The lncRNA MALAT1 rs619586 G Variant Confers Decreased Susceptibility to Recurrent Miscarriage

In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. Introduction Recurrent miscarriage is defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation (Jaslow et al., 2010; Diejomaoh, 2015). The occurrence of recurrent miscarriage is associated with many factors, including genetic factors, immunological dysfunction, endocrine disorders, unhealthy lifestyles and defects of the reproductive organs (Saravelos and Regan, 2014; Sen et al., 2014; Garrido-Gimenez and Alijotas-Reig, 2015; Kaur and Gupta, 2016; Pereza et al., 2017; Shi et al., 2017). In recent years, many studies have revealed a relationship between miscarriage and cardiovascular disease. Cardiovascular disease and recurrent miscarriage share risk factors, and women who experience miscarriages may have an increased risk of cardiovascular disease (Kharazmi et al., 2010; El Achi et al., 2018). For example, women with a history of miscarriage appear to have an increased risk of ischemic heart disease (Wagner et al., 2015). Smith et al. (2011) reported that the parents of women who have experienced recurrent miscarriage also have an increased risk of ischemic heart disease, and Kharazmi et al. (2010) suggests that women who experience spontaneous pregnancy loss may have an increased risk of myocardial infarction (Zhu et al., 2018). Moreover, studies hav...
Source: Frontiers in Physiology - Category: Physiology Source Type: research