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Total 689 results found since Jan 2013.
Strategies for treatment of disease-associated dementia beyond Alzheimer disease: An update
Curr Neuropharmacol. 2022 Apr 11. doi: 10.2174/1570159X20666220411083922. Online ahead of print.ABSTRACTMemory, cognition, dementia, and neurodegeneration are complexly interlinked processes through various mechanistic pathways leading to a range of clinical outcomes. These are strongly associated with pathological conditions like Alzheimer's disease, Parkinson's disease, schizophrenia, stroke and are a growing concern for their timely diagnosis and management. Several cognition-enhancing interventions for management include non-pharmacological interventions like diet, exercise, and physical activity, while pharmacological...
Source: Current Neuropharmacology - April 12, 2022 Category: Drugs & Pharmacology Authors: Khan Sabiya Samim Gopal L Khatik Ashok K Datusalia Source Type: research
Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases
Neurochem Res. 2022 Apr 5. doi: 10.1007/s11064-022-03591-3. Online ahead of print.ABSTRACTThe medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD). Apart from PD, Mucuna pruriens is now being studied in models of other nervous systems disorders such as Al...
Source: Neurochemical Research - April 5, 2022 Category: Neuroscience Authors: Walia Zahra Hareram Birla Saumitra Sen Singh Aaina Singh Rathore Hagera Dilnashin Richa Singh Priyanka Kumari Keshri Priyanka Gautam Surya Pratap Singh Source Type: research
Mechanisms of Action of a Herbal Formula Huangqi Guizhi Wuwu Tang for the Management of Post-Stroke Related Numbness and Weakness: A Computational Molecular Docking Study
In conclusion, HGWT may provide therapeutic benefits through strong interactions between herbal compounds and target proteins of PDE5A and ESR1. Further experimental studies are needed to unequivocally support this result which can be valuable to increase the quality of life of post-stroke patients. Keywords Herbal medicine, Complementary and alternative medicine, Natural product, Post-stroke, Computational analysis.PMID:35369720 | DOI:10.1177/2515690X221082989
Source: Molecular Medicine - April 4, 2022 Category: Molecular Biology Authors: Sanghyun Lee Andrew Hung Hong Li Angela Wei Hong Yang Source Type: research
Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and ClinicalTrials.gov: a narrative review
CONCLUSIONS: Irregular and inadequate reporting, untimely update and publication, insufficient information on traditional medicine unique characteristics, and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases. More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials.PMID:35322645 | DOI:10.19852/j.cnki.jtcm.2022.01.010
Source: Journal of Traditional Chinese Medicine - March 24, 2022 Category: Complementary Medicine Authors: Jing-Jing Wei Rong-Juan Guo Guo-Jing Fu Xiao Liang Zhen-Min Xu Xing Liao Min Jia Zi-Xiu Zeng Wan-Qing DU Wei-Wei Jiao Lin-Juan Sun Hong-Mei Liu Chun-Li Guo Chen-Guang Tong Yun-Ling Zhang Source Type: research
