New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD)

RARITAN, N.J., May 23, 2022 – Findings from the XARELTO® (rivaroxaban) Phase 3 COMPASS Long-Term Open Label Extension (LTOLE) study and the XARELTO® in Combination with Acetylsalicylic Acid (XATOA) registry have been published in the European Society of Cardiology’s (ESC) European Heart Journal, Cardiovascular Pharmacotherapy. Additionally, the XATOA registry was presented at the American Congress of Cardiology’s 71st Annual Scientific Session (ACC.22). These studies provide further evidence supporting the role of dual pathway inhibition (DPI) with the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in patients with CAD and/or PAD. The COMPASS LTOLE study found that continued treatment with XARELTO® 2.5 mg twice daily plus aspirin 75 to 100 mg once daily for up to three years was associated with similar or lower incidence rates for major cardiovascular events (MACE) - cardiovascular (CV) death, stroke, or myocardial infarction (MI) - and for bleeding than those seen during the randomized treatment phase. Separately, the XATOA registry provides real-world evidence of the benefit of DPI with the XARELTO® vascular dose in patients with CAD and/or PAD. Patients with CAD and/or PAD are at risk of secondary thrombotic events associated with CV disease including stroke, MI, ischemic limb events, and CV-related death.[1] Antiplatelet therapies, such as aspirin, are used to help prevent thrombosis by inhibiting platelet aggregation.[1] Antithrombo...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news