Endocrine Disruptors and Health Effects in Africa: A Call for Action

Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspondence to M. Bornman, Dean’s Office and School of Health Systems and Public Health, Faculty of Health Sciences, Health Sciences Building, Room 4.14, Bophelo Rd., Gezina, Private Bag X323, Pretoria 0001, South Africa. Telephone: 012 319 2206. Email: Riana.Bornman@up.ac.za None of the authors is employed or was funded by any of the companies sponsoring the Endocrine Disrupting Chemicals (EDCs) in Africa meeting from which this commentary draws information and opinion. B.B. receives royalties from various patents related to PPARgamma, SXR, and BXR. J.D. is employed by the International Persistent Organic Pollutants (POPs) Elimination Network (IPEN), a network of public interest nongovernmental organizations working in more than 100 countries to reduce and eliminate the harm to human health and the environment from toxic chemicals. J.D. receives no personal ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research

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The objective of this study was to evaluate the change over time in the number of alternative surgical procedures (meniscectomy and meniscus repair) and regional variation in France using data from the French agency for information on hospital care (ATIH).HypothesisWe hypothesized that the number of meniscectomy procedures will decrease, and the number of repair procedures will increase over time at various healthcare facilities.Patients and methodsBetween 2005 and 2017, the number of hospitalizations in the Medicine-Surgery-Obstetrics wards for meniscectomy (NFFC003 and NFCC004) or meniscus repair (NFEC001 and NFEC002) wa...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
DiscussionOur starting hypothesis was confirmed for the complication rate and clinical outcomes. The benefits of dual mobility cups are emphasized. While the indications for TFR are rare, they will likely increase in the coming years.Level of evidence: IV, Retrospective cohort study…
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Conclusion: Tacrolimus may be associated with optic neuropathy and PRES at the initial presentation to an ophthalmologist.Case Rep Ophthalmol 2019;10:140 –144
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db(db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. The retinal thickness was measured using optical coherence tomography (OCT) at 4 weeks after treatments. The retinal expression and serum levels of vascular formation, inflammation, and oxidative stress-associated molecules were examined. Our results demonstrated...
Source: Ophthalmic Research - Category: Opthalmology Source Type: research
Conclusions: Eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings show similar prevalence of SCME and CIME, independent of the severity of the retinopathy. Retinal edema is located mainly in the INL and appears to be mostly extracellular except in the earliest stages of diabetic retinal disease where intracellular edema predominates.Ophthalmic Res
Source: Ophthalmic Research - Category: Opthalmology Source Type: research
Publication date: Available online 24 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Brooke Liang, Sara S. Lange, L. Stewart Massad, Rebecca Dick, Kathryn A. Mills, Andrea R. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Katherine C. Fuh, David G. Mutch, Matthew A. Powell, Lindsay M. KurokiAbstractObjectiveTo assess the renal outcomes of gynecologic oncology patients who present with hydronephrosis and acute kidney injury (AKI), have
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee DoAbstractPostmenopausal obesity is becoming a serious global health concern. Soyasaponin Ab (SA) inhibits adipocyte differentiation; however, the preventive and therapeutic potential of SA in postmenopausal obesity has not been clearly established. Here, we investigated the anti-obesity effects of SA in postmenopausal obesity in vitro and in vivo. SA inhibited adipocytic differentiation of 3T3-L1 cells and reduced lipid accumulati...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
In conclusion, STH have shown a chemo-preventive action on different colon cancer cell models.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study aimed to investigate the effect of stevioside on fatty liver. Rats with hyperlipidemic fatty liver were treated with 75–150 mg/kg stevioside for 6 weeks. After oral administration of stevioside, the levels of serum and hepatic lipids and degree of hepatic steatosis were decreased. Stevioside treatment increased the expressions of hepatic peroxisome proliferator-activated receptor (PPAR)α and carnitine palmitoyltransferase-1A proteins and decreased the expressions of hepatic sterol regulatory element-binding protein-1c, fatty acid synthase and diacylglycerol acyltransferase proteins. Following tre...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun WangAbstractDiabetes mellitus (DM) and its related complications are the serious public health concern globally. This is the first review highlight on major functional foods and herbs with anti-diabetic activity particularly focus on type 2 diabetes mellitus (T2DM) with special reference to clinical trials and their proposed anti-diabetic mechanisms. This contribution summarizes the current prevalence of DM, etiology and pathophysiology, complications related to DM, current conventional treatm...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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