Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs

This article presents an overview on recent advances in optical non-invasive diagnostics of the peripheral hemodynamics of the upper and lower limbs in rheumatological and endocrinological profile patients. Among these are laser Doppler flowmetry (LDF), tissue reflectance oximetry (TRO), pulse oximetry (PO) and fluorescent spectroscopy (FS). The laser Doppler flowmetry method allows for investigating the blood flow in the microcirculatory bed in vivo. The method is based on probing the tissue with laser radiation and analyzing back reflected from the tissue radiation partially scattered from moving red blood cells (Bonner and Nossal, 1990; Krupatkin and Sidorov, 2013). The tissue reflectance oximetry method provides information about the tissue oxygen saturation (StO2) of the examined biological tissue microcirculation and allows for calculation of the relative blood volume (Vb) in the surface layers of soft tissues (skin, mucous membranes). This technology is based on the ability of oxygenated and deoxygenated hemoglobin to absorb light in the red and near infrared range (Casavola et al., 1999; Wallace et al., 2009). Mechanisms that cause abnormal microcirculation in pathological processes can be quantified by use of wavelet transform for the records of LDF and TRO signals. The amplitude-frequency analysis of oscillations in skin blood flow allows distinguishing five frequency ranges corresponding to metabolic (endothelial) (Kvandal et al., 2003), neurogenic, myogenic (S&...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
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