Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes
Conclusions
The combination of risk/protective factors encompassing genetic (PRS) and non-genetic information (PPS) holds promise for overcoming the epidemiological weakness of the CHR-P paradigm. The PPS conceptually and empirically developed here will facilitate future research in this field and hopefully advance our ability to detect individuals at-risk for psychosis and forecast their clinical outcomes.
Ethics Statement
This study was supported by the King's College London Confidence in Concept award from the Medical Research Council (MRC) (MC_PC_16048) to PF-P. This study also represents independent research part funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders had no influence on the design, collection, analysis and interpretation of the data, writing of the report and decision to submit this article for publication.
Author Contributions
PF-P conceived the study under the supervision of RU. DO acquired the data. AR and JR coordinated the statistical analysis. PF-P and DO drafted the manuscript, and AR, JR, and RU made substantial contribution to the revision of the initial manuscript and interpretation of data.
Conflict of Interest Statement
The authors declare that the research was con...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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