HspB8 is Neuroprotective during Oxygen Glucose Deprivation and Reperfusion.

In conclusion, our data demonstrated that increased HspB8 expression and its nuclear shift in mouse N2A neuroblastoma cells protected against I/R injury, resulting in reduced apoptosis with the decrease of the release of cytochrome c from mitochondria to cytosol. Therefore, HspB8 might play a fundamental role in opposing and alleviating I/R injury in primary myocardial cells, and it may constitute a new therapeutic target for cerebral ischemic diseases.
PMID: 25557374 [PubMed - as supplied by publisher]

Source: Current Neurovascular Research - January 2, 2015 Category: Neurology Authors: Yang B, Zhang H, Mo X, Xiao H, Hu Z Tags: Curr Neurovasc Res Source Type: research