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1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University.
Author Contributions
JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.”
Surgical Preparation
The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research
Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study
Conclusions: Pre-injury psychiatric and pre-injury headache/migraine symptoms are risk factors for worse functional and post-concussive outcomes at 3- and 6-months post-mTBI. mTBI patients presenting to acute care should be evaluated for psychiatric and headache/migraine history, with lower thresholds for providing TBI education/resources, surveillance, and follow-up/referrals.
Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01565551.
Introduction
Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality worldwide. In 2013 ~2.8 million TBI cases were recorded an...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research
Trips to the toilet at night suggest high blood pressure
People who get up to use the toilet at night may have high blood pressure, study suggests Related items fromOnMedica ‘Health warnings needed on ready meals and Chinese takeaways’ Food industry misses almost half of salt targets Brexit could result in thousands of extra CVD deaths Heart disease and stroke deaths plummet in Scotland Cycling and treadmill workstations better for health
Source: OnMedica Latest News - April 1, 2019 Category: UK Health Source Type: news
Factors Influencing Quality of Life in Stroke Patients: Focus on Eating Habits
This study aimed to identify lifestyle factors about eating habits that may affect the quality of life (QOL) in elderly stroke patients. Methods: Fifty elderly patients with a first-ever stroke were enrolled. QOL was assessed by the Stroke and Aphasia QOL Scale-39-J. Lifestyle factors about eating habits were collected using questionnaires (Questions 1-17) for the intake of salt, calcium, magnesium, potassium, taurine, fiber, and protein, and the frequency of breakfast.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2019 Category: Neurology Authors: Reina Chiba, Saya Tominaga, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Toshiko Tomisawa, Junko Chiba, Joji Hagii, Minoru Yasujima, Tomohiro Osanai Source Type: research
South Africa: Salt Is Bad for You - but How It Affects Your Body Is Still Frontier Science
[The Conversation Africa] Research has shown that excess salt intake is harmful to people's health. It can lead to high blood pressure and increase the risk of heart disease and stroke.
Source: AllAfrica News: Health and Medicine - March 12, 2019 Category: African Health Source Type: news
Comparing Strategies to Prevent Stroke and Ischemic Heart Disease in the Tunisian Population: Markov Modeling Approach Using a Comprehensive Sensitivity Analysis Algorithm.
Conclusions: The primary prevention of cardiovascular disease via a reduction in dietary salt consumption appeared much more effective than secondary or tertiary prevention approaches. Our simple but comprehensive model offers a potentially attractive methodological approach that might now be extended and replicated in other contexts and populations.
PMID: 30838048 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - March 7, 2019 Category: Statistics Tags: Comput Math Methods Med Source Type: research
Salt Awareness Week
' World Salt Awareness Week ' is a global event t o bring attention to salt intake and the risks to health it can bring, including high blood pressure and increased risk of stroke and heart disease. This year, the awareness week is being observed 4-10 March, 2019.Cochrane Nutrition Field' saim is to support and enable evidence-informed decision-making for nutrition policy and practice by advancing the preparation and use of high-quality, globally relevant nutrition-related Cochrane reviews. Cochrane Nutrition covers a wide spectrum of nutrition-related issues and questions, ranging from clinical to public health nutrition....
Source: Cochrane News and Events - March 6, 2019 Category: Information Technology Authors: Muriah Umoquit Source Type: news
Evaluation of Pathological Association between Stroke-Related QTL and Salt-Induced Renal Injury in Stroke-Prone Spontaneously Hypertensive Rat.
Abstract
The stroke-prone spontaneously hypertensive rat (SHRSP) suffers from severe hypertension and hypertensive organ damage such as cerebral stroke and kidney injury under salt-loading. By a quantitative trait locus (QTL) analysis between SHRSP and SHR (the stroke-resistant parental strain of SHRSP), two major QTLs for stroke susceptibility were identified on chromosomes 1 and 18 of SHRSP, which were confirmed in congenic strains constructed between SHRSP and SHR. As the progression of renal dysfunction was suggested to be one of the key factors inducing stroke in SHRSP, we examined effects of the stroke-relat...
Source: Biomed Res - February 23, 2019 Category: Research Authors: Reza MF, Ngarashi D, Koike M, Misumi M, Ohara H, Nabika T Tags: Biomed Res Int Source Type: research
Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents
Publication date: June 2019Source: Materials Science and Engineering: C, Volume 99Author(s): Nataliia Beshchasna, Au Yeung Kwan Ho, Muhammad Saqib, Honorata Kraśkiewicz, Łukasz Wasyluk, Oleg Kuzmin, Oana Cristina Duta, Denisa Ficai, Roxana Doina Trusca, Anton Ficai, Vladimir F. Pichugin, Jörg Opitz, Ecaterina AndronescuAbstractStents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide...
Source: Materials Science and Engineering: C - February 2, 2019 Category: Materials Science Source Type: research
Interventions for treating urinary incontinence after stroke in adults.
CONCLUSIONS: There is insufficient evidence to guide continence care of adults in the rehabilitative phase after stroke. As few trials tested the same intervention, conclusions are drawn from few, usually small, trials. CIs were wide, making it difficult to ascertain if there were clinically important differences. Only four trials had adequate allocation concealment and many were limited by poor reporting, making it impossible to judge the extent to which they were prone to bias. More appropriately powered, multicentre trials of interventions are required to provide robust evidence for interventions to improve urinary inco...
Source: Cochrane Database of Systematic Reviews - February 1, 2019 Category: General Medicine Authors: Thomas LH, Coupe J, Cross LD, Tan AL, Watkins CL Tags: Cochrane Database Syst Rev Source Type: research
Nearly Half of Americans Have Some Form of Heart Disease
About 48% of adults in the U.S. have some type of heart or blood vessel disease, according to a new annual report from the American Heart Association published in the journal Circulation. The finding, based on data collected from 2016, means that almost half of Americans have had a heart attack, stroke, angina, abnormal heart rhythms, or narrowing of the arteries.
The new report also shows that deaths from heart disease, after declining in recent years, rose from 2015 to 2016, from 836,546 to 840,678.
Dr. Mariell Jessup, chief science and medical officer at the American Heart Association, said much of the increase in the p...
Source: TIME: Health - January 31, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Heart Disease Source Type: news
10 New Year ’s Resolutions Doctors Actually Want You to Make
Each year, Americans’ most popular New Year’s resolutions are more or less the same: get healthy, get organized, save money. But doctors at the American Medical Association (AMA) have some more specific thoughts in mind for 2019.
The AMA this week released a list of 10 wellness-focused resolutions that could “help Americans make the most impactful, long-lasting improvements to their health in 2019.” Here’s what they are — and how to make them happen.
Learn your risk for type 2 diabetes
Diabetes is one of the most common chronic health conditions in the U.S., affecting an estimated 30 mil...
Source: TIME: Health - December 21, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime Holidays 2018 public health Source Type: news
10 New Year's Resolutions Doctors Actually Want You to Make
Each year, Americans’ most popular New Year’s resolutions are more or less the same: get healthy, get organized, save money. But doctors at the American Medical Association (AMA) have some more specific thoughts in mind for 2019.
The AMA this week released a list of 10 wellness-focused resolutions that could “help Americans make the most impactful, long-lasting improvements to their health in 2019.” Here’s what they are — and how to make them happen.
Learn your risk for type 2 diabetes
Diabetes is one of the most common chronic health conditions in the U.S., affecting an estimated 30 mil...
Source: TIME: Health - December 21, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime Holidays 2018 public health Source Type: news
‘ Meat Taxes ’ Would Save Lives And Cut Health Care Costs, Study Says
(CNN) — It would drive up the price of your barbecue but a global “meat tax” could save 220,000 lives and cut health care bills by $41 billion each year, according to a new study.
The numbers are based on evidence that links meat consumption to increased risk of heart disease, cancer, stroke and diabetes.
Three years ago, the World Health Organization declared red meat such as beef, lamb and pork to be carcinogenic when eaten in processed forms, including sausages, bacon and beef jerky.
Health officials have also declared that unprocessed red meat like steak and burgers are “probably” carcinog...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 7, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Offbeat Local TV Meat Source Type: news
