Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions

Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and life-threatening disease characterized by a progressive decline in lung function (Gross and Hunninghake, 2001). It is associated with an extremely poor prognosis and limited curative therapies (Raghu et al., 2011; Richeldi et al., 2017), causing the median survival time of patient from diagnosis to 2–4 years and very high lethality (Bjoraker et al., 1998; Ley et al., 2011; Richeldi et al., 2017). The pathogenesis of IPF was hypothesized to be due to the excessive deposition of dysregulated extracellular matrix (ECM) proteins leading to fibroblast proliferation and abnormal re-epithelialization, following alveolar injury and progressive respiratory failure (Wynn and Ramalingam, 2012). Since varieties of chronic respiratory diseases may be accompanied with the remodeling of right ventricle (Fishman, 1976), abnormal lung function also can affect the hea...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 21 January 2020Source: Genes &DiseasesAuthor(s): W.E.I. Zilun, Y.A.N.G. Yining, L.I. Qiaoling, Y.I.N. Yong, W.E.I. Zhonghai, Z.H.A.N.G. Wenfeng, M.U. Dan, N.I. Jie, S.U.N. Xuan, X.U. BiaoAbstract and KeywordsHypertension (HT) is the most common public-health challenge and shows a high incidence around the world. Cardiovascular diseases are the leading cause of mortality and morbidity among the elderly (age> 65 years) in the United States. Now, there is widespread acceptance of the causal link between HT and acute myocardial infarction (MI). This is the first data-mining study to id...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
ConclusionHigh levels of lifestyle-related cancer-risk behaviors were found in most of the Hong Kong construction workers studied. The present study contributes to understanding how cancer-related lifestyle risk behaviors cluster among construction workers and relative impact factors of risk behaviors. It is essential to tailor health behavior interventions focused on multiple risk behaviors among different groups for further enlarging the effects on cancer prevention.
Source: Safety and Health at Work - Category: Occupational Health Source Type: research
Publication date: Available online 21 January 2020Source: Urology Case ReportsAuthor(s): Joseph Santiapillai, Sachin AgrawalAbstractA 61 year old gentleman had a large renal cyst, thought to be causing a ‘pseudo-hydrocalyx’ leading to recurrent stones. Definitive treatment with laparoscopic deroofing was planned, however intra-operatively this was abandoned due to complex anatomy and scared adherent tissue. Patient went on to have a flexible ureteroscopy and ‘through and through’ puncture of an intrarenal cyst with PCNL to treat his stones and renal cyst simultaneously. CT scan 12 months later showe...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
We report one case, in which the patient presented to the emergency department with lower urinary tract symptoms, fever and consumptive syndrome. Acute prostatitis was initially suspected, but subsequently prostate adenocarcinoma was diagnosed.This case enables us to consider the possibility of prostate adenocarcinoma as the diagnose in patients with fever of unknown origin, and the role of procalcitonin to rule out the presence of infection.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Charalampos Fragkoulis, Georgios Papadopoulos, Konstantinos Ntoumas
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Jae Heon Kim, In Gab Jeong
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Taylor P. Kohn, Jaden R. Kohn, Ryan C. Owen, R. Matthew Coward
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Alberto Ferlin
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Chang Wook Jeong, Samuel L. Washington, Annika Herlemann, Scarlett L. Gomez, Peter R. Carroll, Matthew R. CooperbergAbstractBackgroundActive surveillance (AS)/watchful waiting (WW) strategy for localized prostate cancer (PCa) is increasingly and broadly endorsed as a preferred option for initial treatment of men with very low- and low-risk PCa, but outcomes can be difficult to analyze in traditional, population-based registries. The recently released Surveillance, Epidemiology, and End Results (SEER) Prostate with WW dataset provides an op...
Source: European Urology - Category: Urology & Nephrology Source Type: research
.
Source: Social Work in Health Care - Category: International Medicine & Public Health Authors: Source Type: research
More News: Academia | Academies | Anesthesia | Angioplasty | Antidoxidants | Arthritis | Astragalus | Avandia | Biotechnology | Brain | Brain Cancers | Bronchial Tumour | Bronchiolitis | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chemistry | China Health | Chloride | Cholesterol | Complementary Medicine | Computers | Coronary Angioplasty | CT Scan | Databases & Libraries | Dexamethasone | Diabetes | Drugs & Pharmacology | Education | Endocrinology | Epithelial Cancer | Genetics | Glomeruli | Grants | Harvard | Heart | Heart Disease | Heart Transplant | Herbs | Ischemic Stroke | Japan Health | Laboratory Medicine | Liver | Liver Transplant | Lung Cancer | Lung Transplant | Medical Ethics | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Neurosurgery | Oral Cancer | Pathology | Percutaneous Coronary Intervention | PET Scan | Pharmaceuticals | Poland Health | Reproduction Medicine | Respiratory Medicine | Rheumatology | Science | Scleroderma | Sodium | Sodium Chloride | Statin Therapy | Statistics | Stroke | Study | Training | Transplant Surgery | Transplants | Turmeric | Universities & Medical Training | Urology & Nephrology | USA Health | X-Ray