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Total 411 results found since Jan 2013.

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

The lncRNA MALAT1 rs619586 G Variant Confers Decreased Susceptibility to Recurrent Miscarriage
In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. Introduction Recurrent miscarriage is defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation (Jaslow et al., 2010; Diejomaoh, 2015). The occurrence of recurrent miscarriage is associated with many factors, including genetic factors, immunological dysfunction, endocrine disorders, unhealthy lifestyles and defects of the reproductive organs (Saravelos and Regan, 2014; Sen et al., 2014; Garrido-Gimen...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research

Exercise can cut cardiovascular risk for breast cancer survivors
More exercise is a good idea for most people, but it's especially important for breast cancer survivors, who have an increased risk of suffering a stroke or heart attack, a new study says.
Source: Health News - UPI.com - March 29, 2019 Category: Consumer Health News Source Type: news

An umbrella review of the evidence for equine ‐assisted interventions
ConclusionsThe evidence for equine ‐assisted interventions for adults and children across a range of conditions and presentations is equivocal. The current evidence base is marred by multiple methodological weaknesses and thus, therapeutic interventions that include a horse cannot be asserted as best practice at this time. Rigorous research is indicated to determine the utility of equine‐assisted interventions.
Source: Australian Journal of Psychology - February 20, 2019 Category: Psychiatry & Psychology Authors: Cindy Stern, Anna Chur ‐Hansen Tags: SPECIAL ISSUE Source Type: research

A prospective study of health conditions related to alcohol consumption cessation among 97,852 drinkers aged 45 and over in Australia.
CONCLUSIONS: Diagnosis with a variety of health conditions appears to prompt drinking cessation in older adults. This article is protected by copyright. All rights reserved. PMID: 30758044 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - February 13, 2019 Category: Addiction Authors: Sarich P, Canfell K, Banks E, Paige E, Egger S, Joshy G, Korda R, Weber M Tags: Alcohol Clin Exp Res Source Type: research

Breast Cancer Screening Participation of Women with Chronic Diseases in Korea: Analysis of the 2012 Korean National Health and Nutrition Examination Survey
In conclusion, low participation rate in breast cancer screening in women with some chronic diseases was identified. The results from this study may provide an important contribution for helping to maintain and increase participation in cancer screening of patients with chronic diseases. PMID: 30678433 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - January 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Carbohydrate quality and human health: a series of systematic reviews and meta-analyses
Publication date: Available online 10 January 2019Source: The LancetAuthor(s): Andrew Reynolds, Jim Mann, John Cummings, Nicola Winter, Evelyn Mete, Lisa Te MorengaSummaryBackgroundPrevious systematic reviews and meta-analyses explaining the relationship between carbohydrate quality and health have usually examined a single marker and a limited number of clinical outcomes. We aimed to more precisely quantify the predictive potential of several markers, to determine which markers are most useful, and to establish an evidence base for quantitative recommendations for intakes of dietary fibre.MethodsWe did a series of systema...
Source: The Lancet - January 11, 2019 Category: General Medicine Source Type: research

Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy
We sought to interrogate previous reports that fitness in breast cancer patients was less than expected for community norms. As compared with healthy control subjects, we observed reduced oxygen consumption capacity in recently diagnosed breast cancer patients prior to treatment. This reduced capacity was associated with smaller heart size and reduced peak exercise cardiac output. This may suggest that reduced exercise conditioning is associated with breast cancer risk. AbstractWomen with early ‐stage breast cancer have reduced peak exercise oxygen uptake (peakVO2). The purpose of this study was to evaluate peakVO2 and r...
Source: Physiological Reports - January 10, 2019 Category: Physiology Authors: Rhys I. Beaudry, Erin J. Howden, Steve Foulkes, Ashley Bigaran, Piet Claus, Mark J. Haykowsky, Andre La Gerche Tags: Original Research Source Type: research

Image-based screening.
Abstract Screening is a special issue in medical questions concerning disease prevention. Preconditions for screening are clearly defined by the World Health Organization. High prevalence, effectiveness of therapy, availability of accepted test procedure and consensus concerning the economic concerns are necessary for successful implementation of a screening program. Preventive diagnostic studies can only be understood if one is familiar with the statistical terms sensitivity, specificity, prevalence, incidence and bias (especially overdiagnosis and lead time bias). Aspects of radiation protection are especially...
Source: Der Radiologe - December 14, 2018 Category: Radiology Authors: Layer G Tags: Radiologe Source Type: research

Monoclonal Gammopathy of Undetermined Significance - Patient Characteristics and Referral Patterns
ConclusionMGUS is often incidentally detected as part of a work up for other medical conditions, and our results reveal that there is a variety of reasons for which monoclonal testing is performed. With recent developments in our understanding of the significance of monoclonal gammopathy and its association with certain renal and organ damage (Fermand et al., 2018; Leung et al., 2012), there may be a change in how the paraproteinemia investigations are utilized by clinicians in different disciplines. It will be important to recognize and establish appropriate indications for testing. Furthermore, MGUS patients present with...
Source: Blood - November 21, 2018 Category: Hematology Authors: Lee, H., Street, L., Tay, J., Grossman, J., Thaell, J. F., Goodyear, D., McCulloch, S., Duggan, P., Neri, P., Jimenez-Zepeda, V. Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III Source Type: research