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Spanish translation section
(Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Tags: Spanish abstracts Source Type: research

Scientific Surgery
(Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Tags: Scientific surgery Source Type: research

Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastases
ConclusionSignificant enrichment for CMS4 was observed in colorectal peritoneal carcinomatosis. Surgical relevanceCytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) improves survival of selected patients with colorectal peritoneal carcinomatosis, but recurrence is common. Histopathological and molecular analysis of colorectal peritoneal carcinomatosis could provide clues for development of novel therapies.In this study, colorectal peritoneal carcinomatosis was found to be enriched for tumours with high stromal content and CMS4‐positive status.To further improve prognosis for patie...
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: I. Ubink, W. J. van Eden, P. Snaebjornsson, N. F. M. Kok, J. van Kuik, W. M. U. van Grevenstein, M. M. Lacl é, J. Sanders, R. J. A. Fijneman, S. G. Elias, I. H. M. Borel Rinkes, A. G. J. Aalbers, O. Kranenburg Tags: Original article Source Type: research

Effect of Akt activation and experimental pharmacological inhibition on responses to neoadjuvant chemoradiotherapy in rectal cancer
BackgroundNeoadjuvant chemoradiotherapy (CRT) is one of the preferred initial treatment strategies for locally advanced rectal cancer. Responses are variable, and most patients still require surgery. The aim of this study was to identify molecular mechanisms determining poor response to CRT. MethodsGlobal gene expression and pathway enrichment were assessed in pretreatment biopsies from patients with non‐metastatic cT2–4 N0–2 rectal cancer within 7 cm of the anal verge. Downstream Akt activation was assessed in an independent set of pretreatment biopsies and in colorectal cancer cell lines using immunohistoch...
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: F. C. Koyama, C. M. Lopes Ramos, F. Ledesma, V. A. F. Alves, J. M. Fernandes, B. B. Vailati, G. P. S ão Julião, A. Habr‐Gama, J. Gama‐Rodrigues, R. O. Perez, A. A. Camargo Tags: Original article Source Type: research

Defining the molecular pathology of pancreatic body and tail adenocarcinoma
ConclusionPDACs of the body and tail demonstrate aggressive tumour biology that may explain worse clinical outcomes. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: S. B. Dreyer, N. B. Jamieson, R. Upstill ‐Goddard, P. J. Bailey, C. J. McKay, , A. V. Biankin, D. K. Chang Tags: Original article Source Type: research

Outcomes after prophylactic gastrectomy for hereditary diffuse gastric cancer
ConclusionThe considerable morbidity and functional consequences of gastrectomy should be considered when counselling individuals with an inherited predisposition to diffuse gastric cancer. Intraoperative frozen‐section examination is recommended to remove all risk‐bearing gastric mucosa. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: R. T. van der Kaaij, J. P. van Kessel, J. M. van Dieren, P. Snaebjornsson, O. Balagu é, F. van Coevorden, L. E. van der Kolk, K. Sikorska, A. Cats, J. W. van Sandick Tags: Original article Source Type: research

Genotype and risk of tumour rupture in gastrointestinal stromal tumour
ConclusionGastric GISTs with KIT exon 11 deletions involving codons 557 and 558 are at increased risk of tumour rupture. This high‐risk feature can be identified in the diagnostic evaluation and should be included in the assessment when neoadjuvant imatinib treatment is considered. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: K. Boye, J. ‐M. Berner, I. Hompland, Ø. S. Bruland, S. Stoldt, K. Sundby Hall, B. Bjerkehagen, T. Hølmebakk Tags: Original article Source Type: research

Minimizing inequality in access to precision medicine in breast cancer by real ‐time population‐based molecular analysis in the SCAN‐B initiative
ConclusionPopulation‐based collection of fresh tumour tissue is feasible given a decisive joint effort between academia and collaborative healthcare groups, and with governmental support. An infrastructure for genomic analysis and prompt data output paves the way for novel systemic therapy for patients from all hospitals, irrespective of size and location. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: L. Ryd én, N. Loman, C. Larsson, C. Hegardt, J. Vallon‐Christersson, M. Malmberg, H. Lindman, A. Ehinger, L. H. Saal, Å. Borg Tags: Original article Source Type: research

Long ‐term outcome of prophylactic thyroidectomy in children carrying RET germline mutations
ConclusionEarly prophylactic thyroidectomy is a viable surgical concept in experienced hands, sparing older children the postoperative morbidity associated with delayed neck surgery. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: A. Machens, M. Elwerr, K. Lorenz, F. Weber, H. Dralle Tags: Original article Source Type: research

Genetic analysis of surgical margins in oral cavity cancer
ConclusionMolecular assessment of surgical margins can help identify patients at risk of local recurrence. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: S. A. Liu, C. C. Wang, R. S. Jiang, W. Y. Wang, J. C. Lin Tags: Original article Source Type: research

Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery
ConclusionInterrogating the intestinal microbiome using next‐generation sequencing technology has the potential to influence cancer outcomes following colonic resection. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: S. Gaines, C. Shao, N. Hyman, J. C. Alverdy Tags: Review Source Type: research

Quality ‐of‐life implications of risk‐reducing cancer surgery
ConclusionAlthough the overwhelming quality‐of‐life implications of surgery are neutral to positive, risk‐reducing surgery is irreversible and can be associated with short‐ and long‐term side‐effects. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: A. M. Altman, J. Y. C. Hui, T. M. Tuttle Tags: Review Source Type: research

Circulating tumour cells and DNA as liquid biopsies in gastrointestinal cancer
ConclusionLiquid biopsies have applications in gastrointestinal cancers to improve clinical decision‐making. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: O. Nordg ård, K. Tjensvoll, B. Gilje, K. Søreide Tags: Review Source Type: research

Clinicopathological, genomic and immunological factors in colorectal cancer prognosis
ConclusionCurrent strategies for managing CRC are strongly dependent on clinicopathological staging, although molecular testing is increasingly being implemented into routine clinical practice. As immunological biomarkers are further validated, their testing may also become routine. To obtain clinically useful information from new biomarkers, it is important to implement them into a model that includes all underlying fundamental factors, as this will enable the best possible outcomes and deliver true precision medicine. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: K. M. Marks, N. P. West, E. Morris, P. Quirke Tags: Review Source Type: research

Extent of surgery for phaeochromocytomas in the genomic era
ConclusionAdrenal‐sparing surgery should be the standard approach for patients who have already been diagnosed with MEN2 or VHL when operating on the first side, whereas complete removal of the affected adrenal gland(s) is generally recommended for patients with SDHB or MAX germline mutations. Routine assessment of a patient's genotype, even after the first operation, can be crucial for adopting an appropriate strategy for follow‐up and future surgery. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: H. M. Rossitti, P. S öderkvist, O. Gimm Tags: Review Source Type: research

Modalities for image ‐ and molecular‐guided cancer surgery
ConclusionEach modality has its strengths and weaknesses; no single technique will be suitable for all surgical procedures. Strict selection of modalities per cancer type and surgical requirements is required as well as combining techniques to find the optimal balance. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: M. A. Stammes, S. L. Bugby, T. Porta, K. Pierzchalski, T. Devling, C. Otto, J. Dijkstra, A. L. Vahrmeijer, L. ‐F. de Geus‐Oei, J. S. D. Mieog Tags: Review Source Type: research

Meta ‐analysis of the prognostic value of CpG island methylator phenotype in gastric cancer
BackgroundCpG island methylator phenotype (CIMP) has been identified as a distinct molecular subtype of gastric cancer, yet associations with survival are conflicting. A meta‐analysis was performed to estimate the prognostic significance of CIMP. MethodsEmbase, MEDLINE, PubMed, PubMed Central and Cochrane databases were searched systematically for studies related to the association between CIMP and survival in patients undergoing potentially curative resection for gastric cancer. ResultsA total of 918 patients from ten studies were included, and the median proportion of tumours with CIMP‐high (CIMP‐H) status was 40&m...
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: A. G. M. T. Powell, S. Soul, A. Christian, W. G. Lewis Tags: Systematic review Source Type: research

Patient ‐derived organoid models help define personalized management of gastrointestinal cancer
ConclusionHigh‐throughput drug screening on organoids, combined with next‐generation sequencing, proteomic analysis and other state‐of‐the‐art molecular diagnostic methods, can shape cancer treatment to become more effective with fewer side‐effects. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: M. R. Aberle, R. A. Burkhart, H. Tiriac, S. W. M. Olde Damink, C. H. C. Dejong, D. A. Tuveson, R. M. van Dam Tags: Review Source Type: research

Impact of genomics on the surgical management of melanoma
ConclusionSurgery remains central for managing primary melanoma, and is an important element of integrated multidisciplinary care in advanced disease, particularly for patients with resectable metastases. The field will undergo further change as clinical trials address the relationships between surgery, radiotherapy and systemic therapy for patients with high‐risk, early‐stage and advanced melanoma. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: P. M. Ferguson, G. V. Long, R. A. Scolyer, J. F. Thompson Tags: Review Source Type: research

Role of micro ‐RNAs in breast cancer surgery
ConclusionThe molecular era has changed understanding of cancer. Micro‐RNAs have the potential for use in personalized cancer strategies. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: P. McAnena, A. Lowery, M. J. Kerin Tags: Review Source Type: research

Emerging methods in colorectal cancer screening
Gene‐specific possibilities (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: E. J. Ryan, E. M. Creagh Tags: Leading article Source Type: research

Introducing genomics into cancer care
A national view (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: S. Hill Tags: Leading article Source Type: research

Cancer surgery in the genomic era
Introduction (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: D. C. Winter, M. Sund Tags: Leading article Source Type: research

Issue Information
(Source: British Journal of Surgery)
Source: British Journal of Surgery - January 17, 2018 Category: Surgery Tags: Issue Information Source Type: research

Carotid plaque volume in patients undergoing carotid endarterectomy
BackgroundThe main indication for carotid endarterectomy (CEA) is severity of carotid artery stenosis, even though most strokes in carotid disease are embolic. The relationship between carotid plaque volume (CPV) and symptoms of cerebral ischaemia, and the measurement of CPV by minimally invasive tomographic ultrasound imaging, were investigated. MethodsThe volume of the endarterectomy specimen was measured using a validated saline suspension technique in patients undergoing CEA. Time from last symptom and severity of stenosis measured by duplex ultrasonography were recorded. Middle cerebral artery emboli were counted usin...
Source: British Journal of Surgery - January 1, 2018 Category: Surgery Authors: S. Ball, S. Rogers, K. Kanesalingam, R. Taylor, E. Katsogridakis, C. McCollum Tags: Original article Source Type: research

Spanish translation section
(Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Tags: Spanish abstracts Source Type: research

Scientific Surgery
(Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Tags: Scientific surgery Source Type: research

Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25 ‐year ultrasound population screening programme
ConclusionThe prevalence of screen‐detected small and medium AAAs has decreased over the past 25 years, but growth rates have remained similar. Men with a subaneurysmal aorta at age 65 years have a substantial risk of developing a large AAA by the age of 80 years. (Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Authors: C. Oliver ‐Williams, M. J. Sweeting, G. Turton, D. Parkin, D. Cooper, C. Rodd, S. G. Thompson, J. J. Earnshaw, Tags: Original article Source Type: research

The art of surgery
(Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Tags: The art of surgery Source Type: research

Randomized clinical trial of duct ‐to‐mucosa versus invagination pancreaticojejunostomy after pancreatoduodenectomy
ConclusionThis study did not demonstrate a superiority of invagination over duct‐to‐mucosa pancreaticojejunostomy in the risk of POPF. However, in high‐risk patients with a soft pancreas, invagination may reduce the risk of clinically relevant POPF compared with duct‐to‐mucosa. Registration number: UMIN000005890 (http://www.umin.ac.jp). (Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Authors: Y. Senda, Y. Shimizu, S. Natsume, S. Ito, K. Komori, T. Abe, K. Matsuo, T. Sano Tags: Randomized clinical trial Source Type: research

Cost ‐effective surgery for better outcomes
Surgeons should be cost‐aware (Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Authors: S. Paterson ‐Brown Tags: Leading article Source Type: research

Do intra ‐abdominal adhesions cause pain?
Hard to prove (Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Authors: J. MacFie Tags: Leading article Source Type: research

Issue Information
(Source: British Journal of Surgery)
Source: British Journal of Surgery - December 19, 2017 Category: Surgery Tags: Issue Information Source Type: research

Systematic review and network meta ‐analysis of methods of mesh fixation during laparoscopic ventral hernia repair
ConclusionBoth crude recurrence rates and the network meta‐analysis favoured fixation with sutures during laparoscopic ventral hernia repair. (Source: British Journal of Surgery)
Source: British Journal of Surgery - December 1, 2017 Category: Surgery Authors: J. J. Baker, S. Öberg, K. Andresen, T. W. Klausen, J. Rosenberg Tags: Systematic review Source Type: research

Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors
ConclusionNMP technology can be used to increase the number of DCD kidney transplants by assessing their quality before transplantation. (Source: British Journal of Surgery)
Source: British Journal of Surgery - December 1, 2017 Category: Surgery Authors: S. A. Hosgood, E. Thompson, T. Moore, C. H. Wilson, M. L. Nicholson Tags: Original article Source Type: research

Meta ‐analysis of the procedural risks of carotid endarterectomy and carotid artery stenting over time
BackgroundStroke/death rates within 30 days of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in RCTs inform current clinical guidelines. However, the risks may have changed in recent years with wider use of effective stroke prevention therapies, especially statins, improved patient selection and growing operator expertise. The aim of this study was to investigate whether the procedural stroke/death risks from CEA and CAS have changed over time. MethodsMEDLINE and Embase were searched systematically from inception to May 2016 for observational cohort studies of CEA and CAS. Studies included reported on more...
Source: British Journal of Surgery - December 1, 2017 Category: Surgery Authors: K. Lokuge, D. D. de Waard, A. Halliday, A. Gray, R. Bulbulia, B. Mihaylova Tags: Systematic review Source Type: research

Experimental study of delivery of humidified ‐warm carbon dioxide during open abdominal surgery
ConclusionHWCO2 diffusion into the abdomen in the context of open surgery afforded tissue protection and accelerated tissue repair in mice, while preserving normothermia. Surgical relevanceDamage to the peritoneum always occurs during open abdominal surgery, by exposure to desiccating air and by mechanical trauma/damage owing to the surgical intervention. Previous experimental studies showed that humidified‐warm carbon dioxide (HWCO2) reduced peritoneal damage during laparoscopic insufflation. Additionally, this intervention decreased experimental peritoneal carcinomatosis compared with the use of conventional dry‐cold...
Source: British Journal of Surgery - November 28, 2017 Category: Surgery Authors: S. Carpinteri, S. Sampurno, J. Malaterre, R. Millen, M. Dean, J. Kong, T. Chittleborough, A. Heriot, A. C. Lynch, R. G. Ramsay Tags: Original article Source Type: research

Comparison of gaze behaviour of trainee and experienced surgeons during laparoscopic gastric bypass
BackgroundEye tracking presents a novel tool that could be used to profile skill levels in surgery objectively. The primary aim of this study was to identify differences in gaze behaviour between expert and junior surgeons performing a laparoscopic Roux‐en‐Y gastric bypass (LRYGB) for obesity. MethodsThis prospective observational study used a lightweight eye‐tracking apparatus to determine the difference in gaze behaviours between expert (more than 75 procedures) and junior (75 or fewer procedures) surgeons at defined stages of LRYGB. Primary endpoints were normalized dwell time and fixation frequency. Secondary end...
Source: British Journal of Surgery - November 28, 2017 Category: Surgery Authors: S. Erridge, H. Ashraf, S. Purkayastha, A. Darzi, M. H. Sodergren Tags: Original article Source Type: research

Early versus late recurrence of intrahepatic cholangiocarcinoma after resection with curative intent
The objective of this study was to investigate the characteristics, treatment and prognosis of early versus late recurrence of intrahepatic cholangiocarcinoma (ICC) after hepatic resection. MethodsPatients who underwent resection with curative intent for ICC were identified from a multi‐institutional database. Data on clinicopathological characteristics, initial operative details, timing and sites of recurrence, recurrence management and long‐term outcomes were analysed. ResultsA total of 933 patients were included. With a median follow‐up of 22 months, 685 patients (73·4 per cent) experienced recurrenc...
Source: British Journal of Surgery - November 28, 2017 Category: Surgery Authors: X. ‐F. Zhang, E. W. Beal, F. Bagante, J. Chakedis, M. Weiss, I. Popescu, H. P. Marques, L. Aldrighetti, S. K. Maithel, C. Pulitano, T. W. Bauer, F. Shen, G. A. Poultsides, O. Soubrane, G. Martel, B. G. Koerkamp, E. Itaru, T. M. Pawlik Tags: Original article Source Type: research

Quality of life in a randomized trial of early closure of temporary ileostomy after rectal resection for cancer (EASY trial)
ConclusionAlthough the randomized study found that early closure of the temporary ileostomy was associated with significantly fewer complications, this clinical advantage had no effect on the patients' HRQOL. Registration number: NCT01287637 (https://www.clinicaltrials.gov). (Source: British Journal of Surgery)
Source: British Journal of Surgery - November 23, 2017 Category: Surgery Authors: J. Park, A. K. Danielsen, E. Angenete, D. Bock, A. C. Marinez, E. Haglind, J. E. Jansen, S. Skullman, A. Wedin, J. Rosenberg Tags: Original article Source Type: research

Growth rates of pulmonary metastases after liver transplantation for unresectable colorectal liver metastases
ConclusionPatients treated by LT for unresectable CLM have a good prognosis following resection of pulmonary metastases. Doubling time did not appear to be worse with the immunosuppression used after LT. (Source: British Journal of Surgery)
Source: British Journal of Surgery - November 23, 2017 Category: Surgery Authors: H. Grut, S. Solberg, T. Seierstad, M. E. Revheim, T. S. Egge, S. G. Larsen, P. D. Line, S. Dueland Tags: Original article Source Type: research

Preliminary results of a cohort study of induction chemotherapy ‐based treatment for locally recurrent rectal cancer
ConclusionThe incorporation of ICT in neoadjuvant regimens for locally recurrent rectal cancer is a promising strategy. (Source: British Journal of Surgery)
Source: British Journal of Surgery - November 23, 2017 Category: Surgery Authors: D. M. G. I. van Zoggel, S. J. Bosman, M. Kusters, G. A. P. Nieuwenhuijzen, J. S. Cnossen, G. J. Creemers, G. van Lijnschoten, H. J. T. Rutten Tags: Original article Source Type: research

Impact of weight loss and eating difficulties on health ‐related quality of life up to 10 years after oesophagectomy for cancer
ConclusionEating difficulties are associated with deterioration in several aspects of HRQoL up to 10 years after surgery for oesophageal cancer. (Source: British Journal of Surgery)
Source: British Journal of Surgery - November 22, 2017 Category: Surgery Authors: P. Anandavadivelan, A. Wikman, A. Johar, P. Lagergren Tags: Original article Source Type: research

Influence of national centralization of oesophagogastric cancer on management and clinical outcome from emergency upper gastrointestinal conditions
ConclusionCentralization of low incidence conditions such as oesophageal perforation to high‐volume cancer centres provides a greater level of expertise and ultimately reduces mortality. (Source: British Journal of Surgery)
Source: British Journal of Surgery - November 20, 2017 Category: Surgery Authors: S. R. Markar, H. Mackenzie, T. Wiggins, A. Askari, A. Karthikesalingam, O. Faiz, S. M. Griffin, J. D. Birkmeyer, G. B. Hanna Tags: Original article Source Type: research

Upregulation of epidermal gap junctional proteins in patients with venous disease
ConclusionConnexins were overexpressed in patients with simple varicose veins, with a stepwise increased expression through venous eczema to ulceration. Connexin 43 is a potential biomarker for venous disease. This finding suggests that varicose veins predispose skin to poor wound healing. Surgical relevanceThe overexpression of connexins, a family of gap junctional proteins, is known to cause poor healing in venous leg ulceration. It is not known whether there is any association with superficial venous disease. Here, connexin proteins were overexpressed in patients with uncomplicated varicose veins, before histological sk...
Source: British Journal of Surgery - November 16, 2017 Category: Surgery Authors: M. Kanapathy, R. Simpson, L. Madden, C. Thrasivoulou, A. Mosahebi, D. L. Becker, T. Richards Tags: Original article Source Type: research

Spanish translation section
(Source: British Journal of Surgery)
Source: British Journal of Surgery - November 16, 2017 Category: Surgery Tags: Spanish abstracts Source Type: research

Multicentre study of the impact of morbidity on long ‐term survival following hepatectomy for intrahepatic cholangiocarcinoma
(Source: British Journal of Surgery)
Source: British Journal of Surgery - November 16, 2017 Category: Surgery Tags: Corrigendum Source Type: research

Scientific surgery
(Source: British Journal of Surgery)
Source: British Journal of Surgery - November 16, 2017 Category: Surgery Tags: Scientific surgery Source Type: research

Value of social media in advancing surgical research
Spreading the word (Source: British Journal of Surgery)
Source: British Journal of Surgery - November 16, 2017 Category: Surgery Authors: J. Mayol, J. Dziakova Tags: Leading article Source Type: research

Issue Information
(Source: British Journal of Surgery)
Source: British Journal of Surgery - November 16, 2017 Category: Surgery Tags: Issue Information Source Type: research