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Condition: Motor Neurone Disease

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Total 256 results found since Jan 2013.

Pain and muscles properties modifications after botulinum toxin type A (BTX-A) and radial Extracorporeal Shock Wave (rESWT) combined treatment.
CONCLUSIONS: Radial Extracorporeal Shock Wave Therapy could be an effective physical treatment aimed at the reduction of upper and lower limbs spasticity and could lead to the improvement of trophic conditions of the spastic muscles in post-stroke. PMID: 30843498 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 8, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Inj...
Source: The Lancet Neurology - March 16, 2019 Category: Neurology Source Type: research

Prevalence and Treatment Characteristics of Spastic Hypertonia on First-Time Admission to Acute Inpatient Rehabilitation
Conclusions Spasticity is a common sequela of upper motor neuron injury for patients admitted to inpatient rehabilitation. Early recognition and management are essential to prevent contractures, minimize pain, and maximize functional recovery.
Source: American Journal of Physical Medicine and Rehabilitation - March 23, 2022 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Neurons in the brain switch identity and re-route fibres | Mo Costandi
New findings could one day lead to gene therapies for stroke and spinal cord injuriesThese drawings by Santiago Ramón y Cajal show the cellular structure of three different areas of the human cerebral cortex. The cortex is the seat of higher mental functions such as language and decision-making, and contains dozens of distinct, specialised areas. As Cajal's drawings show, it has a characteristic layered structure, which differs somewhat from one area to the next, so that the layers vary in thickness according to the number of cells they contain. Cells throughout the cortex are arranged in a highly ordered manner. Those in...
Source: Guardian Unlimited Science - February 26, 2013 Category: Science Tags: Blogposts Health guardian.co.uk Neuroscience Source Type: news

A Compilation of Spasticity Studies Evaluating Onabotulinumtoxin A (P3.042)
CONCLUSIONS: OnabotulinumtoxinA has been extensively studied for treatment of spasticity against a variety of rating scales/assessments and outcomes measures.Study Sponsored by: Allergan, Inc.Disclosure: Dr. Patel has received personal compensation for activities with Allergan Inc. Dr. Manack has received personal compensation for activities with Allergan Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Patel, P., Manack, A. Tags: Neural Repair and Neuro-rehabilitation: Clinical Source Type: research

When is feeding via a percutaneous endoscopic gastrostomy indicated?
Purpose of review: This review addresses current controversies regarding appropriate indications for percutaneous endoscopic gastrostomy (PEG) insertion. We address specific indications, namely, dementia, stroke, aspiration, motor neurone disease/amyotrophic lateral sclerosis, and head and neck cancer. We recommend practical strategies for improving patient selection. Recent findings: There is now a general consensus in the United States that PEG feeding does not benefit patients with advanced dementia. ‘Early’ PEG insertion following stroke is similarly of no benefit. It is currently unclear whether patients with amyo...
Source: Current Opinion in Gastroenterology - February 6, 2015 Category: Gastroenterology Tags: NUTRITION: Edited by Eamonn M.M. Quigley Source Type: research

Manifestations of an Uncommon Pontine Insult, Eight-and-a-Half Syndrome (P1.029)
CONCLUSIONS: EHS involves a specific constellation of clinical findings which include OHS and LMN facial palsy, all ipsilateral to the side of the lesion at the level of the pons. On the basis of our review, true EHS is a very rare manifestation. EHS variants, while still unique, are more common.Disclosure: Dr. mannel has nothing to disclose. Dr. Saada has nothing to disclose. Dr. Antonios has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mannel, R., Saada, F., Antonios, N. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

New therapeutic option for drop foot with the ActiGait peroneal nerve stimulator – A technical note
Publication date: Available online 9 July 2015 Source:World Neurosurgery Author(s): K. Daniel Martin , Witold Polanski , Gabriele Schackert , Stephan B. Sobottka A drop foot occurs in up to 20% of stroke patients and leads to an increased risk of falls. Until recently, only a foot orthosis or surface stimulation were able to improve the gait of these patients. Recent studies have shown that direct peroneal nerve stimulation with an implantable four-channel peroneal nerve stimulator (ActiGait) allows independent electrode adjustment and leads to better functional results and an improved quality of life. The application of...
Source: World Neurosurgery - July 10, 2015 Category: Neurosurgery Source Type: research

Neuroprotective Mechanisms Mediated by CDK5 Inhibition.
This article discusses current evidence for the involvement of CDK5 deregulation in neurodegenerative disorders and neurodegeneration associated with stroke through various mechanisms. These include upregulation of cyclin D1 and overactivation of CDK5 mediated neuronal cell death pathways, aberrant hyperphosphorylation of human tau proteins and/or neurofilament proteins, formation of neurofibrillary lesions, excitotoxicity, cytoskeletal disruption, motor neuron death (due to abnormally high levels of CDK5/p25) and colchicine-induced apoptosis in cerebellar granule neurons. A better understanding of the role of CDK5 inhibit...
Source: Current Pharmaceutical Design - November 24, 2015 Category: Drugs & Pharmacology Authors: Mushtaq G, Greig NH, Anwar F, Al-Abbasi FA, Zamzami MA, Al-Talhi HA, Kamal MA Tags: Curr Pharm Des Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.
In this study we compared the efficacy and safety of baclofen vs tolperisone in spasticity. One hundred fifty patients with cerebral palsy or post stroke or spinal cord injury associated spasticity were enrolled in present study. Group I comprised of Seventy-five patients receiving baclofen and group II comprised of 75 patients receiving tolperisone. For efficacy measurement 4 evaluation methods were used, 1) Modified Ashworth Scale for muscle tone, 2) Medical research council scale for muscle strength and 3) Barthel Index for functional outcome 4) Coefficient of efficacy. In efficacy evaluation, both groups showed signifi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 9, 2017 Category: Drugs & Pharmacology Authors: Agarwal S, Patel T, Shah N, Patel BM Tags: Biomed Pharmacother Source Type: research

Multiple Acute Ischemic Strokes due to Cerebral AVM Vascular Steal Phenomenon (P2.298)
Conclusions:This is a case of multiple bilateral cortical and subcortical ischemic strokes in a setting of a large, long-standing cerebral AVM and an otherwise unremarkable stroke workup. TCD showed severely dampened VMR bilaterally which strongly suggests a failure of cerebral auto-regulation and a potential vascular steal phenomenon secondary to the AVM.Disclosure: Dr. Bhatt has nothing to disclose. Dr. Cajigas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Koch has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bhatt, N., Cajigas, I., Malik, A., Koch, S. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Neurological complication related to atrial myxomas
Conclusions This case highlights both the recognised neurologic complications of atrial myxoma in a single patient and presents the characteristic angiographic findings. The diagnosis of cerebral aneurysms can be delayed up to five years1. Evaluation should therefore be considered following a histologic diagnosis of atrial myxoma.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Baird-Gunning, J., Lalloo, S., Lueck, C. J., Das, C. Tags: Abstracts Source Type: research

Electrodiagnostic and nerve ultrasonographic features in upper limb spasticity: an observational study.
Authors: Picelli A, Tamburin S, Berto G, Chemello E, Gandolfi M, Saltuari L, Waldner A, Smania N Abstract To better understand the effects of spasticity on peripheral nerves, we evaluated the electrodiagnostic and nerve ultrasonographic features of the median and ulnar nerves in adults with upper limb spasticity. Twenty chronic stroke patients with spastic hemiparesis underwent nerve conduction study and nerve ultrasonography of the median and ulnar nerves at both upper limbs. Affected versus unaffected upper limb comparisons showed significant differences in the median and ulnar nerve distal motor latencies, compo...
Source: Functional Neurology - October 20, 2017 Category: Neurology Tags: Funct Neurol Source Type: research