Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the laboratory experiments, analyzed the data, and drafted the manuscript. YX, XpQ, HjL, CL, and GyL analyzed and discussed the data. XqQ and LH edited the manuscript. All authors read and approved the final manuscript. Funding This study was funded by grants #31671188 and #81670002 from National Nature Science Foundation of China, grant #2018JJ2463 and 2019JJ40329 from the Hunan Natural Science Foundation, and grant #16C0159 from the project supported by Scientific Research Fund of Hunan Provincial Education Department. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Abbasi, Z., Behnam-Rassouli, F., Ghahramani Seno, M. M., and Fereidoni, M. (2018). A transient insulin system dysfunction i...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research