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Condition: Motor Neurone Disease

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Total 256 results found since Jan 2013.

The upgoing thumb sign: An interobserver/intraobserver reliability study
Conclusions: The upgoing thumb sign is a subtle upper limb neurologic finding, with a high level of interobserver and intraobserver reliability. The test is easy to perform and can be interpreted accurately.
Source: Neurology Clinical Practice - December 11, 2017 Category: Neurology Authors: Abootalebi, S., Azarpazhooh, M. R., Sposato, L., Hachinski, V. Tags: Research Source Type: research

Quantitative assessment for flexed-elbow deformity during gait following botulinum toxin A treatment
Involuntary flexed-elbow deformity is one of the most common deformities caused by spasticity and a positive sign of upper motor neuron syndrome [1]. In recent years, botulinum toxin A (BoNTA) has been widely used to reduce spasticity in cases of cerebral palsy [2,3], stroke [4 –8], traumatic brain injury [9], and spinal cord injury [10]. A meta-analysis [4] and several randomized controlled trials [5–8] reported the beneficial effects of BoNTA injection for upper-limb spasticity in stroke patients.
Source: Gait and Posture - April 6, 2018 Category: Orthopaedics Authors: Hiroki Tanikawa, Hitoshi Kagaya, Keisuke Inagaki, Yusuke Kotsuji, Keita Suzuki, Kenta Fujimura, Masahiko Mukaino, Satoshi Hirano, Eiichi Saitoh, Yoshikiyo Kanada Tags: Full length article Source Type: research

Does acupuncture help patients with spasticity? A narrative review
Publication date: Available online 5 November 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Yi Zhu, Yujie Yang, Jianan LiAbstractSpasticity is a motor disorder encountered after upper motor neuron lesions. It adversely affects quality of life in most patients and causes long-term burden of care and has significant financial implications. The effect of conventional therapies for spasticity including physical therapy, surgery, and pharmacotherapy are not always satisfying because of the short-term effects or side effects in some patients. Acupuncture is a part of traditional medicine originating from C...
Source: Annals of Physical and Rehabilitation Medicine - November 6, 2018 Category: Rehabilitation Source Type: research

Recruitment gain of spinal motor neuron pools in cat and human.
Abstract The output from a motor nucleus is determined by the synaptic input to the motor neurons and their intrinsic properties. Here, we explore whether the source of synaptic inputs to the motor neurons (cats) and the age or post-stroke conditions (humans) may change the recruitment gain of the motor neuron pool. In cats, the size of Ia EPSPs in triceps surae motor neurons (input) and monosynaptic reflexes (MSRs; output) was recorded in the soleus and medial gastrocnemius motor nerves following graded stimulation of dorsal roots. The MSR was plotted against the EPSP thereby obtaining a measure of the recruitmen...
Source: Experimental Brain Research - September 5, 2019 Category: Neuroscience Authors: Nielsen JB, Morita H, Wenzelburger R, Deuschl G, Gossard JP, Hultborn H Tags: Exp Brain Res Source Type: research

Pilot Study of Quantitative Methods for Differentiating Pharyngeal Swallowing Mechanics by Dysphagia Etiology
This study demonstrated that swallowing mechanics among cohorts of dysphagic patients can be differentiated using kinematics and CASM, providing different but complementary quantitative methods for investigating the impact of various disease states on swallowing function.
Source: Dysphagia - May 13, 2020 Category: Speech-Language Pathology Source Type: research

Soleus H-Reflex Change in Poststroke Spasticity: Modulation due to Body Position
CONCLUSIONS: The motor neuron excitability of both sides was not suppressed but instead upregulated in the standing position in subjects with spasticity, which may suggest that there was abnormal regulation of the Ia pathway on both sides.PMID:34917144 | PMC:PMC8670919 | DOI:10.1155/2021/9955153
Source: Neural Plasticity - December 17, 2021 Category: Neurology Authors: Wenting Qin Anjing Zhang Mingzhen Yang Chan Chen Lijun Zhen Hong Yang Lingjing Jin Fang Li Source Type: research

Burden of neurological diseases in Asia from 1990 to 2019: a systematic analysis using the Global Burden of Disease Study data
Conclusions This study demonstrated the burden of neurological diseases in Asia. To reduce the burden of neurological diseases, strategies suitable for each country’s real healthcare needs and challenges are needed; this study can serve as the cornerstone of these strategies.
Source: BMJ Open - September 7, 2022 Category: General Medicine Authors: Kang, S., Eum, S., Chang, Y., Koyanagi, A., Jacob, L., Smith, L., Shin, J. I., Song, T.-J. Tags: Open access, Epidemiology Source Type: research

AI makes non-invasive mind-reading possible by turning thoughts into text
Advance raises prospect of new ways to restore speech in those struggling to communicate due to stroke or motor neurone diseaseAn AI-based decoder that can translate brain activity into a continuous stream of text has been developed, in a breakthrough that allows a person ’s thoughts to be read non-invasively for the first time.The decoder could reconstruct speech with uncanny accuracy while people listened to a story – or even silently imagined one – using only fMRI scan data.Previous language decoding systems have required surgical implants, and the latest advance raises the prospect of new ways to restore speech i...
Source: Guardian Unlimited Science - May 1, 2023 Category: Science Authors: Hannah Devlin Science correspondent Tags: Artificial intelligence (AI) Neuroscience Technology US news World news Medical research Source Type: news

FDA Clears Stimulation System for Foot Drop in Children FDA Clears Stimulation System for Foot Drop in Children
The device could help boost mobility and confidence in kids with stroke, cerebral palsy, and other motor neuron disorders. FDA Approvals
Source: Medscape Today Headlines - January 25, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Alert Source Type: news

Myotendinous lengthening of the elbow flexor muscles to improve active motion in patients with elbow spasticity following brain injury
The objective of this study was to evaluate the outcomes of a novel technique of fractional myotendinous lengthening of the elbow flexors in patients with volitional motor control and spastic elbow flexion deformities after brain injury.Methods: A retrospective review of 42 consecutive patients with spastic elbow flexion deformities and upper motor neuron (UMN) syndrome was performed. Each patient had volitional motor control but limited elbow extension and underwent myotendinous lengthening of the elbow flexor muscles. Outcome measures included pre and post-operative active and passive arc of motion, Modified Ashworth Sca...
Source: Journal of Shoulder and Elbow Surgery - January 28, 2013 Category: Orthopaedics Authors: Oke A. Anakwenze, Surena Namdari, Jason E. Hsu, Joshua Benham, Mary Ann Keenan Tags: Elbow Source Type: research

Brain-to-brain interface transmits information from one rat to another | Mo Costandi
Electronically-linked brains could facilitate rehabilitation and revolutionize computingIn Star Trek, the Borg is a menacing race of cybernetically-enhanced beings who conquer other races and assimilate them. They do not act as individuals, but rather as an interconnected group that makes decisions collectively. Assimilation involves integrating other life forms into the Collective, using brain implants that connect them to the "hive mind," such that their biology and technology can help the Borg to become the perfect race. This is a popular concept that can be found elsewhere in science fiction, but scientists have now mo...
Source: Guardian Unlimited Science - February 28, 2013 Category: Science Tags: Blogposts guardian.co.uk Technology Neuroscience Source Type: news

Management of spasticity revisited
Spasticity is common after stroke and other neurological conditions and causes considerable limitations of movement, activities of daily living and participation. Interaction with other components of the upper motor neurone syndrome (UMNS) and the heterogeneity of patients' presentations together with limited tools for outcome measurement have hampered the production of randomised controlled trial data for management strategies. Specialist multi-disciplinary goal-centered management programmes are the mainstay of treatment. Pharmacological therapies have limited effect, and physical and positional management are crucial. T...
Source: Age and Ageing - June 17, 2013 Category: Geriatrics Authors: Graham, L. A. Tags: Review Source Type: research

Longitudinal research into alzheimer's disease, fronto-temporal dementia and other dementias
Conclusion The BNSU provides an easy method of referral of patients with dementia for their inclusion in research.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Rossor, M., Ahmed, R., Liang, Y., Douglas, J., Mahoney, C., Warren, J., Schott, J., Fox, N. Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuroimaging, Neuromuscular disease, Stroke, Memory disorders (psychiatry), Psychiatry of old age Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians Source Type: research