Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway

Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Funding The work was supported by the National Natural Science Foundation of China (81660371), Scientific Research Fund of The Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, Scientific Research Fund of Jiangxi Provincial Education Department (GJJ180792), and Innovative Teamwork Project of Gannan Medical University (TD201707). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Aoyama, E., Watari, I., Podyma-Inoue, K. A., Yanagishita, M., and Ono, T. (2014). Expression of glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells. Int. J. Mol. M...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research