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Condition: Motor Neurone Disease
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Total 256 results found since Jan 2013.
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160214. Online ahead of print.ABSTRACTAMP-activated protein kinase (AMPK) is a serine/threonine kinase and a driving or deterrent factor in the development of neurodegenerative diseases and dementia. AMPK affects intracellular proteins like the mammalian target of rapamycin (mTOR). Peroxisome proliferator-activated receptor-γ coactivator 1-α (among others) contributes to a wide range of intracellular activities based on its downstream molecules such as energy balancing (ATP synthesis), extracellular inflammation, cell growth, and neuronal cell d...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Marjan Nikbakhtzadeh Fatemeh Shaerzadeh Ghorbangol Ashabi Source Type: research
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle
This article is protected by copyright. All rights reserved.PMID:34101193 | DOI:10.1113/JP280867
Source: The Journal of Physiology - June 8, 2021 Category: Physiology Authors: Richard L Lieber Ben Binder-Markey Source Type: research
An Atypical Presentation of Left Lateral Medullary Syndrome & #8211; A Case Report
We report a case of a 62-year-old diabetic, hypertensive male who presented with symptoms involving the left lateral dorsal medulla along with partial Horner's syndrome, left lateral rectus palsy, and left lower motor neuron–type facial palsy. Atypical presentation in LMS could be explained by infraction of left facial colliculus in addition to the left lateral medulla. Association of these entities with Wallenberg's syndrome is atypical features in our case, which questioned the diagnosis of a simple LMS.
Source: Neurology India - December 23, 2021 Category: Neurology Authors: Pushpendra N Renjen Ramesh Krishnan Dinesh Chaudhari Kamal Ahmad Source Type: research
Post-varicella neurological complications: A preliminary observation from a tertiary care centre of Eastern India
Conclusion: Chickenpox is a common viral disease and most patients recover without any complication. Although rare, neurological complications following acute varicella infection may have myriad presentations ranging from lower motor neuron facial palsy to life-threatening encephalitis. Compared to other studies, varicella encephalitis and ataxia were not so common in our study group. Response to therapy was uniformly good except in the patients presenting with ataxia. Response was particularly good to central and peripheral demyelinating disorders.
Source: Annals of Indian Academy of Neurology - May 25, 2022 Category: Neurology Authors: Subhadeep Gupta Atanu Biswas Atanu Chandra Biman Kanti Ray Arpan Dutta Alak Pandit Source Type: research
079 Unmasking of motor neuron disease by botulinum toxin therapy
A 75 year-old male with a history of a right hemiparesis due to past h/o stroke sustained a T3 vertebral body compression fracture after a fall and was treated conservatively. Six months later, in a rehabilita- tion clinic he reported that following discharge there had been a gradual deterioration in his mobility and strength, particularly on the right side. His right upper limb had become more stiff and painful with decreased range of movements. Two months later he received Dysport injections to the right elbow flexors, right brachioradialis, soleus and right flexor carpi radialis. Four days later, he developed worsening ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Paluri, S., Hassan, M., Lambert, T. Tags: Poster Presentations Source Type: research
Feasibility, Acceptability, and Efficacy of Mindfulness Training in People with Upper Motor Neuron Disorders: A Systematic Review
CONCLUSION: Based on current data, MBIs are feasible and offer a promising approach to address the biopsychosocial needs of individuals with UMNDs. MBIs are associated with a high acceptance rate among participants with notable improvements in depression, anxiety, fatigue, and quality of life post-intervention. Future studies are needed to evaluate alternate models of delivery of MBIs and the dose-response relationship.PMID:35760105 | DOI:10.1016/j.apmr.2022.05.020
Source: Health Physics - June 27, 2022 Category: Physics Authors: Radha Korupolu Aila Malik Chelsea Ratcliff Susan Robinson-Whelen Heather B Taylor Source Type: research
Diagnosis of hydrocephalus by cranial transillumination
A full-term neonate was examined to have significant macrocephaly (>>97th percentile), widened cranial sutures and a large bulging anterior fontanelle (AF). A light-emitting diode source applied on the AF revealed asymmetrical cranial transillumination, predominantly on the right (figure 1A). He was alert with spontaneous movements of all limbs but had generalised upper motor neuron (UMN) signs of hypertonia and hyper-reflexia. These signs indicated raised intracranial pressure from a possible right hemispheric cystic lesion. MRI showed a large right open-lip schizencephaly with encysted cerebrospinal fluid (CSF) tha...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2022 Category: Perinatology & Neonatology Authors: Lian, B. X., Ng, N. B. H., Wang, F., Nga, V. D. W., Tan, A. P., Lin, J. Tags: Images in neonatal medicine Source Type: research
Sensors, Vol. 23, Pages 866: Automatic Identification of Involuntary Muscle Activity in Subacute Patients with Upper Motor Neuron Lesion at Rest & mdash;A Validation Study
In this study, we computed sensitivity (Se), specificity (Sp), and overall accuracy (Acc) of this algorithm by comparing it with the classification provided by two expert assessors. Based on sample size estimation, 6020 10 s-long sEMG epochs were classified by both the algorithm and the assessors. Epochs were randomly extracted from long-lasting sEMG signals collected in-field from 14 biceps brachii (BB) muscles of 10 patients (5F, age range 50–71 years) hospitalized in an acute rehabilitation ward following a stroke or a post-anoxic coma and complete upper limb (UL) paralysis. Among the 14 BB muscles assesse...
Source: Sensors - January 12, 2023 Category: Biotechnology Authors: Andrea Merlo Isabella Campanini Tags: Article Source Type: research
Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee
Clin Neurophysiol. 2023 Mar 29;150:131-175. doi: 10.1016/j.clinph.2023.03.010. Online ahead of print.ABSTRACTThe review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on clinical diagnostic utility of transcranial magnetic stimulation (TMS) in neurological diseases. Most TMS measures rely on stimulation of motor cortex and recording of motor evoked potentials. Paired-pulse TMS techniques, incorporating conventio...
Source: Clinical Neurophysiology - April 17, 2023 Category: Neurology Authors: Steve Vucic Kai-Hsiang Stanley Chen Matthew C Kiernan Mark Hallett David H Benninger Vincenzo Di Lazzaro Paolo M Rossini Alberto Benussi Alfredo Berardelli Antonio Curr à Sandro M Krieg Jean-Pascal Lefaucheur Yew Long Lo Richard A Macdonell Marcello Mass Source Type: research
