Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases

Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that elucidates the role of Nrf2 activation in specific tissues, such as adipose tissue, liver, pancreas and others, is important for better understanding of the multiple roles of Nrf2. Additional studies may also provide new redox balance-targeted therapy for the treatment of metabolic diseases and consequent mitigation of cardiovascular risk. FIGURE 1 Figure 1. Mechanisms involved in the actions of reactive oxygen species that lead to metabolic diseases and cardiovascular risk development. Metabolic diseases are closely associated with increased generation of reactive oxygen species (ROS) due to reduced Nrf2 antioxidant activity. This phenomenon culminates in target-organ damage and metabolism disorders, such as adipogenesis and adipose tissue inflammation, increased production of hepatic cholesterol, decreased insulin secretion, insulin resistance, los...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionILTHS induced oxidative stress responses and inflammatory molecules, which can lead to impaired neurogenesis and ultimately neuronal death, whereas, KRG, being the antioxidant inhibited neuronal damage and increased cell viability.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Publication date: Available online 24 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Laura Galian-Gay, Blanca Gordon, Josep Ramón Marsal, Agnès Rafecas, Antonia Pijuan Domènech, Miguel Angel Castro, Maria T. Subirana Domènech, Carlos Sureda, Berta Miranda, Gerard Martí, David García-Dorado, Laura Dos SubiràAbstractIntroduction and objectivesAlthough pulmonary valve stenosis (PVS) is considered a low risk congenital heart disease, there have been reports of complications and the need for reintervention throughout follow-up. The aims ...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 24 May 2019Source: Canadian Journal of CardiologyAuthor(s): Riina M. Kandolin, Christiane C. Wiefels, Cláudio Tinoco Mesquita, Aun-Yeong Chong, Paul Boland, David Glineur, Louise Sun, Rob S. Beanlands, Lisa M. MielniczukAbstractThis review describes the current evidence and controversies for viability imaging to direct revascularization decisions and the impact on patient outcomes. Balancing procedural risks and possible benefit from revascularization is a key question in patients with heart failure of ischemic origin (IHF). Different stages of ischemia induce adaptive changes in m...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Cancer PolicyAuthor(s): Steve Langton, Derek Lowe, Simon N Rogers, Annette Plüddemann, Clare BankheadAbstractBackgroundThe ‘two-week rule’ (TWR) fast-track cancer referral system for head and neck cancers was introduced by the UK government in 2000, to facilitate earlier diagnosis. However, little work has compared stage on diagnosis of cancer before and after the implementation of the system.Objectives•Describe the presentation of oral cancer in Merseyside from 1992-2012.•To evaluate whether stage on presentation has improved after...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
ConclusionsThe investigative team developed a novel breast cancer treatment DA that is acceptable to women ≥70 years with a history of ER+, HER2-, early stage breast cancer. Next, the DA's efficacy needs to be tested with diverse older women newly diagnosed with breast cancer.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Upma Sharma, Pallavi Singhal, Kapil Bandil, Rajeshwar Patle, Anoop kumar, Kausar Neyaz, Surojit Bose, Ajay Kumar Dewan, Ravi Mehrotra, Veena Sharma, Mausumi BharadwajAbstractBackground: Despite being most preventable malignancies associated with smoked and smokeless tobacco products, squamous cell carcinoma of oral cavity is one of the most common malignancy in India. The aim of the present study was to evaluate the role of TLRs in oral pre-cancerous, cancerous cases and their genotypic correlation with HPV/EBV, co-infection &lifestyle habits...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: Cancer CellAuthor(s): Ruidong Xue, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng LiSummaryWe performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
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Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Benchoula K, Khatib A, Jaffar A, Ahmed QU, Sulaiman WMAW, Wahab RA, El-Seedi HR Abstract Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and...
Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
Researchers compared robot-assisted upper limb training vs enhanced therapy or standard care in patients recovering from stroke, and find no advantage for the robotic assist.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
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