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The presentation and management of platelet disorders in pregnancy
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 21, 2018 Category: Hematology Authors: Bernardus G Goldman, Mark P Hehir, Sahr Yambasu, Edward M O'Donnell Tags: Original Article Source Type: research

Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms
ConclusionWe found positive associations between level of physical activity and QoL, independently of fatigue being present. More research is needed before physical activity can be introduced as a targeted intervention to reduce fatigue and increase QoL in the management of patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 21, 2018 Category: Hematology Authors: Rasmus Tolstrup Larsen, Lars Hermann Tang, Nana Brochmann, Esben Meulengracht Flachs, Anne Illemann Christensen, Hans Carl Hasselbalch, Ann ‐Dorthe Zwisler Tags: Original Article Source Type: research

Chimerism and gene therapy — Lessons learned from non‐conditioned murine bone marrow transplantation models
ConclusionBy extrapolating our murine data, and data from some previous studies to a human non‐conditioned autologous CD34+ HSPC transplantation setting, we conclude that approximately 44 million CD34+ HSPCs would be needed to achieve 20% donor chimerism in a 70‐kg human, which could serve as a starting point for the future use of HSCPs in gene and cell therapy. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 20, 2018 Category: Hematology Authors: Katerina Jazbec, Mojca Je ž, Boštjan Smrekar, Simona Miceska, Jasmina‐Živa Rožman, Urban Švajger, Janja Završnik, Tadej Malovrh, Primož Rožman Tags: ORIGINAL ARTICLE Source Type: research

Bacterial neuraminidase ‐mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure
ConclusionCollectively, our data reveal that alteration of erythrocyte sialylation status by bacterial neuraminidase favors eryptotic cell death, an effect potentially contributing to reduced erythrocyte lifespan and anemia in sepsis.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 17, 2018 Category: Hematology Authors: Syed M. Qadri, David A. Donkor, Ishac Nazy, Donald R. Branch, William P. Sheffield Tags: Original Article Source Type: research

Daratumumab resistance is frequent in advanced stage multiple myeloma patients irrespectively of CD38 expression, and is related to dismal prognosis
ConclusionsResponses to daratumumab and combinations in patients with advanced MM, particularly with extramedullary disease, are low and short lived, stressing the administration of this agent should be early in the course of the disease.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 17, 2018 Category: Hematology Authors: M Pick, V Vainstein, N Goldschmidt, D Lavie, D Libster, A Gural, S Grisariu, B Avni, D Ben Yehuda, M.E Gatt Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - February 15, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Healthcare resource utilisation associated with skeletal ‐related events in European patients with multiple myeloma: results from a prospective, multinational, observational study
ConclusionsAll SREs were associated with substantial HRU; therefore, preventing SREs in MM will reduce the economic and resource burden on healthcare systems.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 14, 2018 Category: Hematology Authors: John Ashcroft, Ignacio Duran, Herbert Hoefeler, Vito Lorusso, Diana Lueftner, Marco Campioni, Michele Intorcia, Amit Bahl Tags: Original Article Source Type: research

Disease and treatment characteristics of polycythemia vera patients in Belgium: Results from a scientific survey
ConclusionThis survey provides better insight into the characteristics of Belgian PV patients and currently used treatment strategies. It shows that 232 (67.6%) PV patients continue to receive HU despite being potentially HU‐resistant. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 7, 2018 Category: Hematology Authors: Timothy Devos, Yves Beguin, Lucien Noens, Koen Eygen, Pierre Zach ée, Philippe Mineur, Laurent Knoops, Chantal Doyen, Koen Theunissen, Fleur Samantha Benghiat, Michael Reusens, Wim Pluymers Tags: ORIGINAL ARTICLE Source Type: research

Omitting cytogenetic assessment from routine treatment response monitoring in chronic myeloid leukemia is safe
ConclusionWe conclude that it is safe to omit routine cytogenetics for response assessment during treatment and to only use molecular monitoring, in order to prevent ambiguous classifications, reduce costs, and reduce the need for invasive bone marrow sampling. Cytogenetic re‐assessment should still be performed when molecular response is suboptimal. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 7, 2018 Category: Hematology Authors: Inge G.P. Geelen, Noortje Thielen, Jeroen J.W.M. Janssen, Mels Hoogendoorn, Tanja J.A. Roosma, Peter J.M. Valk, Otto Visser, Jan J. Cornelissen, Peter E. Westerweel Tags: ORIGINAL ARTICLE Source Type: research

Systematic review of infectious events with the Bruton tyrosine kinase inhibitor ibrutinib in the treatment of hematologic malignancies
ConclusionsIbrutinib use requires prudent consideration of the impacts on host immunity. We identified a high rate of serious adverse infectious events within prospective clinical trials. Data suggest a role of both BTK and ITK inhibition for the increased events. There was considerable variability in the reporting of adverse events between trials, journals, and conference reports. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 6, 2018 Category: Hematology Authors: Benjamin F. Tillman, James M. Pauff, Gowri Satyanarayana, Mahsa Talbott, Jeremy L. Warner Tags: REVIEW ARTICLE Source Type: research

Efficacy, safety and cost of pomalidomide in relapsed and refractory multiple myeloma
Abstract ObjectivesTo investigate the efficacy, safety and cost of a pomalidomide‐dexamethasone regimen in patients with relapsed and refractory multiple myeloma (RRMM). MethodsAll patients (n=63) treated with pomalidomide‐dexamethasone for RRMM in our university hospital between August 2013 and October 2015 were included. ResultsPomalidomide was discontinued early due to progression (before the 4th cycle) in 17 (27%) patients. No case was discontinued for intolerance. The only independent factor that predicted early pomalidomide discontinuation was time from diagnosis to pomalidomide initiation
Source: European Journal of Haematology - February 2, 2018 Category: Hematology Authors: Pauline Gueneau, Marie ‐Lorraine Chretien, Amelie Cansac‐Miet, Ludwig Aho, Ingrid Lafon, Camille Favennec, Julien Guy, Denis Caillot, Mathieu Boulin Tags: Original Article Source Type: research

Safety of Direct Oral Anticoagulants versus Warfarin in Patients with Chronic Liver Disease and Atrial Fibrillation
ConclusionNo significant differences in bleeding rates were noted in patients treated with warfarin and DOAC agents. Further studies evaluating DOAC agents are needed to better understand the optimal anticoagulation strategy in setting of CLD.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Pavel Goriacko, Keith T. Veltri Tags: Original Article Source Type: research

Thromboembolism prophylaxis in patients with Philadelphia ‐negative myeloproliferative neoplasms ‐ clinical practice among Nordic specialists
ConclusionsThe results of this study highlight the importance of considering all risk factors for thrombosis and an optimal collaboration with the primary health care sector.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: O. W. Bjerrum, J. Samuelsson, W. Ghanima, M. Kauppila, C. L. Andersen, Tags: Original Article Source Type: research

Rituximab, cladribine and cyclophosphamide (RCC) induction with rituximab maintenance in chronic lymphocytic leukemia: PALG ‐ CLL4 (ML21283) trial
Abstract ObjectivesPALG CLL4 is the first, randomized, phase IIIb study with cladribine, cyclophosphamide and rituximab (RCC) induction and subsequent maintenance with rituximab in previously untreated chronic lymphocytic leukemia (CLL) patients. MethodsThe induction treatment consisted of six RCC cycles regimen. Patients with complete response (CR) or partial response (PR) after an induction phase were randomized into a maintenance arm with rituximab or an observational arm. ResultsIn the intention‐to‐treat population, 97 patients completed the induction phase with an overall response rate (ORR) of 73.2% (CR 22.7%, PR...
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Tadeusz Robak, Jerzy Blonski, Aleksander Bart łomiej Skotnicki, Magdalena Piotrowska, Tomasz Wróbel, Justyna Rybka, Janusz Kłoczko, Łukasz Bołkun, Bożena Katarzyna Budziszewska, Urszula Walczak, Anatoly Uss, Marta Fidecka, Piotr Smolewski Tags: Original Article Source Type: research

The 2014 BCSH criteria and the 2016 WHO criteria for essential thrombocythemia: a comparison in a large ‐scale cohort
ConclusionThe BCSH criteria diagnosed ET in a broader range of patients encompassing a significant number of patients who would otherwise be diagnosed as prePMF or MPN‐u.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Tomonori Ochiai, Hajime Yasuda, Marito Araki, Kyohei Misawa, Soji Morishita, Mai Nudejima, Yumi Hironaka, Shuichi Shirane, Yoko Edahiro, Akihiko Gotoh, Akimichi Ohsaka, Norio Komatsu Tags: Original Article Source Type: research

Rituximab in combination with chemotherapy for the treatment of chronic lymphocytic leukaemia in clinical practice
ConclusionChemoimmunotherapy with rituximab is feasible and safe in a wide variety of clinical settings in CLL, including the treatment of older patients with comorbidities (ClinicalTrials. gov NCT01178086).This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Marcel Reiser, Steffen D örfel, Manfred Hensel, Mark Hoesl, Wolf‐Oliver Jordan, Michael Koenigsmann, Dirk Meyer, Dietmar Reichert, Andreas Schwarzer, Moritz Marquardt, Kerstin Kellershohn, Kathleen Jentsch‐Ullrich Tags: Original Article Source Type: research

Chronic Lymphoproliferative Disorder of NK ‐cells: A Single‐Institution Review with Emphasis on Relative Utility of Multimodality Diagnostic Tools
ConclusionsPatients with CLPD‐NK have an indolent clinical course and frequent hematologic manifestations that are responsive to single‐agent therapy. Mutations in STAT3 are common and portend more pronounced clinical manifestations.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - February 1, 2018 Category: Hematology Authors: Habibe Kurt, Jeffrey L. Jorgensen, Hesham M. Amin, Keyur P. Patel, Sa A. Wang, Pei Lin, Rashmi Kanagal ‐Shamanna, Sanam Loghavi, Beenu Thakral, Haitham A. Khogeer, Elias J. Jabbour, Shaoying Li, C. Cameron Yin, L. Jeffrey Medeiros, Joseph D. Khoury Tags: Original Article Source Type: research

MLL ‐rearranged acute myeloid leukemia: Influence of the genetic partner in allo‐HSCT response and prognostic factor of MLL 3′ region mRNA expression
ConclusionWe show that the MLL genetic partner could have implications in allo‐HSCT response and we propose three genes whose expression could be useful for the prognosis of this leukemia in patients undergoing allo‐HSCT: 3′ region of MLL, EVI1 and FLT3.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 31, 2018 Category: Hematology Authors: Sergio Burillo ‐Sanz, Rosario M Morales‐Camacho, Teresa Caballero‐Velázquez, Estrella Carrillo, Javier Sánchez, Olga Pérez‐López, Inmaculada Pérez de Soto, José González Campos, Concepción Prats‐Martín, Ricardo Bernal, M Teresa Vargas Tags: Original Article Source Type: research

MiRNA ‐15a, miRNA‐16, miRNA‐126, miRNA‐146a, miRNA‐223 expression in autologous hematopoietic stem cell transplantation and their impact on engraftment
ConclusionsIn conclusion, all investigated microRNAs changed significantly in the course of transplantation. Our results suggest that the miRNAs may participate in hematopoietic recovery in the early post‐transplant period and influence engraftment efficiency after HSCT.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 30, 2018 Category: Hematology Authors: Mateusz Nowicki, Janusz Szemraj, Agnieszka Wierzbowska, Ma łgorzata Misiewicz, Roman Małachowski, Agnieszka Pluta, Olga Grzybowska–Izydorczyk, Tadeusz Robak, Anna Szmigielska‐Kapłon Tags: Original Article Source Type: research

Expression pattern of PD ‐L1 and PD‐L2 in classical Hodgkin lymphoma, primary mediastinal large B‐cell lymphoma, and gray zone lymphoma
ConclusionWe identified increased staining of PD‐L1 in cHL and that of PD‐L2 in PMBL. GZL had a pattern similar to that of cHL.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 28, 2018 Category: Hematology Authors: Yosuke Tanaka, Akiko Miyagi Maeshima, Junko Nomoto, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Kensei Tobinai, Yukio Kobayashi Tags: Original Article Source Type: research

Zebrafish larvae as a model to demonstrate secondary iron overload
ConclusionThis study presented a clear evidence of the effectiveness of zebrafish larvae to use as a tool to study iron overload and open the door for studying the efficiency of potential new iron chelating compounds other than commercially available ones.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 27, 2018 Category: Hematology Authors: Gheyath K. Nasrallah, Nadin N. Younes, Missbah H. Baji, Amjad M. Shraim, Ibrahim Mustafa Tags: Original Article Source Type: research

Genetic variation in IL28B (IFNL3) and response to interferon ‐alpha treatment in myeloproliferative neoplasms
ConclusionThese results imply an effect of IL28B genotype on the outcome of IFN‐α treatment in MPN.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 25, 2018 Category: Hematology Authors: Marie Lindgren, Jan Samuelsson, Lars Nilsson, H åvar Knutsen, Waleed Ghanima, Johan Westin, Peter L Johansson, Björn Andréasson Tags: Original Article Source Type: research

Pre ‐treatment with standard‐dose intravenous methylprednisolone does not improve outcomes in newly diagnosed immune thrombocytopenia (ITP)
Abstract ObjectiveTo assess the benefits and harms to initiate corticosteroids with intravenous methylprednisolone at a conventional dose (1 mg/kg/d) to treat adults with immune thrombocytopenia (ITP). MethodsPopulation stemmed from the prospective multicenter CARMEN registry and included newly diagnosed hospitalized ITP adults with platelet counts
Source: European Journal of Haematology - January 23, 2018 Category: Hematology Authors: Ana ïs Essilini, Thibault Comont, Johanne Germain, Natacha Brun, Claire Dingremont, Brice Castel, Sophie Arista, Serge Madaule, Laurent Sailler, Maryse Lapeyre‐Mestre, Odile Beyne‐rauzy, Bertrand Godeau, Daniel Adoue, Guillaume Moulis, Tags: Original Article Source Type: research

Risk ‐adapted GVHD prophylaxis with post‐transplantation cyclophosphamide in adults after related, unrelated and haploidentical transplantations
ConclusionThe suggested risk‐adapted PTCy‐based prophylaxis is feasible and is associated with low GVHD incidence and mortality in all types of grafts. The study was registered on clinicaltrials. gov (NCT02294552).This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 23, 2018 Category: Hematology Authors: Ivan S. Moiseev, Olga V. Pirogova, Alexandr L. Alyanski, Elena V. Babenko, Tatyana L. Gindina, Elena I. Darskaya, Olga A. Slesarchuk, Tatyana A. Bykova, Alexei B. Chukhlovin, Dmitrii E. Pevtcov, Sergey N. Bondarenko, Boris V. Afanasyev Tags: Original Article Source Type: research

Low plasma protein Z levels are associated with an increased risk for perioperative bleedings
Summary Background and objectivesProtein Z deficiency has been implicated both in bleeding diatheses and thrombophilia. Considering its ambiguous nature and the conflicting clinical data so far, we set out to evaluate the impact of low protein Z (PZ) on perioperative bleeding in patients who underwent surgical (ENT) interventions involving a high risk of bleeding. Patients and methodsAfter exclusion of other coagulation disorders, 154 Patients were stratified into quartiles according to PZ plasma concentrations to evaluate the relation between PZ and bleeding complications. ResultsLow PZ levels were associated with increased blood loss (p
Source: European Journal of Haematology - January 23, 2018 Category: Hematology Authors: Clemens Hinterleitner, Klaus ‐Peter Kreisselmeier, Ann‐Christin Pecher, Paul‐Stefan Mauz, Lothar Kanz, Hans‐Georg Kopp, Karl G. Jaschonek Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - January 22, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Significance of thrombocytopenia in patients with primary and postessential thrombocythemia/polycythemia vera myelofibrosis
Abstract Severe thrombocytopenia (platelets
Source: European Journal of Haematology - January 17, 2018 Category: Hematology Authors: Lucia Masarova, Ahmad Alhuraiji, Prithviraj Bose, Naval Daver, Naveen Pemmaraju, Jorge Cortes, Sherry Pierce, Hagop Kantarjian, Srdan Verstovsek Tags: ORIGINAL ARTICLE Source Type: research

Thrombopoietin receptor agonists in patients with persistent or chronic immune thrombocytopenia
ConclusionsOur study provides some initial data on the potential benefits of the treatment with TPO‐RAs that may allow splenectomy to be safely deferred for prolonged periods. More research is needed to evaluate the impact of the treatment with TPO‐RAs prior to splenectomy. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 15, 2018 Category: Hematology Authors: Jacopo Agnelli Giacchello, Federica Valeri, Mario Boccadoro, Alessandra Borchiellini Tags: ORIGINAL ARTICLE Source Type: research

Outcome following second allogeneic hematopoietic cell transplantation: A single ‐center experience
Abstract ObjectiveSecond allogeneic hematopoietic cell transplantation (HCT) may be indicated following relapse or graft failure following first HCT. Our retrospective single‐center study sought to investigate parameters that influence post‐second allogeneic HCT survival. MethodWe investigated 92 patients who underwent second allogeneic HCT between 1980 and 2016 for relapse or graft failure following first HCT. Median age at second HCT was 41 years (range 16‐68), performed for relapse in 59 patients (64%) and for graft failure in 33 patients (36%). ResultsOn univariate analysis, 3‐year OS of the entire cohort was 3...
Source: European Journal of Haematology - January 11, 2018 Category: Hematology Authors: Hassan A. Aljasem, Hans A. Messner, Jeffrey H. Lipton, Dennis Dong Hwan Kim, Auro Viswabandya, Santhosh Thyagu, Uday Deotare, Fotios V. Michelis Tags: ORIGINAL ARTICLE Source Type: research

DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and −KTS isoforms—From initial observations to recent global genomic analyses
Abstract The Wilms' tumour gene 1 protein (WT1) is a zinc finger transcription factor found indispensable for foetal development. WT1 has also been implicated in the development of tumours in several organ systems, including acute myeloid leukaemia (AML). Four main WT1 isoforms come from 2 alternative splice events. One alternative splice results in the inclusion or exclusion of 3 amino acids, KTS, between zinc fingers 3 and 4 in the WT1 protein. The KTS insert has been extensively investigated due to the functional implications for DNA and RNA binding. In this review, we provide an overview of the research into the isofor...
Source: European Journal of Haematology - January 10, 2018 Category: Hematology Authors: Tove Ullmark, Giorgia Montano, Urban Gullberg Tags: REVIEW ARTICLE Source Type: research

Two novel unstable hemoglobin variants due to in ‐frame deletions of key amino acids in the β‐globin chain
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 1, 2018 Category: Hematology Authors: Karen Gabriela Scheps, Marcia Anah í Hasenahuer, Gustavo Parisi, Héctor M. Targovnik, Eliana García, Ernesto Samuel Veber, Renée Crisp, Graciela Elena, Viviana Varela, María Silvina Fornasari Tags: Original Article Source Type: research

Chimerism and Gene Therapy – Lessons Learned from Non‐Conditioned Murine Bone Marrow Transplantation Models
ConclusionBy extrapolating our murine data, and data from some previous studies to a human non‐conditioned autologous CD34+ HSPC transplantation setting, we conclude that approximately 44 million CD34+ HSPCs would be needed to achieve 20% donor chimerism in a 70 kg human, which could serve as a starting point for the future use of HSCPs in gene and cell therapy.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 1, 2018 Category: Hematology Authors: Katerina Jazbec, Mojca Je ž, Boštjan Smrekar, Simona Miceska, Jasmina‐Živa Rožman, Urban Švajger, Janja Završnik, Tadej Malovrh, Primož Rožman Tags: Original Article Source Type: research

Case Report: Treatment of light ‐chain amyloidosis with daratumumab monotherapy in two patients
Abstract Immunoglobulin light‐chain amyloidosis (AL) affects multiple organs, most prominently the kidney and the heart. Renal and cardiac impairment are both associated with poor prognosis and most patients die as a consequence of renal or cardiac failure. Monoclonal antibodies such as daratumumab (human IgG1 anti‐CD38) and elotuzumab (anti‐SLAMF7) have shown promising efficacy for the treatment of relapsed and refractory multiple myeloma. In this case report we show 2 patients with severe AL, one with severe heart failure and one with heart and renal failure, undergoing treatment with daratumumab. Both patients sho...
Source: European Journal of Haematology - January 1, 2018 Category: Hematology Authors: Charlotte Gran, G östa Gahrton, Evren Alici, Hareth Nahi Tags: CASE REPORT Source Type: research

Omitting cytogenetic assessment from routine treatment response monitoring in CML is safe
ConclusionWe conclude that it is safe to omit routine cytogenetics for response assessment during treatment and to only use molecular monitoring, in order to prevent ambiguous classifications, reduce costs and reduce the need for invasive bone marrow sampling. Cytogenetic re‐assessment should still be performed when molecular response is suboptimal.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 30, 2017 Category: Hematology Authors: Inge G.P. Geelen, Noortje Thielen, Jeroen J.W.M. Janssen, Mels Hoogendoorn, Tanja J.A. Roosma, Peter J.M. Valk, Otto Visser, Jan J. Cornelissen, Peter E. Westerweel Tags: Original Article Source Type: research

Disease and treatment characteristics of polycythaemia vera patients in Belgium: results from a scientific survey
ConclusionThis survey provides better insight on the characteristics of Belgian PV patients and currently used treatment strategies. It shows that 232 (67.6%) PV patients continue to receive hydroxyurea (HU) despite being potentially HU‐resistant.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 29, 2017 Category: Hematology Authors: Timothy Devos, Yves Beguin, Lucien Noens, Koen Van Eygen, Pierre Zach ée, Philippe Mineur, Laurent Knoops, Chantal Doyen, Koen Theunissen, Fleur Samantha Benghiat, Michael Reusens, Wim Pluymers Tags: Original Article Source Type: research

Systematic review of infectious events with the BTK inhibitor ibrutinib in the treatment of haematologic malignancies
ConclusionsIbrutinib use requires prudent consideration of the impacts on host immunity. We identified a high rate of serious adverse infectious events within prospective clinical trials. Data suggest a role of both BTK and ITK inhibition for the increased events. There was considerable variability in the reporting of adverse events between trials, journals, and conference reports.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 29, 2017 Category: Hematology Authors: Benjamin F. Tillman, James M. Pauff, Gowri Satyanarayana, Mahsa Talbott, Jeremy L. Warner Tags: Review Article Source Type: research

Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia
Abstract ObjectivesTo investigate the link between serum erythroferrone levels and iron status parameters in pediatric patients with iron deficiency anemia. MethodsThe study consisted of 66 children (36 with iron deficiency anemia and 30 healthy age‐ and gender‐matched controls) who were investigated for serum levels of iron, total iron binding capacity (TIBC) using automated chemistry analyzer, serum ferritin using electrochemiluminescence immunoassay and ERFE by specific enzyme‐linked immunosorbent assay (ELISA) kit. ResultsSerum erythroferrone levels in iron deficiency anemia patients (197.00 ± 85.51 pg/ml)...
Source: European Journal of Haematology - December 28, 2017 Category: Hematology Authors: Fady M. El Gendy, Mahmoud A. EL ‐Hawy, Amira MF. Shehata, Hanaa E. Osheba Tags: Original Article Source Type: research

Monoclonal Gammopathies: Electronic Subspecialty Consultation
Abstract ImportanceElectronic consultation (e‐consult) is an important component of care for patients in the Veterans Health Administration who require sub‐specialty consultation but not urgent face to face evaluation. Monoclonal gammopathy of undetermined significance (MGUS) is a common reason for e‐consult. While often benign, MGUS requires careful evaluation and persistent surveillance over time. ObjectiveTo identify areas to improve MGUS care delivery by e‐consult. MethodsWe performed a retrospective review of our e‐consult database and identified a cohort of 152 MGUS patients triaged for e‐consult over a f...
Source: European Journal of Haematology - December 27, 2017 Category: Hematology Authors: Nicholas Burwick, Jacob Stein, David A. Garcia, Virginia C. Broudy, Robert E. Richard Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - December 20, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Case Report: A Cryptosporidium infection in a patient with relapsed T ‐lymphoblastic lymphoma undergoing allogeneic stem cell transplantation
Abstract Cryptosporidium infection is a rare cause of enterocolitis. In immunocompromised patients, cryptosporidiosis may lead to debilitating and life‐threatening diarrhea and malabsorption, occasionally with multi‐organ involvement. Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) requires long‐term immunosuppressive therapy, while cellular immunity is usually compromised due to intensive conditioning chemotherapy. Diarrhea in patients who underwent allo‐HSCT may be a sign of an infection, but can also be the result of intestinal graft‐versus‐host disease (GvHD). Here, we describe the case of ...
Source: European Journal of Haematology - December 17, 2017 Category: Hematology Authors: Joanna Schiller, Sebastian Klein, Marianne Engels, Reinhard B üttner, Jan Rybniker, Gerd Fätkenheuer, Christof Scheid, Christian Wybranski, Alexander Quaas, Hans Christian Reinhardt, Ruth Flümann Tags: CASE REPORT Source Type: research

Hodgkin's variant of Richter's transformation during ibrutinib therapy in a series of CLL patients; the Polish Adult Leukemia Group report (PALG)
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 15, 2017 Category: Hematology Authors: Krzysztof Jamroziak, Agnieszka Szymczyk, Marek Hus, Ma łgorzata Wojciechowska, Wanda Knopinska‐Posłuszny, Jadwiga Hołojda, Kazimierz Hałaburda, Krzysztof Warzocha, Elżbieta Iskierka‐Jażdżewska Tags: Letter to the Editor Source Type: research

Flow Cytometric Analysis of Cerebrospinal Fluid in Adult Patients with Acute Lymphoblastic Leukemia during Follow ‐Up
Abstract ObjectiveTo explore the value of flow cytometric (FCM) analysis of cerebrospinal fluid (CSF) in the diagnosis of central nervous system involvement in adult patients with acute lymphoblastic leukemia (ALL) during follow‐up Methods2871 CSF samples from 357 adult patients with newly diagnosed ALL between the year of 2009 and 2015 were analysed retrospectively. These patients were divided into 3 groups according to CSF results, FCM+/conventional cytology (CC)+ group, FCM+/CC‐ group, and FCM‐/CC‐ group, respectively. The overall survival (OS) of the three groups was analysed ResultsFifteen (4.2%) and 26 (7.3%)...
Source: European Journal of Haematology - December 14, 2017 Category: Hematology Authors: Xiaoyuan Gong, Dong Lin, Huijun Wang, Ying Wang, Bingcheng Liu, Hui Wei, Chunlin Zhou, Kaiqi Liu, Shuning Wei, Benfa Gong, Guangji Zhang, Yuntao Liu, Xingli Zhao, Yan Li, Runxia Gu, Shaowei Qiu, Yingchang Mi, Jianxiang Wang Tags: Original Article Source Type: research

DNA and RNA binding by the Wilms ’ tumour gene 1 (WT1) protein +KTS and ‐KTS isoforms ‐ from initial observations to recent global genomic analyses
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 14, 2017 Category: Hematology Authors: Tove Ullmark, Giorgia Montano, Urban Gullberg Tags: Review Article Source Type: research

Cytochemical flow analysis of intracellular G6PD and aggregate analysis of mosaic G6PD expression
ConclusionsConsistent cytoflourometric G6PD analysis facilitates inter‐laboratory comparison of cellular G6PD profiles and contributes to understanding primaquine associated hemolytic risk.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 14, 2017 Category: Hematology Authors: Michael Kalnoky, Germana Bancone, Maria Kahn, Cindy S Chu, Nongnud Chowwiwat, Pornpimon Wilaisrisak, Sampa Pal, Nicole LaRue, Brandon Leader, Francois Nosten, Gonzalo J Domingo Tags: Original Article Source Type: research

Assessment of procoagulant potential in patients with reactive thrombocytosis and its association with platelet count
ConclusionsAs determined by thrombin generation, RT was associated with in‐vitro prothrombotic tendency, which correlated with platelet count. This may explain the increased thromboembolic risk previously reported in RT patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 14, 2017 Category: Hematology Authors: Amihai Rottenstreich, Ela Shai, Geffen Kleinstern, Galia Spectre, David Varon, Yosef Kalish Tags: Original Article Source Type: research

Outcome following second allogeneic hematopoietic cell transplantation: a single center experience
Abstract ObjectiveSecond allogeneic hematopoietic cell transplantation (HCT) may be indicated following relapse or graft failure following first HCT. Our retrospective single‐center study sought to investigate parameters that influence post‐second allogeneic HCT survival MethodWe investigated 92 patients that underwent second allogeneic HCT between 1980 and 2016 for relapse or graft failure following first HCT. Median age at second HCT was 41 years (range 16‐68), performed for relapse in 59 patients (64%) and for graft failure in 33 patients (36%) ResultsOn univariate analysis, 3‐year OS of the entire cohort was 35...
Source: European Journal of Haematology - December 14, 2017 Category: Hematology Authors: Hassan A. Aljasem, Hans A. Messner, Jeffrey H. Lipton, Dennis Dong Hwan Kim, Auro Viswabandya, Santhosh Thyagu, Uday Deotare, Fotios V. Michelis Tags: Original Article Source Type: research

Impact of comorbidities constituting the hematopoietic cell transplant (HCT) ‐comorbidity index on the outcome of patients undergoing allogeneic HCT for acute myeloid leukemia
ConclusionAmong the comorbidities that compose the HCT‐CI, diabetes and cardiovascular comorbidity independently predict NRM in patients undergoing allogeneic HCT for AML. This information should be taken into consideration regarding post‐transplant monitoring and care. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 13, 2017 Category: Hematology Authors: Manar M. I. Khalil, Jeffrey H. Lipton, Eshetu G. Atenafu, Vikas Gupta, Dennis D. Kim, John Kuruvilla, Auro Viswabandya, Hans A. Messner, Fotios V. Michelis Tags: ORIGINAL ARTICLE Source Type: research

Predictive value of 18F ‐FDG PET/CT scanning in combination with clinical parameters in patients with newly diagnosed multiple myeloma
Conclusions18F‐FDG PET/CT in combination with clinical parameters provided an accurate and simple method for risk stratification of patients with newly diagnosed MM.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 11, 2017 Category: Hematology Authors: Honglei Tu, Yong He, Tianhe Huang, Songguk Choe, Xiaoli lan, Xiaoyi Duan, Haseeb Sattar, Chongjiao Li, Fuling Zhou Tags: Original Article Source Type: research

Significance of thrombocytopenia in patients with primary and post ‐essential thrombocythemia/polycythemia vera myelofibrosis
Abstract Severe thrombocytopenia (platelets
Source: European Journal of Haematology - December 11, 2017 Category: Hematology Authors: Lucia Masarova, Ahmad Alhuraiji, Prithviraj Bose, Naval Daver, Naveen Pemmaraju, Jorge Cortes, Sherry Pierce, Hagop Kantarjian, Srdan Verstovsek Tags: Original Article Source Type: research

Cost ‐utility analysis of idelalisib in combination with rituximab in relapsed or refractory chronic lymphocytic leukaemia
ConclusionIR can be considered a cost‐effective treatment compared to R, in the treatment of R/R CLL patients for the Spanish NHS.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - December 11, 2017 Category: Hematology Authors: Luis Felipe Casado, Jos é Ángel Hernández, Isidro Jarque, María Echave, Miguel Angel Casado, Antonio Castro Tags: Original Article Source Type: research