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Recent applications of Kampo treatment for neurological diseases
ConclusionKampo medicine is being applied in new and effective ways to treat various neurological diseases. Hopefully, more clinicians will recognize the usefulness of such Kampo medicines and utilize them in their daily practice.
Source: Traditional and Kampo Medicine - January 5, 2023 Category: Complementary Medicine Authors: Shin ‐ichi Muramatsu, Mayumi Tamada, Yoshinao Harada, Masaki Raimura, Seungwon Kwon Tags: REVIEW Source Type: research

A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis
AbstractCerebral ischemic stroke causes substantial white matter injury, which is further aggravated by neuroinflammation mediated by microglia/astrocytes. Given the anti-neuroinflammatory action of telmisartan and the enhancing blood-brain barrier (BBB) permeability potential of resuscitation-inducing aromatic herbs, 13 hybrids (3a-m) of telmisartan (or its simplified analogues) with resuscitation-inducing aromatic agents were designed, synthesized, and biologically evaluated. Among them, the optimal compound3a (the ester hybrid of telmisartan and (+)-borneol) potently inhibited neuroinflammation mediated by microglia/ast...
Source: Translational Stroke Research - December 29, 2022 Category: Neurology Source Type: research

Molecules, Vol. 28, Pages 126: In Vitro Evaluation of & alpha;-amylase and & alpha;-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from Pterocarpus erinaceus Poir
Molecules, Vol. 28, Pages 126: In Vitro Evaluation of α-amylase and α-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from Pterocarpus erinaceus Poir Molecules doi: 10.3390/molecules28010126 Authors: Romeo Toko Feunaing Alfred Ngenge Tamfu Abel Joel Yaya Gbaweng Larissa Mekontso Magnibou Fidele Ntchapda Celine Henoumont Sophie Laurent Emmanuel Talla Rodica Mihaela Dinica Diabetes mellitus is a metabolic disorder which is one of the leading causes of mortality and morbidities in elderly humans. Chronic diabetes can lead to kidney failure, blindness, limb a...
Source: Molecules - December 23, 2022 Category: Chemistry Authors: Romeo Toko Feunaing Alfred Ngenge Tamfu Abel Joel Yaya Gbaweng Larissa Mekontso Magnibou Fidele Ntchapda Celine Henoumont Sophie Laurent Emmanuel Talla Rodica Mihaela Dinica Tags: Article Source Type: research

Real-World Study Confirms Benefit of XARELTO ® (rivaroxaban) for Secondary Prevention of Venous Thromboembolism in Cancer Patients
TITUSVILLE, NJ, December 9, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced observational data from eight years of clinical practice showing that the oral Factor Xa inhibitor XARELTO® (rivaroxaban) is associated with comparable effectiveness and safety to the Factor Xa inhibitor apixaban for the treatment of cancer-associated thromboembolism (CAT) in a broad cohort of patients with various cancer types. Patients with CAT are at a higher risk of venous thromboembolism (VTE), which is the second-leading cause of death in people with cancer.1Data from the Observational Study in Cancer-A...
Source: Johnson and Johnson - December 9, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news

Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke
Bai-Mi-Decoction (BMD), which is composed of Eugenia caryophyllata, Myristica fragrans, Moschus berezovskii, and Crocus sativu, is a characteristic TCM multi-herb formula for brain disease. However, the mechanism of protective effects of BMD on ischemic stroke (IS) still has not been clarified. Our study is designed to elucidate the protective effects and underlying mechanisms of BMD on IS by employing pharmacodynamic and serum and brain metabolomic methods. In this experiment, 90 adult male Sprague–Dawley rats were randomly divided into the sham operation group (SHAM, vehicle), middle cerebral artery occlusion–reperfu...
Source: Frontiers in Pharmacology - November 24, 2022 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 27, Pages 7963: A New Therapeutic Trend: Natural Medicine for Ameliorating Ischemic Stroke via PI3K/Akt Signaling Pathway
Wei Lan Ischemic stroke (IS) is an acute cerebrovascular disease caused by sudden arterial occlusion, which is characterized by a high morbidity, mortality, and disability rate. It is one of the most important causes of nervous system morbidity and mortality in the world. In recent years, the search for new medicine for the treatment of IS has become an attractive research focus. Due to the extremely limited time window of traditional medicine treatment, some side effects may occur, and accompanied by the occurrence of adverse reactions, the frequency of exploration with natural medicine is significantly increased. P...
Source: Molecules - November 17, 2022 Category: Chemistry Authors: Xian Liu Xinyu Xiao Xue Han Lan Yao Wei Lan Tags: Review Source Type: research

Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders
CONCLUSION: The emergence of miRNAs as pathological regulatory factors provides a new direction for the study of bioactive compounds in Traditional Chinese medicine and the elucidating of their epigenetic effects. Elucidating the regulatory relationship between bioactive compounds and miRNAs may help to identify new therapeutic targets and promoting the application of these compounds in precision medicine through their targeted molecular activity.PMID:36368284 | DOI:10.1016/j.phymed.2022.154501
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Xiaoyu Dong Jianfei Nao Source Type: research

From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders
Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These day...
Source: Frontiers in Pharmacology - November 10, 2022 Category: Drugs & Pharmacology Source Type: research

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy
In this study we investigated whether Ori exerted a protective effect against reperfusion injury-induced neuronal loss and the underlying mechanisms. Mice were subjected to transient middle cerebral artery occlusion (tMCAO), and were injected with Ori (5, 10, 20 mg/kg, i.p.) at the beginning of reperfusion. We showed that Ori treatment rescued neuronal loss in a dose-dependent manner by specifically inhibiting caspase-9-mediated neuronal apoptosis and exerted neuroprotective effects against reperfusion injury. Furthermore, we found that Ori treatment reversed neuronal mitochondrial damage and loss after reperfusion injury....
Source: Acta Pharmacologica Sinica - October 10, 2022 Category: Drugs & Pharmacology Authors: Lei Li Jing-Jing Song Meng-Xue Zhang Hui-Wen Zhang Hai-Yan Zhu Wei Guo Cai-Long Pan Xue Liu Lu Xu Zhi-Yuan Zhang Source Type: research

Herbal supplements may trigger dangerous heart rhythm disorders in young people - expert
Cardiovascular adverse events such as atrial fibrillation have strong ties to other complications including stroke, experts have warned.
Source: Daily Express - Health - October 9, 2022 Category: Consumer Health News Source Type: news

Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE < sup > -/- < /sup > Mice Fed High-Fat Diet
CONCLUSION: Radix notoginseng, Radix salviae liguliobae, and Radix astragali are the main ingredients of GMTG for treating AS. Further, GMTG could regulate the level of serum lipids and inhibit inflammatory immune response, which resulted in anti-AS effects such as plaque stabilization, reduction of plaque burden, and plaque remodeling. GMTG is a promising multi-target treatment for AS.PMID:36148321 | PMC:PMC9489104 | DOI:10.2147/DDDT.S372143
Source: Atherosclerosis - September 23, 2022 Category: Cardiology Authors: Mengqi Yang Huachen Jiao Yan Li Lei Zhang Juan Zhang Xia Zhong Yitao Xue Source Type: research

Mechanism of < em > Salvia miltiorrhiza Bge < /em > . for the Treatment of Ischemic Stroke Based on Bioinformatics and Network Pharmacology
In this study, SymMap was used to screen the 50 bioactive scored components and 65 putative targets of Salvia miltiorrhiza Bge., and their targets were standardized using the UniProt platform. The disease targets related to stroke were collected by comparative toxicogenomics database (CTD), GeneCards, and quantitative structure-activity relationships-TargetNet (QSAR-TargetNet). Thereafter, the protein-protein interaction (PPI) network was constructed using the STRING platform and visualized by Cytoscape (3.8.2) software. Then, the Metascape platform was used to analyze the Gene Ontology (GO) enrichment analysis and Kyoto E...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2022 Category: Complementary Medicine Authors: Jiaqi Wu Ming Li Ang Li Xunming Ji Source Type: research