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Cancer: Neuroblastoma

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Total 79 results found since Jan 2013.

Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1.
Abstract Emerging evidence has suggested a significant role of long non-coding RNAs (lncRNAs) in ischemic stroke by acting as competing endogenous RNAs (ceRNAs) for microRNAs (miRNAs) to regulate certain RNA transcripts. AK038897 is an lncRNA that was reported to be upregulated in rat brains in response to transient focal ischemia. We aimed to investigate the possible regulatory role of AK038897 in ischemic stroke. We detected increased AK038897 and decreased miR-26a-5p levels in mouse brains following middle cerebral artery occlusion/reperfusion (MCAO/R) and in neuro-2A (N2a) neuroblastoma cells following oxygen-...
Source: Experimental Neurology - January 28, 2019 Category: Neurology Authors: Wei R, Zhang L, Hu W, Wu J, Zhang W Tags: Exp Neurol Source Type: research

PAQR3 protects against oxygen –glucose deprivation/reperfusion-induced injury through the ERK signaling pathway in N2A cells
AbstractCerebral ischemia –reperfusion injury is pivotal in the development of multiple-subcellular organelle and tissue injury after acute ischemic stroke. Recently, the Golgi apparatus (GA) has been shown to be a key subcellular organelle that plays an important role in neuroprotection against oxygen–glucose deprivatio n/reperfusion (OGD/R) injury. PAQR3, a scaffold protein exclusively localized in the GA, was originally discovered as a potential tumor suppressor protein. PAQR3 acts as a spatial regulator of Raf-1 that binds Raf-1 and sequesters it to the GA, where it negatively modulates the Ras/Raf/MEK/ERK signa li...
Source: Journal of Molecular Histology - May 24, 2020 Category: Laboratory Medicine Source Type: research

Effects of uric acid on oxidative and nitrosative stress and other related parameters in SH-SY5Y human neuroblastoma cells.
Uric acid (UA) is the end -product of purine catabolism in humans and higher primates and comprises about 65% of the total antioxidant capacity of plasma [1]. Urate circulates in humans at concentrations that are near its limit of solubility and many times higher than those in most other mammals. In patients with ischemic stroke, the most common type of stroke which is a leading cause of disability and the second most common cause of dementia, UA reduces the incidence of early clinical deterioration and improves outcomes compared to placebo [2].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 30, 2020 Category: Biomedical Science Authors: Frederic M ármol, Juan Sanchez, Albert Martínez-Pinteño Source Type: research

Evaluation of targeted oxidative stress induced by oxygen-ozone < em > in vitro < /em > after ischemic induction
Redox Rep. 2022 Dec;27(1):259-269. doi: 10.1080/13510002.2022.2143104.ABSTRACTEncephalic vascular accident, or stroke, is the most common pathology of the central nervous system in humans, the second leading cause of death and physical and cognitive disabilities, in developing countries. It presents as an ischemic (more common) or hemorrhagic form. Ozone therapy has been shown to be effective in neuromodulation, neuroprotection, and nerve regeneration. The present study aimed to evaluate the effect of targeted mild ozone after inducing cerebral ischemia in vitro. Neuroblastoma lineage cells (SH-SY5Y) and canine amniotic me...
Source: Redox Report : communications in free radical research - November 10, 2022 Category: Biochemistry Authors: Jessica Rodrigues Orlandin Sarah Ingrid Pinto Santos Luciana Cristina Machado Paulo Fantinato Neto Fabiana Fernandes Bressan Naira Caroline Godoy Pieri Kaiana Recchia Meline de Paula Coutinho Priscilla Avelino Ferreira Pinto Annalisa Santucci Valter Trava Source Type: research

Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states
Abstract Hemopexin provides neuroprotection in mouse models of stroke and intracerebral hemorrhage and protects neurons in vitro against heme or reactive oxygen species (ROS) toxicity via heme oxygenase‐1 (HO1) activity. To model human brain neurons experiencing hemorrhages and inflammation, we used human neuroblastoma cells, heme‐hemopexin complexes and physiologically‐relevant ROS, e.g. H2O2 and HOCl, to provide novel insights into the underlying mechanism whereby hemopexin safely maintains heme and iron homeostasis. Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~2‐fold a...
Source: Journal of Neurochemistry - January 25, 2013 Category: Neurology Authors: Peter Hahl, Taron Davis, Cecilia Washburn, Jack T. Rogers, Ann Smith Tags: Original Article Source Type: research

Nogo-A couples with Apg-1 through interaction and coordinate expression under hypoxic and oxidative stress
Nogo-A is the largest isoform of the Nogo/RTN4 proteins and has been characterized as a major myelin associated inhibitor of regenerative nerve growth in the adult central nervous system (CNS). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The specificity of Nogo-A resides in its central domain, NiG. We identified Apg-1, a member of the stress induced Hsp110 family, as a novel interactor of NiG/Nogo-A. The interaction is selective because Apg-1 interacts with Nogo-A/RTN4-A but not with RTN1-A, the closest paralog of Nogo-A. Conversely, Nogo-A binds to Apg-1 but not to Apg...
Source: BJ Cell - August 2, 2013 Category: Biochemistry Authors: F Kern, R I. Stanika, B Sarg, M Offterdinger, D Hess, G J. Obermair, H Lindner, C E. Bandtlow, L Hengst, R Schweigreiter Tags: BJ Biomolecules Source Type: research

{Delta}9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPAR{gamma} DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE
Conclusions Even though 9–THC and pioglitazone are both protective against MPP+ only 9–THC induces PPAR dependent mitochondrial biogenesis, a mechanism that may be beneficial for the treatment of PD.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Zeissler, M.-L., Eastwood, J., Oliver Hanemann, C., Zajicek, J., Carroll, C. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Parkinson's disease, Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Abstract 12/15-lipoxygenase (12/15-LOX) is involved in organelle homeostasis by degrading mitochondria in maturing red blood cells and by eliminating excess peroxisomes in liver. Furthermore, 12/15-LOX contributes to diseases by exacerbating oxidative stress-related injury, notably in stroke. Nonetheless, it is unclear what the consequences are of abolishing 12/15-LOX activity. Mice in which the alox15 gene has been ablated do not show an obvious phenotype, and LOX enzyme inhibition is not overtly detrimental. We show here that liver histology is also unremarkable. However, electron microscopy demonstrated that 12...
Source: Experimental Cell Research - November 26, 2013 Category: Cytology Authors: Jang I, Park S, Won Cho J, Yigitkanli K, van Leyen K, Roth J Tags: Exp Cell Res Source Type: research

Endothelial Nitric Oxide Synthase Protects Neurons against Ischemic Injury through Regulation of Brain-Derived Neurotrophic Factor Expression.
CONCLUSION: Collectively, our results indicate that the neuroprotection of neuron-derived eNOS against the cerebral ischemia was mediated through the regulation of BDNF secretion. In conclusion, our discovery provides a novel explanation for the neuroprotective effect of eNOS under pathological ischemic conditions such as stroke. PMID: 24397751 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 8, 2014 Category: Neuroscience Authors: Li ST, Pan J, Hua XM, Liu H, Shen S, Liu JF, Li B, Tao BB, Ge XL, Wang XH, Shi JH, Wang XQ Tags: CNS Neurosci Ther Source Type: research

Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells
Conclusions: This study confirms a role for type-1 IFN signalling in the neuro-inflammatory response following OGD in vitro and suggests its modulation through therapeutic blockade of IFNAR1 may be beneficial in reducing hypoxia-induced neuro-inflammation.
Source: Journal of Neuroinflammation - March 6, 2014 Category: Neurology Authors: Myles MinterMoses ZhangRobert AtesJuliet TaylorPeter Crack Source Type: research

Antioxidative effects of Panax notoginseng saponins in brain cells
Graphical abstract: Abstract: Oxidative stress resulting from accumulation of reactive oxygen species (ROS) is involved in cell death associated with neurological disorders such as stroke, Alzheimer's disease and traumatic brain injury. Antioxidant compounds that improve endogenous antioxidant defenses have been proposed for neural protection. The purpose of this study was to investigate the potential protective effects of total saponin in leaves of Panax notoginseng (LPNS) on oxidative stress and cell death in brain cells in vitro. Lactate dehydrogenase (LDH) assay indicated that LPNS (5μg/ml) reduced H2O2-induced cell d...
Source: Phytomedicine - June 9, 2014 Category: Drugs & Pharmacology Authors: Ningna Zhou, Yang Tang, Richard F. Keep, Xiaoxia Ma, Jianming Xiang Tags: Neurology Source Type: research

CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation.
In this study, we showed that CIIA suppressed neuronal cell death induced by oxygen and glucose deprivation followed by reoxygenation (OGD/R), which mimics ischemia and reperfusion in vivo, in neuroblastoma cell lines as well as primary cortical neurons. Furthermore, CIIA inhibited the OGD/R-induced stimulation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream kinases including c-Jun amino-terminal kinase and p38 kinase, concomitantly blocking ASK1 homo-oligomerization and the binding between ASK1 and TRAF2. CIIA also repressed the OGD/R-induced activation of caspase-3 in neuronal cells. Taken together, our...
Source: Molecular and Cellular Biochemistry - August 7, 2014 Category: Biochemistry Authors: Hwang SG, Shim J, Choi EJ Tags: Mol Cell Biochem Source Type: research

HspB8 is Neuroprotective during Oxygen Glucose Deprivation and Reperfusion.
In conclusion, our data demonstrated that increased HspB8 expression and its nuclear shift in mouse N2A neuroblastoma cells protected against I/R injury, resulting in reduced apoptosis with the decrease of the release of cytochrome c from mitochondria to cytosol. Therefore, HspB8 might play a fundamental role in opposing and alleviating I/R injury in primary myocardial cells, and it may constitute a new therapeutic target for cerebral ischemic diseases. PMID: 25557374 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - January 2, 2015 Category: Neurology Authors: Yang B, Zhang H, Mo X, Xiao H, Hu Z Tags: Curr Neurovasc Res Source Type: research

Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells.
This study was conducted to evaluate the effects of seven dibenzocyclooctadiene lignans of Schisandra chinensis and explore the possible mechanisms in the human neuroblastoma SH-SY5Y cells exposed on serum and glucose deprivation (SGD) injury. The structure-activity relationships were also analyzed. Cell viability and lactate dehydrogenase (LDH) release were determined to evaluate cell injury. Inflammation and apoptosis-related protein levels were detected to elucidate the possible mechanisms. Schisantherin A, schizandrin C and schizandrol B were found to have stronger protective effects than schizandrin A, schizandrin B a...
Source: Cell Biology International - August 20, 2015 Category: Cytology Authors: E Q, Tang M, Zhang X, Shi Y, Wang D, Gu Y, Li S, Liang X, Wang Z, Wang C Tags: Cell Biol Int Source Type: research