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Infectious Disease: Hepatitis

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Total 168 results found since Jan 2013.

Repurposing of Clinically Approved Poly-(ADP-Ribose) Polymerase Inhibitors for the Therapy of Sepsis
Sepsis’ pathogenesis involves multiple mechanisms that lead to a dysregulation of the host's response. Significant efforts have been made in search of interventions that can reverse this situation and increase patient survival. Poly (ADP-polymerase) (PARP) is a constitutive nuclear and mitochondrial enzyme, which functions as a co-activator and co-repressor of gene transcription, thus regulating the production of inflammatory mediators. Several studies have already demonstrated an overactivation of PARP1 in various human pathophysiological conditions and that its inhibition has benefits in regulating intracellular proces...
Source: Shock - November 26, 2021 Category: Emergency Medicine Tags: Review Articles Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Complications of Hepatocellular Carcinoma patients post living Donor Liver Transplantation
ConclusionThere was no statistical significance for those within or out side the Milan criteria or UCSF criteria and its impact on the occurrence of graft rejection, sepsis, vascular complications, death, HCC recurrence and biliary complications post-transplant.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Janssen Demonstrates Commitment to Advancing Science and Innovation in the Treatment of Solid Tumors at ESMO Annual Congress
September 8, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than ten data presentations from its lung cancer, bladder cancer and prostate cancer portfolio and pipeline will be featured during the European Society for Medical Oncology (ESMO) Annual Congress 2021 virtual meeting, September 16–21. Further details about these data and the science Janssen is advancing will be made available throughout ESMO via the Janssen Oncology Virtual Newsroom.“With a diverse oncology portfolio and pipeline spanning bladder cancer, lung cancer and prostate cancer, Janssen...
Source: Johnson and Johnson - September 8, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination
Chickenpox is the clinical manifestation of primary infection with varicella zoster virus (VZV) and a mild disease in the vast majority of cases. However, complications occur, primarily bacterial infections of vesicles, sometimes with deeper infection and sepsis, as well as neurological complications; e.g. encephalitis, meningitis, or classically acute cerebellitis with ataxia. Rare complications such as pneumonitis, hepatitis and haemorrhagic complications may occur (Gershon et al., 2018). There is even an increased risk of stroke in the time period 6 months after a chickenpox episode (Thomas et al., 2014).
Source: International Journal of Infectious Diseases - August 8, 2021 Category: Infectious Diseases Authors: K Widgren, L Persson Berg, A M örner, L Lindquist, A Tegnell, J Giesecke, M Studahl Source Type: research

Nonalcoholic Fatty Liver Disease, Liver Fibrosis and Cardiovascular Disease in the Adult US Population
ConclusionsIn this population-based study, we did not identify an independent association between steatosis and fibrosis and CVD. Large prospective cohort studies are needed to provide a more definitive evidence on this topic.
Source: Frontiers in Endocrinology - July 26, 2021 Category: Endocrinology Source Type: research

Hospitalization for adverse events under abiraterone or enzalutamide exposure in real-world setting: a French population-based study on prostate cancer patients
CONCLUSION: Our study provides knowledge on abiraterone and enzalutamide real-life safety profiles, especially for events leading to hospitalisation. Despite several limitations, including the lack of clinical data, the safety signal for AKI under abiraterone is in line with results of an analysis of the French pharmacovigilance database, which requires further specific investigations. Enlightening the clinicians' therapeutic choices for patients treated for prostate cancer, our study should lead to clinicians to be cautious in the use of abiraterone.PMID:34224605 | DOI:10.1111/bcp.14972
Source: Clinical Prostate Cancer - July 5, 2021 Category: Cancer & Oncology Authors: Lucie-Marie Scailteux Fabien Despas Fr édéric Balusson Boris Campillo-Gimenez Romain Mathieu S ébastien Vincendeau Andr é Happe Emmanuel Nowak Sandrine Kerbrat Emmanuel Oger Source Type: research

Systematic Investigation of the Effect of Powerful Tianma Eucommia Capsule on Ischemic Stroke Using Network Pharmacology
CONCLUSIONS: Seven new putative target genes (ACHE, ADRA1A, AR, CHRM3, F7, GABRA1, and PRSS1) were observed in this work. Based on the result of GO and KEGG analysis, this work will be helpful to further demonstrate the molecular mechanism of PTEC treatment of IS.PMID:34194527 | PMC:PMC8203382 | DOI:10.1155/2021/8897313
Source: Evidence-based Complementary and Alternative Medicine - July 1, 2021 Category: Complementary Medicine Authors: Pengcheng Feng Guixia Li Yan Huang Jinhong Pei Source Type: research

Impact of DAA Treatment on Cardiovascular Disease Risk in Chronic HCV Infection: An Update
Hepatitis C virus (HCV) infection is a systemic disease associated with multiple significant extrahepatic manifestations. Emerging studies indicate association between the HCV infection and a higher incidence of major adverse cardiovascular events such as: coronary artery disease, heart failure, stroke and peripheral artery disease, when compared to general population. Atherosclerosis is a common pathophysiologic mechanism of cardiovascular disease (CVD) development which is the leading cause of mortality in the Western world. Proposed mechanisms of HCV-induced atherosclerosis includes systemic inflammation due to the chro...
Source: Frontiers in Pharmacology - May 11, 2021 Category: Drugs & Pharmacology Source Type: research

P030  Antiphospholipid syndrome and giant cell arteritis: a coincidence or connection?
Conclusion In summary, this is a case of GCA and APS, treated with prednisolone, aspirin, warfarin and tocilizumab. There is increasing evidence describing the presence of antiphospholipid antibodies in patients with vasculitis. However, the role of these antibodies in GCA and the clinical significance rema ins unclear. This case reports highlights the need for physicians to consider APS in patients who have a history of GCA and subsequently develop arterial or venous embolic events.Disclosure L. Sammut: None.E. Htut: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Social Determinants of Health: Enhancing Health Equity
Nutrition and dietetics practitioners traditionally focus on modifying behavior to improve patient outcomes, but the Academy of Nutrition and Dietetics (Academy) also recognizes the role of social determinants of health (SDOH) when examining root causes of chronic diseases, such as high blood pressure, coronary heart disease, hepatitis, and stroke, particularly for minority and underserved populations.1
Source: Journal of the American Dietetic Association - April 13, 2021 Category: Nutrition Authors: Tony Peregrin Tags: From the Academy Source Type: research

Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-analysis of Incidence, Outcomes and Predictors
COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19.
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Isabel Siow, Keng Siang Lee, John J.Y. Zhang, Seyed Ehsan Saffari, Adeline Ng, Barnaby Young Source Type: research

Adverse drug reactions profiles for abiraterone and enzalutamide: A pharmacovigilance descriptive analysis.
CONCLUSION: The analysis of the French pharmacovigilance database cases allows to confirm an expected and monitored risk profile in the risk management plan for both drugs. Several signals have arisen, some of which will be investigated through a pharmacoepidemiology study. PMID: 33376005 [PubMed - as supplied by publisher]
Source: Therapie - December 13, 2020 Category: Psychiatry & Psychology Authors: Scailteux LM, Lacroix C, Bergeron S, Despas F, Sassier M, Triquet L, Picard S, Oger E, Polard E, et le réseau français des Centres régionaux de pharmacovigilance Tags: Therapie Source Type: research

Neurological complications of hepatitis C infections.
Abstract Chronic hepatitis C virus (HCV) infection is a highly prevalent systemic disease, which can cause a variety of neurological complications. The HCV-associated symptoms can be differentiated into central and peripheral nervous systems as well as the musculature. Important pathomechanisms are HCV-associated autoimmunity (e.g. mixed cryoglobulinemia with polyneuropathy) and direct neurotoxic effects of the virus (e.g. HCV-associated cognitive deficits). Distal symmetric polyneuropathies, small fiber neuropathies and cognitive deficits are the most prevalent neurological manifestations. Furthermore, HCV infe...
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Authors: Kleefeld F, Arendt G, Neuen-Jacob E, Maschke M, Husstedt I, Obermann M, Schmidt H, Hahn K, Deutsche Gesellschaft für Neuro-AIDS und Neuro-Infektiologie (DGNANI) Tags: Nervenarzt Source Type: research