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Total 133 results found since Jan 2013.

Performance of quick sequential organ failure assessment (qSOFA) score for prognosis of heat-related hospitalized patients
The incidence of heat-related illnesses is likely to increase with the intensification of global warming.1-3 For instance, more than 70,000 deaths were attributed to the 2003 European heat wave,4 and 55,000 deaths occurred in the unprecedented 2010 Russian heat wave.5 Both exposure to high temperatures and excessive heat production during strenuous exercise can result in heat-related illnesses.1,6 Heat stroke (HS) represents the most severe heat-related illness and is classically characterized by a high core temperature (> 40  °C) and central nervous system abnormalities such as delirium and convulsions.
Source: Heart and Lung - March 2, 2020 Category: Intensive Care Authors: Ying Guo, Yongbin Wang, Cheng'en Ma, Rui Li, Tao Li Source Type: research

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
ConclusionsIn subjects with uncontrolled BP on existing antihypertensive therapy, switching to perindopril arginine 10  mg/indapamide 2.5 mg was associated with statistically significant decreases in BP and higher rates of target BP achievement in all BMI groups, including more than 70% of overweight and obese patients.Trial RegistrationISRCTN ID, ISRCTN14315146 (retrospectively registered 18/11/2019).
Source: Cardiology and Therapy - January 31, 2020 Category: Cardiology Source Type: research

Time Trends in Cardiovascular Disease Mortality Across the BRICS: An Age-Period-Cohort Analysis of Key Nations with Emerging Economies Using the Global Burden of Disease Study 2017.
Conclusions: With the exception of Brazil, reductions of CVD mortality across the BRICS have been less than in North America, such that China, India and South Africa contribute an increasing proportion of global CVD deaths. Brazil's example suggests that prevention policies can both reduce the risks for younger birth cohorts and shift the risks for all age groups over time. PMID: 31941371 [PubMed - as supplied by publisher]
Source: Circulation - January 15, 2020 Category: Cardiology Authors: Zou Z, Cini K, Dong B, Ma Y, Ma J, Burgner DP, Patton GC Tags: Circulation Source Type: research

Efficacy and safety of thermic helium-oxygen (t-He/O2) mixture in reducing hypoxemia in acute ischemic stroke patients
Conclusions: t-He/O2 70/30% mixture is safe and effectively reduces severity of hypoxemia in AIS patients.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Kim, T., Chuchalin, A., Martynov, M., Gusev, E., Shogenova, L., Panin, A. Tags: Acute critical care Source Type: research

Influence of tobacco smoking on the state of endothelial function in residents of the Arctic zone of Western Siberia
We examined a total of 367 residents (29.7% of men, mean age of 47.8±13.5 years) during research expeditions in the village of Krasnosel’kup, village of Tolka and Ratta of Krasnoselkupsky district.The state of the vascular system, its ability to provide adequate blood supply to organs and tissues, was studied by the parameters of the vascular stiffness index (blood flow rate, SI, m/s). We studied a sample of values of the index of rigidity of vessels of above normal occur significantly more often among smokers of the respondents (U-7103.5; p=0.02) than non-smokers. In the analysis of the parameters of the refl...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Popov, A., Protasova, I., Lobanov, A., Andronov, S., Kochkin, R. Tags: Tobacco, smoking control and health educ. Source Type: research

Possible synergistic effect of apoE and LRP1 genotypes on metabolic syndrome development in Serbian patients.
Abstract The modern way of life contributes to the higher frequency of a complex state medically called metabolic syndrome (MetS), which is an inevitable consequence of several most common diseases of modern civilization. Patients with MetS have three times higher risk of experiencing a heart attack or a stroke and twice higher possibility to die from them. Serbia holds the infamous third place in Europe in mortality from heart disease, just behind Russia and Ukraine. The study explores the correlation of every combination of genotypes of apoE (apolipoprotein E) and LRP1 (low density receptor- related protein 1) g...
Source: Molecular Biology Reports - September 19, 2019 Category: Molecular Biology Authors: Vučinić N, Stankov K, Đan M, Barjaktarović I, Stokić E, Strajnić LJ, Obreht D, Đan I Tags: Mol Biol Rep Source Type: research

Predictors of Unfavorable Outcomes in Patients with Atrial Fibrillation and Concomitant Heart Failure with Different Ejection Fractions: RIF-CHF Register One-Year Follow-Up.
Conclusions: Each group of patients with different ejection fractions is characterized by its own pattern of factors associated with the development of unfavorable outcomes. The demographic and clinical characteristics of patients with midrange ejection fraction demonstrate that these patients need to be studied as a separate cohort. PMID: 31223501 [PubMed]
Source: Cardiology Research and Practice - June 22, 2019 Category: Cardiology Authors: Zhirov I, Safronova N, Osmolovskaya Y, Alshevskaya A, Moskalev A, Tereshchenko S Tags: Cardiol Res Pract Source Type: research

Tick-borne Encephalitis: Stroke-like Presentation
We report a unique case of clinical symptoms and radiological findings compatible with a stroke-like inflammatory lesion in the thalamus, suggesting microangiopathy from TBEV. Our case shows that TBEV could be a possible cause of stroke-like lesions.
Source: Journal of Stroke and Cerebrovascular Diseases - June 9, 2019 Category: Neurology Authors: Andreas Eleftheriou, Fredrik Lundin, Evangelos Alexandros Petropoulos Tags: Case Report Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Multifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. II. Modeling
In this study, we elaborate on a tentative interpretation of the observed intermittent dynamics during AF as the signature of synaptic plasticity. Typical individual GJC transition times between open and closed states were shown to be much longer than those of membrane polarization but compare well with membrane recovery time (≳ 100ms) (Spray et al., 1984; Neyton and Trautmann, 1986; Wang et al., 1992; Bukauskas and Verselis, 2004; Desplantez et al., 2007). Moreover, slow gating modulations have been evidenced due to cytoplasmic protons (low pH) and free calcium (Spray et al., 1984; Burt and Sray, 1988; Kumar and G...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

The Prevalence and Clinical Features of Fabry Disease in Hemodialysis Patients: Russian Nationwide Fabry Dialysis Screening Program
Conclusions: Screening in at-risk patients remains the feasible approach to diagnose Fabry disease in patients with ESRD and their family members, given a low awareness of Fabry disease among the Russian nephrologists.Nephron
Source: Nephron - January 27, 2019 Category: Urology & Nephrology Source Type: research

Podcast: Cerebrolysin for acute ischaemic stroke
When someone has an acute ischemic stroke, urgent and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin is widely used in post-Soviet countries, Eastern Europe, Central and Southeast Asia. In April 2017, the latest update of this review was published by researchers from Kazan Federal University in Russia and Chinara Razzakova, a PhD student from the university interviewed one of the authors, Liliya Eugenevna, for this podcast." This Cochrane Review is about a medicine called cerebrolysin, which is used...
Source: Cochrane News and Events - January 10, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news