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Condition: Motor Neurone Disease
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Total 256 results found since Jan 2013.
Effect of post-stroke spasticity on voluntary movement of the upper limb
Hemiparesis following stroke is often accompanied by spasticity. Spasticity is one factor among the multiple components of the upper motor neuron syndrome that contributes to movement impairment. However, the ...
Source: Journal of NeuroEngineering and Rehabilitation - May 13, 2021 Category: Rehabilitation Authors: Hadar Lackritz, Yisrael Parmet, Silvi Frenkel-Toledo, Melanie C. Bani ña, Nachum Soroker, John M. Solomon, Dario G. Liebermann, Mindy F. Levin and Sigal Berman Tags: Research Source Type: research
Acupuncture improves the structure of spastic muscle and decreases spasticity by enhancing GABA, KCC2, and GABAAγ2 in the brainstem in rats after ischemic stroke
Conclusions
Acupuncture after MCAO improves the structure of spastic muscle and decreases spasticity probably at least partly by enhancing GABA, KCC2, and GABAAγ2 in the brainstem in SAS rats.
Source: NeuroReport - May 23, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research
Pattern of neurological disease seen among patients admitted in tertiary care hospital
Background:
Neurologic disorders are not uncommon at in patient departments of different hospitals. We have conducted the study to see the pattern and burden of neurologic disorders at different inpatient departments of a tertiary care centre.Methodology: This retrospective observational study was carried out from the records and referral notes of neurology department of Dhaka Medical College Hospital (DMCH) from July 2011 to June 2012. A total 335 patients were evaluated by consultant neurologists during this period.Result: Majority of the patients (59.7%) presented after the age of forty years. The mean age at presentati...
Source: Epidemiologic Perspectives and Innovations - March 31, 2014 Category: Epidemiology Authors: Rajib Nayan ChowdhuryA T HasanYusuf Ur RahmanShafikul Islam KhanAhmed Riyad HussainShamim Ahsan Source Type: research
Ankle clonus
We present a video case of impressive left ankle clonus in a patient with old right middle cerebral artery stroke.
Clonus is a series of involuntary, rhythmic, muscular contractions, and relaxations. It may be caused by interruption of the upper motor neuron fibers such as stroke, multiple sclerosis, or by metabolic alterations such as severe hepatic failure or serotonin syndrome. We present a video case of impressive left ankle clonus in a patient with old right middle cerebral artery stroke.
Source: Clinical Case Reports - April 9, 2015 Category: Journals (General) Authors: Shoaib Bilal Fareedy, Ranjan Pathak Tags: Clinical Video Source Type: research
A cross-sectional evaluation of home health service in patients with chronic neurologic diseases in a province of Turkey
In this study, we aimed to compare patients’ characteristics, comorbid risk factors, medical supplies, and caregivers’ demographics between stroke patients and patients with other chronic neurological diseases receiving home health services. In our study, between November 2013 and March 2014, chronic neurological disease (CND) patients having home health services were enrolled in the study. During patient visits, patients were assessed by the questionnaire comprising the modified Rankin scale (mRS), Barthel index, Zarit caregiver burden scale, and mini nutritional assessment (MNA). Stroke patients were classified as Gr...
Source: Acta Neurologica Belgica - July 19, 2015 Category: Neurology Source Type: research
Asynchronization in Changes of Electrophysiology and Pathology of Spinal Cord Motor Neurons in Rats Following Middle Cerebral Artery Occlusion.
CONCLUSIONS: Both electrophysiological and pathological studies showed transsynaptic degeneration after stroke. This study identified the asynchronization in changes of electrophysiology and pathology. The abnormal physiological changes and function impairment can be detected in the early stage and recovered quickly, while the pathological loss of motor neuron can be detected only in a later stage.
PMID: 26521791 [PubMed - in process]
Source: Chinese Medical Journal - November 1, 2015 Category: Journals (General) Authors: Lin N, Liu MS, Fan SY, Guan YZ, Cui LY Tags: Chin Med J (Engl) Source Type: research
Neuronal cell sheet of cortical motor neuron phenotype derived from human iPS cells.
Abstract
<p>Transplantation of stem cells which differentiate into more mature neural cells brings about functional improvement in pre-clinical studies of stroke. Previous transplant approaches in diseased brain have utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used as graft. However, these cells had no specific relationship to the damaged tissue of stroke patients and brain injury. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity as cortical motor neuro...
Source: Cell Transplantation - March 17, 2017 Category: Cytology Authors: Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Takada E, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T Tags: Cell Transplant Source Type: research
Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs.
Abstract
Transplantation of stem cells that differentiate into more mature neural cells brings about functional improvement in preclinical studies of stroke. Previous transplant approaches in the diseased brain utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used for grafting. However, these cells had no specific relationship to the damaged tissue of stroke and brain injury patients. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity of cortical motor neurons. In o...
Source: Cell Transplantation - August 1, 2017 Category: Cytology Authors: Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T Tags: Cell Transplant Source Type: research
Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillBärnighaus...
Source: The Lancet Neurology - September 19, 2017 Category: Neurology Source Type: research
Toward an epidemiology of poststroke spasticity
Poststroke spasticity (PSS)-related disability is emerging as a significant health issue for stroke survivors. There is a need for predictors and early identification of PSS in order to minimize complications and maladaptation from spasticity. Reviewing the literature on stroke and upper motor neuron syndrome, spasticity, contracture, and increased muscle tone measured with the Modified Ashworth Scale and the Tone Assessment Scale provided data on the dynamic time course of PSS. Prevalence estimates of PSS were highly variable, ranging from 4% to 42.6%, with the prevalence of disabling spasticity ranging from 2% to 13%. Da...
Source: Neurology - January 14, 2013 Category: Neurology Authors: Wissel, J., Manack, A., Brainin, M. Tags: ARTICLE Source Type: research
Patient Registry of Outcomes in Spasticity (PROS) Care World (P3.050)
Conclusion: Findings suggest dosing differences for commonly treated patterns of UMN dysfunction and improved Ashworth and pain scores. This robust database can guide clinicians in the management of patients with spasticity.Disclosure: Dr. Esquenazi has nothing to disclose. Dr. Mayer has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Esquenazi, A., Mayer, N., Lee, S. Tags: Neural Repair and Neuro-rehabilitation: Clinical Source Type: research
'Computer helps patients with severe MND communicate'
Conclusion
It's hard to imagine the situation of being alert, aware of what's happening around you, but unable to move, respond or communicate with the outside world.
So it is comforting, then, to hear that people with complete locked-in syndrome may be able to communicate – and may be relatively content with their situation.
However, it's important to remember the limitations of this study.
It's very small. Only four people took part, and full results are available for only three of them.
The results may only apply to people with this very specific type of neurodegenerative disease, not to people with other types of pa...
Source: NHS News Feed - February 1, 2017 Category: Consumer Health News Tags: Neurology Source Type: news
'Breakthrough in communication for patients with severe MND', study claims
Conclusion
It's hard to imagine the situation of being alert, aware of what's happening around you, but unable to move, respond or communicate with the outside world.
So it is comforting, then, to hear that people with complete locked-in syndrome may be able to communicate – and may be relatively content with their situation.
However, it's important to remember the limitations of this study.
It's very small. Only four people took part, and full results are available for only three of them.
The results may only apply to people with this very specific type of neurodegenerative disease, not to people with other types of pa...
Source: NHS News Feed - February 1, 2017 Category: Consumer Health News Tags: Neurology Source Type: news
Treatment Options for Neurogenic Drop Foot: A Systematic Literature Research.
Conclusion The analysis demonstrates the importance of considering causes and severity of drop foot as well as patients' pre- and post-operative conditions for choosing treatment options. For active, high-demand patients, neural implants are valuable treatment options.
PMID: 28431452 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - April 23, 2017 Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Technologically-advanced assessment of upper-limb spasticity: a pilot study.
CONCLUSIONS: By using the robotic device some spasticity parameters can be continuously recorded during the rehabilitation treatment in order to objectively measure the effectiveness of the interventions provided.
CLINICAL REHABILITATION IMPACT: The standardized evaluation parameters recorded using robotic devices may provide several advantages: 1) the measures for spasticity assessment can be monitored during every rehabilitation session (even during each movement), 2) these measurements are able to highlight even small changes, 3) the recovery plateau can be detected early thus avoiding further rehabilitation sessio...
Source: European Journal of Physical and Rehabilitation Medicine - September 4, 2017 Category: Rehabilitation Authors: Posteraro F, Crea S, Mazzoleni S, Berteanu M, Ciobanu I, Vitiello N, Cempini M, Gervasio S, Mrachacz-Kersting N Tags: Eur J Phys Rehabil Med Source Type: research
