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Nutrition: Herbs
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Total 689 results found since Jan 2013.
Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research
Exploration of the Mechanism of Salvianolic Acid for Injection Against Ischemic Stroke: A Research Based on Computational Prediction and Experimental Validation
Ischemic stroke (IS) is an acute neurological injury that occurs when a vessel supplying blood to the brain is obstructed, which is a leading cause of death and disability. Salvia miltiorrhiza has been used in the treatment of cardiovascular and cerebrovascular diseases for over thousands of years due to its effect activating blood circulation and dissipating blood stasis. However, the herbal preparation is chemically complex and the diversity of potential targets makes difficult to determine its mechanism of action. To gain insight into its mechanism of action, we analyzed “Salvianolic acid for injection” (SAFI), a tr...
Source: Frontiers in Pharmacology - May 25, 2022 Category: Drugs & Pharmacology Source Type: research
New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD)
RARITAN, N.J., May 23, 2022 – Findings from the XARELTO® (rivaroxaban) Phase 3 COMPASS Long-Term Open Label Extension (LTOLE) study and the XARELTO® in Combination with Acetylsalicylic Acid (XATOA) registry have been published in the European Society of Cardiology’s (ESC) European Heart Journal, Cardiovascular Pharmacotherapy. Additionally, the XATOA registry was presented at the American Congress of Cardiology’s 71st Annual Scientific Session (ACC.22). These studies provide further evidence supporting the role of dual pathway inhibition (DPI) with the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 100 mg...
Source: Johnson and Johnson - May 23, 2022 Category: Pharmaceuticals Source Type: news
Herb Formula (GCis) Prevents Pulmonary Infection Secondary to Intracerebral Hemorrhage by Enhancing Peripheral Immunity and Intestinal Mucosal Immune Barrier
This study provides a herb formula (GCis) that could enhance peripheral immunity and intestinal mucosal immune barrier to prevent pulmonary infection induced by ICH. It would be beneficial in the prevention of severe clinical infections.
Source: Frontiers in Pharmacology - May 23, 2022 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 27, Pages 3099: The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.
Source: Molecules - May 12, 2022 Category: Chemistry Authors: Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang Tags: Review Source Type: research
Interaction of compounds derived from the Chinese medicinal formula Huangqi Guizhi Wuwu Tang with stroke-related numbness and weakness targets: An in-silico docking and molecular dynamics study
This study aims to investigate the molecular mechanisms of components from HGWT targeting specific proteins related to numbness and weakness through computational docking and molecular dynamics (MD) simulations. A total of 786 compounds from HGWT were retrieved from a herbal compound database and docked against a candidate SRNW target protein, with the asernestioside B (HQ068)-mitogen-activated protein kinase 3 (MAPK3) complex predicted to exhibit the highest binding affinity (-10.4 kcal/mol) and number of ligand-receptor contacts. Subsequent molecular dynamics (MD) simulations were performed in triplicate on the apo-MAPK3...
Source: Molecular Medicine - May 4, 2022 Category: Molecular Biology Authors: Sanghyun Lee Ann Rann Wong Angela Wei Hong Yang Andrew Hung Source Type: research
NeuroProtect, a Candidate Formula From Traditional Chinese Medicine, Attenuates Amyloid- β and Restores Synaptic Structures in APP/PS1 Transgenic Mice
Conclusion: These findings reveal a beneficial effect of NP on AD progression under an early intervention strategy and provide a food supplement for AD prevention.
Source: Frontiers in Pharmacology - May 2, 2022 Category: Drugs & Pharmacology Source Type: research
Development of the Korean Medicine Core Outcome Set for Stroke Sequelae: Herbal Medicine Treatment of Elderly Patients With Stroke Sequelae in Primary Clinics
Conclusion: This COS will help primary care researchers assess the effectiveness of pharmacotherapy, including HM, for elderly patients with stroke sequelae. Future studies should focus on reflecting the opinions of all stakeholders.
Source: Frontiers in Pharmacology - April 25, 2022 Category: Drugs & Pharmacology Source Type: research
Xueshuantong injection combined with Salvianolate lyophilized injection improves the synaptic plasticity against focal cerebral ischemia/ reperfusion injury in rats through PI3K/ AKT/ mTOR and RhoA/ROCK pathways
In this study, we investigated the neuroprotective effects of XST combined with SLI in the recovery stage of middle cerebral artery occlusion / reperfusion (MCAO/R) injury rat. Wistar rats were subjects to MCAO/R, then were treated with SLI or XST alone, or with their combination (1X1S) via tail injection daily for 14 days. The pathological status of the brain was detected by neurological deficit scores, TTC, regional cerebral blood flow and Nissl staining. Golgi-Cox staining was used to assess dendritic, axonal and synaptic remodeling. The expression of MAP-2, β-Tubulin, PSD95, SYN, BDNF and VEGF were analyzed by western...
Source: Brain Research - April 24, 2022 Category: Neurology Authors: Qing Yuan Fu-Jiang Wang Zhuang-Zhuang Jia Tong Zhang Jin Sun Xin-Yuan Du Shao-Xia Wang Li-Juan Chai Li-Min Hu Source Type: research
Strategies for treatment of disease-associated dementia beyond Alzheimer disease: An update
Curr Neuropharmacol. 2022 Apr 11. doi: 10.2174/1570159X20666220411083922. Online ahead of print.ABSTRACTMemory, cognition, dementia, and neurodegeneration are complexly interlinked processes through various mechanistic pathways leading to a range of clinical outcomes. These are strongly associated with pathological conditions like Alzheimer's disease, Parkinson's disease, schizophrenia, stroke and are a growing concern for their timely diagnosis and management. Several cognition-enhancing interventions for management include non-pharmacological interventions like diet, exercise, and physical activity, while pharmacological...
Source: Current Neuropharmacology - April 12, 2022 Category: Drugs & Pharmacology Authors: Khan Sabiya Samim Gopal L Khatik Ashok K Datusalia Source Type: research
