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Total 262 results found since Jan 2013.

Did post-Soviet Russians drink themselves to death?
By Vladimir Popov and Jomo Kwame SundaramMOSCOW and KUALA LUMPUR, Oct 23 2018 (IPS)Although initially obscured by The Economist, among others, the sudden and unprecedented increase in Russian adult male mortality during 1992-1994 is no longer denied. Instead, the debate is now over why?Having advocated ‘shock therapy’, a ‘big bang’, ‘sudden’ or rapid post-Soviet transition, Jeffrey Sachs and others have claimed that the sudden collapse in Russian adult male life expectancy was due to a sudden increase in alcohol consumption, playing into popular foreign images of vodka-binging Russian men. In Russia, vodka is a...
Source: IPS Inter Press Service - Health - October 23, 2018 Category: International Medicine & Public Health Authors: Vladimir Popov and Jomo Kwame Sundaram Tags: Development & Aid Economy & Trade Europe Global Governance Headlines Health TerraViva United Nations Source Type: news

A3 Adenosine Receptor Antagonists and Partial Agonists (U.S. Patent Application Number 13/056,997)
Disclosed are A3 adenosine receptor antagonists and/or partial agonists of formula (I): wherein R1 to R5 are as described herein, as well as pharmaceutical compositions thereof and methods of use thereof. The antagonists or partial agonists find use in treating a number of diseases including cancer, glaucoma, inflammatory diseases, asthma, stroke, myocardial infarction, allergic reactions, rhinitis, poison ivy induced responses, urticaria, scleroderma, arthritis, brain arteriole diameter constriction, bronchoconstriction, and myocardial ischemia, as well as in preventing cardiac ischemia. Also disclosed are radiolabeled co...
Source: NIDDK Research Resources - August 16, 2018 Category: Endocrinology Source Type: research

Pellets in the Eye: Cerebral Aneurysm and Encephalomyeloneuropathy as Presenting Syndromes
Lead poisoning following retained gunshot pellets resulting in recurrent episodes of encephalomyeloneuropathy is rare and association of intracranial aneurysm with lead poisoning is interesting. The case report describes about a 58-year ayurvedic doctor who was hospitalized for recurrent abdominal pain and limb weakness appearing spontaneously and improving in a few days to weeks. He had 20 such attacks in last 30  years starting at 25 years after the gunshot wound that resulted in retention of 2 lead pellets in his skull.
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2018 Category: Neurology Authors: Sanjeev K. Bhoi, Suprava Naik, Jayantee Kalita, Usha K. Misra Tags: Case Report Source Type: research

Extensive brain infarction and acute kidney injury in a young adult with methanol intoxication: A case report and review of the literature 
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CONCLUSIONS: Methanol intoxication should be in the differential diagnosis of patients with brain infarction and high anion gap metabolic acidosis. Early use of renal replacement therapy may be life-saving and should be tailored on an individual basis.
. PMID: 29932410 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - June 22, 2018 Category: Urology & Nephrology Authors: Vasquez-Rios G, Alkhankan H, Sawaya BP, Neyra JA Tags: Clin Nephrol Source Type: research

Carotid ergotism with retinal ischemia
Ergot poisoning was first described more than 2,000 years ago with the consumption of food contaminated with mycotoxins. It acquired special importance during the 20th century because of an excessive consumption of ergot pharmaceuticals as symptomatic treatment of migraine.1,2
Source: Neurology Clinical Practice - April 9, 2018 Category: Neurology Authors: Altuna-Azkargorta, M., Herrera-Isasi, M., Zandio-Amorena, B., Bacaicoa-Saralegui, M. C. Tags: Migraine, All Clinical Neurology, All Cerebrovascular disease/Stroke, Critical care Case Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Multiple admissions to the coronary care unit due to falsely elevated cardiac troponin.
Abstract The measurement of cardiac troponin, released from injured cardiomyocytes, is of paramount importance in the diagnosis of acute myocardial infarction. Elevated troponin can be encountered, however, in patients with cardiomyopathy, significant cardiac arrhythmias, vasculitis, right-sided heart strain, critical systemic illnesses, stroke, drug toxicity (such as Adriamycin), poisons (such as snake venoms), renal failure, seizure, and rhabdomyolysis. If the clinical picture is not consistent with any of these causes, a false-positive result should be considered. We herein describe a 94-year-old man with a pri...
Source: Baylor University Medical Center Proceedings - April 1, 2018 Category: Universities & Medical Training Authors: Ayan M, Gheith Z, Ananthula A, Salih M, Vallurupalli S, Mehta JL Tags: Proc (Bayl Univ Med Cent) Source Type: research

Neurological diseases and risk of suicide attempt: a case –control study
ConclusionNine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.
Source: Journal of Neurology - March 21, 2018 Category: Neurology Source Type: research

Binge Drinkers Have About 7 Drinks At a Time, CDC Says
It’s no secret that binge drinking is common in the U.S., as a visit to most college campuses will demonstrate. But a new report from the Centers for Disease Control and Prevention (CDC) finds that the practice is widespread beyond the college years, well into adulthood. More than 37 million Americans, or 17% of the adult population, reported binge drinking — defined as consuming four or more drinks in one sitting for women, or five or more for men — at least once in 2015, according to the report. Many people binge drank far more frequently than that: The average number of episodes per binge drinker was 5...
Source: TIME: Health - March 16, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime public health Source Type: news

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research

Relapse of Takayasu arteritis as a cause of suicidal poisoning and subsequent major ischemic stroke successfully treated with thrombolytic therapy - Komatina N, Lepi ć T, Labović B, Stevović T, Petronijević M, Radovinović-Tasić S, Obradović D.
INTRODUCTION: Takayasu arteritis (TA) is a rare large vessel arteritis, affecting primarily aorta and its major branches. Its clinical manifestations can vary significantly - from asymptomatic to serious vascular events. Acute neurological complications ar...
Source: SafetyLit - January 16, 2018 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Isolated persistent acute global amnesia after acute abuse of 3,4-methylenedioxy-methamphetamine (MDMA)
Acute global amnesia can occur, due to bilateral hippocampus dysfunction. Causes include the idiopathic syndrome of transient global amnesia, bilateral posterior circulation stroke,. toxic anoxia due to carbon monoxyde poisoning and substance abuse probably combining hypoxia and direct hippocampal neurotoxicity.
Source: Journal of the Neurological Sciences - January 4, 2018 Category: Neurology Authors: Fabien Hauw, Elodie Meppiel, Olivier Steichen, Pierre-Louis Conan, Jean Capron, Thomas de Broucker Tags: Letter to the Editor Source Type: research

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Received: 22 December 2016 Revised: 17 September 2017 Accepted: 19 September 2017 Published: 19 October 2017 Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Role of Nitric Oxide from Neurological Disease to Cancer.
Authors: Maher A, Abdel Rahman MF, Gad MZ Abstract Until the beginning of the 1980s, nitric oxide (NO) was just a toxic molecule of a lengthy list of environmental pollutants such as cigarette smoke and smog. In fact, NO had a very bad reputation of being destroyer of ozone, suspected carcinogen and precursor of acid rain. However, by the early 1990s it was well recognized by the medical research community. Over the last two decades, the picture has been totally changed. Diverse lines of evidence have converged to show that this sometime poison is a fundamental player in the everyday business of the human body. NO ...
Source: Advances in Experimental Medicine and Biology - August 27, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research