Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury

Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. Modafinil appears to have the potential to improve wakefulness in patients with TBI. A prospective, double-blinded, randomized, crossover trial of modafinil for the management of fatigue in ischemic stroke patients is currently being conducted, and further studies demonstrating consistent results are needed before making a conclusive decision. Keywords: Traumatic brain injury, TBI, excessive daytime sleep, modafinil, fatigue, stroke, head injury Each year in the United States, as many as 1.7 million individuals are thought to experience some form of a traumatic brain injury (TBI)- inducing event.1,2 Falls appear to be the most common cause of head injury leading to TBI (28%).3 Other medical events can also result in TBI, such as stroke, automotive accidents, and neurologic degenerative diseases. Two of the most commonly reported complications following T...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

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AbstractGambling is a popular activity among older adults. Despite this increase in popularity little research has examined gambling among this group. This is especially true for minority older adults, like Francophones in Ontario. The purpose of this study was to better understand gambling in a sample of older Francophones from North-Eastern Ontario, the first study to do so. A sample of 181 older (over 55  years) Francophones from Northeastern Ontario (M age = 68.7, SD 7.6) was recruited. This sample was compared to a sample of older adults with English as their native language that had been previously...
Source: Journal of Gambling Studies - Category: Addiction Source Type: research
AbstractInternet gambling has been widely legalised in recognition of its capacity to, and the importance of, providing consumer protection tools to prevent and minimise gambling-related harms. Most licensed Internet gambling sites are required to provide consumer protection tools, including activity statements, deposit limits, and time-outs (temporary self-exclusion). However, few Internet gambling customers engage with the tools. An online survey of 564 customers of Australian Internet gambling sites aimed to understand the extent to which consumer protection tools are used, characteristics of those using these tools, an...
Source: Journal of Gambling Studies - Category: Addiction Source Type: research
CONCLUSIONS: These preliminary findings suggest that CRF and by proxy physical activity may be important factors in understanding the increased risk of cardiovascular and metabolic disease associated with PTSD. PMID: 32060558 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
CONCLUSIONS: These findings support the use of patient experiences and feedback to aide product development. In addition, post-9/11 veterans support the use of eScreening to assist health screening. However, evaluating the eScreening program in more diverse veteran groups and Veterans Affairs settings is needed to improve the generalizability of these findings to the larger veteran population. PMID: 32060553 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Teixeira JC, Jackson PJ Abstract Distinguishing between central and peripheral causes of vertigo can be challenging not only in an acute setting but also in chronic settings. A thorough review of systems and physical exam can assist providers in differentiating central versus peripheral etiologies and the need for urgent imaging. In this case, a 47-year-old man presented with vertigo, right-sided hearing loss, right-sided headache, and right-sided facial pain that began 4 weeks before while the patient was on a cruise ship. His physical exam findings were notable for anisocoria with right pupil 3.5 an...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
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Source: Journal of Mental Health Policy and Economics - Category: Psychiatry Tags: J Ment Health Policy Econ Source Type: research
While the unemployment rate remains low in central Arkansas, income growth in the region has lagged behind that of the rest of the United States, notes the Metroplan report “Metro Trends: Economic Review and Outlook.”
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
This is the first study to comprehensively measure both anatomical and non ‚Äźanatomical OSA traits during sleep in those with COPD + OSA (Overlap syndrome) and compare them to those with OSA alone. No consistent differences were found between the two groups, while worsened lung function did impact upper airway function and control of breathing. These findings have impli cations towards mechanisms underlying OSA, as well as management of sleep apnea. AbstractOverlap syndrome (OVS) is the concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), and is associated with poor outc...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Kolomeets NS, Uranova NA Abstract There is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity found in the major psychiatric disorders. The putamen, which is an important hub in the cortico-striato-thalamo-cortical loop, has been implicated in a broad spectrum of psychiatric illnesses and is a central target of their treatments. Previously we reported a reduction in the numerical density of oligodendrocytes and oligodendrocyte clusters in the prefrontal and parietal cortex in schizophrenia. Oligodendrocyte clusters contai...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
In this study, gels showed complex intelligence similar to natural skin, and might find applications in artificial intelligence, human-mechanial interactions, and smart wearable devices.Graphical abstract
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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