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Nutrition: Herbs
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Total 689 results found since Jan 2013.
Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke
Eur J Pharmacol. 2023 Apr 11:175717. doi: 10.1016/j.ejphar.2023.175717. Online ahead of print.ABSTRACTAn ischemic stroke usually causes blood-brain barrier (BBB) damage and excessive oxidative stress (OS) levels. Kinsenoside (KD), a major effective compound extracted in Chinese herbal medicine Anoectochilus roxburghii (Orchidaceae), has anti-OS effects. The present study focused on exploring KD's protection against OS-mediated cerebral endothelial cell damage and BBB damage within the mouse model. Intracerebroventricular administration of KD upon reperfusion after 1 h ischemia decreased infarct volumes, neurological defici...
Source: European Journal of Pharmacology - April 13, 2023 Category: Drugs & Pharmacology Authors: Nan Qiao Zhaohong An Zeyu Fu Xingyu Chen Qingyi Tong Yonghui Zhang Hong Ren Source Type: research
Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke
Curr Mol Med. 2023 Apr 10. doi: 10.2174/1566524023666230410101724. Online ahead of print.ABSTRACTIschemic stroke is one of the major causes of global mortality, which puts great demands on health systems and social welfare. Ischemic stroke is a complex pathological process involving a series of mechanisms such as ROS accumulation, Ca2 + overload, inflammation, and apoptosis. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients has led scientists to find new treatments. The use of herbal medicine, as an alternative or complementary therapy, is increasing worldwide. For centurie...
Source: Current Molecular Medicine - April 11, 2023 Category: Molecular Biology Authors: Shakiba Azami Fatemeh Forouzanfar Source Type: research
The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials
Conclusion: Based on this meta-analysis, we found that in the treatment of T2DM patients with CAS, combined with CHM may have more advantages than WM alone, which can further reduce CIMT and carotid plaque Crouse score, regulate glucose and lipid metabolism, improve insulin resistance and enhance islet β-cell function. Meanwhile, CHM is relatively safe. However, limited by the quality and heterogeneity of included studies, the efficacy and safety of CHM remain uncertain. More high-quality studies are still needed to provide more reliable evidence for the clinical application of CHM. Systematic Review Registration: https:/...
Source: Atherosclerosis - April 10, 2023 Category: Cardiology Authors: Zehua Zhang Yulin Leng Zhengtao Chen Xiaoxu Fu Qingzhi Liang Xi Peng Hongyan Xie Hong Gao Chunguang Xie Source Type: research
Effects of Δ < sup > 9 < /sup > -Tetrahydrocannabinol and the Aminoalkylindole K2/Spice Constituent JWH-073 on Cardiac Tissue and Mesenteric Vascular Reactivity
This study used in vitro, in vivo, and ex vivo approaches to investigate potential differences on cardiac tissue and vascular effects betweenJWH-073 and Δ9-THC. Male C57BL/6 mice were treated with JWH-073 or Δ9-THC and cardiac injury was assessed by histology. Effects of JWH-073 and Δ9-THC on H9C2 cell viability and ex vivo mesenteric vascular reactivity were also determined. Results: JWH-073 or Δ9-THC induced typical cannabinoid effects of antinociception and hypothermia but did not promote death of cardiac myocytes. No differences in cell viability were observed in cultured H9C2 cardiac myocytes after 24 h of treatme...
Source: Cell Research - April 3, 2023 Category: Cytology Authors: Chris S Breivogel Bonnie M Brenseke Khalil Eldeeb Katlyn Nichols Amreen Jonas Artik H Mistry Laura Barbalato Nicholas Luibil Allyn C Howlett Sandra Leone-Kabler Rob P H Hilgers Victor M Pulgar Source Type: research
Attenuating lipid metabolism in atherosclerosis: The potential role of Anti-oxidative effects on low-density lipoprotein of herbal medicines
Atherosclerosis (AS) is a multifactorial chronic disease with great harm to the health of human being, which is a basic pathogenesis of many cardiovascular diseases and ultimately threatens human life. Abnormal blood lipid level is one of the most common diagnostic indicators of AS in clinic, and lipid metabolism disorder is often observed in patients with AS. Cholesterol is an important lipid in the human body, which is of great significance for maintaining normal life activities. Generally, cholesterol is transported to peripheral tissues by low-density lipoprotein (LDL), and then transported to the liver by high-density...
Source: Frontiers in Pharmacology - March 31, 2023 Category: Drugs & Pharmacology Source Type: research
The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials
Conclusion: Based on this meta-analysis, we found that in the treatment of T2DM patients with CAS, combined with CHM may have more advantages than WM alone, which can further reduce CIMT and carotid plaque Crouse score, regulate glucose and lipid metabolism, improve insulin resistance and enhance islet β-cell function. Meanwhile, CHM is relatively safe. However, limited by the quality and heterogeneity of included studies, the efficacy and safety of CHM remain uncertain. More high-quality studies are still needed to provide more reliable evidence for the clinical application of CHM.Systematic Review Registration:https://w...
Source: Frontiers in Pharmacology - March 23, 2023 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 28, Pages 2598: Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia
This study explored the effects of Gas and HBA on cognitive dysfunction in VD and their possible molecular mechanisms. The VD model was established by bilateral common carotid artery ligation (2-vessel occlusion, 2-VO) combined with an intraperitoneal injection of sodium nitroprusside solution. One week after modeling, Gas (25 and 50 mg/kg, i.g.) and HBA (25 and 50 mg/kg, i.g.) were administered orally for four weeks, and the efficacy was evaluated. A Morris water maze test and passive avoidance test were used to observe their cognitive function, and H&amp;E staining and Nissl staining were used to observe the neur...
Source: Molecules - March 13, 2023 Category: Chemistry Authors: Sha Wu Rong Huang Ruiqin Zhang Chuang Xiao Lueli Wang Min Luo Na Song Jie Zhang Fang Yang Xuan Liu Weimin Yang Tags: Article Source Type: research
