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Total 370 results found since Jan 2013.

Spatial CT perfusion data helpful in automatically locating vessel occlusions for acute ischemic stroke patients
ConclusionThe spatial layout of the hypoperfused region can help to automatically indicate the vessel occlusion location for acute ischemic stroke patients. However, variations in vessel architecture between patients seemed to limit the capacity of CTP data to distinguish between vessel occlusion locations more accurately.
Source: Frontiers in Neurology - March 29, 2023 Category: Neurology Source Type: research

The frequency of CYP2C19 loss-of-function variants in patients with non-cardioembolic ischemic stroke or transient ischemic attack in the Dutch population
Discussion and conclusion: About a quarter of patients with non-cardioembolic ischemic stroke or TIA in the Dutch population carry a CYP2C19 LOF variant. This is lower than estimates found in studies with Asian populations, but similar to estimates found among Caucasian patients in other parts of the world.
Source: Cerebrovascular Diseases - March 22, 2023 Category: Neurology Source Type: research

Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry
Conclusions EVT should be considered in selected patients with AIS with an isolated PCA occlusion, presenting with moderate–severe neurological deficits, as EVT was technically feasible in most of our patients and about half had good clinical outcome. In case of lower NIHSS score, a more conservative approach seems warranted, since periprocedural complications are not uncommon. Nonetheless, EVT seems reasonably safe considering the absence of sICH in our study.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Brouwer, J., Ergezen, S., Mulder, M. J. H. L., Lycklama a Nijeholt, G. J., van Es, A. C. G. M., van der Lugt, A., Dippel, D. W. J., Majoie, C. B. L. M., Roos, Y. B. W. E. M., Coutinho, J. M., Emmer, B. J., on behalf of the MR CLEAN Registry investigators, Tags: Ischemic stroke Source Type: research

MRI for all: Cheap portable scanners aim to revolutionize medical imaging
.news-article__hero--featured .parallax__element{ object-position: 47% 50%; -o-object-position: 47% 50%; } The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing. The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research

Electrophysiological evidence for the enhancement of gesture-speech integration by linguistic predictability during multimodal discourse comprehension
Cogn Affect Behav Neurosci. 2023 Feb 23. doi: 10.3758/s13415-023-01074-8. Online ahead of print.ABSTRACTIn face-to-face discourse, listeners exploit cues in the input to generate predictions about upcoming words. Moreover, in addition to speech, speakers produce a multitude of visual signals, such as iconic gestures, which listeners readily integrate with incoming words. Previous studies have shown that processing of target words is facilitated when these are embedded in predictable compared to non-predictable discourses and when accompanied by iconic compared to meaningless gestures. In the present study, we investigated ...
Source: Cognitive, Affective and Behavioral Neuroscience - February 23, 2023 Category: Neuroscience Authors: Florian Hintz Yung Han Khoe Antje Strau ß Adam Johannes Alfredo Psomakas Judith Holler Source Type: research

Cohort profile: the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) Study-an ongoing prospective cohort study of patients at high cardiovascular risk in the Netherlands
This article provides an update of the rationale, design, included patients, measurements and findings from the start in 1996 to date. Participants The UCC-SMART Study includes patients aged 18–90 years referred to the University Medical Center Utrecht, the Netherlands, for management of cardiovascular disease (CVD) or severe cardiovascular risk factors. Since September 1996, a total of 14 830 patients have been included. Upon inclusion, patients undergo a standardised screening programme, including questionnaires, vital signs, laboratory measurements, an ECG, vascular ultrasound of carotid arteries and aorta, ankle...
Source: BMJ Open - February 20, 2023 Category: General Medicine Authors: Castelijns, M. C., Helmink, M. A. G., Hageman, S. H. J., Asselbergs, F. W., de Borst, G. J., Bots, M. L., Cramer, M. J., Dorresteijn, J. A. N., Emmelot-Vonk, M. H., Geerlings, M. I., de Jong, P. A., van der Kaaij, N. P., Kappelle, L. J., Lely, A. T., van Tags: Open access, Cardiovascular medicine Source Type: research

Safety and effectiveness of rivaroxaban for prevention of stroke in patients with nonvalvular atrial fibrillation: analysis of routine clinical data from four countries
CONCLUSIONS: Incidences of intracranial bleeding were generally lower with rivaroxaban than with SOC, whereas incidences of gastrointestinal and urogenital bleeding were generally higher. The safety profile of rivaroxaban for NVAF in routine practice is consistent with findings from randomized controlled trials and other studies.PMID:36795067 | DOI:10.1080/14740338.2023.2181334
Source: Expert Opinion on Drug Safety - February 16, 2023 Category: Drugs & Pharmacology Authors: Luis Alberto Garc ía-Rodríguez Ana Ruig ómez Tania Schink Annemarie Voss Elisabeth Smits Karin M A Swart Yanina Balabanova Kiliana Suzart-Woischnik Gunnar Brobert Ron M C Herings Source Type: research

Unlucky numbers: Fighting murder convictions that rest on shoddy stats
LEIDEN, THE NETHERLANDS— When a Dutch nurse named Lucia de Berk stood trial for serial murder in 2003, statistician Richard Gill was aware of the case. But he saw no reason to stick his nose into it. De Berk was a pediatric nurse at Juliana Children’s Hospital in The Hague. In 2001, after a baby died while she was on duty, a colleague told superiors that De Berk had been present at a suspiciously high number of deaths and resuscitations. Hospital staff immediately informed the police. When investigators reexamined records from De Berk’s shifts, they found 10 suspicious incidents. Three other hospitals where D...
Source: Science of Aging Knowledge Environment - January 19, 2023 Category: Geriatrics Source Type: research

Risk of Bleeding Complications With Different Peri-Operative Antithrombotic Regimens During Carotid Endarterectomy: a National Registry Analysis
Antithrombotic therapy is one of the cornerstones of the prevention of (recurrent) ocular or cerebral ischaemic events in patients with carotid artery stenosis. Randomised controlled trials on antithrombotic therapy for patients with minor ischaemic stroke and transient ischaemic attack (TIA) have recommended dual antiplatelet therapy (DAPT) in the three weeks following the index event. However, these trials excluded patients undergoing carotid revascularisation. To date, the optimal antithrombotic therapy during the peri-operative period of carotid endarterectomy (CEA) remains unclear.
Source: Journal of Vascular Surgery - January 19, 2023 Category: Surgery Authors: S.J.A. Donners, J.M. Mekke, E.S. van Hattum, R.J. Toorop, G.J. de Borst, Dutch Audit for Carotid Interventions (DACI) Collaborators Source Type: research

Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study
CONCLUSIONS: Patients suffering from cardiovascular events and mortality were characterized by prior cardiovascular events as compared to patients who did not experience any events. Antiplatelet therapy was not optimally protective despite high medication adherence, and HTPR was independently associated with the occurrence of events. More research is needed on alternative treatment strategies such as dual antiplatelet therapy or combinations with anticoagulant drugs.TRIAL REGISTRATION: The Medical Ethics Committee (METC) of the MUMC+ approved the study (NL63235.068.17) and the study was registered in the Netherlands Trial ...
Source: Atherosclerosis - January 10, 2023 Category: Cardiology Authors: B M M Kremers J H C Daemen H Ten Cate H M H Spronk B M E Mees A J Ten Cate-Hoek Source Type: research

Drivers of healthcare costs in patients with ischaemic stroke: a hospital-based retrospective cohort study
Conclusion The number of admitted days was the most important driver of costs in all subgroups of patients with ischaemic stroke. This implicates that to reduce healthcare costs for patients who had a stroke, focus should be on reducing length of hospital stay.
Source: BMJ Open - January 3, 2023 Category: General Medicine Authors: Mensing, L. A., Kappelle, L. J., Koffijberg, H., Ruigrok, Y. M. Tags: Open access, Neurology Source Type: research

Measuring communication as a core outcome in aphasia trials: Results of the ROMA-2 international core outcome set development meeting
CONCLUSIONS & IMPLICATIONS: Consensus was achieved that TST was the preferred communication OMI for inclusion in the ROMA COS. It is currently available in the original Dutch version and has been adapted into English, German and Greek. Further consideration must be given to the best way to measure communication in people with mild aphasia. Development of a patient-reported measure for satisfaction with/impact of treatment and multilingual versions of all OMIs of the COS is still required. Implementation of the ROMA COS would improve research outcome measurement and the quality, relevance, transparency, replicability and ef...
Source: International Journal of Language and Communication Disorders - December 30, 2022 Category: Speech-Language Pathology Authors: Sarah J Wallace Linda Worrall Tanya A Rose Reem S W Alyahya Edna Babbitt Suzanne Beeke Carola de Beer Arpita Bose Audrey Bowen Marian C Brady Caterina Breitenstein Stefanie Bruehl Lucy Bryant Bonnie B Y Cheng Leora R Cherney Paul Conroy David A Copland Cl Source Type: research

Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke: results from the MR CLEAN Registry
CONCLUSIONS: Functional outcomes were comparable after EVT with and without CAS. CAS during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.PMID:36572506 | DOI:10.1136/svn-2022-001891
Source: Atherosclerosis - December 26, 2022 Category: Cardiology Authors: Sabine L Collette Michael P Rodgers Marianne A A van Walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper M Martens Gert J de Borst Gert Jan R Luijckx Charles B L M Majoie Aad van der Lugt Reinoud P H Bokkers Maarten Uyttenboogaart MR Source Type: research