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Epidemiology of young stroke in the ludhiana population-based stroke registry
Conclusion: Hypertension, diabetes mellitus, drug addiction, and tobacco intake were significantly associated with young stroke. Outcome was also better in younger people.
Source: Annals of Indian Academy of Neurology - February 22, 2022 Category: Neurology Authors: Monika Singla Gagandeep Singh Paramdeep Kaur Jeyaraj D Pandian Source Type: research

Hypertension is associated with increased mortality in patients with tuberculosis in Guinea-Bissau
Tuberculosis (TB) continues to be a major health problem in low- and middle-income countries (LMICs). In 2019, WHO estimated that there were 10 million new cases of TB, and 1.4 million deaths due to TB worldwide (World Health Organization, 2020). At the same time, LMICs face a rapid increase in the burden of noncommunicable diseases such as diabetes mellitus (DM) and cardiovascular diseases (CVD), including coronary heart disease and stroke. More than 75% of cardiovascular deaths occur in LMICs (World Health Organization, 2014).
Source: International Journal of Infectious Diseases - July 2, 2021 Category: Infectious Diseases Authors: Anneline B Seegert, Cecilie B Patsche, Armando Sifna, Victor F Gomes, Christian Wejse, Merete Storgaard, Frauke Rudolf Source Type: research

Vaccination in Older Adults: An Underutilized Opportunity to Promote Healthy Aging in India
AbstractOver the last 50 years, the Indian population aged 50 years and above (older adults) has quadrupled and is expected to comprise 404 million people in 2036, representing 27% of the country ’s projected population. Consequently, the contribution of chronic disease to older adults’ total burden of diseases in India is likely to escalate. Disease burden is notably amplified by immunosenescence, a deterioration of the immune system that develops with age, leading to increasing suscept ibility to infectious diseases and other comorbidities. Older adults with infectious diseases have a higher incidence and likelihood ...
Source: Drugs and Aging - June 14, 2021 Category: Geriatrics Source Type: research

(Ultra-)long-acting insulin analogues for people with type 1 diabetes mellitus
CONCLUSIONS: Comparing insulin detemir with NPH insulin for T1DM showed lower risk of severe hypoglycaemia in favour of insulin detemir (moderate-certainty evidence). However, the 95% prediction interval indicated inconsistency in this finding. Both insulin detemir and insulin glargine compared with NPH insulin did not show benefits or harms for severe nocturnal hypoglycaemia. For all other main outcomes with overall low risk of bias and comparing insulin analogues with each other, there was no true beneficial or harmful effect for any intervention. Data on patient-important outcomes such as QoL, macrovascular and microvas...
Source: Cochrane Database of Systematic Reviews - March 4, 2021 Category: General Medicine Authors: Bianca Hemmingsen Maria-Inti Metzendorf Bernd Richter Source Type: research

Stroke Epidemiology in Oceania: A Review
Conclusions: Stroke is a major healthcare problem in Oceania. Variations in stroke epidemiology are found between countries in Oceania. Data are lacking in some; more research into the burden of stroke in Oceania is needed. With the expected increase in life expectancy and vascular risk factors, the burden of stroke in Oceania will likely rise. Some of the disparities in stroke burden may be addressed by great investment in healthcare.Neuroepidemiology
Source: Neuroepidemiology - February 18, 2021 Category: Epidemiology Source Type: research

Efficacy of individualized education in patients with type 2 diabetes mellitus: A randomized clinical study protocol
Conclusion: Individualized diabetes education may improve the clinical outcomes in patients with type 2 DM. Trial registration: The protocol was registered in Research Registry (researchregistry6232).
Source: Medicine - December 11, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

High BMI: an important health risk factor among older adults in Ghana.
CONCLUSION: Prevalence of obesity and overweight in Ghana is high and increasing, which poses a health risk at the individual and population levels. Inter-sectorial and multidisciplinary measures in line with the national non-communicable disease policies aimed at curbing this trend are imperative. PMID: 33054895 [PubMed - as supplied by publisher]
Source: Public Health Nutrition - October 15, 2020 Category: International Medicine & Public Health Authors: Yorke E, Tetteh J, Boima V, Yawson AE Tags: Public Health Nutr Source Type: research

Risk Factor Control in Stroke Survivors with Diagnosed and Undiagnosed Diabetes: A Ghanaian Registry Analysis
According to the World Health Organization (WHO), more than 80% of worldwide diabetes (DM)-related deaths presently occur in low- and middle- income countries (LMIC). DM-related deaths is projected to double over the next 20 years.1,2 As of 2012, ∼14 million Africans (4.8%) had diabetes mellitus (DM), and 81% were undiagnosed (vs. 50% worldwide), making Africa the continent with the highest proportion of people with undiagnosed DM.3 Projections for sub-Saharan Africa (SSA) indicate diabetes will rise by 71–23.9 million by 2030 (predicted global increase is 37%).
Source: Journal of Stroke and Cerebrovascular Diseases - September 22, 2020 Category: Neurology Authors: Fred Stephen Sarfo, John Akassi, Martin Agyei, Samuel Kontoh, Bruce Ovbiagele Source Type: research

Prevalence of stroke survivors in Parakou in northern Benin: A door-to-door community survey.
CONCLUSION: Our study showed a high prevalence of stroke in Titirou and suggested urgent action for prevention. PMID: 32303341 [PubMed - as supplied by publisher]
Source: Revue Neurologique - April 20, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Educational interventions on nutrition among older adults: A systematic review and meta-analysis of randomized clinical trials
Unhealthy food habits are associated with non-communicable diseases (NCD) [1 –3] and nutritional deficiencies [4]. According to the World Health Organization (WHO) [5], more than half of all deaths were due to ten main causes, with the leading killers being ischaemic heart disease and stroke. Diets characterized by a low intake of fruit and vegetable (FV) and fibre increas e the risk of hypertension, diabetes mellitus (DM), obesity, cardiovascular diseases (CVD), gastrointestinal cancers, nutritional deficiencies, pancreatic diseases, depression and the development of cognitive impairment and dementia [4–7].
Source: Maturitas - March 18, 2020 Category: Primary Care Authors: Felix Jesus Neves, Luciana Yuki Tomita, Angela Sun Li Wu Liu, Solange Andreoni, Luiz Roberto Ramos Source Type: research

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.
CONCLUSIONS: Metformin compared with placebo or diet and exercise reduced or delayed the risk of T2DM in people at increased risk for the development of T2DM (moderate-quality evidence). However, metformin compared to intensive diet and exercise did not reduce or delay the risk of T2DM (moderate-quality evidence). Likewise, the combination of metformin and intensive diet and exercise compared to intensive diet and exercise only neither showed an advantage or disadvantage regarding the development of T2DM (very low-quality evidence). Data on patient-important outcomes such as mortality, macrovascular and microvascular diabe...
Source: Cochrane Database of Systematic Reviews - December 2, 2019 Category: General Medicine Authors: Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B Tags: Cochrane Database Syst Rev Source Type: research

Assessing global COPD awareness with Google Trends
Although chronic obstructive pulmonary disease (COPD) prevalence and mortality rates rise continuously, patients often remain undiagnosed, probably due to a lack of disease-related awareness. The aim of this study was to quantify public interest in COPD by analysing the frequency of web queries via Google. Data from 2004 to 2018 were collected using the search engine query data analysis tool Google Trends. The relative search volume of the topic "chronic obstructive pulmonary disease" was compared with the relative search volume of nine topics representing the major causes of death in high-income countries according to the...
Source: European Respiratory Journal - June 26, 2019 Category: Respiratory Medicine Authors: Boehm, A., Pizzini, A., Sonnweber, T., Loeffler-Ragg, J., Lamina, C., Weiss, G., Tancevski, I. Tags: COPD and smoking Original Articles: COPD Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

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