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Total 689 results found since Jan 2013.

< em > Angelica gigas < /em > : Signature Compounds, < em > In Vivo < /em > Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges
Am J Chin Med. 2022 Jul 23:1-53. doi: 10.1142/S0192415X2250063X. Online ahead of print.ABSTRACTAngelica gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in Korea. AGN root ethanolic extract dietary supplements are marketed in the United States for memory health and pain management. We comprehensively reviewed the anticancer, analgesic, pro-memory and other bio-activities of AGN extract and its signature phytochemicals decursin, decursinol angelate, and decursinol a decade ago in 2012 and updated their anticancer activities in 2015. In the last decade, significant progress has been made for u...
Source: The American Journal of Chinese Medicine - July 25, 2022 Category: Complementary Medicine Authors: Junxuan L ü Cheng Jiang Todd D Schell Monika Joshi Jay D Raman Chengguo Xing Source Type: research

Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Brain Research - July 25, 2022 Category: Neurology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research

Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Cell Research - July 25, 2022 Category: Cytology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research

An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis
Angiogenesis, the formation of new capillaries from pre-existing vascular networks, plays an important role in many physiological and pathological processes. The use of pro-angiogenic agents has been proposed as an attractive approach for promoting wound healing and treating vascular insufficiency-related problems, such as ischemic heart disease and stroke, which are the leading causes of death worldwide. Traditional herbal medicine has a long history; however, there is still a need for more in-depth studies and evidence-based confirmation from controlled and validated trials. Many in vitro and in vivo studies have reporte...
Source: Frontiers in Pharmacology - July 19, 2022 Category: Drugs & Pharmacology Source Type: research

Stroke warning: Popular herbal supplement associated with 'haemorrhagic stroke' in study
A STROKE is a serious life-threatening medical condition that happens when the blood supply to part of the brain is cut off. A popular herbal supplement was associated with one of the main types of stroke in a first-of-its-kind case study.
Source: Daily Express - Health - July 18, 2022 Category: Consumer Health News Source Type: news

Letter to the Editor: PNF and Gait Post-Stroke
We read with interest the article by Gunning et al. (The Effectiveness of the Proprioceptive Neuromuscular Facilitation (PNF) Method on Gait Parameters in Patients with Stroke: A Systematic Review)1 and were moved to comment on the authors ’ conclusions. The abstract of this article stated “current research suggests that PNF is an effective treatment for the improvement of gait parameters in patients with stroke”. Publication of such a statement led us to review the articles cited. We do not concur that these articles provide su fficient evidence that PNF is an effective treatment for improving gait parameters in patients with stroke.
Source: Archives of Physical Medicine and Rehabilitation - July 18, 2022 Category: Rehabilitation Authors: Herb Karpatkin, Heather Hayes, Lauren Snowdon, Parminder K. Padgett, Laura Doyle, Jennifer Lotter, Ryan Knight, Hallie Zeleznik, T. George Hornby Source Type: research

Letter to the Editor on "The Effectiveness of the Proprioceptive Neuromuscular Facilitation Method on Gait Parameters in Patients with Stroke: A Systematic Review ”
We read with interest the article by Gunning et al ( “The Effectiveness of the Proprioceptive Neuromuscular Facilitation (PNF) Method on Gait Parameters in Patients With Stroke: A Systematic Review”)1 and were moved to comment on the authors’ conclusions. The abstract of this article stated, “Current research suggests that PNF is an effective treatment for the improvement of gait parameters in patients with stroke.” Publication of such a statement led us to review the articles cited. We do not concur that these articles provide sufficient evidence that PNF is an effective treatment for improving gait parameters i...
Source: Archives of Physical Medicine and Rehabilitation - July 18, 2022 Category: Rehabilitation Authors: The Moving Forward Taskforce of the Academy of Neurologic Physical Therapy:, Herb Karpatkin, Heather Hayes, Lauren Snowdon, Parminder K. Padgett, Laura Doyle, Jennifer Lotter, Ryan Knight, Hallie Zeleznik, T. George Hornby Tags: LETTER TO THE EDITOR Source Type: research

Traditional Chinese Medicine for Post-stroke Sleep Disorders: The Evidence Mapping of Clinical Studies
ConclusionsPSSDs treated with TCM have been widely assessed in clinical studies. For better evidence translation, clinical trials on specific CHM interventions and high-quality systematic reviews on acupuncture for post-stroke insomnia should be conducted. For a better solution to clinical questions, TCM on SBDs after stroke and the benefits of Chinese mind-body exercises for post-stroke insomnia should be explored in future clinical studies.
Source: Frontiers in Psychiatry - June 15, 2022 Category: Psychiatry Source Type: research

Exploration of Lamiaceae in Cardio Vascular Diseases and Functional Foods: Medicine as Food and Food as Medicine
In the current scenario, cardiovascular disease (CVD) is one of the most life-threatening diseases that has caused high mortality worldwide. Several scientists, researchers, and doctors are now resorting to medicinal plants and their metabolites for the treatment of different diseases, including CVD. The present review focuses on one such family of medicinal plants, called Lamiaceae, which has relieving and preventive action on CVD. Lamiaceae has a cosmopolitan distribution and has great importance in the traditional system of medicine. Lamiaceae members exhibit a wide range of activities like antioxidant, antihyperlipidem...
Source: Frontiers in Pharmacology - June 14, 2022 Category: Drugs & Pharmacology Source Type: research

Panax notoginseng Saponins Stimulates Neurogenesis and Neurological Restoration After Microsphere-Induced Cerebral Embolism in Rats Partially Via mTOR Signaling
P. Notoginseng Saponins (PNS), the main active component of herbal medicine Panax notoginseng, has been widely used to treat cerebrovascular diseases. It has been acknowledged that PNS exerted protection on nerve injuries induced by ischemic stroke, however, the long-term impacts of PNS on the restoration of neurological defects and neuroregeneration after stroke have not been thoroughly studied and the underlying molecular mechanism of stimulating neurogenesis is difficult to precisely clarify, much more in-depth researches are badly needed. In the present study, cerebral ischemia injury was induced by microsphere embolis...
Source: Frontiers in Pharmacology - June 13, 2022 Category: Drugs & Pharmacology Source Type: research

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research

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