Anthrose Based Compositions and Related Methods US 2015/0265691
This invention provides a vaccine comprising (i) a conjugate of an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in a subject, wherein the anthrose-containing saccharide is conjugated to a biomolecule via a linker, and (ii) a pharmaceutically acceptable carrier. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - October 16, 2018 Category: Endocrinology Source Type: research
S1P1 Luciferase Signaling Mouse
S1P1 luciferase signaling mice enable the bioluminescent detection of sphingosine-1-phosphate receptor 1 (S1P1) activation in real time. A synthetic S1P1 signaling pathway, designed to report the interaction between S1P1and β-arrestin2 via the firefly split luciferase fragment complementation system, is genetically encoded in these mice. Upon receptor activation and subsequent β-arrestin2 recruitment, an active luciferase enzyme complex is produced, which can be detected by in vivo bioluminescence imaging. Learn more onPubMed.Mice can be obtained by contacting the NIDDK Technology Advancement Office. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Sgpp2 KO Mouse
Also known as:Sgpp2tm1Rlp, sphingosine-1-phosphate (S1P) phosphatase 2 KO mouseIntracellular metabolism of sphingosine-1-phosphate (S1P) is controlled, in part, by two homologous S1P phosphatases (SPPases), 1 and 2, which are encoded by theSgpp1 andSgpp2 genes, respectively. SPPase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway.Sgpp2 KO mice exhibit decreased adaptive pancreatic β-cell proliferation and β-cell endoplasmic reticulum stress, revealing the importance of the sphingolipid recycling pathway in β-cell physiology. Learn more onPubMed.Mice can be obtained by con...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
GD3 Synthase KO Mouse
Also known as:St8sia1tm1Rlp,GD3S KO mouseGD3 synthase (GD3S), encoded bySt8sia1, is a sialyltransferase expressed in the nervous system, that is responsible for the synthesis of b-series gangliosides.St8sia1 KO mice, even with an absence of b-series gangliosides, appear to undergo normal development and have a normal life span. WhenSt8sia1 mutant mice are crossbred with mice carrying a disruptedB4galnt1gene, the double KO mice express GM3 as their major ganglioside. In contrast to the single KO mice, the double KO mice display a sudden death phenotype and are extremely susceptible to induction of lethal seizures by sound s...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
GalNAcT KO Mouse
Also known as:B4galnt1tm1Rlp, GM2/GD2 synthase KO mouseB4galnt1 KO mice lack complex gangliosides and instead express high levels of simple gangliosides GM3 and GD3. The KO mice display decreased central myelination, axonal degeneration in both the central and peripheral nervous systems, and demyelination in peripheral nerves. The male KO mice are infertile due to defective spermatogenesis. Learn more onPubMed.Mice can be obtained from MMRRC. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Asah2 KO Mouse
Also known as:Asah2tm1Rlp, neutral ceramidase KO mouseAsah2KO mice lack expression of neutral ceramidase, which is highly expressed in the intestinal epithelia.Asah2 KO mice are viable and grossly normal, lack expression of neutral ceramidase and have a defective capacity to degradation dietary sphingolipids. Learn more onPubMed.Mice can be obtained from MMRRC. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Floxed Sptlc1 Mouse
Also known as:Sptlc1tm1.1RlpTheSptlc1tm1.1Rlp allele has loxp sites flanking exons 4 and 5. When the Cre gene is expressed under the control of the Adipoq promotor, theSptlc1 expression and sphingolipid levels is reduced in adipocytes. The mice are useful for producing the conditional disruption of theSptlc1, an essential subunit of serine palmitoyl transferase. Learn more onPubMed.Mice can be obtained from MMRRC. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Floxed Ugcg Mouse
Also known as:Ugcgtm4Rlp, floxed glucosylceramide synthase mouse, floxedGlcT mouseUgcgtm4Rlp allele has loxp sites in intron 6 and in the 3 ’ untranslated region. Cre expression would be predicted to delete exons 6,7,8 and 9. Cre recombinase expression in the nervous system under control of thenestin promoter causes a substantial reduction ofUgcg expression and of ganglioside content. The mice deficient inUgcg expression in the nervous system showa loss of Purkinje cells and abnormal neurologic behavior. Learn more onPubMed.Mice can be obtained from MMRRC. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
GM3 Synthase KO Mouse
Also known as:St3gal5tm1Rlp,St3gal5 KO mouseTheSt3gal5 KO mice are viable and appear grossly normal but show a heightened sensitivity to insulin. A basis for the increased insulin sensitivity in the mutant mice is enhanced insulin receptor phosphorylation in skeletal muscle. The mutant mice are protected from high-fat diet-induced insulin resistance. Learn more onPubMed.Mice can be obtained from MMRRC. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
S1P1 GFP Signaling Mouse
Also known as:S1pr1tm3.1(tTA,-Arrb2)Rlp, S1P1 Tango mouseTheseS1pr1 knockin mice have a bicistronic transcription unit inserted at the C-terminus of exon 2 of the sphingosine-1-phosphate receptor 1 (S1pr1) gene. Specifically, the allele contains two fusion proteins, a tetracycline-regulated transactivator (tTA)-tobacco etch virus (TEV) protease recognition sequence (tevs) fusion protein and anArrb2 (murine β-arrestin)-TEV protease fusion protein, separated by an internal ribosome entry site (IRES). Homozygous mice are viable and fertile. S1PR1 is a G protein-coupled receptor (GPCR) that acts as a regulator of vascular dev...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Gm2 Activator Deficiency Disease Mouse
Also known as:Gm2atm1Rlp ,Gm2a KO mouse, AB Variant of GM2 gangliosidosis mouseGm2a KO mice demonstrate neuronal storage of GM2 ganglioside in restricted regions of the brain (piriform, entorhinal cortex, amygdala, and hypothalmic nuclei) reminiscent of the asymptomatic Tay-Sachs disease mice. They also display abnormal ganglioside storage in the cerebellum and exhibit defects in balance and coordination. Mice homozygous for theGm2atm1Rlp targeted mutation serve as a model of the human genetic disease known as the AB Variant of GM2-gangliosidosis or GM2 activator deficiency (OMIM#272750). Learn more onPubMed.Mice can be ob...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Tay-Sachs Disease Mouse
Also known as:Hexatm1Rlp,Hexa KO mouseTheseHexa knock-out mice exhibit accumulation of GM2 ganglioside in the central nervous system. They are suitable for use in applications related to the study of Tay-Sachs disease in humans. Learn more onPubMed.Mice can be obtained from Jackson Labs. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Sandhoff Disease Mouse
Also known as:Hexbtm1Rlp,Hexb KO mouseHexb KO mice develop motor defects beginning at about 3 months of age. The defects progressively worsen and homozygous mice die by 4.5 months of age. Mice display gangliosidosis; mice abnormally accumulate GM2 and GA2 ganglioside and serve as a model of Sandhoff disease. Learn more onPubMed.Mice can be obtained from Jackson Labs. (Source: NIDDK Research Resources)
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
GbaL444P Knock-in Mouse
Also known as:Gbatm1Rlp, Type 3 Gaucher disease mouseGaucher disease, the most common lysosomal storage disease, is caused by mutations in the gene encoding the lysosomal enzyme, glucocerebrosidase encoded by the Gba gene. The L444P mutation in GBA is associated with type 3 Gaucher disease. TheGbatm1Rlp allele carries the L444P mutation. Mice homozygous for theGbatm1Rlp allele have reduced glucocerebrosidase activity and diewithin 48 hr of birth, of a compromised epidermal permeability barrier caused by defective glucosylceramide metabolism in the epidermis. Learn more onPubMed.Mice can be obtained from MMRRC. (Source: NID...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
Floxed S1pr1 Mouse
Also known as:S1pr1tm2.1Rlp, floxedS1P1 mouseS1pr1 is a member of the sphingosine-1-phosphate G-protein coupled receptor family.S1pr1 is essential for vascular maturation during embryonic development and is involved in in the regulation of innate and adaptive immune responses by controlling lymphocyte egress from the thymus, spleen, bone marrow, and lymph nodes. It has also been implicated in the regulation of vascular function. TheseS1pr1loxP/loxP mice possessloxP sites flanking exon 2 of the sphingosine-1-phosphate receptor 1 (S1pr1) gene. Mice that are homozygous for the floxed allele are viable and fertile. When these ...
Source: NIDDK Research Resources - September 17, 2018 Category: Endocrinology Source Type: research
