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Total 145 results found since Jan 2013.

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

The Discovery and Development of Liraglutide and Semaglutide
We describe one such approach, albumin binding, and explain how it was applied in the development of the human GLP-1 analog liraglutide once daily and, subsequently, semaglutide once weekly. The pharmacology of these two long-acting GLP-1 analogs, in terms of improving glycemic control, reducing body weight and decreasing cardiovascular (CV) risk, is also reviewed, together with some novel biology. In addition, we describe the importance of accurate target (GLP-1 receptor) tissue expression analysis. Now an established class of agents, GLP-1-based therapies represent a significant advance in the treatment of T2D. All curr...
Source: Frontiers in Endocrinology - April 11, 2019 Category: Endocrinology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

ADAMTS5 deficiency in mice does not affect cardiac function.
This article is protected by copyright. All rights reserved. PMID: 30958594 [PubMed - as supplied by publisher]
Source: Cell Biology International - April 7, 2019 Category: Cytology Authors: Hemmeryckx B, Carai P, Lijnen H Tags: Cell Biol Int Source Type: research

NLRP3 Inflammasome Inhibition with MCC950 Improves Diabetes-Mediated Cognitive Impairment and Vasoneuronal Remodeling After Ischemia
Publication date: Available online 25 February 2019Source: Pharmacological ResearchAuthor(s): Rebecca Ward, Weiguo Li, Yasir Abdul, LaDonya Jackson, Guangkuo Dong, Sarah Jamil, Jessica Filosa, Susan C. Fagan, Adviye ErgulAbstractDiabetes increases the risk and worsens the progression of cognitive impairment via the greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are not fully understood. It is now accepted that cardiovascular health is critical for brain health and any neurorestorative approaches to prevent/delay cognitive deficits should target the conceptual neurovascular unit (NVU) ...
Source: Pharmacological Research - February 26, 2019 Category: Drugs & Pharmacology Source Type: research

Prolonged High Fat Diet Worsens the Cellular Response to a Small, Covert-like Ischemic Stroke
Publication date: Available online 4 February 2019Source: NeuroscienceAuthor(s): Kathleen E. Fifield, Todd M. Rowe, Joanna B. Raman-Nair, Michiru Hirasawa, Jacqueline L. VanderluitAbstractObesity is associated with worse neurological outcomes following overt ischemic strokes. The majority of strokes however, are covert, small strokes that often evade detection. How obesity impacts the cellular response to covert strokes is unclear. Here, we used a diet-induced obesity model by feeding mice a high fat diet (HFD) and examining its impact on the behavioral and cellular responses to either an Endothelin-1-induced focal ischemi...
Source: Neuroscience - February 5, 2019 Category: Neuroscience Source Type: research

Photoacoustic microscopy of obesity-induced cerebrovascular alterations
Publication date: Available online 13 December 2018Source: NeuroImageAuthor(s): Rui Cao, Jun Li, Chenchu Zhang, Zhiyi Zuo, Song HuAbstractCerebral small vessel disease has been linked to cognitive, psychiatric and physical disabilities, especially in the elderly. However, the underlying pathophysiology remains incompletely understood, largely due to the limited accessibility of these small vessels in the live brain. Here, we report an intravital imaging and analysis platform for high-resolution, quantitative and comprehensive characterization of pathological alterations in the mouse cerebral microvasculature. By exploiting...
Source: NeuroImage - December 15, 2018 Category: Neuroscience Source Type: research

Adenosine and adenosine-5 ′-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet
We have previously reported that ingestion of adenosine (ADN) and adenosine-5 ′-monophosphate (AMP) improves abnormal glucose metabolism in the stroke-prone spontaneously hypertensive rat model of non-obesity-a...
Source: BMC Complementary and Alternative Medicine - November 14, 2018 Category: Complementary Medicine Authors: Ardiansyah, Yuto Inagawa, Takuya Koseki, Afifah Zahra Agista, Ikuo Ikeda, Tomoko Goto, Michio Komai and Hitoshi Shirakawa Tags: Research article Source Type: research

Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis.
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet
The prevalence of obesity has been dramatically increasing globally over decades [1]. Obesity is caused by a complex interaction of genetic and environmental factors, and is also suggested to be the result of a long-term imbalance between energy intake and expenditure [2]. Calorie-rich foods that are high in fat or carbohydrates combining with sedentary lifestyles are the most common factors underlying the global obesity epidemic [3]. High-fat diets (HFD) increase adipose tissue and induce metabolic and cardiovascular disorders (such as atherosclerosis, type 2 diabetes, stroke, and hypertension [4, 5]), especially in those...
Source: Nutrition - October 10, 2018 Category: Nutrition Authors: Cheng Kong, Renyuan Gao, Xuebing Yan, Linsheng Huang, Huanlong Qin Source Type: research

Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity.
Conclusion: Heat stimulation by M-RF treatment induced upregulation of UCP1 and FGF21 expression in serum and/or WATs, which was correlated with reduced total body and WAT weight gain in DIO mice. PMID: 30275865 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - October 4, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Even High-Fat Dairy Might Be Good for You
The study couldn't prove cause-and-effect, but folks who ate three servings of dairy per day had an overall lower risk of death during the study period than people who ate no dairy. They also had a lower risk of stroke and death from heart disease, researchers found.
Source: WebMD Health - September 12, 2018 Category: Consumer Health News Source Type: news