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Total 689 results found since Jan 2013.

Synergistic Network Pharmacology for Traditional Chinese Medicine Liangxue Tongyu Formula in Acute Intracerebral Hemorrhagic Stroke
CONCLUSION: The LXTYF attenuates AICH partially by antioxidation, anti-inflammatory, and antiapoptosis and lowers blood pressure roles through regulating the targets involved MAPK, calcium, apoptosis, and TNF signaling pathway, which provide notable clues for further experimental validation.PMID:33727915 | PMC:PMC7936909 | DOI:10.1155/2021/8874296
Source: Neural Plasticity - March 17, 2021 Category: Neurology Authors: Yang Chen Ju Dong Dongqing Yang Qin Qian Pengcheng Wang Xiaojuan Yang Wei Li Guochun Li Xu Shen Fushun Wang Source Type: research

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke
CONCLUSIONS: Our study demonstrated that BHD exerted the effect of treating IS by regulating multitargets and multichannels with multicomponents through the method of network pharmacology and molecular docking.PMID:33727944 | PMC:PMC7937485 | DOI:10.1155/2021/8815447
Source: Evidence-based Complementary and Alternative Medicine - March 17, 2021 Category: Complementary Medicine Authors: Qiang Gao Danfeng Tian Zhenyun Han Jingfeng Lin Ze Chang Dandan Zhang Dayong Ma Source Type: research

Chinese herbal injections combined with rt-PA intravenous thrombolysis for acute ischemic stroke: A systematic review and meta-analysis protocol
Conclusion: The conclusion of the meta-analysis will provide a basis for judging whether CHIs combined with intravenous thrombolysis is an effective measure for the treatment of AIS. Ethics and dissemination: Ethical approval is not needed because this study will be based on data that already published. We will publish the findings of this study in a peer-reviewed journal and related conferences. PROSPERO registration number: CRD42020215546.
Source: Medicine - March 12, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

UPLC-ESI-Q-TOF/MS based metabolic profiling of protosappanin B in rat plasma, bile, feces, urine and intestinal bacteria samples
CONCLUSION: The results showed that the small intestinal and biliary routes play an important role in the clearance and excretion of PTB. The main sites of metabolism in the PTB chemical structure were the phenolic hydroxyl and the side-chains on the eight-element ring.PMID:33605854 | DOI:10.2174/1389200222666210219123846
Source: Current Drug Metabolism - February 19, 2021 Category: Drugs & Pharmacology Authors: Wei-Ying Chen Guang-Yan Liang Zuo-Liang Zheng Yun-Shan Wu Fang-Fang Xu Bo Liu De-An Guo Source Type: research

UPLC-ESI-Q-TOF/MS based metabolic profiling of protosappanin B in rat plasma, bile, feces, urine and intestinal bacteria samples.
CONCLUSION: The results showed that the small intestinal and biliary routes play an important role in the clearance and excretion of PTB. The main sites of metabolism in the PTB chemical structure were the phenolic hydroxyl and the side-chains on the eight-element ring. PMID: 33605854 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - February 19, 2021 Category: Drugs & Pharmacology Authors: Chen WY, Liang GY, Zheng ZL, Wu YS, Xu FF, Liu B, Guo DA Tags: Curr Drug Metab Source Type: research

Withania Somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems.
Conclusion: The current review substantially deciphered the protective role of W. somnifera against various neurological disorders. However, future studies are further required better to understand the molecular mechanisms behind their neuroprotective nature. PMID: 33538666 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - February 3, 2021 Category: Drugs & Pharmacology Authors: Syed AA, Reza MI, Singh P, Thombre GK, Gayen JR Tags: Curr Drug Metab Source Type: research

Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Abstract Post-stroke depression(PSD) is a common complication and associates with poor physical recovery, low quality of life and high mortality after cerebral infarction. However, the pathogenesis of PSD have not been elucidated thoroughly now, and there is a lack of effective therapy in clinic. It reported that Saikosaponin A, one of the main constituents from Chinese herb Bupleurum chinense, has pharmacological activity in anti-depression. Thus, this study aimed to elucidate the potential effects and mechanisms of Saikosaponin A on the depression-like behavior after cerebral ischemic injury in rats. The rat mod...
Source: Behavioural Brain Research - January 22, 2021 Category: Neurology Authors: Wang AR, Mi LF, Zhang ZL, Hu MZ, Zhao ZY, Liu B, Li YB, Zheng S Tags: Behav Brain Res Source Type: research

Network pharmacology reveals the mechanism of activity of Tongqiao Huoxue Decoction Extract against middle cerebral artery occlusion-induced cerebral ischemia reperfusion injury
Some clinical therapies such as tissue repair by replacing injured with functional tissues have been reported, yet there is the great explore potential for traditional herbal-induced regeneration with good safety. Tongqiao Huoxue Decoction (TQHXD), a well-known classical traditional Chinese Medicinal formula, has been widely used for clinical treatment of stroke. However, biological activity and mechanisms of action of its constituents towards conferring protection against cerebral ischemia reperfusion (I/R) injury remain unclear. In this present study, we evaluated TQHXD quality using HPLC, then screened for its potential...
Source: Frontiers in Pharmacology - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Therapeutic effect of Chinese herbal medicines for post-stroke depression: A meta-analysis of randomized controlled trials
This study aimed to assess the efficacy and safety of combination of CHM with routine western medicines versus routine western medicines alone in patients with post-stroke depression (PSD). Methods: Electronic databases such as PubMed, EmBase, Cochrane library, and China National Knowledge Infrastructure were systematically searched from inception till October 2019. Studies designed as randomized controlled trials (RCTs) and that investigated the therapeutic effects of CHM plus routine western medicines (CHM group) versus routine western medicines alone (control group) in PSD patients were eligible. The relative ris...
Source: Medicine - January 8, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPAR γ pathway after cerebral ischemia/reperfusion injury in rats.
Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats. Int Immunopharmacol. 2021 Jan 08;92:107335 Authors: Li L, Gan H, Jin H, Fang Y, Yang Y, Zhang J, Hu X, Chu L Abstract Microglia/macrophages play a dual role in brain injury and repair following cerebral ischemia/reperfusion. Promoting microglia/macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype has been considered as a potential treatment for ischemic stroke. Astragaloside IV (AS-IV) is a pr...
Source: International Immunopharmacology - January 8, 2021 Category: Allergy & Immunology Authors: Li L, Gan H, Jin H, Fang Y, Yang Y, Zhang J, Hu X, Chu L Tags: Int Immunopharmacol Source Type: research

Molecules, Vol. 26, Pages 302: Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice
Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model.
Source: Molecules - January 8, 2021 Category: Chemistry Authors: Ahtesham Hussain Jin Sook Cho Jong-Seok Kim Young Ik Lee Tags: Article Source Type: research

NeuroAid II (MLC901) in Haemorrhagic Stroke
Stroke is a leading cause of death and disability. NeuroAid (MLC601), which originates from Traditional Chinese Medicine, comprises herbal and animal components, and has been shown to improve the functional status of patients after ischaemic stroke. The use of NeuroAid II (MLC901), which comprises only the herbal components of MLC601, in haemorrhagic stroke has not been previously reported. Our patient is a 63-year-old male with a significant stroke risk factor of hypertension. He developed visual field defect, aphasia, unilateral weakness, and hemisensory loss. CT scan showed a left thalamic haemorrhage. In addition to an...
Source: Case Reports in Neurology - December 14, 2020 Category: Neurology Source Type: research