Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway Huaiqing Luo1, Yang Xiang1, Xiangping Qu1, Huijun Liu1, Chi Liu1, Guangyi Li2, Li Han3*† and Xiaoqun Qin1*† 1Department of Physiology, School of Basic Medical Science, Central South University, Changsha, China 2Department of Anatomy, Histology and Embryology, Changsha Medical University, Changsha, China 3Department of Physiology, School of Basic Medical Science, Changsha Medical University, Changsha, China Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation. Apelin-13, a predominant neuropeptide with inhibiting effect on inflammation, has beneficial effects on cognition memory and neuronal damage. However, whether apelin-13 can protect neurons to ameliorate cognitive deficits in AD by inhibiting the inflammatory response remains largely unknown. To test this hypothesis, rats were intracerebroventricularly (ICV) injected with streptozotocin (3 mg/kg) alone or in combination with apelin-13 (2 μg). And tyrosine receptor kinase B (TrkB) blocker K252a (200 nM) was administrated 10 min before apelin injection. Furthermore, cognitive performance was assessed by new object recognition (NOR) and Y-maze tests. Protein expressio...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionWe provide an overview of mortality related to SE in China as the HQMS database covers a large number of cases of SE in China, making it one of the most efficient tools for mortality investigation. The use of electronic medical records in China creates several challenges and here we discuss lessons learned. The methodology will be improved and will be used in future studies.
Source: Seizure - Category: Neurology Source Type: research
This study examined the impact of psychiatric comorbidity on QOL in patients admitted to two level 4 epilepsy monitoring units (EMUs).MethodsIn this prospective observational study, 200 patients admitted to two level 4 EMUs completed standardized surveys including the Quality of Life in Epilepsy (QOLIE-31-P), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Beck Depression Inventory-II (BDI-II). Hierarchal multiple regression was performed to assess impact on QOL.ResultsOf the 200 participants, 113 had a diagnosis of epilepsy, 36 had a diagnosis of PNES, and 51 were excluded for nondia...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
AbstractPurposeCirculating caspase-3 levels at 24  h of ischemic stroke were found to be associated with poorer functional neurological outcome in a previous study. The aim of this study was to determine whether there is an association between serum caspase-3 levels and early mortality in patients with malignant middle cerebral artery infarction ( MMCAI).MethodsWe included patients with MMCAI defined as computer tomography showing ischemic changes in more than 50% of the middle cerebral artery territory and Glasgow Coma Scale  ≤ 8. Serum caspase-3 levels at days 1, 4, and 8 of MMCAI were determined.Re...
Source: Neurocritical Care - Category: Neurology Source Type: research
CONCLUSIONS: Children and adolescents with MM who are community ambulators, of an emerging independent age, and live in hot climates are at risk of environmental buttocks burns. Enhanced education in environmental thermal burn prevention is important. This education should be particularly focused on the child as they spend more time in settings without their parents. In addition, this enhanced education should extend to those who support the child or teen such as teachers, coaches, family and friends. PMID: 31744035 [PubMed - as supplied by publisher]
Source: Journal of Pediatric Rehabilitation Medicine - Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
This study investigated technostress among university students in technology-enhanced learning (TEL) from a multidimensional person-environment misfit perspective: technostress on the dimensions of person-organization (P–O) misfit, person-TEL (P-TEL) misfit, and person-people (P–O) misfit, respectively. A research model was created to examine how the three dimensions of technostress were related to one another and how they predicted students' burnout, persistence in TEL, and perceived performance. It was validated by 740 university students from three public universities in China. The findings show that P&ndash...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
DiscussionOur findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 20 November 2019Source: Alzheimer's &DementiaAuthor(s): Hector M. González, Wassim Tarraf, Myriam Fornage, Kevin A. González, Albert Chai, Marston Youngblood, Maria de los Angeles Abreu, Donglin Zeng, Sonia Thomas, Gregory A. Talavera, Linda C. Gallo, Robert Kaplan, Martha L. Daviglus, Neil SchneidermanAbstractHispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
DiscussionEarly “subtle cognitive decline” among Aβ+ CN on a sensitive cognitive composite demonstrably increases risk for imminent clinical disease progression and functional impairment.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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