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Multimorbidity patterns and association with mortality in 0.5 million Chinese adults
CONCLUSION: Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults.PMID:35191418 | DOI:10.1097/CM9.0000000000001985
Source: Chinese Medical Journal - February 22, 2022 Category: General Medicine Authors: Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li China Kadoorie Biobank Collaborative Group Source Type: research

Knockdown of NAA25 Suppresses Breast Cancer Progression by Regulating Apoptosis and Cell Cycle
Front Oncol. 2022 Jan 13;11:755267. doi: 10.3389/fonc.2021.755267. eCollection 2021.ABSTRACTNAA25 gene variants were reported as risk factors for type 1 diabetes, rheumatoid arthritis and acute arterial stroke. But it's unknown whether it could contribute to breast cancer. We identified rs11066150 in lncHSAT164, which contributes to breast cancer, in our earlier genome-wide long non-coding RNA association study on Han Chinese women. However, rs11066150 A/G variant is also located in NAA25 intron. Based on the public database, such as TCGA and Curtis dataset, NAA25 gene is highly expressed in breast cancer tissues and this ...
Source: Cancer Control - January 31, 2022 Category: Cancer & Oncology Authors: Jingkai Xu Zhi Li Xianbo Zuo Guozheng Li Xuejun Zhang Bo Zhang Yong Cui Source Type: research

Development and validation of a nomogram for predicting stroke risk in rheumatoid arthritis patients
In conclusion, the nomogram can be used for individualized preoperative prediction of stroke risk in RA patients.PMID:34081620 | DOI:10.18632/aging.203071
Source: Aging - June 3, 2021 Category: Biomedical Science Authors: Fangran Xin Lingyu Fu Bowen Yang Haina Liu Tingting Wei Cunlu Zou Bingqing Bai Source Type: research

Stroke risk in arthritis: A systematic review and meta-analysis of cohort studies
by Wei Liu, Wei Ma, Hua Liu, Chunyan Li, Yangwei Zhang, Jie Liu, Yu Liang, Sijia Zhang, Zhen Wu, Chenghao Zang, Jianhui Guo, Liyan Li Background and objectiveStroke is a major contributor to the global burden of disease. Although numerous modifiable risk factors (RF) for stroke have been identified, some remain unexplained. Increasing studies have investigated stroke risk in arthritis, but their results are inconsistent. We aimed to synthesize, quantify, and compare the risk of stroke for the major types of arthritis in cohort studies by using a systematic review and meta-analysis approach. MethodsWe searched Chinese and E...
Source: PLoS One - March 16, 2021 Category: Biomedical Science Authors: Wei Liu Source Type: research

The increased risk of atrial fibrillation in inflammatory arthritis: a systematic review and meta-analysis of cohort studies.
Conclusion: Patients with inflammatory arthritis have increased risk of AF, probably due to the underlying chronic inflammation. Although various confounders have been adjusted like medications use and comorbidities, the risk of AF is still significantly increased in inflammatory arthritis patients. Abbreviations: AF: Atrial fibrillation; AS: Ankylosing spondylitis; CI: Confidence interval; HR: Hazard ratio; NOS: Newcastle-Ottawa scale; NSAIDs: Non-steroid anti-inflammatory drugs; PsA: Psoriatic arthritis; RA: Rheumatoid arthritis; SpA: Spondyloarthritis; TNFi: Tumor necrosis factors inhibitor; uSpA: Undifferentiated spond...
Source: Immunological Investigations - February 12, 2021 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Relationships between Chronic Diseases and Depression among Middle-aged and Elderly People in China: A Prospective Study from CHARLS
SummaryGiven the rapid increase in the prevalence of chronic diseases in aging populations, this prospective study including 17 707 adults aged ≥45 years from China Health and Retirement Longitudinal Study was used to estimate the associations between chronic disease, multimorbidity, and depression among middle-aged and elderly adults in China, and explore the mediating factors. Depressive symptoms were assessed using the 10-item Centre f or Epidemiological Studies Depression Scale (CES-D-10) questionnaire. Twelve chronic physical conditions, including hypertension, diabetes, dyslipidemia, cancer, chronic lung disease, l...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 1, 2020 Category: Research Source Type: research

Multimorbidity in Community-Dwelling Older Adults in Beijing: Prevalence and Trends, 2004 –2017
ConclusionsMultimorbidity is common and the overall and age-, sex-, and region-specific multimorbidity prevalence has been increasing over the past 13 years. Public health policies should account for the more complex care needs and growing costs associated with increasing prevalence of chronic disease and multimorbidity in Chinese older adults.
Source: The Journal of Nutrition, Health and Aging - September 14, 2020 Category: Nutrition Source Type: research

Hypertension and comorbidities in rural and urban Chinese older people: an epidemiological sub-analysis from the SAGE study.
CONCLUSIONS: Our study implies that health promotion policies targeting older people should be developed. Rural areas should be a priority, and investment in the quality of healthcare in rural areas is urgently needed. PMID: 32886761 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - September 3, 2020 Category: Cardiology Authors: Li H, Hu YJ, Lin H, Xia H, Guo Y, Wu F Tags: Am J Hypertens Source Type: research

A Review of the Botany, Traditional Use, Phytochemistry, Analytical Methods, Pharmacological Effects, and Toxicity of Angelicae Pubescentis Radix.
Authors: Yang L, Hou A, Wang S, Zhang J, Man W, Guo X, Yang B, Jiang H, Kuang H, Wang Q Abstract Angelicae Pubescentis Radix (AP), as a traditional Chinese medicine (TCM), has been used for thousands of years in China. In this paper, the botany, traditional use, phytochemistry, analytical methods, quality control, pharmacological effects, and toxicity of AP were reviewed. It can provide a reference for the further research and lay a foundation for the rational clinical application of AP. The relevant information on AP was collected from scientific databases (such as Baidu Scholar, CNKI, Google Scholar, PubMed, Scie...
Source: Evidence-based Complementary and Alternative Medicine - August 25, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis
We performed a retrospective cohort study to investigate the association between the risk of ischemic stroke (IS) and the use of Chinese herbal products (CHP) in combination with western medicine (WM) among patients with rheumatoid arthritis (RA). The data were sourced from the registry for beneficiaries, inpatient and ambulatory care claims, and Registry for Catastrophic Illness from the National Health Insurance Research Database (NHIRD) in Taiwan between 1997 and 2011. Patients, who were newly diagnosed with RA between 1997 and 2010, were classified as the CHP group or non-CHP group depending on the presence of absence ...
Source: Frontiers in Pharmacology - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

Use of Chinese herbal medicines by rheumatoid arthritis patients was associated with lower risk of stroke: A retrospective cohort study.
CONCLUSION: The CHMs use was associated with lower risk of stroke for RA patients, suggesting that it could be integrated into conventional therapy to prevent subsequent stroke incident. PMID: 31331548 [PubMed - in process]
Source: Complementary Therapies in Medicine - July 25, 2019 Category: Complementary Medicine Authors: Lai NS, Livneh H, Fan YH, Lu MC, Liao HH, Tsai TY Tags: Complement Ther Med Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

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