Monoclonal Gammopathy of Undetermined Significance - Patient Characteristics and Referral Patterns

ConclusionMGUS is often incidentally detected as part of a work up for other medical conditions, and our results reveal that there is a variety of reasons for which monoclonal testing is performed. With recent developments in our understanding of the significance of monoclonal gammopathy and its association with certain renal and organ damage (Fermand et al., 2018; Leung et al., 2012), there may be a change in how the paraproteinemia investigations are utilized by clinicians in different disciplines. It will be important to recognize and establish appropriate indications for testing. Furthermore, MGUS patients present with a wide range of comorbidities at the time of diagnosis. Interdisciplinary care will play a key role in discerning how much of the organ dysfunction and patients' symptoms are secondary to their underlying medical conditions versus the effect of monoclonal gammopathy.DisclosuresMcCulloch: Celgene: Honoraria; Takeda: Other: Travel expenses. Neri: Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria.
Source: Blood - Category: Hematology Authors: Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III Source Type: research

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CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
CONCLUSION: The results raise the possibility of an association between recurrent facial nerve palsy and migraines. Prospective studies in patients with even fewer episodes of facial nerve palsy could shed more light on this association. PMID: 32940194 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
CONCLUSION: Our study expands the mutation spectrum of WSF1 mutations with three novel mutations. Homozygosity mapping may provide enrichment for molecular genetic analysis and early diagnosis of WS1 patients with incomplete phenotype, particularly in consanguineous pedigrees. PMID: 32938580 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
This study aims to determine the incidence of T1D in children under the age of 15 years, living in Tlemcen in Northwest Algeria. METHODS: A retrospective study conducted on data of children (
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Authors: Theodosis-Nobelos P, Filotheidou A, Triantis C Abstract The clinical role of the placebo effect is a topic of increasing interest for the scientific community. Focus is shifting from the inert role of placebos in randomized controlled trials (RCTs) to potential effects in clinical applications, since the phenomenon is thought to be inherent in routine clinical practice, affecting therapy success rates. Mediation of the mind-brain-body relationship involves both psychosocial and neurobiological factors, the interaction of which comprises the placebo mechanisms. Psychosocial factors include environmentally i...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Publication date: December 2020Source: Nano Today, Volume 35Author(s): Tanziela Tanziela, Sana Shaikh, Hui Jiang, Zuhong Lu, Xuemei Wang
Source: Nano Today - Category: Nanotechnology Source Type: research
Publication date: November–December 2020Source: Journal of Materials Research and Technology, Volume 9, Issue 6Author(s): Reza Eivazzadeh-Keihan, Fateme Radinekiyan, Somayeh Asgharnasl, Ali Maleki, Hossein Bahreinizad
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Conclusion This study indicated that chronotherapy with RAS inhibitors improved the renal damage via intrarenal RAS suppression, especially in CKD patients with an impaired renal function and nocturnal hypertension. PMID: 32938851 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion The plasma C-peptide levels at 0 and 120 minutes in the MTT provide essential information for the clinical management of patients with type 2 diabetes mellitus. PMID: 32938850 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion Snoring was shown to be a frequent pathophysiology in active workers. It was a health indicator for active workers, and especially in men, intervention for snoring may reduce the risk of developing lifestyle-related diseases. PMID: 32938849 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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