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Monoclonal gammopathy of undetermined significance as viewed by haematology healthcare professionals
ConclusionsWith an ageing population, it is important to consider management strategies for MGUS patients. Our findings will assist those in making these arrangements. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 14, 2017 Category: Hematology Authors: Charlene M. McShane, Blain Murphy, Kah Heng Lim, Lesley A. Anderson Tags: ORIGINAL ARTICLE Source Type: research

Erythroblast macrophage protein (Emp): Past, present, and future
Abstract This review is a journey of the landmark erythroblast macrophage protein (Emp) discovered in 1994, and it walks chronologically through the progress that has been made in understanding the biological function of this protein. Historically, Emp was the first identified cell attachment molecule and is expressed in both erythroblasts and macrophages and mediates their attachments to form erythroblastic islands. The absence of Emp erythroblasts shows defects in differentiation and enucleation. Emp‐deficient macrophages display immature morphology characterized by small sizes, round shapes, and the lack of cytoplasmi...
Source: European Journal of Haematology - November 14, 2017 Category: Hematology Authors: Gulnaz T. Javan, Amandeep Salhotra, Sheree J. Finley, Shivani Soni Tags: REVIEW ARTICLE Source Type: research

Testicular vein thrombosis: Incidence of recurrent venous thromboembolism and survival
ConclusionsIdentifying TVT should prompt a search for a regional malignancy. Despite the high cancer prevalence and low utilization of anticoagulants, recurrent venous thrombosis and mortality rates are similar to DVT patients. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 13, 2017 Category: Hematology Authors: Charles J Lenz, Robert D McBane, Kevin P Cohoon, Dawid T Janczak, Benjamin S Simmons, Rayya A Saadiq, Malgorzata Mimier, Ana I Casanegra, Paul R Daniels, Waldemar E Wysokinski Tags: ORIGINAL ARTICLE Source Type: research

A cross ‐sectional clinic based study exploring whether variants within the glutathione S‐transferase, haptoglobin, and uridine 5′‐diphosphoglucuronosyl transferase 1A1 genes are associated with inter‐individual phenotypic variation in sickle cell anaemia in Jamaica
Abstract ObjectivesTo explore putative associations between specific variants in either the glutathione S‐transferase (GST), haptoglobin (HP), or uridine 5′‐diphospho‐glucuronosyltransferase 1A1 (UGT1A1) genes and clinically important phenotypes in sickle cell anaemia (HbSS). MethodsThree hundred and seventy‐one HbSS participants were recruited from the Sickle Cell Clinic of the Sickle Cell Unit at the University of the West Indies, Kingston, Jamaica. Markers within four GST superfamily genes, the HP gene, and the UGT1A1 gene were analyzed using PCR‐based assays. ResultsMultivariable regression revealed sta...
Source: European Journal of Haematology - November 7, 2017 Category: Hematology Authors: Sharon Howell, Kwesi Marshall, Marvin Reid, Norma McFarlane ‐Anderson, Colin McKenzie Tags: Original Article Source Type: research

Pediatric Diamond ‐Blackfan anemia in the Netherlands: an overview of clinical characteristics and underlying molecular defects
ConclusionIn agreement with previous reports, the Dutch pediatric DBA population is both clinically and genetically heterogeneous. National and international registries, together with more extensive genetic testing are crucial in order to increase our understanding of genotype and phenotype correlations of this intriguing disorder.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 7, 2017 Category: Hematology Authors: B Dooijeweert, C H Ommen, F J Smiers, R Y J Tamminga, M W te Loo, A E Donker, M Peters, B Granzen, J J P Gille, M B Bierings, A W MacInnes, M Bartels Tags: Original Article Source Type: research

Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines
ConclusionsThe small number of patients limits the reliability of conclusions. With these restrictions, the outcomes of both approaches were similar and show the limitations of ATRA and chemotherapy. The HD ara‐C containing regimen was associated with a lower relapse rate in high risk APL.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 7, 2017 Category: Hematology Authors: Eva Lengfelder, Dennis G örlich, Daniel Nowak, Karsten Spiekermann, Claudia Haferlach, Utz Krug, Karl‐Anton Kreuzer, Jan Braess, Christoph Schliemann, Hans‐Walter Lindemann, Heinz A. Horst, Xaver Schiel, Michael Flasshove, Anna Hecht, Susanne Schnitt Tags: Original Article Source Type: research

Cost –effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities
ConclusionThe isolation of inpatients with acute leukemia during hospital construction periods in HEPA filtered rooms could reduce the incidence of IA and might be a cost‐effective prevention strategy.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 6, 2017 Category: Hematology Authors: Juan Felipe Combariza, Luis Fernando Toro, John Jairo Orozco, Marcos Arango Tags: Original Article Source Type: research

A Cryptosporidium infection in a patient with relapsed T lymphoblastic lymphoma undergoing allogeneic stem cell transplantation
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Joanna Schiller, Sebastian Klein, Marianne Engels, Reinhard B üttner, Jan Rybniker, Gerd Fätkenheuer, Christof Scheid, Christian Wybranski, Alexander Quaas, Hans Christian Reinhardt, Ruth Waßermann Tags: Case Report Source Type: research

Heparanase level and procoagulant activity are reduced in severe sepsis
Abstract BackgroundDuring severe sepsis, levels and activity of all coagulation proteins are reduced. Heparanase is implicated in angiogenesis and tumor progression. We previously demonstrated that heparanase also affected the hemostatic system. It forms a complex and increases the activity of the blood coagulation initiator tissue factor. AimTo evaluate heparanase levels and procoagulant activity as predictors of sepsis severity. Materials and MethodsTwenty one patients with non‐trauma, non‐surgical sepsis admitted to the Intensive Care Unit and 35 controls were recruited. Plasma samples were drawn from the study part...
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Moshe Matan, Daniel King, Eli Peled, Shanny Ackerman, Yaron Bar ‐Lavi, Benjamin Brenner, Yona Nadir Tags: Original Article Source Type: research

Thrombotic Microangiopathy with Concomitant GI aGVHD after Allogeneic Hematopoietic Stem Cell Transplantation: Risk Factors and Outcome
ConclusionsTMA with comcomitant aGVHD is a significant complication after allo‐HSCT, with a worse outcome, including significantly lower OS and higher NRM. There are specific risk factors associated with occurrence and mortality of this complication.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Xiao ‐hui Zhang, Xiao Liu, Qin‐ming Wang, Yun He, Xiao‐lu Zhu, Jia‐min Zhang, Wei Han, Huan Chen, Yu‐hong Chen, Feng‐rong Wang, Jing‐zhi Wang, Yuan‐yuan Zhang, Xiao‐dong Mo, Yao Chen, Yu Wang, Hai‐xia Fu, Ying‐jun Chang, Lan‐ping X Tags: Original Article Source Type: research

Use of viscoelastic tests to predict clinical thromboembolic events: a systematic review and meta ‐analysis
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Yusrah Harahsheh, Kwok M. Ho Tags: Review Article Source Type: research

Study of bone metabolism and angiogenesis in patients undergoing High Dose Chemotherapy/autologous Hematopoietic Stem Cell Transplantation
ConclusionsBone resorption declined during HSCT [decrease of TRACP‐5b (p
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Georgios Boutsikas, Evangelos Terpos, Athanasios Papatheodorou, Pantelis Tsirkinidis, Panayiotis Tsirigotis, Anastasia Meletiou, Eleni Lalou, Vasileios Telonis, Anna Zannou, Alexander Kanellopoulos, Zacharoula Galani, Angeliki Stefanou, Panayiotis Tsaftar Tags: Original Article Source Type: research

A retrospective analysis of post transplant lymphoproliferative disorder following liver transplantation
ConclusionOutcomes reported in this study are favourable and comparable to those reported previously. The addition of rituximab did not appear to have improved outcomes in this series, although a significant proportion of patients were able to avoid chemotherapy.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Feras Al Fararjeh, Shameem Mahmood, Phaedra Tachtatzis, Deborah Yallop, Stephen Devereux, Piers Patten, Kosh Agrawal, Abid Suddle, John O'Grady, Nigel Heaton, Robert Marcus, Shireen Kassam Tags: Original Article Source Type: research

Longitudinal changes in lic and other parameters in patients receiving different chelation regimens: data from LICNET
ConclusionsThese findings suggest as longitudinal variation of the LIC is possible, across all chelation regimens. It confirms as SF levels not always can be used for estimating changes in LIC.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Angela Vitrano, Massimiliano Sacco, Rosamaria Rosso, Alessandra Quota, Daniela Fiorino, Esther Oliva, Calogera Gerardi, Gaetano Roccamo, Vincenzo Spadola, Aldo Filosa, Lorenzo Tes é, Giuseppina Calvaruso, Lorella Pitrolo, Laura Mistretta, Filippo Cassar Tags: Original Article Source Type: research

Expression of DNA repair genes is important molecular findings in CD34  +  stem cells of myelodysplastic syndrome
(Source: European Journal of Haematology)
Source: European Journal of Haematology - October 27, 2017 Category: Hematology Authors: Howard Lopes Ribeiro, Allan Rodrigo Soares Maia, Roberta Taiane Germano Oliveira, Ant ônio Wesley Araújo Santos, Marília Braga Costa, Izabelle Rocha Farias, Daniela de Paula Borges, Silvia Maria Meira Magalhães, Ronald Feitosa Pinheiro Tags: LETTER TO THE EDITOR Source Type: research

Increasing incidence of primary central nervous system lymphoma but no improvement in survival in Sweden 2000 ‐2013
ConclusionThe increasing PCNSL incidence in the elderly was consistent with an increasing incidence of brain tumors of any type and may in part be attributable to improved diagnostics and reporting in this group. New treatment options have not yet translated into general survival improvements in a population‐based setting, although the presence of long‐term survivors among fit patients is encouraging. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 25, 2017 Category: Hematology Authors: Sandra Eloranta, Elsa Br ånvall, Fredrik Celsing, Karin Papworth, Maria Ljungqvist, Gunilla Enblad, Karin Ekström‐Smedby Tags: ORIGINAL ARTICLE Source Type: research

Combination therapy incorporating Bcl ‐2 inhibition with Venetoclax for the treatment of refractory primary plasma cell leukemia with t (11;14)
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 24, 2017 Category: Hematology Authors: Wilson I. Gonsalves, Francis K. Buadi, Shaji K. Kumar Tags: Case Report Source Type: research

An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome
ConclusionsAbundant Tregs (anergic signature) indicate a shorter TTP, particularly in younger patients. This is probably due to a reduced ability of the immune system to attack the tumor cells. Our data warrant further investigation if these suggested immune signatures could predict outcome of immunotherapy such as immune checkpoint inhibitors.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 24, 2017 Category: Hematology Authors: Peter Hollander, Klaus Rostgaard, Karin E. Smedby, Daniel Molin, Angelica Loskog, Peter de Nully Brown, Gunilla Enblad, Rose ‐Marie Amini, Henrik Hjalgrim, Ingrid Glimelius Tags: Original Article Source Type: research

Effects of rituximab and dexamethasone on regulatory and proinflammatory B ‐cell subsets in patients with primary immune thrombocytopenia
Abstract ObjectiveTo investigate the cytokine production and surface marker composition of B cells in adult patients with newly diagnosed primary immune thrombocytopenia (ITP) before and 12 months after treatment with rituximab + dexamethasone (RTX+DXM) or dexamethasone (DXM). MethodsPeripheral blood mononuclear cells were isolated from nine patients treated with RTX+DXM, seven patients treated with DXM, and seven healthy donors. Expression of the cell‐surface markers CD5, CD27, CD25, and CD19, and intracellular content of IL‐6 and IL‐10 were measured by flow cytometry. ResultsPBMCs from ITP patients at baseline...
Source: European Journal of Haematology - October 18, 2017 Category: Hematology Authors: Sif Gudbrandsdottir, Marie Brimnes, Tania K øllgaard, Hans C Hasselbalch, Claus H Nielsen Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - October 17, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Rapid reduction in BCR ‐ABL1 transcript predicts deep molecular response in dasatinib‐treated chronic‐phase chronic myeloid leukaemia patients
ConclusionsPrimary treatment of CML‐CP with dasatinib enabled early achievement of MMR and DMR, particularly in elderly patients, with high safety. Furthermore, RR‐BCR‐ABL13m was found to be a more useful predictor of DMR than HT‐BCR‐ABL1 and BCR‐ABL1 IS. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 16, 2017 Category: Hematology Authors: Kazunori Murai, Kohei Yamaguchi, Shigeki Ito, Takuto Miyagishima, Motohiro Shindo, Kentaro Wakasa, Mitsue Inomata, Takahiro Nagashima, Takeshi Kondo, Nozomu Fujimoto, Satoshi Yamamoto, Masakatsu Yonezumi, Tatsuo Oyake, Shugo Kowata, Yasuhiko Tsukushi, Tak Tags: ORIGINAL ARTICLE Source Type: research

Linear decline of corrected platelet count increment within 24  hours after platelet transfusion in haematological patients: A prospective observational study
ConclusionsFifty‐four platelet transfusion occasions in patients with chemotherapy‐induced bone marrow aplasia were included. The decrease in corrected count increment (CCI) 1‐24 hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1‐3, the decline was 2.0% ± 0.6% (mean ± standard deviation) per hour. For patients in Group 4, the decline of CCI was 2.8% ± 1.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the me...
Source: European Journal of Haematology - October 16, 2017 Category: Hematology Authors: Sigurdur Benediktsson, Vladimir Lazarevic, Lars Nilsson, Jens Kjeldsen ‐Kragh, Ulf Schött, Thomas Kander Tags: ORIGINAL ARTICLE Source Type: research

Erythroblast macrophage protein (Emp): Past, Present and Future
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 15, 2017 Category: Hematology Authors: Gulnaz T. Javan, Amandeep Salhotra, Sheree J. Finley, Shivani Soni Tags: Review Article Source Type: research

Infection surveillance in pediatric hematopoietic stem cell transplantation recipients
ConclusionActive surveillance of HAIs in HSCT children allowed the evaluation of the incidence and profile of HAIs, which is essential for the healthcare of these patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 15, 2017 Category: Hematology Authors: Daniela Caldas Teixeira, Lilian Martins Oliveira Diniz, Paulo Henrique Orlandi Mour ão, Fabiana Maria Kakehashi, Antonio Vaz de Macedo, Helena Duani, Wanessa Trindade Clemente, Karla Emília de Sá Rodrigues, Roberta Maia de Castro Romanelli Tags: Original Article Source Type: research

A randomized, controlled study evaluating effects of amlodipine addition to chelators to reduce iron loading in patients with thalassemia major
Abstract AimCardiomyopathy due to iron overload can be fatal in patients with thalassemia major. Calcium channel blockers seem to be effective to reduce iron loading. Our goal was to study effects of amlodipine addition to chelators on iron loading in patients with thalassemia major. MethodsThis randomized, controlled, and single‐center trial was performed on 56 patients with thalassemia major. Patients were randomized 1:1 to combined group (iron chelator plus amlodipine) or control group (iron chelator) for 1 year. Iron content was measured by magnetic resonance imaging; heart T2*, and liver T2*. Serum ferritin was...
Source: European Journal of Haematology - October 13, 2017 Category: Hematology Authors: Aziz Eghbali, Hamideh Kazemi, Hassan Taherahmadi, Yazdan Ghandi, Mohammad Rafiei, Bahador Bagheri Tags: ORIGINAL ARTICLE Source Type: research

Inpatient vs outpatient autologous hematopoietic stem cell transplantation for multiple myeloma
Abstract BackgroundHigh‐dose chemotherapy and autologous hematopoietic stem cell transplantation (auto‐HCT) are commonly performed for multiple myeloma (MM) patients and may be as safe in the outpatient setting as in the inpatient setting. MethodsWe performed a single‐center retrospective analysis of all MM patients undergoing auto‐HCT between January 2008 and December 2012. We categorized patients as outpatient vs inpatient auto‐HCT and compared clinical characteristics and outcomes between the groups. ResultsOne thousand and forty‐six patients were included (669 inpatients, 377 outpatients). Patients transpla...
Source: European Journal of Haematology - October 8, 2017 Category: Hematology Authors: Nina Shah, A. Megan Cornelison, Rima Saliba, Sairah Ahmed, Yago L. Nieto, Qaiser Bashir, Simrit Parmar, Chitra Hosing, Uday Popat, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar Qazilbash Tags: ORIGINAL ARTICLE Source Type: research

Post ‐transplant consolidation plus lenalidomide maintenance vs lenalidomide maintenance alone in multiple myeloma: A systematic review
Abstract BackgroundIn newly diagnosed multiple myeloma (NDMM), autologous stem cell transplantation (ASCT) remains the standard approach for transplant‐eligible patients. To control the inevitable relapse, post‐transplant consolidation/maintenance strategies are commonly used. However, the benefit of post‐transplant consolidation is still uncertain MethodWe conducted a systematic review of phase II/III studies to compare the efficacy of post‐ASCT consolidation plus lenalidomide maintenance (CON+LEN) vs lenalidomide maintenance alone (LEN alone) in NDMM. A meta‐analysis using fixed and random effects models was pe...
Source: European Journal of Haematology - October 6, 2017 Category: Hematology Authors: Fatimah Al ‐Ani, Martha Louzada Tags: REVIEW ARTICLE Source Type: research

Individualized 6 ‐mercaptopurine increments in consolidation treatment of childhood acute lymphoblastic leukemia: a NOPHO randomized controlled trial
ConclusionThis study found no benefit from individualized 6‐mercaptopurine increments compared to standard therapy.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 6, 2017 Category: Hematology Authors: Morten Tulstrup, Thomas L. Frandsen, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur Gisli Jonsson, Hanne Vibeke Hansen Marquart, Birgitte Klug Albertsen, Mats Heyman, Kjeld Schmiegelow, Tags: Original Article Source Type: research

The serum heavy/light chain immunoassay: A valuable tool for sensitive paraprotein assessment, risk, and disease monitoring in monoclonal gammopathies
ConclusionsDespite the fact that different PCD patients were included, the assessment of the HLC‐immunoassay in MGUS, SMM, MM, and WM, our comparison with standard mp‐assays, and relevant PFS differences may excite future applications, which should be confirmed in prospective multicenter trials. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 5, 2017 Category: Hematology Authors: Christine Greil, Gabriele Ihorst, Felix Gaiser, Ulrich Salzer, Emanuel Bisse, Efstathios Kastritis, Heinz Ludwig, Ralph W äsch, Monika Engelhardt Tags: ORIGINAL ARTICLE Source Type: research

Primary cells in BCR/FGFR1 ‐positive 8p11 myeloproliferative syndrome are sensitive to dovitinib, ponatinib, and dasatinib
ConclusionsThese results suggest that treatment with tyrosine kinase inhibitors may be beneficial for patients with EMS during the search for a suitable stem cell donor and for those not eligible for transplantation. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 4, 2017 Category: Hematology Authors: Niklas Landberg, Arta Dreimane, Marianne Rissler, Rolf Billstr öm, Helena Ågerstam Tags: ORIGINAL ARTICLE Source Type: research

Detection of a new heterozygous germline ETV6 mutation in a case with hyperdiploid acute lymphoblastic leukemia (ALL)
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 1, 2017 Category: Hematology Authors: Nicolas Duployez, Wadih Abou Chahla, Sophie Lejeune, Alice Marceau ‐Renaut, Guillaume Letizia, Thomas Boyer, Sandrine Geffroy, Pauline Peyrouze, Nathalie Grardel, Brigitte Nelken, Gérard Michel, Yves Bertrand, Claude Preudhomme Tags: Case Report Source Type: research

A survey on hematology ‐oncology pediatric AIEOP centres: the challenge of posterior reversible encephalopathy syndrome
ConclusionsThis study demonstrates that PRES is a common neurological complication and occurring preferentially in course of induction treatment of some hematologic malignancies, as ALL and after HSCT. It also highlights great clinical differences in the management and outcome in patients with PRES occurring after chemotherapy or after HSCTThis article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 1, 2017 Category: Hematology Authors: Daniele Zama, Pietro Gasperini, Massimo Berger, Mariagrazia Petris, Maria D. De Pasquale, Simone Cesaro, Maria E. Guerzoni, Elena Mastrodicasa, Francesca Savina, Ottavio Ziino, Valentina Kiren, Paola Muggeo, Rosa M. Mura, Fraia Melchionda, Giulio A. Zanaz Tags: Original Article Source Type: research

Increasing incidence of Primary CNS lymphoma but no improvement in survival in Sweden 2000 ‐2013
ConclusionThe increasing PCNSL incidence in the elderly was consistent with an increasing incidence of brain tumors of any type, and may in part be attributable to improved diagnostics and reporting in this group. New treatment options have not yet translated into general survival improvements in a population‐based setting, although the presence of long‐term survivors among fit patients is encouraging.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 1, 2017 Category: Hematology Authors: S Eloranta, E Br ånvall, F Celsing, K Papworth, M Ljungkvist, G Enblad, K E Smedby Tags: Original Article Source Type: research

Eryptosis in autoimmune haemolytic anaemia
ConclusionEryptosis may frequently occur in AIHA related to IgM or IgA aab. Inhibition of eryptosis may represent a new therapeutic option in the treatment of AIHA.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 28, 2017 Category: Hematology Authors: Thilo Bartolm äs, Beate Mayer, Abdelwahab H. Balola, Abdulgabar Salama Tags: Original Article Source Type: research

Effect of Atrial Fibrillation Duration on Plasma von Willebrand Factor Level
ConclusionsVWF is steadily elevated throughout the course of dysrhythmia in NVAF patients treated with warfarin and in those with higher intensity of left atrium blood stasis.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 27, 2017 Category: Hematology Authors: Waldemar E. Wysokinski, Kevin P. Cohoon, Ewa A. Konik, Rowlens M Melduni, Naser M. Ammash, Samuel J. Asirvatham, Robert D. McBane Tags: Original Article Source Type: research

Effects of rituximab and dexamethasone on regulatory and pro ‐inflammatory B‐cell subsets in patients with primary immune thrombocytopenia
Abstract ObjectiveTo investigate the cytokine production and surface marker composition of B cells in adult patients with newly diagnosed primary immune thrombocytopenia (ITP) before and 12 months after treatment with rituximab + dexamethasone (RTX+DXM) or dexamethasone (DXM) MethodsPeripheral blood mononuclear cells were isolated from 9 patients treated with RTX+DXM, 7 patients treated with DXM and 7 healthy donors. Expression of the cell‐surface markers CD5, CD27, CD25 and CD19, and intracellular content of IL‐6 and IL‐10 were measured by flow cytometry ResultsPBMCs from ITP patients at baseline contained a lower ...
Source: European Journal of Haematology - September 27, 2017 Category: Hematology Authors: Sif Gudbrandsdottir, Marie Brimnes, Tania K øllgaard, Hans C Hasselbalch, Claus H Nielsen Tags: Original Article Source Type: research

A randomized, controlled study evaluating effects of amlodipine addition to chelatorsto reduce iron loading in patients with thalassemia major
Abstract AimCardiomyopathy due to iron overload can be fatal in patients with thalassemia major. Calcium channel blockers seem to be effective to reduce iron loading. Our goal was to study effects of amlodipine addition to chelators on iron loading in patients with thalassemia major. MethodsThis randomized, controlled, and single center trial was performed on 56 patients with thalassemia major. Patients were randomized 1:1 to combined group (iron chelator plus amlodipine) or control group (iron chelator) for one year. Iron content was measured by magnetic resonance imaging; heart T2*, and liver T2*. Serum ferritin was also...
Source: European Journal of Haematology - September 27, 2017 Category: Hematology Authors: Aziz Eghbali, Hamideh Kazemi, Hassan Taherahmadi, Yazdan Ghandi, Mohammad Rafiei, Bahador Bagheri Tags: Original Article Source Type: research

Brentuximab Vedotin in Patients with Relapsed or Refractory Hodgkin Lymphoma who are Ineligible for Autologous Stem Cell Transplant: A Germany and UK Retrospective Study
ConclusionThe results of this study provide real‐world evidence on the feasibility and effectiveness of BV in elderly or frail ASCT‐ineligible patients with rrHL in a real‐world setting.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 26, 2017 Category: Hematology Authors: Paul J. Br öckelmann, Erin A. Zagadailov, Shelby L. Corman, Viktor Chirikov, Courtney Johnson, Cynthia Macahilig, Brian Seal, Mehul R. Dalal, Tim Illidge Tags: Original Article Source Type: research

Linear decline of corrected platelet count increment within 24 hours after platelet transfusion in haematological patients: a prospective observational study
Conclusions54 platelet transfusion occasions in patients with chemotherapy‐induced bone marrow aplasia were included. The decrease of corrected count increment (CCI) 1–24 hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1–3, the decline was 2.0%± 0.6% (mean± standard deviation) per hour. For patients in Group 4, the decline of CCI was 2.8%± 1.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the mean CCI, in the first 24 hours post‐tra...
Source: European Journal of Haematology - September 26, 2017 Category: Hematology Authors: Sigurdur Benediktsson, Vladimir Lazarevic, Lars Nilsson, Jens Kjeldsen ‐Kragh, Ulf Schött, Thomas Kander Tags: Original Article Source Type: research

Hypercalcemia remains an adverse prognostic factor for newly diagnosed multiple myeloma patients in the era of novel antimyeloma therapies
ConclusionHypercalcemia remains a poor prognostic feature in the era of novel agents despite the improvement in the outcomes of patients who present with elevated calcium. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 26, 2017 Category: Hematology Authors: Flora Zagouri, Efstathios Kastritis, Athanasios Zomas, Evangelos Terpos, Eirini Katodritou, Argiris Symeonidis, Sosana Delimpasi, Anastasia Pouli, Theodoros P. Vassilakopoulos, Eurydiki Michalis, Stavroula Giannouli, Zafiris Kartasis, Anna Christoforidou, Tags: ORIGINAL ARTICLE Source Type: research

Thrombopoietin receptor agonist switch in adult primary immune thrombocytopenia patients: A retrospective collaborative survey involving 4 Spanish centres
ConclusionTPO‐RA switching is a feasible strategy in different scenarios with high probability of success. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 23, 2017 Category: Hematology Authors: Sunil Lakhwani, Mar ía Perera, Fernando Fernández‐Fuertes, Mario A. Ríos de Paz, Melisa Torres, José María Raya, Miguel T. Hernández Tags: ORIGINAL ARTICLE Source Type: research

Bone marrow harvest from unrelated donors —up‐to‐date methodology
ConclusionWe describe here the current up‐to‐date standard of bone marrow harvest, which leads to excellent results in majority of donors without causing significant complications during the donation. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 23, 2017 Category: Hematology Authors: Katarzyna Pruszczyk, Kamila Skwierawska, Ma łgorzata Król, Albert Moskowicz, Dariusz Jabłoński, Tigran Torosian, Iwona Piotrowska, Elżbieta Urbanowska, Wiesław Wiktor‐Jędrzejczak, Emilian Snarski Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 23, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Clinical Impact of KMT2C and SPRY4 Expression Levels in Intensively Treated Younger Adult Acute Myeloid Leukemia Patients
ConclusionOur data indicate that KMT2C ELs are associated with specific genetic features and that SPRY4 ELs may add prognostic information.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 22, 2017 Category: Hematology Authors: Sabine Kayser, Maximilian Feszler, Julia Krzykalla, Matthias Schick, Michael Kramer, Axel Benner, Felicitas Thol, Uwe Platzbecker, Carsten M üller‐Tidow, Anthony D. Ho, Gerhard Ehninger, Michael Heuser, Richard F. Schlenk, Christian Thiede, Christoph R Tags: Original Article Source Type: research

Characterization of TP53 Mutations in Low ‐Grade Myelodysplastic Syndromes and Myelodysplastic Syndromes with a Non‐Complex Karyotype
Abstract ObjectivesAlthough commonly associated with high‐grade myelodysplastic syndrome (MDS) and MDS with a complex karyotype, TP53 mutations also occur in low‐grade MDS and MDS with a non‐complex karyotype. In latter cases, their clinicopathological features and the characteristics of TP53 mutations remain poorly characterized. Methods176 MDS cases with TP53 mutations were stratified and characterized based on their karyotype and histologic subtype. ResultsAmong 176 cases, 17% had a non‐complex karyotype and 24% were low‐grade MDS. TP53 mutations often occurred in DNA binding domains and the majority of cases ...
Source: European Journal of Haematology - September 20, 2017 Category: Hematology Authors: Wei Wang, Mark J. Routbort, Zhenya Tang, Chi Young Ok, Keyur P. Patel, Naval Daver, Guillermo Garcia ‐Manero, L. Jeffrey Medeiros, Sa A. Wang Tags: Original Article Source Type: research

Delegate abstracts from the posters presented at the 7th Haemophilia Global Summit Partnering to change the world for people with haemophilia: 7th Haemophilia Global Summit
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 17, 2017 Category: Hematology Tags: Abstract Source Type: research

Partnering to change the world for people with haemophilia: 7th Haemophilia Global Summit, Madrid, Spain 22 –24 September 2016
Abstract The 7th Haemophilia Global Summit was held in Madrid, Spain, in September 2016. With a programme designed, for the 6th consecutive year, by a Scientific Steering Committee of haemophilia experts, the aim of the summit was to share optimal management strategies for haemophilia at all life stages and to provide an opportunity for specialists from across the haemophilia multidisciplinary care team to engage in discussion and debate with leading international experts on current and future areas of research. Topics covered ranged from the optimisation of haemophilia management, emerging issues in clinical care, practic...
Source: European Journal of Haematology - September 17, 2017 Category: Hematology Authors: Gerry Dolan Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 17, 2017 Category: Hematology Tags: Issue Information Source Type: research

Mesenchymal stromal cells contribute to quiescence of therapy ‐resistant leukemic cells in acute myeloid leukemia
ConclusionsOur data suggest that hMSC contribute to quiescence and therapy resistance of persistent AML cells. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 13, 2017 Category: Hematology Authors: Wenwen Wang, Tilmann Bochtler, Patrick Wuchter, Linda Manta, Haiju He, Volker Eckstein, Anthony D. Ho, Christoph Lutz Tags: ORIGINAL ARTICLE Source Type: research

In ‐patient versus out‐patient autologous hematopoietic stem cell transplantation for multiple myeloma
Abstract BackgroundHigh dose chemotherapy and autologous hematopoietic stem cell transplantation (auto‐HCT) is commonly performed for multiple myeloma (MM) patients and may be as safe in the out‐patient setting as in the in‐patient setting. MethodsWe performed a single‐center retrospective analysis of all MM patients undergoing auto‐HCT between January 2008 ‐ December 2012. We categorized patients as out‐patient versus in‐patient auto‐HCT and compared clinical characteristics and outcomes between the groups. Results1046 patients were included (669 in‐patients, 377 out‐patients). Patients transplanted ...
Source: European Journal of Haematology - September 12, 2017 Category: Hematology Authors: Nina Shah, A. Megan Cornelison, Rima Saliba, Sairah Ahmed, Yago L. Nieto, Qaiser Bashir, Simrit Parmar, Chitra Hosing, Uday Popat, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar Qazilbash Tags: Original Article Source Type: research