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Nutrition: Omega 3

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Total 227 results found since Jan 2013.

Survey of the Erythrocyte EPA+DHA Levels in the Heart Attack/Stroke Belt
There is a clear geographical disparity in risk for cardiovascular disease (CVD) in the US, with a “heart attack/stroke belt” (hereafter the CVD belt) located primarily in the south east/central region (Figure 1). Low omega-3 fatty acid levels in the blood are known to be a risk factor for CVD independent of traditional lipid and inflammatory biomarkers, blood pressure, diabetes and smoking s tatus [1-6]. The extent to which a relatively low omega-3 levels contributes to this increased risk in this region is unknown.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 12, 2019 Category: Biomedical Science Authors: W.S. Harris, K.H. Jackson, J.T. Brenna, J.C. Rodriguez, N.L. Tintle, L. Cornish Source Type: research

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map.
Conclusion: Reduced salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk for some cardiovascular outcomes in adults. Combined calcium plus vitamin D might increase risk for stroke. Primary Funding Source: None. PMID: 31284304 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 8, 2019 Category: Internal Medicine Authors: Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, Vaughan L, Okunrintemi V, Riaz IB, Khan MS, Kaluski E, Murad MH, Blaha MJ, Guallar E, Michos ED Tags: Ann Intern Med Source Type: research

The dietary transition and its association with cardiometabolic mortality among Chinese adults, 1982–2012: a cross-sectional population-based study
Publication date: Available online 10 May 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Yuna He, Yanping Li, Xiaoguang Yang, Elena C Hemler, Yuehui Fang, Liyun Zhao, Jian Zhang, Zhenyu Yang, Zhu Wang, Li He, Jing Sun, Dong D Wang, Jingzhong Wang, Jianhua Piao, Xiaofeng Liang, Gangqiang Ding, Frank B HuSummaryBackgroundFew studies have used nationally representative data to describe dietary trends and the related cardiometabolic mortality burden in China. Thus, we aimed to characterise the trends in disease-related dietary factors as well as their associated disease burden among Chinese adults from 1982 to 2012....
Source: The Lancet Diabetes and Endocrinology - May 12, 2019 Category: Endocrinology Source Type: research

The eicosapentaenoic acid:arachidonic acid ratio and its clinical utility in cardiovascular disease.
Authors: Nelson JR, Raskin S Abstract Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid (AA) is a precursor to a number of pro-inflammatory/pro-aggregatory mediators. EPA acts competitively with AA for the key cyclooxygenase and lipoxygenase enzymes to form less inflammatory products. As a result, the EPA:AA ratio may be a marker of chronic inflammation, with a lower ratio corresponding to higher levels of inflammation. It is now well established that inflammation plays an important role in card...
Source: Postgraduate Medicine - May 9, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Physical activity might offset harms of time spent sitting
Reducing sitting time and increasing activity levels both important in reducing CVD mortality Related items fromOnMedica Plant-based diet linked to lower risk of heart failure Heart disease and stroke deaths plummet in Scotland Omega 3 from seafood linked to healthier ageing Type 2 diabetes in 10 times more young people than realised CHD and stroke risk seriously elevated with just one daily cigarette
Source: OnMedica Latest News - April 23, 2019 Category: UK Health Source Type: news

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes
Conclusions The combination of risk/protective factors encompassing genetic (PRS) and non-genetic information (PPS) holds promise for overcoming the epidemiological weakness of the CHR-P paradigm. The PPS conceptually and empirically developed here will facilitate future research in this field and hopefully advance our ability to detect individuals at-risk for psychosis and forecast their clinical outcomes. Ethics Statement This study was supported by the King's College London Confidence in Concept award from the Medical Research Council (MRC) (MC_PC_16048) to PF-P. This study also represents independent researc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies.
CONCLUSIONS: In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention. PMID: 30971107 [PubMed - as supplied by publisher]
Source: Circulation - April 10, 2019 Category: Cardiology Authors: Marklund M, Wu JHY, Imamura F, Del Gobbo LC, Fretts A, de Goede J, Shi P, Tintle N, Wennberg M, Aslibekyan S, Chen TA, de Oliveira Otto MC, Hirakawa Y, Eriksen HH, Kröger J, Laguzzi F, Lankinen M, Murphy RA, Prem K, Samieri C, Virtanen J, Wood AC, Wong K Tags: Circulation Source Type: research

Prescription Fish Oil Pill Vascepa Lowers Heart Attack Risk in Those Already on Statins
MONDAY, March 18, 2019 -- Patients who have high triglycerides and take cholesterol-lowering statins to lower their risk for heart attack or stroke can cut that risk by another 30 percent by adding a high-dose omega-3 fatty acid pill, investigators...
Source: Drugs.com - Daily MedNews - March 18, 2019 Category: General Medicine Source Type: news

Omega-3 Supplement Use, Fish Intake, and Risk of Non-fatal Coronary Artery Disease and Ischemic Stroke in the Million Veteran Program
Observational and clinical trial evidence suggests an inverse association of omega-3 polyunsaturated fatty acid with coronary artery disease (CAD) mortality, although relationships with non-fatal CAD and stroke are less clear. We investigated whether omega-3 fatty acid supplement use and fish intake were associated with incident non-fatal CAD and ischemic stroke among US Veterans.
Source: Clinical Nutrition - March 12, 2019 Category: Nutrition Authors: Rachel E. Ward, Kelly Cho, Xuan-Mai T. Nguyen, Jason L. Vassy, Yuk-Lam Ho, Rachel M. Quaden, David R. Gagnon, Peter W.F. Wilson, J. Michael Gaziano, Luc Djouss é, VA Million Veteran Program Tags: Original article Source Type: research

World Heart Month
In North America and elsewhere, February is   marked as ' Heart Month ' - a time to bring attention to the importance of cardiovascular health, and what we can to reduce our risk of cardiovascular disease.TheCochrane Heart Group was established in 1998. Its   aim is to prepare, maintain and promote the access of systematic reviews of the effect of interventions for treating ischaemic and all other heart diseases and preventing cardiovascular diseases. They have over 30 editors and nearly 1,000 authors. Their wide membership includes clinicians, researchers, and healthcare consumers who share an interest in generating rel...
Source: Cochrane News and Events - February 1, 2019 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
CONCLUSIONS: This is the most extensive systematic assessment of effects of omega-3 fats on cardiovascular health to date. Moderate- and high-quality evidence suggests that increasing EPA and DHA has little or no effect on mortality or cardiovascular health (evidence mainly from supplement trials). Previous suggestions of benefits from EPA and DHA supplements appear to spring from trials with higher risk of bias. Low-quality evidence suggests ALA may slightly reduce CVD event and arrhythmia risk. PMID: 30521670 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 30, 2018 Category: General Medicine Authors: Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, Deane KH, AlAbdulghafoor FK, Summerbell CD, Worthington HV, Song F, Hooper L Tags: Cochrane Database Syst Rev Source Type: research