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Total 689 results found since Jan 2013.

Traditional East Asian herbal medicines for the treatment of poststroke constipation: A protocol for systematic review and meta analysis
Conclusion: Our systematic review will provide evidence to determine whether herbal medicines can be effective interventions for patients with post-stroke constipation. Ethics and dissemination: Ethical approval is not required, as this study was based on a review of published research. This review will be published in a peer-reviewed journal and disseminated electronically and in print. Trial registration number: Research registry reviewregistry1117
Source: Medicine - April 16, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis
Neurochem Res. 2021 Apr 11. doi: 10.1007/s11064-021-03285-2. Online ahead of print.ABSTRACTCerebral ischaemia/reperfusion (I/R) injury-induced irreversible brain injury is a major cause of mortality and functional impairment in ageing people. Gastrodin (GAS), derived from the traditional Chinese herbal medicine Tianma, has been reported to inhibit the progression of stroke, but the mechanism whereby GAS modulates the progression of cerebral I/R remains unclear. The middle cerebral artery occlusion method was used as a model of I/R in vivo. Rats were pretreated with GAS by intraperitoneal injection 7 days before I/R surgery...
Source: Neurochemical Research - April 11, 2021 Category: Neuroscience Authors: Heng-Sheng Zhang Bo Ouyang Xiong-Ying Ji Mei-Fang Liu Source Type: research

Angiogenic Actions of Paeoniflorin on Endothelial Progenitor Cells and in Ischemic Stroke Rat Model
In conclusion, the present study provides evidence that PF is an active monomer of Traditional Chinese Medicine which shows angiogenic actions on endothelial progenitor cells and in ischemic stroke rat model.PMID:33829966 | DOI:10.1142/S0192415X21500415
Source: The American Journal of Chinese Medicine - April 8, 2021 Category: Complementary Medicine Authors: Ruiying Liu Ying Zheng Tao Han Jie Lan Laixi He Jianyou Shi Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays a dominant role in the pathogenesis of ICH injury. Baicalin is a main active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has been reported to exhibit neuroprotective effects against ICH-induced brain injury as well as reduce iron deposition in multiple tissues. Therefore, in this ...
Source: Frontiers in Pharmacology - March 19, 2021 Category: Drugs & Pharmacology Source Type: research

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke
CONCLUSIONS: Our study demonstrated that BHD exerted the effect of treating IS by regulating multitargets and multichannels with multicomponents through the method of network pharmacology and molecular docking.PMID:33727944 | PMC:PMC7937485 | DOI:10.1155/2021/8815447
Source: Evidence-based Complementary and Alternative Medicine - March 17, 2021 Category: Complementary Medicine Authors: Qiang Gao Danfeng Tian Zhenyun Han Jingfeng Lin Ze Chang Dandan Zhang Dayong Ma Source Type: research

Synergistic Network Pharmacology for Traditional Chinese Medicine Liangxue Tongyu Formula in Acute Intracerebral Hemorrhagic Stroke
CONCLUSION: The LXTYF attenuates AICH partially by antioxidation, anti-inflammatory, and antiapoptosis and lowers blood pressure roles through regulating the targets involved MAPK, calcium, apoptosis, and TNF signaling pathway, which provide notable clues for further experimental validation.PMID:33727915 | PMC:PMC7936909 | DOI:10.1155/2021/8874296
Source: Neural Plasticity - March 17, 2021 Category: Neurology Authors: Yang Chen Ju Dong Dongqing Yang Qin Qian Pengcheng Wang Xiaojuan Yang Wei Li Guochun Li Xu Shen Fushun Wang Source Type: research