healthy, sedentary, middle-aged adults. Methods: Sixty-one adults (52±5 years) were randomized to either 10 months of high-intensity exercise training or yoga. At baseline and post-training, all participants underwent maxima...
Source: Circulation: Arrhythmia and Electrophysiology - May 10, 2018 Category: Cardiology Authors: Opondo, M. A., Aiad, N., Cain, M. A., Sarma, S., Howden, E., Stoller, D. A., Ng, J., van Rijckevorsel, P., Hieda, M., Tarumi, T., Palmer, M. D., Levine, B. D. Tags: Arrhythmias, Atrial Fibrillation, Exercise, Risk Factors, Remodeling Original Articles Source Type: research

Clinical Implications of Ablation of Drivers for Atrial Fibrillation: A Systematic Review and Meta-Analysis [Original Articles]
Background: The outcomes from pulmonary vein isolation (PVI) for atrial fibrillation (AF) are suboptimal, but the benefits of additional lesion sets remain unproven. Recent studies propose ablation of AF drivers improves outcomes over PVI, yet with conflicting reports in the literature. We undertook a systematic literature review and meta-analysis to determine outcomes from ablation of AF drivers in addition to PVI or as a stand-alone procedure. Methods: Database search was done using the terms atrial fibrillation and ablation or catheter ablation and driver or rotor or focal impulse or FIRM (Focal Impulse and Rotor Modul...
Source: Circulation: Arrhythmia and Electrophysiology - May 9, 2018 Category: Cardiology Authors: Baykaner, T., Rogers, A. J., Meckler, G. L., Zaman, J., Navara, R., Rodrigo, M., Alhusseini, M., Kowalewski, C. A. B., Viswanathan, M. N., Narayan, S. M., Clopton, P., Wang, P. J., Heidenreich, P. A. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

Ventricular Electrical Activation Delay and High-Frequency Electrocardiograms: Hype or Hope? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Killu, A. M., Cha, Y.-M. Tags: Arrhythmias Editorial Source Type: research

Impact of Female Sex on Clinical Outcomes in the FIRE AND ICE Trial of Catheter Ablation for Atrial Fibrillation [Original Articles]
Background: Data on predictors of long-term clinical outcomes after catheter ablation of atrial fibrillation (AF) are limited. We sought to assess the association of baseline covariates with clinical outcomes in the 750 patients with drug-refractory paroxysmal AF enrolled in FIRE AND ICE. Methods: In a 2-part analysis, univariate and multivariable Cox regression models were first used to identify baseline patient characteristics predictive of catheter ablation efficacy determined by the clinical end points of (1) atrial arrhythmia recurrence (primary efficacy failure), (2) cardiovascular rehospitalization, and (3) repeat ...
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Kuck, K.-H., Brugada, J., Furnkranz, A., Chun, K. R. J., Metzner, A., Ouyang, F., Schluter, M., Elvan, A., Braegelmann, K. M., Kueffer, F. J., Arentz, T., Albenque, J.-P., Kuhne, M., Sticherling, C., Tondo, C., on behalf of the FIRE AND ICE Investigators Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

How Accurate Is Inverse Electrocardiographic Mapping?: A Systematic In Vivo Evaluation [Original Articles]
Background: Inverse electrocardiographic mapping reconstructs cardiac electrical activity from recorded body surface potentials. This noninvasive technique has been used to identify potential ablation targets. Despite this, there has been little systematic evaluation of its reliability. Methods: Torso and ventricular epicardial potentials were recorded simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, epicardial, and endocardial ventricular pacing (70 records in total). Body surface and cardiac electrode positions were determined and registered using magnetic resonance imaging. Epicardial poten...
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Bear, L. R., LeGrice, I. J., Sands, G. B., Lever, N. A., Loiselle, D. S., Paterson, D. J., Cheng, L. K., Smaill, B. H. Tags: Arrhythmias, Electrophysiology, Electrocardiology (ECG) Original Articles Source Type: research

Ablation of the Ligament of Marshall and Left Stellate Ganglion Similarly Reduces Ventricular Arrhythmias During Acute Myocardial Infarction [Original Articles]
Conclusions: LOMLSPV ablation prevented acute myocardial infarction–induced VAs with the same efficiency as LSG ablation, potentially by blocking the sympathetic pathway from the LSG to the heart. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Liu, S., Yu, X., Luo, D., Qin, Z., Wang, X., He, W., Ma, R., Hu, H., Xie, J., He, B., Lu, Z., Jiang, H. Tags: Arrhythmias, Electrophysiology, Ventricular Fibrillation Original Articles Source Type: research

Hot Balloon Versus Cryoballoon Ablation for Atrial Fibrillation: Lesion Characteristics and Middle-Term Outcomes [Original Articles]
Conclusions: Although HBA lesions appear to be smaller than CBA lesions, middle-term outcomes are not statistically different between these balloon modalities. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Nagashima, K., Okumura, Y., Watanabe, I., Nakahara, S., Hori, Y., Iso, K., Watanabe, R., Arai, M., Wakamatsu, Y., Kurokawa, S., Mano, H., Nakai, T., Ohkubo, K., Hirayama, A. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research

Ventricular Electrical Delay Measured From Body Surface ECGs Is Associated With Cardiac Resynchronization Therapy Response in Left Bundle Branch Block Patients From the MADIT-CRT Trial (Multicenter Automatic Defibrillator Implantation-Cardiac Resynchronization Therapy) [Original Articles]
Background: Although cardiac resynchronization therapy (CRT) is beneficial in heart failure patients with left bundle branch block, 30% of these patients do not respond to the therapy. Identifying these patients before implantation of the device is one of the current challenges in clinical cardiology. Methods: We verified the diagnostic contribution and an optimized computerized approach to measuring ventricular electrical activation delay (VED) from body surface 12-lead ECGs. We applied the method to ECGs acquired before implantation (baseline) in the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation-Card...
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Plesinger, F., Jurak, P., Halamek, J., Nejedly, P., Leinveber, P., Viscor, I., Vondra, V., McNitt, S., Polonsky, B., Moss, A. J., Zareba, W., Couderc, J.-P. Tags: Electrophysiology, Heart Failure, Electrocardiology (ECG), Prognosis, Pacemaker Original Articles Source Type: research

In This Issue: April [In This Issue: April]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 17, 2018 Category: Cardiology Tags: In This Issue: April Source Type: research

April 16th Question [Challenge of the Week]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 16, 2018 Category: Cardiology Authors: Noheria, A. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Challenge of the Week Source Type: research

Response by Zghaib et al to Letter Regarding Article, "Standard Ablation Versus Magnetic Resonance Imaging-Guided Ablation in the Treatment of Ventricular Tachycardia" [Response to Letter to the Editor]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2018 Category: Cardiology Authors: Zghaib, T., Ipek, E. G., Hansford, R., Ashikaga, H., Berger, R. D., Marine, J. E., Spragg, D. D., Tandri, H., Zimmerman, S. L., Halperin, H., Brancato, S., Calkins, H., Henrikson, C., Nazarian, S. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Magnetic Resonance Imaging (MRI) Response to Letter to the Editor Source Type: research

Fast and the Furious: Electrogram Drift: Dynamic Analysis of Acquired Electrograms to Optimize Discrimination of Ventricular Tachycardia Substrate [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2018 Category: Cardiology Authors: Killu, A. M., Kella, D., Kapa, S. Tags: Arrhythmias, Electrophysiology Editorial Source Type: research

Recurrence Post-Atrial Fibrillation Ablation: Think Outside the Pulmonary Veins [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2018 Category: Cardiology Authors: Yamaguchi, T., Marrouche, N. F. Tags: Electrophysiology, Atrial Fibrillation Editorial Source Type: research

Creation of Continuous and Transmural Radiofrequency Lesions [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2018 Category: Cardiology Authors: Nakagawa, H. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Editorial Source Type: research

Letter by Penela et al Regarding Article, "Standard Ablation Versus Magnetic Resonance Imaging-Guided Ablation in the Treatment of Ventricular Tachycardia" [Letter to the Editor]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2018 Category: Cardiology Authors: Penela, D., Andreu, D., Berruezo, A. Tags: Arrhythmias Letter to the Editor Source Type: research