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Clinical Impact of KMT2C and SPRY4 Expression Levels in Intensively Treated Younger Adult Acute Myeloid Leukemia Patients
ConclusionOur data indicate that KMT2C ELs are associated with specific genetic features and that SPRY4 ELs may add prognostic information.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 22, 2017 Category: Hematology Authors: Sabine Kayser, Maximilian Feszler, Julia Krzykalla, Matthias Schick, Michael Kramer, Axel Benner, Felicitas Thol, Uwe Platzbecker, Carsten M üller‐Tidow, Anthony D. Ho, Gerhard Ehninger, Michael Heuser, Richard F. Schlenk, Christian Thiede, Christoph R Tags: Original Article Source Type: research

Characterization of TP53 Mutations in Low ‐Grade Myelodysplastic Syndromes and Myelodysplastic Syndromes with a Non‐Complex Karyotype
Abstract ObjectivesAlthough commonly associated with high‐grade myelodysplastic syndrome (MDS) and MDS with a complex karyotype, TP53 mutations also occur in low‐grade MDS and MDS with a non‐complex karyotype. In latter cases, their clinicopathological features and the characteristics of TP53 mutations remain poorly characterized. Methods176 MDS cases with TP53 mutations were stratified and characterized based on their karyotype and histologic subtype. ResultsAmong 176 cases, 17% had a non‐complex karyotype and 24% were low‐grade MDS. TP53 mutations often occurred in DNA binding domains and the majority of cases ...
Source: European Journal of Haematology - September 20, 2017 Category: Hematology Authors: Wei Wang, Mark J. Routbort, Zhenya Tang, Chi Young Ok, Keyur P. Patel, Naval Daver, Guillermo Garcia ‐Manero, L. Jeffrey Medeiros, Sa A. Wang Tags: Original Article Source Type: research

Delegate abstracts from the posters presented at the 7th Haemophilia Global Summit Partnering to change the world for people with haemophilia: 7th Haemophilia Global Summit
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 17, 2017 Category: Hematology Tags: Abstract Source Type: research

Partnering to change the world for people with haemophilia: 7th Haemophilia Global Summit, Madrid, Spain 22 –24 September 2016
Abstract The 7th Haemophilia Global Summit was held in Madrid, Spain, in September 2016. With a programme designed, for the 6th consecutive year, by a Scientific Steering Committee of haemophilia experts, the aim of the summit was to share optimal management strategies for haemophilia at all life stages and to provide an opportunity for specialists from across the haemophilia multidisciplinary care team to engage in discussion and debate with leading international experts on current and future areas of research. Topics covered ranged from the optimisation of haemophilia management, emerging issues in clinical care, practic...
Source: European Journal of Haematology - September 17, 2017 Category: Hematology Authors: Gerry Dolan Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 17, 2017 Category: Hematology Tags: Issue Information Source Type: research

Mesenchymal stromal cells contribute to quiescence of therapy ‐resistant leukemic cells in acute myeloid leukemia
ConclusionsOur data suggest that hMSC contribute to quiescence and therapy resistance of persistent AML cells. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 13, 2017 Category: Hematology Authors: Wenwen Wang, Tilmann Bochtler, Patrick Wuchter, Linda Manta, Haiju He, Volker Eckstein, Anthony D. Ho, Christoph Lutz Tags: ORIGINAL ARTICLE Source Type: research

In ‐patient versus out‐patient autologous hematopoietic stem cell transplantation for multiple myeloma
Abstract BackgroundHigh dose chemotherapy and autologous hematopoietic stem cell transplantation (auto‐HCT) is commonly performed for multiple myeloma (MM) patients and may be as safe in the out‐patient setting as in the in‐patient setting. MethodsWe performed a single‐center retrospective analysis of all MM patients undergoing auto‐HCT between January 2008 ‐ December 2012. We categorized patients as out‐patient versus in‐patient auto‐HCT and compared clinical characteristics and outcomes between the groups. Results1046 patients were included (669 in‐patients, 377 out‐patients). Patients transplanted ...
Source: European Journal of Haematology - September 12, 2017 Category: Hematology Authors: Nina Shah, A. Megan Cornelison, Rima Saliba, Sairah Ahmed, Yago L. Nieto, Qaiser Bashir, Simrit Parmar, Chitra Hosing, Uday Popat, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar Qazilbash Tags: Original Article Source Type: research

Novel Mutations in Thai Patients with Glanzmann Thrombasthenia
ConclusionThis study reported three novel mutations expanding the genotypic spectrum of ITGA2B causing GT.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 9, 2017 Category: Hematology Authors: Rungnapa Ittiwut, Pintip Suchartlikitwong, Yaowaree Kittikalayawong, Chupong Ittiwut, Karan Prasopsanti, Darintr Sosothikul, Vorasuk Shotelersuk, Kanya Suphapeetiporn Tags: Original Article Source Type: research

Expression of DNA repair genes are important molecular findings in CD34+ stem ‐cells of Myelodysplastic Sydrome
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 9, 2017 Category: Hematology Authors: Howard L. Ribeiro Junior, Allan Rodrigo Soares Maia, Roberta Taiane G. de Oliveira, Ant ônio Wesley Araújo dos Santos, Marília Braga Costa, Izabelle Rocha Farias, Daniela de Paula Borges, Silvia Maria M. Magalhães, Ronald F. Pinheiro Tags: Letter to the Editor Source Type: research

Effect of reduced ‐intensity conditioning and the risk of late‐onset non‐infectious pulmonary complications in pediatric patients
ConclusionOur study's findings indicate that the RIC regimen reduces the risk of LONIPCs in pediatric patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 9, 2017 Category: Hematology Authors: Masayuki Nagasawa, Noriko Mitsuiki, Yuki Aoki, Toshiaki Ono, Takeshi Isoda, Kohsuke Imai, Masatoshi Takagi, Michiko Kajiwara, Hirokazu Kanegane, Tomohiro Morio Tags: Original Article Source Type: research

Monoclonal gammopathy of undetermined significance (MGUS) as viewed by haematology healthcare professionals
ConclusionsWith an ageing population, it is important to consider management strategies for MGUS patients. Our findings will assist those in making these arrangements.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 8, 2017 Category: Hematology Authors: Charlene M. McShane, Blain Murphy, Kah Heng Lim, Lesley A. Anderson Tags: Original Article Source Type: research

Post ‐transplant Consolidation plus Lenalidomide Maintenance vs. Lenalidomide Maintenance Alone in Multiple Myeloma: A Systematic Review
Abstract BackgroundIn newly diagnosed multiple myeloma (NDMM), autologous stem cell transplantation (ASCT) remains the standard approach for transplant‐eligible patients. To control the inevitable relapse, post‐transplant consolidation/maintenance strategies are commonly used. However, the benefit of post‐transplant consolidation is still uncertain. MethodWe conducted a systematic review of phase II/III studies to compare the efficacy of post‐ASCT consolidation plus lenalidomide maintenance (CON+LEN) vs. lenalidomide maintenance alone (LEN alone) in NDMM. A meta‐analysis using fixed and random effects models was ...
Source: European Journal of Haematology - September 8, 2017 Category: Hematology Authors: Fatimah Al ‐Ani, Martha Louzada Tags: Review Article Source Type: research

The serum heavy/light chain immunoassay: a valuable tool for sensitive paraprotein assessment, risk and disease monitoring in monoclonal gammopathies
ConclusionsDespite the fact that different PCD patients were included, the assessment of the HLC‐immunoassay in MGUS, SMM, MM and WM, our comparison with standard mp‐assays, and relevant PFS differences may excite future applications, which should be confirmed in prospective multicenter trials.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 8, 2017 Category: Hematology Authors: Christine Greil, Gabriele Ihorst, Felix Gaiser, Ulrich Salzer, Emanuel Bisse, Efstathios Kastritis, Heinz Ludwig, Ralph W äsch, Monika Engelhardt Tags: Original Article Source Type: research

Successful collection of peripheral blood stem cells upon VIDE chemomobilization in sarcoma patients
ConclusionsOur data demonstrate the feasibility of successful PBSC collection upon VIDE chemomobilization even after up to five cycles of induction therapy, while at the same time the increasing risk of bone marrow exhaustion with every consecutive cycle is outlined.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 8, 2017 Category: Hematology Authors: Katharina Kriegsmann, Christoph Heilig, Martin Cremer, Philipp Novotny, Mark Kriegsmann, Thomas Bruckner, Carsten M üller‐Tidow, Gerlinde Egerer, Patrick Wuchter Tags: Original Article Source Type: research

Cost ‐effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T‐cell acute lymphoblastic leukemia
ConclusionsLow frequency of DNMT3A mutations in pediatric T‐ALL is in striking contrast to adult T‐ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing‐HRM approach offers a cost‐effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: Bronis ława Szarzyńska‐Zawadzka, Maria Kosmalska, Łukasz Sędek, Alicja Sonsala, Magdalena Twardoch, Jerzy R. Kowalczyk, Tomasz Szczepański, Michał Witt, Małgorzata Dawidowska Tags: Original Article Source Type: research

Rapid reduction of BCR ‐ABL1 transcript predicts deep molecular response in dasatinib‐treated chronic‐phase chronic myeloid leukaemia patients
ConclusionsPrimary treatment of CML‐CP with dasatinib enabled early achievement of MMR and DMR, particularly in elderly patients, with high safety. Furthermore, RR‐BCR‐ABL13m was found to be a more useful predictor of DMR than HT‐BCR‐ABL1 and BCR‐ABL1 IS.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: Kazunori Murai, Kohei Yamaguchi, Shigeki Ito, Takuto Miyagishima, Motohiro Shindo, Kentaro Wakasa, Mitsue Inomata, Takahiro Nagashima, Takeshi Kondo, Nozomu Fujimoto, Satoshi Yamamoto, Masakatsu Yonezumi, Tatsuo Oyake, Kowata Shugo, Yasuhiko Tsukushi, Tak Tags: Original Article Source Type: research

Dermatopathic Lymphadenopathy with Langerhans Cell Chimerism in Graft ‐versus‐host Disease of the Skin
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: Andreas Kreft, Kristina Kr ümpelmann, Andreas Rosenwald, David Hollemann, Eva Maria Wagner‐Drouet Tags: Case Report Source Type: research

Waldenstr öm′s Macroglobulinemia: two malignant clones in a monoclonal disease? Molecular background and clinical reflection
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: K Growkov á, E Kryukova, Z Kufová, J Filipová, T Ševčíková, L Říhová, M Kaščák, F Kryukov, R Hájek Tags: Review Article Source Type: research

Prevalence and pROgnostic impact of anemia and IRON deficiency in patients hospitalized in an internal medicine ward: the PRO ‐IRON Study
ConclusionsAnemia and iron deficiency were highly prevalent in internal medicine patients. As anemia negatively impacts on in‐hospital mortality, awareness should be raised for effective diagnosis and management of these comorbidities in hospitalized patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: C ândida Fonseca, Manuel Araújo, Patrícia Moniz, Filipa Marques, Inês Araújo, Luís Costa, Joana Rodrigues, Luciana Frade, Arturo Botella, Susana Jesus, Ana Leitão, Luís Campos Tags: Original Article Source Type: research

Primary cells in BCR/FGFR1 positive 8p11 myeloproliferative syndrome are sensitive to dovitinib, ponatinib, and dasatinib
ConclusionsThese results suggest that treatment with tyrosine kinase inhibitors may be beneficial for EMS patients during the search for a suitable stem cell donor and for those not eligible for transplantation.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: Niklas Landberg, Arta Dreimane, Marianne Rissler, Rolf Billstr öm, Helena Ågerstam Tags: Original Article Source Type: research

Thalidomide Induces Haematologic Responses in Patients with β‐Thalassaemia
ConclusionIn this study, thalidomide showed an outstanding effect on β‐thalassaemia patients who required frequent red‐cell transfusions. Thalidomide increased haemoglobin levels without causing serious adverse reactions, but the long‐term curative outcomes and other side effects should be observed continuously.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 29, 2017 Category: Hematology Authors: Jiangming Chen, Weijian Zhu, Ning Cai, Shengdi Bu, Jinyan Li, Lan Huang Tags: Original Article Source Type: research

The management of hodgkin lymphomas in pregnancies
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 29, 2017 Category: Hematology Authors: Y Moshe, O S Bentur, M Lishner, I Avivi Tags: Review Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 22, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Preliminary report: Measurement of apixaban and rivaroxaban in plasma from bleeding patients
ConclusionsOur findings show that Biophen is suitable for measuring apixaban and rivaroxaban concentrations in plasma. However, our results in patients with active bleeding show an overestimation of 26%. This should be taken into account when assessing possible intoxication with apixaban and rivaroxaban in patients presenting with bleeding.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 21, 2017 Category: Hematology Authors: Kathrine O.F. Jensen, Svend H. Hansen, Jens P. Goetze, Amalie Jesting, Jakob Stensballe, Henrik Hansen Tags: Original Article Source Type: research

The aim of iron chelation therapy in thalassaemia
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 19, 2017 Category: Hematology Authors: George J Kontoghiorghes Tags: Letter to the Editor Source Type: research

Low ‐dose bortezomib and dexamethasone as primary therapy in elderly patients with Waldenstrӧm macroglobulinemia
ConclusionsOur findings show that lBD is an effective and tolerable treatment regimen for elderly patients with WM.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 12, 2017 Category: Hematology Authors: Ya ‐Ping Zhang, Xi Yang, Zeng‐Hua Lin, Xin‐Feng Wang, Xin Cao, Xue‐Fen You, Hong‐Ming Huang, Wen‐Yu Shi, Hong Liu Tags: Original Article Source Type: research

Prognostic relevance of oxidative stress measurement in chronic lymphocytic leukaemia
Abstract ObjectiveTo evaluate the prognostic significance of oxidative stress (OS) and antioxidant defence status measurement in patients with chronic lymphocytic leukaemia (CLL). Methodsd‐ROMs test and BAP test were evaluated at diagnosis of 165 patients with CLL and correlated with clinical‐biological features and prognosis. ResultsAn increased oxidative damage (d‐ROMs test) and a reduced antioxidant potential (BAP test) were found in CLL patients than normal controls (P
Source: European Journal of Haematology - August 3, 2017 Category: Hematology Authors: Giovanni D'Arena, Candida Vitale, Omar Perbellini, Marta Coscia, Francesco La Rocca, Vitalba Ruggieri, Carlo Visco, Nicola Matteo Dario Di Minno, Idanna Innocenti, Vincenzo Pizza, Silvia Deaglio, Giovanni Di Minno, Aldo Giudice, Gioacchino Calapai, Pelleg Tags: ORIGINAL ARTICLE Source Type: research

Cell ‐free DNA — Minimally invasive marker of hematological malignancies
Abstract Although tumor cells are the most reliable source of tumor DNA, biopsy of the tumor is an invasive procedure that should be avoided in some cases. The main limitation of any biopsy is sampling of one tumor site, which may not represent all malignant clones due to the heterogeneity of the tumor. These clones respond to treatment differently and thus directly influence survival of the patient. Circulating cell‐free DNA (cfDNA) is released from multiple tumor sites, reflects overall heterogeneity of the tumor, and correlates with its progression. Detection of tumor‐specific genetic and epigenetic aberrations in c...
Source: European Journal of Haematology - August 3, 2017 Category: Hematology Authors: Veronika Kubaczkova, David Vrabel, Lenka Sedlarikova, Lenka Besse, Sabina Sevcikova Tags: REVIEW ARTICLE Source Type: research

Distress and unmet needs during treatment and quality of life in early cancer survivorship: a longitudinal study of haematological cancer patients
ConclusionAnxiety, depression and patient‐care unmet needs during treatment are associated with diminished physical and emotional well‐being in the following months. Psychological distress and unmet supportive care needs experienced during treatment should be addressed to maximise future QoL.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Devesh Oberoi, Victoria M White, John F. Seymour, H. Miles Prince, Simon Harrison, Michael Jefford, Ingrid Winship, David J Hill, Damien Bolton, Jeremy Millar, Nicole Wong Doo, Anne Kay, Graham Giles Tags: Original Article Source Type: research

Expression and significance of Pim ‐3 kinase in adult T‐cell leukemia
ConclusionPim‐3 is a potentially suitable target for the development of novel therapeutic agents against ATL.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Chie Ishikawa, Masachika Senba, Tadashi Hashimoto, Atsushi Imaizumi, Naoki Mori Tags: Original Article Source Type: research

Intracellular iron overload leading to DNA damage of lymphocytes and immune dysfunction in thalassemia major patients
ConclusionTherefore, intracellular iron overload caused DNA fragmentation which may ultimately hamper lymphocyte function and this may contribute to immune dysfunction and increased susceptibility to infections in thalassemia patients as indicated by the good correlation (R2=0.91) between lymphocyte DNA damage and rate of infection found in the present study.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Jyoti Shaw, Ayan Chakraborty, Arijit Nag, Arnab Chattopadyay, Anjan Kr Dasgupta, Maitreyee Bhattacharyya Tags: Original Article Source Type: research

MRP1 protein expression in leukemic stem cells as a negative prognostic marker in acute myeloid leukemia patients
ConclusionsOur data presents for the very first time the high negative correlation between MRP1 protein expression in LSC and AML patients’ remission. It does strongly suggest that MRP1 expression in LSC is an adverse prognostic marker in patients with de novo AML.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Maria Paprocka, Aleksandra Bielawska ‐Pohl, Joanna Rossowska, Agnieszka Krawczenko, Danuta Duś, Marek Kiełbiński, Olga Haus, Maria Podolak‐Dawidziak, Kazimierz Kuliczkowski Tags: Original Article Source Type: research

Retreatment and Prolonged Therapy with Subcutaneous Bortezomib in Patients with Relapsed Multiple Myeloma: A Randomized, Controlled, Phase III Study
ConclusionsThis study showed no significant benefit with experimental vs. standard VD retreatment therapy. Further investigations are required to determine whether the experimental retreatment regimen is a suitable alternative to the current standard retreatment regimen.Trial registration: ClinicalTrials. gov identifier NCT01910987; MMY3033This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Evangelos Terpos, Marco Gobbi, Anna Potamianou, Marjolein Lahaye, Catherine Couturier, Michele Cavo Tags: Original Article Source Type: research

Mesenchymal stromal cells contribute to quiescence of therapy resistant leukemic cells in acute myeloid leukemia
ConclusionsOur data suggest that hMSC contribute to quiescence and therapy resistance of persistent AML cells.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Wenwen Wang, Tilmann Bochtler, Patrick Wuchter, Linda Manta, Haiju He, Volker Eckstein, Anthony D. Ho, Christoph Lutz Tags: Original Article Source Type: research

The prognostic value of a trend in modified SOFA score for  patients with hematological malignancies in the intensive care unit
ConclusionsTrends in SOFA or SOFAhem score are both suitable as prognostic parameter. The trend in SOFAhem score seems to be independently related to mortality in hematological patients admitted to the ICU, and because of the higher odds ratios and lower P‐values compared to the SOFA score, it is probably stronger related to mortality than the classical score, but its prognostic value should be tested in a larger cohort. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Astrid M.P. Demandt, Dani ël A. Geerse, Bram J.P. Janssen, Bjorn Winkens, Harry C. Schouten, Walther N.K.A. Mook Tags: ORIGINAL ARTICLE Source Type: research

Thrombopoietin receptor agonist switch in adult primary immune thrombocytopenia (ITP) patients: A retrospective collaborative survey involving four spanish centers
ConclusionTPO‐RA swithching is a feasible strategy in different scenarios with high probability of success.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 31, 2017 Category: Hematology Authors: Sunil Lakhwani, Maria Perera, Fernando Fern ández‐Fuerte, Mario A. Rios de Paz, Melisa Torres, José María Raya, Miguel T. Hernandez Tags: Original Article Source Type: research

Morphological features of congenital dyserythropoietic anemia type I: the role of electron microscopy in diagnosis
ConclusionsEM studies revealed high morphological frequency of specific ultrastructural changes in erythroblasts which facilitate prompt diagnosis of CDAI. Due to low specificity of BM LM findings, when BM EM is unavailable diagnostic approach should also include other inherited anemias.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 29, 2017 Category: Hematology Authors: Peretz Resnitzky, Dina Shaft, Hanna Shalev, Joseph Kapelushnik, Orly Dgany, Tanya Krasnov, Hannah Tamary Tags: Original Article Source Type: research

Direct acting oral anticoagulants for the treatment of suspected heparin ‐induced thrombocytopenia
ConclusionsIn this small retrospective study of adult patients treated for acute HIT, treatment with DOAC therapy was not associated with in‐hospital thrombotic or hemorrhagic events. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 25, 2017 Category: Hematology Authors: Kyle A. Davis, Daphne O. Davis Tags: ORIGINAL ARTICLE Source Type: research

ABCG2 and CD200 define patients at high risk of relapse in ELN favorable subgroup of AML
ConclusionsOur data confirm a negative impact of ABCG2 and CD200 overexpression also in AML patients considered at favorable risk according to ELN cytogenetic/molecular classification. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 20, 2017 Category: Hematology Authors: Mario Tiribelli, Antonella Geromin, Margherita Cavallin, Sara Di Giusto, Erica Simeone, Renato Fanin, Daniela Damiani Tags: ORIGINAL ARTICLE Source Type: research

Reduced ‐intensity conditioning allogeneic transplantation after salvage treatment with DT‐PACE in myeloma patients relapsing early after autologous transplant
Abstract ObjectiveIn this retrospective single‐centre study, we have looked into the transplant outcomes(overall survival OS, progression‐free survival PFS, GvHD) and the role of chimerism, DLI and pretransplant characteristics in patients who had a suboptimal response (
Source: European Journal of Haematology - July 20, 2017 Category: Hematology Authors: Kate Randall, Maria Kaparou, Evgenia Xenou, Shankara Paneesha, Bhuvan Kishore, Alexandros Kanellopoulos, Richard Lovell, Kathy Holder, Julie Suhr, Lynda Baker, Lynn Ryan, Emmanouil Nikolousis Tags: ORIGINAL ARTICLE Source Type: research

Influence of WHO versus ELN advanced phase chronic myeloid leukemia definitions on overall survival
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 18, 2017 Category: Hematology Authors: Inge G.P. Geelen, Noortje Thielen, Jeroen J.W.M. Janssen, Mark ‐David Levin, Mels Hoogendoorn, Otto Visser, Jan J. Cornelissen, Peter E. Westerweel Tags: Letter to the Editor Source Type: research

Bone marrow harvest from unrelated donors – up to date methodology
ConclusionWe describe here the current up‐to‐date standard of bone marrow harvest which leads to excellent results in majority of donors without causing significant complications during the donationThis article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 18, 2017 Category: Hematology Authors: Katarzyna Pruszczyk, Kamila Skwierawska, Ma łgorzata Król, Albert Moskowicz, Dariusz Jabłoński, Tigran Torosian, Iwona Piotrowska, Elżbieta Urbanowska, Wiesław Wiktor‐Jędrzejczak, Emilian Snarski Tags: Original Article Source Type: research

DA ‐EPOCH‐R for post‐transplant lymphoproliferative disorders
ConclusionsOur findings support several observations in the literature that DA‐EPOCH‐R is efficacious and well‐tolerated for the treatment of advanced, monomorphic PTLD. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 13, 2017 Category: Hematology Authors: Christin B. DeStefano, Vera Malkovska, Hind Rafei, Aarthi Shenoy, Kelly Fitzpatrick, Anita Aggarwal, Joseph P. Catlett Tags: CASE REPORT Source Type: research

Validation of an algorithm identifying incident primary immune thrombocytopenia in the French national health insurance database
ConclusionsThis study showed a very good PPV of this algorithm identifying incident primary ITP patients in the SNIIRAM. Keywordsimmune thrombocytopenia; algorithm; positive predictive value; SNIIRAM; epidemiology.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 10, 2017 Category: Hematology Authors: Salim Mezaache, Helene Derumeaux, Pierre Ferraro, Pascal Capdepon, Jean ‐Christophe Steinbach, Xavier Abballe, Deborah Palas, Nabil Saichi, Karine Desboeuf, Maryse Lapeyre‐Mestre, Laurent Sailler, Guillaume Moulis Tags: Original Article Source Type: research

Cell ‐free DNA – minimally invasive marker of hematological malignancies
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 10, 2017 Category: Hematology Authors: V. Kubaczkova, D. Vrabel, L. Sedlarikova, L. Besse, S. Sevcikova Tags: Review Article Source Type: research

Persisting Hyperbilirubinemia in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Chronically Treated with Eculizumab: The Role of Hepatocanalicular Transporter Variants
ConclusionsHyperbilirubinemia in PNH pts treated with eculizumab might not only be due to an insufficient response but rather a combination of mutations in hepatocanalicular transporter variants, Gilbert syndrome and extravascular hemolysis. Our findings warrant further studies concerning transporter and enzyme variants in PNH to determine their clinical significance.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 10, 2017 Category: Hematology Authors: Ferras Alashkar, Susanne N Weber, Colin Vance, D örte Herich‐Terhürne, Ulrich Dührsen, Frank Lammert, Alexander Röth Tags: Original Article Source Type: research

Differential expression of homologous recombination DNA repair genes in the early and advanced stages of myelodysplastic syndrome
Abstract BackgroundThe high incidence of mutations and cytogenetic abnormalities in patients with myelodysplastic syndrome (MDS) suggests that defects in DNA repair mechanisms. We monitored DNA repair pathways in MDS and their alterations during disease progression. MethodsExpression profiling of DNA repair genes was performed on CD34+ cells and paired samples were used for monitoring of RAD51 and XRCC2 gene expression during disease progression. Immunohistochemical staining for RAD51 was done on histology samples. ResultsRAD51 and XRCC2 showed differential expression between low‐risk and high‐risk MDS (p
Source: European Journal of Haematology - July 6, 2017 Category: Hematology Authors: Jan Valka, Jitka Vesela, Hana Votavova, Michaela Dostalova ‐Merkerova, Zuzana Horakova, Vit Campr, Jana Brezinova, Zuzana Zemanova, Anna Jonasova, Jaroslav Cermak, Monika Belickova Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Haematology)
Source: European Journal of Haematology - July 5, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Hypercalcemia remains an adverse prognostic factor  for newly diagnosed multiple myeloma patients in the era of novel anti‐myeloma therapies
Conclusionhypercalcemia remains a poor prognostic feature in the era of novel agents despite the improvement in the outcomes of patients who present with elevated calcium.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 4, 2017 Category: Hematology Authors: Flora Zagouri, Efstathios Kastritis, Athanasios Zomas, Evangelos Terpos, Eirini Katodritou, Argiris Symeonidis, Sosana Delimpasi, Anastasia Pouli, Theodoros P. Vassilakopoulos, Eurydiki Michalis, Stavroula Giannouli, Zafiris Kartasis, Anna Christoforidou, Tags: Original Article Source Type: research

Outcomes of allogeneic stem cell transplantation in patients with paroxysmal nocturnal hemoglobinuria with or without aplastic anemia
ConclusionRIC regimen was sufficient to eradicate PNH clones with sustained donor‐type engraftment after allogeneic SCT. Therefore, application of allogeneic SCT with RIC should be considered in patients with PNH, in accordance with the severity of the underlying bone marrow failure.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 1, 2017 Category: Hematology Authors: Sung ‐Eun Lee, Sung Soo Park, Young‐Woo Jeon, Jae‐Ho Yoon, Byung‐Sik Cho, Ki‐Sung Eom, Yoo‐Jin Kim, Seok Lee, Chang‐Ki Min, Hee‐Je Kim, Seok‐Goo Cho, Dong‐Wook Kim, Woo‐Sung Min, Jong Wook Lee Tags: Original Article Source Type: research