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Total 370 results found since Jan 2013.

EE568 Tenecteplase or Alteplase for Acute Ischemic Stroke? A Cost-Effectiveness Analysis
Alteplase is widely used as intravenous thrombolytic medication in acute ischemic stroke (AIS). However, tenecteplase, a genetically modified form of alteplase, has recently been shown to result in higher recanalization rates, improved functional outcome and a similar safety profile in AIS patients with large vessel occlusion (LVO) compared to alteplase. Accordingly, this study aims to evaluate the cost-effectiveness of 0.25mg/kg tenecteplase versus 0.9mg/kg alteplase for thrombolysis in AIS patients due to LVO from the Dutch healthcare payer perspective.
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: C Nguyen, MMH Lahr, DJ Van der Zee, H Van Voorst, YBWEM Roos, M Uyttenboogaart, E Buskens Source Type: research

Factors Associated With the Development of Tinnitus and With the Degree of Annoyance Caused by Newly Developed Tinnitus
Objectives: Tinnitus is highly prevalent, but only a few risk factors for developing tinnitus are known and little is known about factors associated with the degree of annoyance of new-onset tinnitus. Longitudinal analysis can reveal risk factors associated with the development of tinnitus and might lead to targeted prevention. The aim of this study is twofold. (1) To identify risk factors that are longitudinally associated with the odds of developing tinnitus 5 years later. (2) To identify factors that are cross-sectionally associated with tinnitus annoyance in adults with new-onset tinnitus. Methods: Baseline,...
Source: Ear and Hearing - October 28, 2022 Category: Audiology Tags: Research Article Source Type: research

Malnutrition risk and oropharyngeal dysphagia in the chronic post-stroke phase
ConclusionIn this specific sample of referred stroke patients, moderate to severe OD and moderate to high risk of malnutrition were common. Despite the use of clinical practice guidelines on stroke and a normal nutritional status at first sight, repeated screening for malnutrition and monitoring the severity and management of OD remain important elements in the care of patients with chronic post-stroke OD.
Source: Frontiers in Neurology - September 28, 2022 Category: Neurology Source Type: research

Trigger Factors for Stroke in Young Adults: A Case-Crossover Study
DISCUSSION: We identified cola consumption, vigorous physical exercise, sexual activity, illicit drug use, fever- and flu-like disease as potential trigger factors for stroke in the young, and found differences in type and number of trigger factors associated with different etiologic subgroups of ischemic stroke. These findings might help in better understanding the pathophysiological mechanisms of (cryptogenic) stroke in the young.PMID:36127143 | DOI:10.1212/WNL.0000000000201341
Source: Atherosclerosis - September 20, 2022 Category: Cardiology Authors: Merel S Ekker Jamie Inge Verhoeven Karlijn Rensink Mijntje M I Schellekens Esther Boot Mayte van Alebeek Paul J A M Brouwers Renate Arntz Gert W van Dijk Rob A R Gons Inge van Uden Tom den Heijer Paul de Kort Karlijn de Laat Anouk Gw van Norden Sarah Verm Source Type: research

Safety during interhospital helicopter transfer of ventilated COVID-19 patients. No clinical relevant changes in vital signs including non-invasive cardiac output
CONCLUSIONS: Interhospital helicopter transfer of ventilated intensive care patients with COVID-19 can be performed safely and does not result in clinically relevant changes in vital signs.PMID:36123727 | DOI:10.1186/s12931-022-02177-5
Source: Respiratory Care - September 19, 2022 Category: Respiratory Medicine Authors: Cornelis Slagt Eduard Johannes Spoelder Marijn Cornelia Theresia Tacken Maartje Frijlink Sjoerd Servaas Guus Leijte Lucas Theodorus van Eijk Geert Jan van Geffen Source Type: research

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM < sub > 2.5 < /sub > , BC, NO < sub > 2 < /sub > , and O < sub > 3 < /sub > : An Analysis of European Cohorts in the ELAPSE Project
CONCLUSIONS: Long-term exposure to PM2.5, NO2, and BC was positively associated with natural-cause and cause-specific mortality in the pooled cohort and the administrative cohorts. Associations were found well below current limit values and guidelines for PM2.5 and NO2. Associations tended to be supralinear, with steeper slopes at low exposures with no indication of a threshold. Two-pollutant models documented the importance of characterizing the ambient mixture with both NO2 and PM2.5. We mostly found negative associations with O3. In two-pollutant models with NO2, the negative associations with O3 were attenuated to esse...
Source: Cancer Control - September 15, 2022 Category: Cancer & Oncology Authors: Brunekreef Bert Strak Maciej Chen Jie J Andersen Zorana Atkinson Richard Bauwelinck Mariska Bellander Tom Boutron Marie-Christine Brandt J ørgen Carey Iain Cesaroni Giulia Forastiere Francesco Fecht Daniela Gulliver John Hertel Ole Hoffmann Barbara de Ho Source Type: research

IJERPH, Vol. 19, Pages 11110: Estimating the Burden of Stroke: Two-Year Societal Costs and Generic Health-Related Quality of Life of the Restore4Stroke Cohort
Conclusions: The non-healthcare costs have a substantial impact on the first- and second-year total societal costs post-stroke. Therefore, to obtain a complete picture of all the relevant costs related to a stroke, a societal perspective with a follow-up of at least two years is highly recommended. Additionally, more research is needed to investigate the decline in QoL found in stroke patients above the age of 75 years.
Source: International Journal of Environmental Research and Public Health - September 5, 2022 Category: Environmental Health Authors: Ghislaine van Mastrigt Caroline van Heugten Anne Visser-Meily Leonarda Bremmers Silvia Evers Tags: Article Source Type: research

How is atrial fibrillation detected in everyday healthcare? Results of a  Dutch cohort study
CONCLUSION: Diagnosing AF is a multidisciplinary process. The irregular heartbeat was most often detected by the GP, but cardiologists diagnosed most cases. One-third of all newly diagnosed AF was silent.PMID:36048351 | DOI:10.1007/s12471-022-01719-2
Source: Netherlands Heart Journal - September 1, 2022 Category: Cardiology Authors: N Verbiest-van Gurp S B Uittenbogaart S C M van de Moosdijk U F van Sprang J A Knottnerus H E J H Stoffers W A M Lucassen Source Type: research

High Blood Pressure and Diabetes Are Linked. Here ’ s How to Reduce Your Risk for Both
High blood pressure—also known as hypertension—and Type 2 diabetes are two of the most common medical conditions in the U.S. Unfortunately, they often occur together. Some research has found that 85% of middle-aged or older adults who have Type 2 diabetes also have hyper­tension, and both conditions elevate a person’s risk for heart disease, stroke, and kidney disease. These increased risks are significant, and in some cases grave. Researchers have found that people with Type 2 ­diabetes are up to four times more likely to develop cardiovascular disease than those who don’t have the conditio...
Source: TIME: Health - August 29, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Disease freelance healthscienceclimate Source Type: news

P64 NIMBUS geometric clot extractor for tough clots: SPERO study results and clot composition
ConclusionsIn challenging cases with tough clot, first pass of NIMBUS retrieved clot richer in fibrin and lower in RBC content than clot retrieved with the first pass of standard MT devices.ReferencesFennell VS, Setlur Nagesh SV, Meess KM, Gutierrez L, James RH, Springer ME, Siddiqui AH. What to Do about Fibrin Rich ‘Tough Clots’? Comparing the Solitaire Stent Retriever with a Novel Geometric Clot Extractor in an in vitro Stroke Model. J Neurointerv Surg 2018 Sep;10(9):907–910. DOI: 10.1136/Neurintsurg-2017-013507. EPUB 2018 Jan 19. PMID: 29352061. Do you have any conflict of interest to declare?: YesConf...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: van den Berg, R., Ribo, M., Arnberg, F., Estrade, L., Thornton, J., Tomasello Weitz, A., Gontu, V., Karam, A., Hernandez, D., Clarencon, F., Buhk, J.-H., Wiesmann, M., Nouri, N., Bricout, N., Desal, H., Januel, A., Doyle, K., Liebeskind, D., Brouwer, P., Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

Risk of bleeding complications per different perioperative antithrombotic regimes during carotid endarterectomy: a national registry analysis
CONCLUSION: The effectiveness and safety of DAPT did not differ from single antiplatelet therapy (SAPT) in patients undergoing CEA and needs further evaluation in prospective studies. Considering additional data from the literature and guideline recommendations DAPT should be started immediately after stroke until 30 days after CEA followed by SAPT, due to possible reduction in the risk of recurrency.PMID:36031046 | DOI:10.1016/j.ejvs.2022.08.020
Source: PubMed: Eur J Vasc Endovasc ... - August 28, 2022 Category: Surgery Authors: Simone Ja Donners Joost M Mekke Eline S van Hattum Raechel J Toorop Gert J de Borst Dutch Audit for Carotid Interventions (DACI) Collaborators Source Type: research

Risk of Bleeding Complications With Different Peri-Operative Antithrombotic Regimens During Carotid Endarterectomy: a National Registry Analysis
Antithrombotic therapy is one of the cornerstones of the prevention of (recurrent) ocular or cerebral ischaemic events in patients with carotid artery stenosis. Randomised controlled trials on antithrombotic therapy for patients with minor ischaemic stroke and transient ischaemic attack (TIA) have recommended dual antiplatelet therapy (DAPT) in the three weeks following the index event. However, these trials excluded patients undergoing carotid revascularisation. To date, the optimal antithrombotic therapy during the peri-operative period of carotid endarterectomy (CEA) remains unclear.
Source: European Journal of Vascular and Endovascular Surgery - August 28, 2022 Category: Surgery Authors: Simone J.A. Donners, Joost M. Mekke, Eline S. van Hattum, Raechel J. Toorop, Gert J. de Borst, Dutch Audit for Carotid Interventions (DACI) Collaborators Source Type: research

Editor's Choice – Risk of Bleeding Complications With Different Peri-Operative Antithrombotic Regimens During Carotid Endarterectomy: a National Registry Analysis
Antithrombotic therapy is one of the cornerstones of the prevention of (recurrent) ocular or cerebral ischaemic events in patients with carotid artery stenosis. Randomised controlled trials on antithrombotic therapy for patients with minor ischaemic stroke and transient ischaemic attack (TIA) have recommended dual antiplatelet therapy (DAPT) in the three weeks following the index event. However, these trials excluded patients undergoing carotid revascularisation. To date, the optimal antithrombotic therapy during the peri-operative period of carotid endarterectomy (CEA) remains unclear.
Source: European Journal of Vascular and Endovascular Surgery - August 28, 2022 Category: Surgery Authors: Simone J.A. Donners, Joost M. Mekke, Eline S. van Hattum, Raechel J. Toorop, Gert J. de Borst, Dutch Audit for Carotid Interventions (DACI) Collaborators Source Type: research