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Total 145 results found since Jan 2013.

Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes
CONCLUSIONS: Our findings indicate that d-flow-induced CCRL2 promotes atherosclerotic plaque formation via a novel CCRL2-chemerin-β2 integrin axis, providing potential targets for the prevention or therapeutic intervention of atherosclerosis.PMID:37279540 | DOI:10.1093/cvr/cvad085
Source: Atherosclerosis - June 6, 2023 Category: Cardiology Authors: Chaojun Tang Guona Chen Fan Wu Yiren Cao Fei Yang Tao You Chu Liu Menglu Li Shuhong Hu Lijie Ren Qiongyu Lu Wei Deng Ying Xu Guixue Wang Hanjoong Jo Yonghong Zhang Yi Wu Brian A Zabel Li Zhu Source Type: research

SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses
CONCLUSIONS: This study suggests that SHRSP5/Dmcr rats could be a useful novel model for investigate the mechanism of secondary sarcopenia disorder associated with nonalcoholic steatohepatitis.PMID:37209870 | DOI:10.1016/j.aanat.2023.152104
Source: Annals of Anatomy - May 20, 2023 Category: Anatomy Authors: Shusei Yamamoto Koki Honma Moe Fujii Mai Kakimoto Sora Kirihara Hinako Nakayama Kazuya Kitamori Ikumi Sato Satoshi Hirohata Shogo Watanabe Source Type: research

Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity
by Taylor McFadden, Natasha Gaito, Isabella Carucci, Everett Fletchall, Kayla Farrell, Timothy J. Jarome Obesity is a complex medical condition that is linked to various health complications such as infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for responding to the etiology of this disease. The hypothalamus coordinates many integral activities such as hormone regulation and feed intake and numerous studies have observed altered hypothalamic gene regulation in obesity models. Previously, it was reported that the promoter region of the satiety gene,Pomc, has increased DNA met...
Source: PLoS One - April 10, 2023 Category: Biomedical Science Authors: Taylor McFadden Source Type: research

Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice
ConclusionsFemale mice are more resistant to the negative effects of an HFD on body weight, metabolism, and hearing. Females showed increased peripheral and intra-cochlear adiponectin and AdipoR1 levels, and HC ribbon synapses. These changes may mediate resistance to HFD-induced hearing loss seen in female mice.
Source: Biology of Sex Differences - February 21, 2023 Category: Biology Source Type: research

Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice
FASEB J. 2023 Mar;37(3):e22752. doi: 10.1096/fj.202200056R.ABSTRACTAtherosclerosis is a chronic inflammatory condition of our arteries and the main underlying pathology of myocardial infarction and stroke. The pathogenesis is age-dependent, but the links between disease progression, age, and atherogenic cytokines and chemokines are incompletely understood. Here, we studied the chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) in atherogenic Apoe-/- mice across different stages of aging and cholesterol-rich high-fat diet (HFD). MIF promotes atherosclerosis by mediating leukocyte recruitment, ...
Source: Atherosclerosis - February 16, 2023 Category: Cardiology Authors: Christine Krammer Bishan Yang Sabrina Reichl Simon Besson-Girard Hao Ji Verena Bolini Corinna Schulte Heidi Noels Kai Schlepckow Georg Jocher Georg Werner Michael Willem Omar El Bounkari Aphrodite Kapurniotu Ozgun Gokce Christian Weber Sarajo Mohanta J ü Source Type: research

Mechanism of Tao Hong Decoction in the treatment of atherosclerosis based on network pharmacology and experimental validation
CONCLUSION: THD plays a vital role in treating AS with multiple targets and pathways. Angiogenesis regulation, oxidative stress regulation, and immunity regulation consist of the crucial regulation cores in the mechanism. This study identified essential genes and pathways associated with the prognosis and pathogenesis of AS from new insights, demonstrating a feasible method for researching THD's chemical basis and pharmacology.PMID:36776258 | PMC:PMC9909180 | DOI:10.3389/fcvm.2023.1111475
Source: Atherosclerosis - February 13, 2023 Category: Cardiology Authors: SiJin Li Ping Liu Xiaoteng Feng Min Du Yifan Zhang YiRu Wang JiaRou Wang Source Type: research

Molecules, Vol. 28, Pages 390: Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus
In this study, C57BL/6 mice were treated with high-fat diets (HFDs) combined with streptozotocin (STZ) injection to mimic type 2 diabetes mellitus (T2DM). Focal cerebral ischemia in T2DM mice was established via injection of the vasoconstrictor peptide endothelin-1 (ET-1) into the hippocampus. Three different treatment plans were used in this study. In one plan, 1 mg/kg of PRE084 (intraperitoneally) was administered for 7 d before ET-1 injection; the mice were sacrificed 24 h after ET-1 injection. In another plan, PRE084 treatment was initiated 24 h after ET-1 injection and lasted for 7 d. In the third plan, PRE084 treatme...
Source: Molecules - January 2, 2023 Category: Chemistry Authors: Wenjing Song Yang Yao Heling Zhang Xin Hao Liping Zhou Zhixiao Song Tiantian Wei Tianyan Chi Peng Liu Xuefei Ji Libo Zou Tags: Article Source Type: research

Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn
AbstractAtherosclerosis, a chronic inflammatory disease that often leads to myocardial infarction and stroke, is mainly caused by lipid accumulation. Eukaryotic initiation factor 6 (Eif6) is a rate-limiting factor in protein translation of transcription factors necessary for lipogenesis. To determine whetherEif6 affects atherosclerosis,Eif6+/ − mice were crossed intoApoe −/− background.Apoe −/−/Eif6+/− mice on high fat diet showed significant reduction in atherosclerotic lesions and necrotic core content in aortic root sections in comparison withApoe −/− mice. RNA-Seq was used to investigate the effect of E...
Source: IUBMB Life - December 6, 2022 Category: Research Authors: Yang Chen, Zhenzhen Wang, Xuemei Xian, Yun Zhuang, Jiajia Chang, Xiaoqiang Zhan, Xufeng Han, Quangang Chen, Zhangping Yang, Renjin Chen Tags: RESEARCH ARTICLE Source Type: research

Influence of Management of Intensive Weight, Blood Pressure, and Lipids on Disease Severity in Patients with Carotid Atherosclerosis
CONCLUSIONS: A program for management of body weight, blood pressure, and blood lipids can effectively control the severity of carotid atherosclerosis, can prevent the disease's progression, and can be promoted as a clinical application.PMID:36455146
Source: Atherosclerosis - December 1, 2022 Category: Cardiology Authors: Yongjian Liu Xiaojing Yan Jin Zhou Litao Chen Zhixing Du Jianmin Pang Liya Jiao Dan Li Yongmin Deng Source Type: research

Dog models of human atherosclerotic cardiovascular diseases
Mamm Genome. 2022 Oct 15. doi: 10.1007/s00335-022-09965-w. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Eighty-five percent of CVD-associated deaths are due to heart attacks and stroke. Atherosclerosis leads to heart attack and stroke through a slow progression of lesion formation and luminal narrowing of arteries. Dogs are similar to humans in terms of their cardiovascular physiology, size, and anatomy. Dog models have been developed to recapitulate the complex phenotype of human patients and understand the underlying mechanism of CVD. Different methods, inc...
Source: Atherosclerosis - October 15, 2022 Category: Cardiology Authors: Hui Zhao Enqi Liu Yong Q Zhang Source Type: research