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Condition: Motor Neurone Disease

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Total 256 results found since Jan 2013.

Effect of mindfulness meditation on brain-computer interface performance.
Abstract Electroencephalogram based Brain-Computer Interfaces (BCIs) enable stroke and motor neuron disease patients to communicate and control devices. Mindfulness meditation has been claimed to enhance metacognitive regulation. The current study explores whether mindfulness meditation training can thus improve the performance of BCI users. To eliminate the possibility of expectation of improvement influencing the results, we introduced a music training condition. A norming study found that both meditation and music interventions elicited clear expectations for improvement on the BCI task, with the strength of ex...
Source: Consciousness and Cognition - November 22, 2013 Category: Neurology Authors: Tan LF, Dienes Z, Jansari A, Goh SY Tags: Conscious Cogn Source Type: research

How to measure fatigue in neurological conditions? A systematic review of psychometric properties and clinical utility of measures used so far.
Conclusion:Although many measures of fatigue in neurological conditions have published, none met all of the criteria for psychometric robustness and clinical utility but the Neurological Fatigue Indices are the best and can be used with caution. PMID: 24519920 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - February 11, 2014 Category: Rehabilitation Authors: Tyson SF, Brown P Tags: Clin Rehabil Source Type: research

Corticobasal syndrome associated with antiphospholipid syndrome without cerebral infarction
Antiphospholipid syndrome (APS) is a rare autoimmune coagulopathy with various systemic and neurologic symptoms. Ischemic stroke and TIA are common neurologic manifestations of APS, while migraine, epilepsy, chorea, and multiple sclerosis–like syndromes have also been reported.1,2 Dementia is an unusual manifestation of APS, and the presentation of APS with corticobasal syndrome (CBS) has rarely been reported.3,4 CBS is a progressive neurologic syndrome characterized by asymmetric cortical dysfunction, such as apraxia, alien limb phenomenon, or cortical sensory changes accompanied by akineto-rigid syndrome or dystoni...
Source: Neurology - February 24, 2014 Category: Neurology Authors: Lee, D.-W., Eum, S.-W., Moon, C. O., Ma, H.-I., Kim, Y. J. Tags: All Medical/Systemic disease, Corticobasal degeneration CLINICAL/SCIENTIFIC NOTES Source Type: research

Neurodegenerative disease: The next occupational disease epidemic?
Globally, neurological disorders account for about 4% of all deaths and about 5% of disability-adjusted life-years from non-communicable disease.1 Diagnosis of a neurological disease can be devastating, and in most instances there is no cure. A recent editorial in the Lancet2 commented that neurological diseases remain neglected and ignored: ‘unlike cancer, stroke, and diabetes, which all have strategies and clinical champions, degenerative disorders are heterogeneous and complex’. Neurological disease includes a broad spectrum of conditions, several of which have occupational causes. The motor neurone diseases...
Source: Occupational and Environmental Medicine - August 7, 2014 Category: Occupational Health Authors: Pearce, N., Kromhout, H. Tags: Other exposures Editorial (Hot topic) Source Type: research

The 17 syndrome
A 58-year-old man woke from uneventful right cerebellopontine angle surgery (grade I schwannoma resection) with severe, lower motor neurone (LMN) facial diplegia and near-complete nuclear horizontal ophthalmoplegia, uncorrectable by vestibulo-ocular reflex. Vertical gaze and convergence were normal. Examination was otherwise normal, excepting right sensorineural anacusis (a short HD video will be shown). CT brain revealed expected post-operative changes. MRI wasn't possible due to a pacemaker, inserted for symptomatic bradyarrhythmias. There has been no improvement after 12 months. We attribute this presentation to infarct...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Evans, M. R., Weeks, R. Tags: Abstracts Source Type: research

Motor unit number estimation and quantitative needle electromyography in stroke patients
To evaluate the effect of upper motor neuron damage upon motor units’ function by means of two separate and supplementary electrophysiological methods.
Source: Journal of Electromyography and Kinesiology - September 25, 2014 Category: Neurology Authors: Ioanna Kouzi, Eftichia Trachani, Evangelos Anagnostou, Christina-Anastasia Rapidi, John Ellul, George C. Sakellaropoulos, Elisabeth Chroni Source Type: research

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement.
Abstract Scientific appreciation for the subtlety of brain sulfur chemistry has lagged, despite understanding that the brain must maintain high glutathione (GSH) to protect against oxidative stress in tissue that has both a high rate of oxidative respiration and a high content of oxidation-prone polyunsaturated fatty acids. In fact, the brain was long thought to lack a complete transsulfuration pathway (TSP) for cysteine synthesis. It is now clear that not only does the brain possess a functional TSP, but brain TSP enzymes catalyze a rich array of alternative reactions that generate novel species including the gas...
Source: Free Radical Biology and Medicine - November 6, 2014 Category: Biology Authors: Hensley K, Denton TT Tags: Free Radic Biol Med Source Type: research

A fine neuroscience vintage
I recently bumped into a cardiologist mate who had just won a silver medal for his first wild barrel ferment Chardonnay from the vineyard he started with a haematologist, their wine label aptly named Blood Brothers. He told me his approach to cultivating a fine harvest. While many factors play a role he said, the raw product and how it is nurtured, remains the key. The grape variety and how it responds to the prevailing climate at the time of harvest are the critical factors in producing a fine wine vintage. After our conversation, I was impelled to draw a parallel between his wine making and the process of extracting prac...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 17, 2014 Category: Neurosurgery Authors: Kiernan, M. C. Tags: Genetics, Long term care, Immunology (including allergy), Dementia, Epilepsy and seizures, Motor neurone disease, Movement disorders (other than Parkinsons), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Spinal cord, Stroke, Memory Source Type: research

Lost memories might be able to be restored, new UCLA study indicates
New UCLA research indicates that lost memories can be restored. The findings offer some hope for patients in the early stages of Alzheimer’s disease. For decades, most neuroscientists have believed that memories are stored at the synapses — the connections between brain cells, or neurons — which are destroyed by Alzheimer’s disease. The new study provides evidence contradicting the idea that long-term memory is stored at synapses. “Long-term memory is not stored at the synapse,” said David Glanzman, a senior author of the study, and a UCLA professor of integrative biology and physiology and of neurobiology. “...
Source: UCLA Newsroom: Health Sciences - December 19, 2014 Category: Universities & Medical Training Source Type: news

Pathophysiology of Spasticity: Implications for Neurorehabilitation.
Abstract Spasticity is the velocity-dependent increase in muscle tone due to the exaggeration of stretch reflex. It is only one of the several components of the upper motor neuron syndrome (UMNS). The central lesion causing the UMNS disrupts the balance of supraspinal inhibitory and excitatory inputs directed to the spinal cord, leading to a state of disinhibition of the stretch reflex. However, the delay between the acute neurological insult (trauma or stroke) and the appearance of spasticity argues against it simply being a release phenomenon and suggests some sort of plastic changes, occurring in the spinal cor...
Source: Biomed Res - December 26, 2014 Category: Research Authors: Trompetto C, Marinelli L, Mori L, Pelosin E, Currà A, Molfetta L, Abbruzzese G Tags: Biomed Res Int Source Type: research

A Single-Center, Randomized, Double-Blind, Placebo-Controlled, Six-Month Clinical Trial Followed by an Open-Label Extension to Evaluate the Safety, Tolerability and Clinical Endpoint Responsiveness of the Phosphodiesterase Type 4 (PDE4) Inhibitor Ibudilast (MN-166) in Subjects with Amyotrophic Lateral Sclerosis (ALS) - STEP-IBUDILAST-ALS-DB-OLE-1 (I8-1B)
CONCLUSIONS: Interim evaluation of the primary objective-safety/tolerability and secondary objective-clinical endpoint responsiveness of MN-166 60 mg/day versus placebo administered for six months with riluzole in subjects with ALS will be presented for the first 30 patients. Study Supported by: Medicinova and Carolinas ALS Research FundDisclosure: Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Institute of Neurological Disorders and Stroke. Dr. Bravver has nothing to disclose. Dr. Sanjak has nothing to disc...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brooks, B., Bravver, E., Sanjak, M., Langford, V., Lary, C., Alwan, M., Nemeth, J., Russo, P., Smith, N., Lucas, N., Nichols, M., Belcher, S., Wright, K., Ward, A., Holsten, S., Fischer, M., Bockenek, W., Desai, U., Lindblom, S. C., Pacicco, T., Matsuda, Tags: Advances in ALS and Other Motor Neuron Diseases Data Blitz Presentations Source Type: research

Symptomatic Cerebral Air Embolism after Central Venous Catheter Removal. (P1.034)
CONCLUSIONS: Central air embolism is a rare complication of central venous catheter removal or insertion. GRE or DWI is useful for diagnosis of cerebral air embolism. Clinician should be aware of this uncommon complication and take the necessary precaution to prevent it.Disclosure: Dr. Ferdous has nothing to disclose. Dr. Tantikittichaikul has nothing to disclose. Dr. Hasan has nothing to disclose. Dr. Eldokla has nothing to disclose. Dr. Kim has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ferdous, J., Tantikittichaikul, S., Hasan, R., Eldokla, A., Kim, J. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Phenotypes and Genotypes of Mitochondrial Disease- Findings from A National Mitochondrial Disease Cohort (P2.061)
Conclusion: This national cohort offers a unique opportunity to deep phenotype a large group of mitochondrial disease patients, bridge the gap in our understanding of disease progression, develop clinical guideline on patient care and facilitate patient recruitment for any future trials.Disclosure: Dr. Ng has nothing to disclose. Dr. Gorman has nothing to disclose. Dr. Nesbitt has nothing to disclose. Dr. Pitceathly has nothing to disclose. Dr. Grady has nothing to disclose. Dr. Schaefer has nothing to disclose. Dr. Bright has nothing to disclose. Dr. Feeney has nothing to disclose. Dr. Rahman has nothing to disclose. Dr. ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ng, Y. S., Gorman, G., Nesbitt, V., Pitceathly, R., Grady, J., Schaefer, A., Bright, A., Feeney, C., Rahman, S., Poulton, J., Taylor, R., Hanna, M., Turnbull, D., McFarland, R. Tags: ALS and Motor Neuron Disease Source Type: research

Amyotrophic Lateral Sclerosis (ALS) with Laboratory Abnormalities of Unknown Significance (LAUS) --Where Does It Begin and Where Does It End? (P4.144)
CONCLUSIONS: Further detailed analysis of progression rate by site of onset, sex, age, treatment will require assimilation of clinic-based datasets of properly analyzed ALS-LAUS patients from multiple clinic sites. The appropriate role of IVIg in ALS-LAUS patients requires further study following explication of the natural history of these patients compared with non-ALS-LAUS patients. The determination as to whether auto-antibodies to additional antigens may play a role in the progression rate of ALS-LAUS compared with sporadic ALS needs to be systematically studied. Study Supported by: Carolinas ALS Research FundDisclosur...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brooks, B., Bravver, E., Langford, V., Alwan, M., Smith, N., Lucas, N., Nichols, M., Belcher, S., Lary, C., Nemeth, J., Russo, P., Wright, K., Ward, A., Holsten, S., Fischer, M., Bockenek, W., Desai, U., Lindblom, S. C., Pacicco, T., Sanjak, M. Tags: Neuroepidemiology: ALS Source Type: research

Female gender doubles executive dysfunction risk in ALS: a case-control study in 165 patients
Conclusions Results highlight a significant vulnerability of ALS female patients to develop cognitive dysfunctions peculiar to the disease, independently of bulbar onset. The explicative hypotheses of the data are focused on two interpretative lines not mutually exclusive: the role of gonadal hormones and gender-related brain asymmetry pre-existing to the disease. These findings, never reported before in the literature, can have important implications for models of ALS pathogenesis and for future clinical trial designs.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2015 Category: Neurosurgery Authors: Palmieri, A., Mento, G., Calvo, V., Querin, G., D'Ascenzo, C., Volpato, C., Kleinbub, J. R., Bisiacchi, P. S., Soraru, G. Tags: Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Memory disorders (psychiatry) Cognitive neurology Source Type: research